Research Topics
Genomes and Genes
| R E StraubSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genesR E Straub
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
Mol Psychiatry 7:542-59. 2002..However, our internal replications, when considered along with the positive results obtained in multiple other samples, suggests that most of these six regions are likely to contain genes that influence liability to schizophrenia...
Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophreniaRichard E Straub
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
Am J Hum Genet 71:337-48. 2002..We conclude that further investigation of dysbindin is warranted...- Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expressionR E Straub
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, NIH, US Department of Health and Human Services, Bethesda, MD 20892 1379, USA
Mol Psychiatry 12:854-69. 2007..These coincident results implicate GAD1 in the etiology of schizophrenia and suggest that the mechanism involves altered cortical GABA inhibitory activity, perhaps modulated by dopaminergic function... - Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further studyR E Straub
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 1534, USA
Mol Psychiatry 4:129-44. 1999.... - A schizophrenia locus may be located in region 10p15-p11R E Straub
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond 23219 1534, USA
Am J Med Genet 81:296-301. 1998..When evaluated in the context of our genome scan results, the evidence suggests the possibility of a fourth vulnerability locus for schizophrenia in these Irish families, in region 10p15-p11... - An association study of DRD5 with smoking initiation and progression to nicotine dependenceP F Sullivan
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Am J Med Genet 105:259-65. 2001..These data are not consistent with a strong etiological role for DRD5 in the etiology of these complex smoking behaviors... - Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophreniaKristin K Nicodemus
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
Hum Genet 120:889-906. 2007..In addition, we were able to replicate other studies, including allelic directionality. The use of epistatic models may improve replication of psychiatric candidate gene studies... - Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)M C Gornick
Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892 1600, USA
J Autism Dev Disord 35:831-8. 2005..Four adjacent SNPs were associated (p values=.0009-.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment... - The trimmed-haplotype test for linkage disequilibriumC J MacLean
Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298, USA
Am J Hum Genet 66:1062-75. 2000..We present a method for summarizing the LD evidence, in any pedigree, that can be employed in trimmed-haplotype analysis as well as in other methods... - Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: evidence for possible etiologic heterogeneityK S Kendler
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond 23298 0126, USA
Am J Psychiatry 154:191-8. 1997..The authors sought to determine whether the clinical manifestations of schizophrenia and other psychotic disorders are correlated in affected sibling pairs... - Sibling correlation of deficit syndrome in the Irish study of high-density schizophrenia familiesD E Ross
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0710, USA
Am J Psychiatry 157:1071-6. 2000..Little is known about the familial or genetic aspects of the deficit syndrome. The purpose of this study was to determine whether deficit versus nondeficit subtypes are correlated in sibling pairs affected with schizophrenia... - Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigreesK S Kendler
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
Am J Med Genet 88:29-33. 1999..Thus, in Irish families selected for a high density of schizophrenia, M-M LD may be very common within 0.5 cM and frequent up to distances of 2 cM... - Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish familiesR E Straub
Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond 23298, USA
Mol Psychiatry 2:148-55. 1997..Comparison of individual family multipoint H-LOD scores at the regions of interest on chromosomes 6p, 8p and 5q showed that only a minority of families yield high lod scores in two or three regions... - Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group IIID F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA
Am J Hum Genet 67:652-63. 2000..0038). More-modest support for linkage was observed for chromosome 10p, with logistic-regression analysis of linkage producing an empirical P=. 045 and with significant evidence for intersample heterogeneity (empirical P=.0096)... - Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia FamiliesK S Kendler
Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0710, USA
Am J Psychiatry 157:402-8. 2000..Recent linkage studies suggest that multiple genes are important in the etiology of schizophrenia. The authors examined the hypothesis of whether the clinical variability in schizophrenia is due to genetic heterogeneity... - Analysis of epistasis in linked regions in the Irish study of high-density schizophrenia familiesP F Sullivan
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Am J Med Genet 105:266-70. 2001..No correlation reached our a priori level of statistical significance. Using this statistical approach, we did not find evidence of important epistatic effects among these six regions in the ISHDSF... - Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophreniaM F Egan
Clinical Brain Disorders Branch, Building 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:6917-22. 2001..These data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia... - Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependenceP F Sullivan
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Am J Med Genet 105:479-84. 2001..If these results replicate in other samples, the serotonergic system may be involved in the etiology of smoking initiation given the rate-limiting role of TPH in the biosynthesis of serotonin... - Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependenceM A Silverman
Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23219 1534, USA
Am J Med Genet 96:646-53. 2000..None of the four polymorphisms we tested, nor their estimated haplotypes, were associated with smoking initiation or progression to nicotine dependence... - Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association studyAyman H Fanous
Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Am J Med Genet B Neuropsychiatr Genet 125:69-78. 2004..However, given prior evidence of involvement of the proteins encoded by these genes in psychopathology, our results suggest that more attention should be focused on the impact of these alleles on clinical features of schizophrenia... - Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patientsCynthia Shannon Weickert
MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
Schizophr Res 98:105-10. 2008..Our results indicate that previously reported dysbindin-1 protein reductions may be due in part to decreased dysbindin-1 mRNA and that reduced dysbindin-1 may contribute to hippocampal formation synaptic pathology in schizophrenia... - Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaMichael F Egan
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:12604-9. 2004..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia... 
Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia riskK K Nicodemus
Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Mol Psychiatry 13:873-7. 2008....- Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia FamiliesK S Kendler
Departments of Psychiatry and Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
Am J Psychiatry 153:1534-40. 1996..This study was an attempt to replicate evidence for a vulnerability locus for schizophrenia and associated disorders in the 8p22-21 region reported by Pulver and colleagues... - GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume lossA M Addington
Child Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
Mol Psychiatry 10:581-8. 2005..These observations, when taken together with the positive results reported recently in two independent adult-onset schizophrenia pedigree samples, suggest that the gene encoding GAD67 may be a common risk factor for schizophrenia... - Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1Shiny V Mathew
Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
Hum Mol Genet 16:2921-32. 2007..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression... - Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controlsCatherine M Diaz-Asper
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 63:72-9. 2008..Recently, other single nucleotide polymorphisms (SNPs) across the gene have emerged as additional risk factors for schizophrenia: namely rs737865, rs165599, and rs2097603. In a large sample, we examined whether these SNPs affect WM... - Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controlsKristin K Nicodemus
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 67:991-1001. 2010..NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis... - Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophreniaCynthia Shannon Weickert
MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
Hum Mol Genet 17:2293-309. 2008..Thus, the variation in the ESR1 gene is associated with schizophrenia and the mechanism of this association may involve alternative gene regulation and transcript processing... - Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specifiedAnjene M Addington
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1600, USA
Biol Psychiatry 55:976-80. 2004..Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder... - Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humansHao Yang Tan
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 118:2200-8. 2008..These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis... - Support for association between ADHD and two candidate genes: NET1 and DRD1Aaron J Bobb
Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1600, USA
Am J Med Genet B Neuropsychiatr Genet 134:67-72. 2005..Because family-based and case-control methods gave divergent results, both should be used in genetic studies of ADHD... - The G72/G30 gene complex and cognitive abnormalities in schizophreniaTerry E Goldberg
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
Neuropsychopharmacology 31:2022-32. 2006..We present evidence that SNP variations in the G72 gene region increase risk of cognitive impairment in schizophrenia. SNP variations were not strongly associated with clinical diagnosis in family-based analyses... - Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalizationYukihiko Iizuka
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1385, USA
J Neurosci 27:12390-5. 2007..Such an increase in DRD2 signaling relative to DRD1 would contribute to the imbalances in dopaminergic neurotransmission characteristic of schizophrenia... - Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha geneLiang Huo
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 62:925-33. 2007..Premenstrual dysphoric disorder (PMDD) is a heritable mood disorder that is triggered by gonadal steroids during the luteal phase in susceptible women... - Genetic variation in CACNA1C affects brain circuitries related to mental illnessKristin L Bigos
Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 67:939-45. 2010..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored... - GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophreniaX Chen
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
Mol Psychiatry 16:1117-29. 2011..On the basis of these results, we concluded that CMYA5 is associated with schizophrenia and further investigation of the gene is warranted... - Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophreniaR Hashimoto
Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Mol Psychiatry 9:299-307. 2004..Subtle abnormalities in the expression patterns of NRG-1 mRNA isoforms in DLPFC may be associated with schizophrenia... - RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activityBarbara K Lipska
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1385, USA
Hum Mol Genet 15:2804-12. 2006..These data suggest that RGS4 mRNA expression is associated with cortical dopamine signaling and illustrate the importance of genetic and/or environmental background in gene expression studies in schizophrenia... - Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and functionLucas Kempf
Department of Health and Human Services, Unit of Systems Neuroscience in Psychiatry, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Genet 4:e1000252. 2008..Our findings suggest a role for functional genetic variation in POX on neostriatal-frontal circuits mediating risk and protection for schizophrenia... - Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortexStefano Marenco
