Charles A Strott

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms
    Hirotoshi Fuda
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Biochem J 365:497-504. 2002
  2. ncbi Sulfonation and molecular action
    Charles A Strott
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Endocr Rev 23:703-32. 2002
  3. ncbi Cholesterol sulfate in human physiology: what's it all about?
    Charles A Strott
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4510, USA
    J Lipid Res 44:1268-78. 2003
  4. ncbi Cloning, characterization and tissue expression of rat SULT2B1a and SULT2B1b steroid/sterol sulfotransferase isoforms: divergence of the rat SULT2B1 gene structure from orthologous human and mouse genes
    Atsushi Kohjitani
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, The National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4510, USA
    Gene 367:66-73. 2006
  5. ncbi Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition
    Young C Lee
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 4510, USA
    FEBS Lett 579:3639-45. 2005
  6. ncbi Oxysterols are substrates for cholesterol sulfotransferase
    Hirotoshi Fuda
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4510, USA
    J Lipid Res 48:1343-52. 2007
  7. ncbi Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes
    Yuko Higashi
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    J Invest Dermatol 122:1207-13. 2004
  8. ncbi Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of RORα
    Osamu Hanyu
    Section on Steroid Regulation, the Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Biochem Biophys Res Commun 428:99-104. 2012
  9. ncbi Expression of cholesterol sulfotransferase (SULT2B1b) in human platelets
    Hidekatsu Yanai
    Section on Steroid Regulation, Endocrinology, and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4510, USA
    Circulation 109:92-6. 2004
  10. ncbi Regulation of SULT2B1a (pregnenolone sulfotransferase) expression in rat C6 glioma cells: relevance of AMPA receptor-mediated NO signaling
    Atsushi Kohjitani
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Neurosci Lett 430:75-80. 2008

Collaborators

Detail Information

Publications15

  1. ncbi Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms
    Hirotoshi Fuda
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Biochem J 365:497-504. 2002
    ..In contrast, expression of PAPS synthase 1 is relatively low in the cartilage of immature guinea-pigs, including the growth plate of long bones, whereas PAPS synthase 2 is the highly expressed isoenzyme...
  2. ncbi Sulfonation and molecular action
    Charles A Strott
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Endocr Rev 23:703-32. 2002
    ....
  3. ncbi Cholesterol sulfate in human physiology: what's it all about?
    Charles A Strott
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4510, USA
    J Lipid Res 44:1268-78. 2003
    ..The accumulating evidence demonstrating a regulatory function for cholesterol sulfate appears solid; the challenge now is to work out the molecular mechanisms whereby this interesting molecule carries out its various roles...
  4. ncbi Cloning, characterization and tissue expression of rat SULT2B1a and SULT2B1b steroid/sterol sulfotransferase isoforms: divergence of the rat SULT2B1 gene structure from orthologous human and mouse genes
    Atsushi Kohjitani
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, The National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4510, USA
    Gene 367:66-73. 2006
    ..Furthermore, unlike the case with human and mouse SULT2B1 genes where differential splicing is necessitated since a portion of exon IA is fused with exon IB to complete the SULT2B1b mRNA, this step is not required with the rat gene...
  5. ncbi Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition
    Young C Lee
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 4510, USA
    FEBS Lett 579:3639-45. 2005
    ..Sp1 and Sp2 transcription factors identified by supershift analyses induced reporter gene activity, an effect markedly augmented by histone deacetylase inhibition...
  6. ncbi Oxysterols are substrates for cholesterol sulfotransferase
    Hirotoshi Fuda
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4510, USA
    J Lipid Res 48:1343-52. 2007
    ..Thus, SULT2B1b, by acting on a variety of oxysterols, offers a potential pathway for modulating in vivo the injurious effects of these compounds...
  7. ncbi Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes
    Yuko Higashi
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    J Invest Dermatol 122:1207-13. 2004
    ..Additionally, 88% of cholesterol sulfate in NHEK was membrane-associated further suggesting a cellular location for cholesterol sulfate action...
  8. ncbi Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of RORα
    Osamu Hanyu
    Section on Steroid Regulation, the Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Biochem Biophys Res Commun 428:99-104. 2012
    ..In conclusion, the results of this study indicate that cholesterol sulfate induces filaggrin expression through increased RORα expression. Further studies are required to fully elucidate the mechanisms involved...
  9. ncbi Expression of cholesterol sulfotransferase (SULT2B1b) in human platelets
    Hidekatsu Yanai
    Section on Steroid Regulation, Endocrinology, and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4510, USA
    Circulation 109:92-6. 2004
    ..Among its many demonstrated regulatory actions is its ability to influence blood clotting and fibrinolysis. Additionally, cholesterol sulfate is a constituent of human platelets, where it has been shown to support platelet aggregation...
  10. ncbi Regulation of SULT2B1a (pregnenolone sulfotransferase) expression in rat C6 glioma cells: relevance of AMPA receptor-mediated NO signaling
    Atsushi Kohjitani
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Neurosci Lett 430:75-80. 2008
    ..These findings suggest that expression of SULT2B1a, which catalyzes PREGS production, is inhibited by activation of excitatory amino acid receptors of the AMPA subtype, via facilitation of intracellular NO signaling...
  11. ncbi Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms
    Karen A Lee
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:44593-9. 2003
    ..In addition, the amino-terminal helix comprising residues Asp19 to Lys26, which determines the specificity difference between the SULT2B1 isoforms, becomes ordered upon pregnenolone binding, covering the substrate binding pocket...
  12. ncbi Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase
    Hirotoshi Fuda
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Biol Chem 277:36161-6. 2002
    ..Thus, if the gene for SULT2B1 employs exon 1B, cholesterol sulfotransferase is synthesized, whereas if exon 1A is used, pregnenolone sulfotransferase is produced...
  13. ncbi Conservation of the hydroxysteroid sulfotransferase SULT2B1 gene structure in the mouse: pre- and postnatal expression, kinetic analysis of isoforms, and comparison with prototypical SULT2A1
    Chikara Shimizu
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, The National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Endocrinology 144:1186-93. 2003
    ....
  14. ncbi Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina
    Jung Wha Lee
    Section on Mechanisms of Retinal Diseases, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Eye Res 83:465-9. 2006
    ..These data, when taken in context of the known functions of CYP27A1 imply that expression in the retina serves to modify the biological activity of oxidized sterols that are either transported or generated locally by photo-oxidation...
  15. ncbi Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2
    Chikara Shimizu
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 4510, U S A
    Biochem J 363:263-71. 2002
    ..Co-transfection experiments using SL2 cells yielded additional support for the involvement of Sp1 in transcriptional regulation of the PAPS synthase 2 gene; the involvement of Sp2 and/or Sp3 remains to be clarified further...