Xin Zhuan Su


Affiliation: National Institutes of Health
Country: USA


  1. Cai B, Wu J, Yu X, Su X, Wang R. FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions. MBio. 2017;8: pubmed publisher
  2. Zhang C, Li Z, Cui H, Jiang Y, Yang Z, Wang X, et al. Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite Development. MBio. 2017;8: pubmed publisher
    ..This study provides expression and functional information for many PyApiAP2 genes, which can be explored for disease management. ..
  3. Yu X, Du Y, Cai C, Cai B, Zhu M, Xing C, et al. Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity. Nat Commun. 2018;9:4964 pubmed publisher
    ..Our study identifies a previously unrecognized role of inflammasome activation in the negative regulation of IFN-I signaling pathways and provides potential targets for developing effective malaria vaccines. ..
  4. Xia L, Wu J, Pattaradilokrat S, Tumas K, He X, Peng Y, et al. Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention. Sci Rep. 2018;8:15280 pubmed publisher
    ..Controlled activation of these pathways may provide important strategies for better disease management and for developing an effective vaccine. ..
  5. Lam N, Long X, Su X, Lu F. Artemisinin and its derivatives in treating helminthic infections beyond schistosomiasis. Pharmacol Res. 2018;133:77-100 pubmed publisher
    ..We concluded that ART and its derivatives are potentially effective drugs for treating various helminthic diseases of public health significance. ..
  6. Nair S, Pattaradilokrat S, Zilversmit M, Dommer J, Nagarajan V, Stephens M, et al. Genome-wide polymorphisms and development of a microarray platform to detect genetic variations in Plasmodium yoelii. Mol Biochem Parasitol. 2014;194:9-15 pubmed publisher
    ..The highly accurate and reliable microarray developed in this study will greatly facilitate our ability to study the genetic basis of important traits and the disease it causes. ..
  7. Wu J, Cai B, Sun W, Huang R, Liu X, Lin M, et al. Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response. Cell Rep. 2015;12:661-72 pubmed publisher
    ..This study demonstrates an effective strategy for studying gene function, establishes a functional gene database, and identifies regulators in IFN-I pathways. ..
  8. Huang B, Deng C, Yang T, Xue L, Wang Q, Huang S, et al. Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy. Parasit Vectors. 2015;8:634 pubmed publisher
    ..Our results provide insights into P. falciparum populations regarding mutations in the gene associated with artemisinin resistance and will be useful for developing and updating anti-malarial guidance in Comoros. ..
  9. Li J, Cai B, Qi Y, Zhao W, Liu J, Xu R, et al. UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies. Malar J. 2016;15:30 pubmed publisher
    ..The discoveries of UTR introns and differentially spliced introns between P. yoelii subspecies raise interesting questions on the potential role of these introns in regulating gene expression and evolution of malaria parasites. ..

More Information


  1. López Barragán M, Lemieux J, Quinones M, Williamson K, Molina Cruz A, Cui K, et al. Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum. BMC Genomics. 2011;12:587 pubmed publisher
    ..Future gene expression studies should make use of directional cDNA libraries. Antisense transcripts may partly explain the observed discrepancy between levels of mRNA and protein expression. ..
  2. Jiang H, Yi M, Mu J, Zhang L, Ivens A, Klimczak L, et al. Detection of genome-wide polymorphisms in the AT-rich Plasmodium falciparum genome using a high-density microarray. BMC Genomics. 2008;9:398 pubmed publisher
    ..Our method for accurate mSFP detection and the mSFP identified will greatly facilitate large-scale studies of genome variation in the P. falciparum parasite and provide useful resources for mapping important parasite traits. ..
  3. Lu F, Jiang H, Ding J, Mu J, Valenzuela J, Ribeiro J, et al. cDNA sequences reveal considerable gene prediction inaccuracy in the Plasmodium falciparum genome. BMC Genomics. 2007;8:255 pubmed
    ..This study provides valuable information for genome annotation that will be critical for functional analyses. ..
  4. Yu X, Cai B, Wang M, Tan P, Ding X, Wu J, et al. Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality. Immunity. 2016;45:1093-1107 pubmed publisher
    ..Thus, our findings have identified a critical regulatory mechanism of type I IFN signaling in pDCs and stage-specific function of immune cells in generating potent immunity against lethal YM infection. ..
  5. Nair S, Xu R, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, et al. A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence. Nat Commun. 2017;8:223 pubmed publisher
    ..Here the authors comparatively map virulence loci using the offspring from a P. yoelii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance. ..
  6. Lacerda Queiroz N, Riteau N, Eastman R, Bock K, Orandle M, Moore I, et al. Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model. Sci Rep. 2017;7:10438 pubmed publisher