Research Topics
| R L StrausbergSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Tumor microenvironments, the immune system and cancer survivalRobert L Strausberg
J, Craig Venter Institute, 9, 704 Medical Center Drive, Rockville, MD 20850, USA
Genome Biol 6:211. 2005..Recent microarray analyses of lymphomas suggest that the prognosis of cancer patients is related to an interplay between cancer cells and their microenvironment, including the immune response...
The cancer genome anatomy project: online resources to reveal the molecular signatures of cancerRobert L Strausberg
National Cancer Institute, Bethesda, MD 20892, USA
Cancer Invest 20:1038-50. 2002- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequencesRobert L Strausberg
National Cancer Institute, Bethessda, MD 20892 2580, USA
Proc Natl Acad Sci U S A 99:16899-903. 2002..All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov)... - An international database and integrated analysis tools for the study of cancer gene expressionR L Strausberg
National Cancer Institute, Bethesda, MD 20892, USA
Pharmacogenomics J 2:156-64. 2002..A suite of informatics tools was designed to facilitate in silico analysis of the gene expression datasets and are available through the NCI Cancer Genome Anatomy Project web site (http://cgap.nci.nih.gov)... - From knowing to controlling: a path from genomics to drugs using small molecule probesRobert L Strausberg
Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Bethesda, MD 20892, USA
Science 300:294-5. 2003..The information generated with such tools should provide a critical link from genomic discovery to drug development... - Sequence-based cancer genomics: progress, lessons and opportunitiesRobert L Strausberg
National Cancer Institute, 31 Center Drive, Room 10A07, Bethesda, Maryland 20892, USA
Nat Rev Genet 4:409-18. 2003.... - In silico analysis of cancer through the Cancer Genome Anatomy ProjectR L Strausberg
National Cancer Institute, Bethesda, MD 20892, USA
Trends Cell Biol 11:S66-71. 2001.... - The Cancer Genome Anatomy Project: new resources for reading the molecular signatures of cancerR L Strausberg
National Cancer Institute, Bethesda MD 20892, USA
J Pathol 195:31-40. 2001..The CGAP web site (http://cgap.nci.nih.gov) provides informatics tools for in silico analysis of the CGAP datasets as well as information for accessing each of the CGAP resources. Published in 2001 by John Wiley & Sons, Ltd... - A new cancer genome anatomy project web resource for the communityC Schaefer
Center for Bioinformatics, National Cancer Institute, Bethesda, Maryland 20892-2590, USA
Cancer J 7:52-60. 2001..One of the newest features of the CGAP web site is an electronic version of the Mitelman Database of Chromosome Aberrations in Cancer... - Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysisC Leethanakul
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, 30 Convent Drive, Building 30, Room 212, Bethesda, MD 20892-4340, USA
Oral Oncol 39:248-58. 2003.... - The Cancer Genome Anatomy Project: EST sequencing and the genetics of cancer progressionD B Krizman
Cancer Genome Anatomy Project, Office of the Director, National Cancer Institute, Bethesda, MD, USA
Neoplasia 1:101-6. 1999..Whereas acquiring the comprehensive molecular analysis of cancer progression may take years, results from initial, short-term goals are currently being realized and are proving very fruitful... - SAGEmap: a public gene expression resourceA E Lash
National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894 USA
Genome Res 10:1051-60. 2000.... - The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: linkage of chromosomal aberrations with the genome sequenceTurid Knutsen
Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Genes Chromosomes Cancer 44:52-64. 2005..These resources, developed as a part of the Cancer Chromosome Aberration Project (CCAP) initiative, aid the search for new cancer-associated genes and foster insights into the causes and consequences of genetic alterations in cancer... - Genetic and genomic tools for Xenopus research: The NIH Xenopus initiativeSteven L Klein
Developmental Biology, Genetics and Teratology Branch, National Institute of Child Health and Human Development, Rockville, Maryland 20852, USA
Dev Dyn 225:384-91. 2002..This review describes the status of these projects and explains how to access their data and resources. Current information about these activities is available on the NIH Xenopus Web site (http://www.nih.gov/science/models/xenopus/)... - Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomasStephen J Chanock
