R L Strausberg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Tumor microenvironments, the immune system and cancer survival
    Robert L Strausberg
    J, Craig Venter Institute, 9, 704 Medical Center Drive, Rockville, MD 20850, USA
    Genome Biol 6:211. 2005
  2. ncbi request reprint The cancer genome anatomy project: online resources to reveal the molecular signatures of cancer
    Robert L Strausberg
    National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Invest 20:1038-50. 2002
  3. pmc Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
    Robert L Strausberg
    National Cancer Institute, Bethessda, MD 20892 2580, USA
    Proc Natl Acad Sci U S A 99:16899-903. 2002
  4. ncbi request reprint An international database and integrated analysis tools for the study of cancer gene expression
    R L Strausberg
    National Cancer Institute, Bethesda, MD 20892, USA
    Pharmacogenomics J 2:156-64. 2002
  5. ncbi request reprint From knowing to controlling: a path from genomics to drugs using small molecule probes
    Robert L Strausberg
    Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Bethesda, MD 20892, USA
    Science 300:294-5. 2003
  6. ncbi request reprint Sequence-based cancer genomics: progress, lessons and opportunities
    Robert L Strausberg
    National Cancer Institute, 31 Center Drive, Room 10A07, Bethesda, Maryland 20892, USA
    Nat Rev Genet 4:409-18. 2003
  7. ncbi request reprint In silico analysis of cancer through the Cancer Genome Anatomy Project
    R L Strausberg
    National Cancer Institute, Bethesda, MD 20892, USA
    Trends Cell Biol 11:S66-71. 2001
  8. ncbi request reprint The Cancer Genome Anatomy Project: new resources for reading the molecular signatures of cancer
    R L Strausberg
    National Cancer Institute, Bethesda MD 20892, USA
    J Pathol 195:31-40. 2001
  9. ncbi request reprint A new cancer genome anatomy project web resource for the community
    C Schaefer
    Center for Bioinformatics, National Cancer Institute, Bethesda, Maryland 20892-2590, USA
    Cancer J 7:52-60. 2001
  10. ncbi request reprint Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysis
    C Leethanakul
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, 30 Convent Drive, Building 30, Room 212, Bethesda, MD 20892 4340, USA
    Oral Oncol 39:248-58. 2003

Detail Information

Publications43

  1. pmc Tumor microenvironments, the immune system and cancer survival
    Robert L Strausberg
    J, Craig Venter Institute, 9, 704 Medical Center Drive, Rockville, MD 20850, USA
    Genome Biol 6:211. 2005
    ..Recent microarray analyses of lymphomas suggest that the prognosis of cancer patients is related to an interplay between cancer cells and their microenvironment, including the immune response...
  2. ncbi request reprint The cancer genome anatomy project: online resources to reveal the molecular signatures of cancer
    Robert L Strausberg
    National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Invest 20:1038-50. 2002
  3. pmc Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
    Robert L Strausberg
    National Cancer Institute, Bethessda, MD 20892 2580, USA
    Proc Natl Acad Sci U S A 99:16899-903. 2002
    ..All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov)...
  4. ncbi request reprint An international database and integrated analysis tools for the study of cancer gene expression
    R L Strausberg
    National Cancer Institute, Bethesda, MD 20892, USA
    Pharmacogenomics J 2:156-64. 2002
    ..A suite of informatics tools was designed to facilitate in silico analysis of the gene expression datasets and are available through the NCI Cancer Genome Anatomy Project web site (http://cgap.nci.nih.gov)...
  5. ncbi request reprint From knowing to controlling: a path from genomics to drugs using small molecule probes
    Robert L Strausberg
    Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Bethesda, MD 20892, USA
    Science 300:294-5. 2003
    ..The information generated with such tools should provide a critical link from genomic discovery to drug development...
  6. ncbi request reprint Sequence-based cancer genomics: progress, lessons and opportunities
    Robert L Strausberg
    National Cancer Institute, 31 Center Drive, Room 10A07, Bethesda, Maryland 20892, USA
    Nat Rev Genet 4:409-18. 2003
    ....
  7. ncbi request reprint In silico analysis of cancer through the Cancer Genome Anatomy Project
    R L Strausberg
    National Cancer Institute, Bethesda, MD 20892, USA
    Trends Cell Biol 11:S66-71. 2001
    ....
  8. ncbi request reprint The Cancer Genome Anatomy Project: new resources for reading the molecular signatures of cancer
    R L Strausberg
    National Cancer Institute, Bethesda MD 20892, USA
    J Pathol 195:31-40. 2001
    ..The CGAP web site (http://cgap.nci.nih.gov) provides informatics tools for in silico analysis of the CGAP datasets as well as information for accessing each of the CGAP resources. Published in 2001 by John Wiley & Sons, Ltd...
  9. ncbi request reprint A new cancer genome anatomy project web resource for the community
    C Schaefer
    Center for Bioinformatics, National Cancer Institute, Bethesda, Maryland 20892-2590, USA
    Cancer J 7:52-60. 2001
    ..One of the newest features of the CGAP web site is an electronic version of the Mitelman Database of Chromosome Aberrations in Cancer...