Genes and Cognition Program, Clinical Brain Disorders Branch, Intramural Research Program, Bldg 10, Rm 4S235, 10 Center Dr, NIMH, NIH, Bethesda, MD 20892, USA
Am J Psychiatry 163:740-2. 2006.... - Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPsBarbara K Lipska
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Hum Mol Genet 15:1245-58. 2006..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia... - Allelic variation in RGS4 impacts functional and structural connectivity in the human brainJoshua W Buckholtz
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
J Neurosci 27:1584-93. 2007..These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness... - Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrainCynthia Shannon Weickert
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Arch Gen Psychiatry 61:544-55. 2004..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain... - Variation in DISC1 affects hippocampal structure and function and increases risk for schizophreniaJoseph H Callicott
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:8627-32. 2005.... - Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMTStefano Marenco
Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:1708-17. 2010..The directionality of the effects, however, is inconsistent with earlier evidence of decreased GABA activity in schizophrenia... - Genetic variation in FGF20 modulates hippocampal biologyHerve Lemaitre
Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 30:5992-7. 2010..These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging... - Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness?Alexandra L Sporn
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 55:989-94. 2004..In this study, we compared evidence for premorbid PDD as a nonspecific manifestation of impaired neurodevelopment seen in schizophrenia, or as an independent risk factor for COS... - The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphologyLukas Pezawas
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
J Neurosci 24:10099-102. 2004.... - Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognitionAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
J Clin Invest 117:672-82. 2007..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia... - SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteinsS C Borinstein
Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
Cell Signal 12:769-79. 2000..Evidence that SETA binds to the CD2 protein, the proto-oncogene c-Cbl, and the signal transduction molecule Grb2, and can dimerize via its C-terminal coiled coil (CC) domain is also presented... - Candidate genes for nicotine dependence via linkage, epistasis, and bioinformaticsPatrick F Sullivan
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA, USA
Am J Med Genet B Neuropsychiatr Genet 126:23-36. 2004..Although the hypotheses resulting from these linkage and bioinformatic analyses are plausible and intriguing, their ultimate worth depends on replication in additional linkage samples and in future experimental studies... - The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophreniaMitsuyuki Matsumoto
Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
Proc Natl Acad Sci U S A 105:6133-8. 2008..Our data implicate SREB2 as a potential risk factor for psychiatric disorders and its pathway as a target for psychiatric therapy... - Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high-density familiesAyman H Fanous
Washington VA Medical Center, Washington, DC, USA
Biol Psychiatry 64:121-7. 2008..Genetic heterogeneity may decrease the signal-to-noise ratio in linkage and association studies. Therefore, linkage studies of clinically homogeneous classes of psychotic illness may result in greater power to detect at least some loci... - Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophreniaIlya Chumakov
Genset S A, F 91030 Evry, France
Proc Natl Acad Sci U S A 99:13675-80. 2002.... - Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: SchizophreniaCathryn M Lewis
Division of Genetics and Development, Guy's, King's and St Thomas' School of Medicine, London, UK
Am J Hum Genet 73:34-48. 2003..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations... - Schizophrenia genes - famine to feastRichard E Straub
Biol Psychiatry 60:81-3. 2006 - Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samplesMichael E Talkowski
Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 60:152-62. 2006..Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles... - Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the diseaseAmanda J Law
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
Proc Natl Acad Sci U S A 103:6747-52. 2006..These data implicate variation in isoform expression as a molecular mechanism for the genetic association of NRG1 with schizophrenia... - Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophreniaTadahiro Numakawa
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashicho, Kodaira, Tokyo 187 8502, Japan
Hum Mol Genet 13:2699-708. 2004..Genetic variants associated with impairments of these functions of dysbindin could play an important role in the pathogenesis of schizophrenia... - A genome-wide scan for modifier loci in schizophreniaAyman H Fanous
Washington VA Medical Center, Washington, DC 20422, USA
Am J Med Genet B Neuropsychiatr Genet 144:589-95. 2007..06. We conclude that genes located near 9q33.1 and 14q24.2 may modify the clinical course and severity of schizophrenia. A gene in 6q may affect several clinical features of illness...