Section of Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4605, USA
Breast Cancer Res 9:R5. 2007.... - Cancer Molecular Analysis Project: weaving a rich cancer research tapestryKenneth H Buetow
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cancer Cell 1:315-8. 2002.... - Large-scale transcriptional activity in chromosomes 21 and 22Philipp Kapranov
Affymetrix, Santa Clara, CA 95051, USA, National Cancer Institute, Bethesda, MD 20892, USA
Science 296:916-9. 2002..When compared with the sequence annotations available for these chromosomes, it is noted that as much as an order of magnitude more of the genomic sequence is transcribed than accounted for by the predicted and characterized exons... - Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptomeAshani T Weeraratna
Laboratory of Immunology, National Institutes of Health, The National Institute on Aging, Baltimore, MD 21224, USA
Oncogene 23:2264-74. 2004..This may provide insights into new genes that may be useful for the diagnosis and therapy of melanoma... - A preliminary transcriptome map of non-small cell lung cancerTakeshi Fujii
Laboratory of Population Genetics, Center for Cancer Research, NIH, Bethesda, Maryland 20892, USA
Cancer Res 62:3340-6. 2002..Integrating chromosomal mapping information with gene expression profiles may help reveal novel molecular changes associated with human lung cancer... - Evaluation of non-formalin tissue fixation for molecular profiling studiesJohn W Gillespie
Pathogenetics Unit, Laboratory of Pathology, National Cancer Institute, Rm. 2C500. Bldg. 10, 9000 Rockville Pike, Bethesda, MD 20892, USA
Am J Pathol 160:449-57. 2002..Complete protocols and additional discussion of relevant issues are available on an accompanying website (http://cgap-mf.nih.gov/)... - The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tagsHelena Brentani
, Departmento de Radiologia, , , 4deg, Brazil
Proc Natl Acad Sci U S A 100:13418-23. 2003.... - Genetic variation in an individual human exomePauline C Ng
J Craig Venter Institute, Rockville, Maryland, United States of America
PLoS Genet 4:e1000160. 2008..We present an approach to analyze the coding variation in humans by proposing multiple bioinformatic methods to hone in on possible functional variation... - The diploid genome sequence of an individual humanSamuel Levy
J Craig Venter Institute, Rockville, Maryland, USA
PLoS Biol 5:e254. 2007..These data depict a definitive molecular portrait of a diploid human genome that provides a starting point for future genome comparisons and enables an era of individualized genomic information... - An anatomy of normal and malignant gene expressionKathy Boon
Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 99:11287-92. 2002..We report here an easily accessible view of nearly any gene's expression in a wide variety of malignant and normal tissues... - An integrated genomic analysis of human glioblastoma multiformeD Williams Parsons
Ludwig Center for Cancer Genetics and Therapeutics, and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
Science 321:1807-12. 2008..These studies demonstrate the value of unbiased genomic analyses in the characterization of human brain cancer and identify a potentially useful genetic alteration for the classification and targeted therapy of GBMs... - Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression dataAnita Grigoriadis
Ludwig Institute for Cancer Research University College London Breast Cancer Laboratory, 91 Riding House Street, London, W1W 7BS, UK
Breast Cancer Res 8:R56. 2006.... - High expression of a cytokeratin-associated protein in many cancersKristi A Egland
South Dakota Health Research Foundation Signal Transduction Institute, University of South Dakota School of Medicine and Sioux Valley Hospitals and Health System, Sioux Falls, SD 57105, USA
Proc Natl Acad Sci U S A 103:5929-34. 2006..We name the protein CAPC, cytokeratin-associated protein in cancer... - An atlas of human gene expression from massively parallel signature sequencing (MPSS)C Victor Jongeneel
Office of Information Technology, Ludwig Institute for Cancer Research, and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
Genome Res 15:1007-14. 2005..The data are available on the Web at http://mpss.licr.org and http://sgb.lynxgen.com... - Comprehensive sampling of gene expression in human cell lines with massively parallel signature sequencingC Victor Jongeneel
Office of Information Technology, Ludwig Institute for Cancer Research, and Swiss Institute of Bioinformatics, 1066 Epalinges, Switzerland