  10. ncbi request reprint Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysis
    C Leethanakul
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, 30 Convent Drive, Building 30, Room 212, Bethesda, MD 20892 4340, USA
    Oral Oncol 39:248-58. 2003
    ....
  11. pmc The Cancer Genome Anatomy Project: EST sequencing and the genetics of cancer progression
    D B Krizman
    Cancer Genome Anatomy Project, Office of the Director, National Cancer Institute, Bethesda, MD, USA
    Neoplasia 1:101-6. 1999
    ..Whereas acquiring the comprehensive molecular analysis of cancer progression may take years, results from initial, short-term goals are currently being realized and are proving very fruitful...
  12. pmc SAGEmap: a public gene expression resource
    A E Lash
    National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894 USA
    Genome Res 10:1051-60. 2000
    ....
  13. pmc The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: linkage of chromosomal aberrations with the genome sequence
    Turid Knutsen
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Genes Chromosomes Cancer 44:52-64. 2005
    ..These resources, developed as a part of the Cancer Chromosome Aberration Project (CCAP) initiative, aid the search for new cancer-associated genes and foster insights into the causes and consequences of genetic alterations in cancer...
  14. ncbi request reprint Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative
    Steven L Klein
    Developmental Biology, Genetics and Teratology Branch, National Institute of Child Health and Human Development, Rockville, Maryland 20852, USA
    Dev Dyn 225:384-91. 2002
    ..This review describes the status of these projects and explains how to access their data and resources. Current information about these activities is available on the NIH Xenopus Web site (http://www.nih.gov/science/models/xenopus/)...
  15. pmc Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas
    Stephen J Chanock
    Section of Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4605, USA
    Breast Cancer Res 9:R5. 2007
    ....
  16. ncbi request reprint Cancer Molecular Analysis Project: weaving a rich cancer research tapestry
    Kenneth H Buetow
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 1:315-8. 2002
    ....
  17. ncbi request reprint Large-scale transcriptional activity in chromosomes 21 and 22
    Philipp Kapranov
    Affymetrix, Santa Clara, CA 95051, USA, National Cancer Institute, Bethesda, MD 20892, USA
    Science 296:916-9. 2002
    ..When compared with the sequence annotations available for these chromosomes, it is noted that as much as an order of magnitude more of the genomic sequence is transcribed than accounted for by the predicted and characterized exons...
  18. ncbi request reprint Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptome
    Ashani T Weeraratna
    Laboratory of Immunology, National Institutes of Health, The National Institute on Aging, Baltimore, MD 21224, USA
    Oncogene 23:2264-74. 2004
    ..This may provide insights into new genes that may be useful for the diagnosis and therapy of melanoma...
  19. ncbi request reprint A preliminary transcriptome map of non-small cell lung cancer
    Takeshi Fujii
    Laboratory of Population Genetics, Center for Cancer Research, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 62:3340-6. 2002
    ..Integrating chromosomal mapping information with gene expression profiles may help reveal novel molecular changes associated with human lung cancer...
  20. pmc Evaluation of non-formalin tissue fixation for molecular profiling studies
    John W Gillespie
    Pathogenetics Unit, Laboratory of Pathology, National Cancer Institute, Rm 2C500 Bldg 10, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Am J Pathol 160:449-57. 2002
    ..Complete protocols and additional discussion of relevant issues are available on an accompanying website (http://cgap-mf.nih.gov/)...
  21. pmc The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags
    Helena Brentani
    Laboratório de Genética Molecular do Câncer, Departmento de Radiologia, Universidade de Sao Paulo, Travessa da Rua Dr Ovídeo Pires de Campos S N, 4deg, Brazil
    Proc Natl Acad Sci U S A 100:13418-23. 2003
    ....
  22. pmc Genetic variation in an individual human exome
    Pauline C Ng
    J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000160. 2008
    ..We present an approach to analyze the coding variation in humans by proposing multiple bioinformatic methods to hone in on possible functional variation...
  23. pmc The diploid genome sequence of an individual human
    Samuel Levy
    J Craig Venter Institute, Rockville, Maryland, USA
    PLoS Biol 5:e254. 2007
    ..These data depict a definitive molecular portrait of a diploid human genome that provides a starting point for future genome comparisons and enables an era of individualized genomic information...
  24. pmc An anatomy of normal and malignant gene expression
    Kathy Boon
    Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 99:11287-92. 2002
    ..We report here an easily accessible view of nearly any gene's expression in a wide variety of malignant and normal tissues...
  25. pmc An integrated genomic analysis of human glioblastoma multiforme
    D Williams Parsons
    Ludwig Center for Cancer Genetics and Therapeutics, and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1807-12. 2008
    ..These studies demonstrate the value of unbiased genomic analyses in the characterization of human brain cancer and identify a potentially useful genetic alteration for the classification and targeted therapy of GBMs...
  26. pmc Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data
    Anita Grigoriadis
    Ludwig Institute for Cancer Research University College London Breast Cancer Laboratory, 91 Riding House Street, London, W1W 7BS, UK
    Breast Cancer Res 8:R56. 2006
    ....