Proc Natl Acad Sci U S A 100:4702-5. 2003.... - Identification of cancer/testis-antigen genes by massively parallel signature sequencingYao Tseng Chen
Weill Medical College of Cornell University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:7940-5. 2005..Thus, MPSS analysis has resulted in a significant extension of our knowledge of CT antigens, leading to the discovery of a distinctive X-linked CT-antigen gene family... - ORESTES are enriched in rare exon usage variants affecting the encoded proteinsNoboru Jo Sakabe
Ludwig Institute for Cancer Research, Sao Paulo Branch, Rua Prof Antonio Prudente 109, 4(o) andar, 01509-010, Sao Paulo, Brazil
C R Biol 326:979-85. 2003..It is shown here that ORESTES probe low abundant messages more efficiently. In addition, most of the variants detected by ORESTES affect the structure of the corresponding proteins... - Mutation of GATA3 in human breast tumorsJerry Usary
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
Oncogene 23:7669-78. 2004..These data suggest that GATA3 is involved in growth control and the maintenance of the differentiated state in epithelial cells, and that GATA3 variants may contribute to tumorigenesis in ESR1-positive breast tumors... - Oncogenomics and the development of new cancer therapiesRobert L Strausberg
Department of Mammalian Genomics, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 2085, USA
Nature 429:469-74. 2004..A systematic and coordinated approach, with the results freely available, should speed up progress. This will best be accomplished through an international academic and pharmaceutical oncogenomics initiative... - Integrative annotation of 21,037 human genes validated by full-length cDNA clonesTadashi Imanishi
Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan
PLoS Biol 2:e162. 2004..The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology... - Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genesKathy Boon
Department of Pathology, Duke University Medical Center, Box 3156, Durham NC 27710, USA
Oncogene 22:7687-94. 2003..The genes highly expressed in the medulloblastoma include PRAME, a cancer-testis antigen and potential targets for immunotherapy... 
Emerging DNA sequencing technologies for human genomic medicineRobert L Strausberg
J Craig Venter Institute, Rockville, MD 20850, USA
Drug Discov Today 13:569-77. 2008....- Evolution of genes and genomes on the Drosophila phylogenyAndrew G Clark
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Nature 450:203-18. 2007..These may prove to underlie differences in the ecology and behaviour of these diverse species... - Promoting transcriptome diversityRobert L Strausberg
The J Craig Venter Institute, Rockville, Maryland 20850, USA
Genome Res 17:965-8. 2007..Much attention is currently focused on understanding the role of alternative promoters in generating transcript diversity, both for non-protein-encoding (ncRNAs) and protein-encoding RNAs... - Evolutionary and biomedical insights from the rhesus macaque genomeRichard A Gibbs
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
Science 316:222-34. 2007..The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species... - The Sorcerer II Global Ocean Sampling expedition: northwest Atlantic through eastern tropical PacificDouglas B Rusch
J Craig Venter Institute, Rockville, Maryland, United States of America
PLoS Biol 5:e77. 2007..Specific functional adaptations can be identified both within individual ribotypes and across the entire community, including proteorhodopsin spectral tuning and the presence or absence of the phosphate-binding gene PstS... - The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein familiesShibu Yooseph
J Craig Venter Institute, Rockville, Maryland, United States of America
PLoS Biol 5:e16. 2007..Our analysis indicates that new families are being discovered at a rate that is linear or almost linear with the addition of new sequences, implying that we are still far from discovering all protein families in nature... - Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomasVikki Rand
Department of Neurosurgery, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 102:14344-9. 2005..Our results demonstrate the utility of applying DNA sequencing technology to systematically assess the coding sequence of genes within cancer genomes... - Ancient noncoding elements conserved in the human genomeByrappa Venkatesh
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
Science 314:1892. 2006..The ancient vertebrate-specific CNEs in the elephant shark and human genomes are likely to play key regulatory roles in vertebrate gene expression...