  27. pmc High expression of a cytokeratin-associated protein in many cancers
    Kristi A Egland
    South Dakota Health Research Foundation Signal Transduction Institute, University of South Dakota School of Medicine and Sioux Valley Hospitals and Health System, Sioux Falls, SD 57105, USA
    Proc Natl Acad Sci U S A 103:5929-34. 2006
    ..We name the protein CAPC, cytokeratin-associated protein in cancer...
  28. pmc An atlas of human gene expression from massively parallel signature sequencing (MPSS)
    C Victor Jongeneel
    Office of Information Technology, Ludwig Institute for Cancer Research, and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
    Genome Res 15:1007-14. 2005
    ..The data are available on the Web at http://mpss.licr.org and http://sgb.lynxgen.com...
  29. pmc Comprehensive sampling of gene expression in human cell lines with massively parallel signature sequencing
    C Victor Jongeneel
    Office of Information Technology, Ludwig Institute for Cancer Research, and Swiss Institute of Bioinformatics, 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 100:4702-5. 2003
    ....
  30. pmc Identification of cancer/testis-antigen genes by massively parallel signature sequencing
    Yao Tseng Chen
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:7940-5. 2005
    ..Thus, MPSS analysis has resulted in a significant extension of our knowledge of CT antigens, leading to the discovery of a distinctive X-linked CT-antigen gene family...
  31. ncbi request reprint ORESTES are enriched in rare exon usage variants affecting the encoded proteins
    Noboru Jo Sakabe
    Ludwig Institute for Cancer Research, Sao Paulo Branch, Rua Prof Antonio Prudente 109, 4 o andar, 01509 010, Sao Paulo, Brazil
    C R Biol 326:979-85. 2003
    ..It is shown here that ORESTES probe low abundant messages more efficiently. In addition, most of the variants detected by ORESTES affect the structure of the corresponding proteins...
  32. ncbi request reprint Mutation of GATA3 in human breast tumors
    Jerry Usary
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Oncogene 23:7669-78. 2004
    ..These data suggest that GATA3 is involved in growth control and the maintenance of the differentiated state in epithelial cells, and that GATA3 variants may contribute to tumorigenesis in ESR1-positive breast tumors...
  33. ncbi request reprint Oncogenomics and the development of new cancer therapies
    Robert L Strausberg
    Department of Mammalian Genomics, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 2085, USA
    Nature 429:469-74. 2004
    ..A systematic and coordinated approach, with the results freely available, should speed up progress. This will best be accomplished through an international academic and pharmaceutical oncogenomics initiative...
  34. pmc Integrative annotation of 21,037 human genes validated by full-length cDNA clones
    Tadashi Imanishi
    Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan
    PLoS Biol 2:e162. 2004
    ..The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology...
  35. ncbi request reprint Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes
    Kathy Boon
    Department of Pathology, Duke University Medical Center, Box 3156, Durham NC 27710, USA
    Oncogene 22:7687-94. 2003
    ..The genes highly expressed in the medulloblastoma include PRAME, a cancer-testis antigen and potential targets for immunotherapy...
  36. doi request reprint Emerging DNA sequencing technologies for human genomic medicine
    Robert L Strausberg
    J Craig Venter Institute, Rockville, MD 20850, USA
    Drug Discov Today 13:569-77. 2008
    ....
  37. ncbi request reprint Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  38. ncbi request reprint Promoting transcriptome diversity
    Robert L Strausberg
    The J Craig Venter Institute, Rockville, Maryland 20850, USA
    Genome Res 17:965-8. 2007
    ..Much attention is currently focused on understanding the role of alternative promoters in generating transcript diversity, both for non-protein-encoding (ncRNAs) and protein-encoding RNAs...
  39. ncbi request reprint Evolutionary and biomedical insights from the rhesus macaque genome
    Richard A Gibbs
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
    Science 316:222-34. 2007
    ..The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species...
  40. pmc The Sorcerer II Global Ocean Sampling expedition: northwest Atlantic through eastern tropical Pacific
    Douglas B Rusch
    J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Biol 5:e77. 2007
    ..Specific functional adaptations can be identified both within individual ribotypes and across the entire community, including proteorhodopsin spectral tuning and the presence or absence of the phosphate-binding gene PstS...
  41. pmc The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families
    Shibu Yooseph
    J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Biol 5:e16. 2007
    ..Our analysis indicates that new families are being discovered at a rate that is linear or almost linear with the addition of new sequences, implying that we are still far from discovering all protein families in nature...
  42. pmc Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
    Vikki Rand
    Department of Neurosurgery, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 102:14344-9. 2005
    ..Our results demonstrate the utility of applying DNA sequencing technology to systematically assess the coding sequence of genes within cancer genomes...
  43. ncbi request reprint Ancient noncoding elements conserved in the human genome
    Byrappa Venkatesh
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    Science 314:1892. 2006
    ..The ancient vertebrate-specific CNEs in the elephant shark and human genomes are likely to play key regulatory roles in vertebrate gene expression...