Mark Stopfer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Sparse odor representation and olfactory learning
    Iori Ito
    National Institute of Child Health and Human Development, US National Institutes of Health, Building 35, Room 3A 102, Bethesda, Maryland 20982, USA
    Nat Neurosci 11:1177-84. 2008
  2. ncbi Olfactory processing: massive convergence onto sparse codes
    Mark Stopfer
    NIH NICHD, 35 Lincoln Drive, Rm 3A 102, msc 3715, Bethesda, Maryland 20892, USA
    Curr Biol 17:R363-4. 2007
  3. ncbi Frequency transitions in odor-evoked neural oscillations
    Iori Ito
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 64:692-706. 2009
  4. ncbi Spontaneous olfactory receptor neuron activity determines follower cell response properties
    Joby Joseph
    National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, MD, USA
    J Neurosci 32:2900-10. 2012
  5. ncbi Temporally diverse firing patterns in olfactory receptor neurons underlie spatiotemporal neural codes for odors
    Baranidharan Raman
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:1994-2006. 2010
  6. ncbi Olfactory coding: tagging and tuning odor-activated synapses for memory
    Zane N Aldworth
    NIH NICHD, Bethesda, MD 20892 USA
    Curr Biol 22:R227-9. 2012
  7. ncbi Dual-labeling method for electron microscopy to characterize synaptic connectivity using genetically encoded fluorescent reporters in Drosophila
    Nobuaki K Tanaka
    National Institutes of Health, National Institute of Child Health and Human Development, 35 Lincoln Drive, msc 3715, Bethesda, MD 20892, USA
    J Neurosci Methods 194:312-5. 2011
  8. ncbi Peripheral and central olfactory tuning in a moth
    Rose C Ong
    National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Rm 3A 102, msc 3715, Bethesda, MD 20892, USA
    Chem Senses 37:455-61. 2012
  9. ncbi Olfactory coding: giant inhibitory neuron governs sparse odor codes
    Nitin Gupta
    National Institutes of Health, National Institute of Child Health and Human Development, Building 35, 35 Lincoln Drive, Rm 3A 102, msc 3715, Bethesda, MD 20892, USA
    Curr Biol 21:R504-6. 2011
  10. ncbi Functional analysis of a higher olfactory center, the lateral horn
    Nitin Gupta
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 32:8138-48. 2012

Collaborators

Detail Information

Publications21

  1. ncbi Sparse odor representation and olfactory learning
    Iori Ito
    National Institute of Child Health and Human Development, US National Institutes of Health, Building 35, Room 3A 102, Bethesda, Maryland 20982, USA
    Nat Neurosci 11:1177-84. 2008
    ..Thus, spikes in Kenyon cells do not constitute the odor representation that coincides with reinforcement, and Hebbian spike timing-dependent plasticity in Kenyon cells alone cannot underlie this learning...
  2. ncbi Olfactory processing: massive convergence onto sparse codes
    Mark Stopfer
    NIH NICHD, 35 Lincoln Drive, Rm 3A 102, msc 3715, Bethesda, Maryland 20892, USA
    Curr Biol 17:R363-4. 2007
    ..Sparse neural coding provides numerous computational advantages. A recent analysis of the locust olfactory system has revealed a surprising circuit solution for achieving remarkably sparse and specific neural representations of odors...
  3. ncbi Frequency transitions in odor-evoked neural oscillations
    Iori Ito
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 64:692-706. 2009
    ..Thus, in the periphery, concentration is encoded mainly by the size of the responsive ORN population, and oscillation frequency is set by the adaptation and saturation of this response...
  4. ncbi Spontaneous olfactory receptor neuron activity determines follower cell response properties
    Joby Joseph
    National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, MD, USA
    J Neurosci 32:2900-10. 2012
    ..Our results show how the olfactory system benefits from making a signal detection decision after a point of maximal information convergence, e.g., after KCs pool inputs from many PNs...
  5. ncbi Temporally diverse firing patterns in olfactory receptor neurons underlie spatiotemporal neural codes for odors
    Baranidharan Raman
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:1994-2006. 2010
    ..Thus, our results demonstrate the origin and subsequent reformatting of spatiotemporal neural codes for odors...
  6. ncbi Olfactory coding: tagging and tuning odor-activated synapses for memory
    Zane N Aldworth
    NIH NICHD, Bethesda, MD 20892 USA
    Curr Biol 22:R227-9. 2012
    ..A recent study in the locust olfactory system shows how neuromodulators can alter the rules of synaptic plasticity to form associative memories through the use of 'tagged' synapses...
  7. ncbi Dual-labeling method for electron microscopy to characterize synaptic connectivity using genetically encoded fluorescent reporters in Drosophila
    Nobuaki K Tanaka
    National Institutes of Health, National Institute of Child Health and Human Development, 35 Lincoln Drive, msc 3715, Bethesda, MD 20892, USA
    J Neurosci Methods 194:312-5. 2011
    ....
  8. ncbi Peripheral and central olfactory tuning in a moth
    Rose C Ong
    National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Rm 3A 102, msc 3715, Bethesda, MD 20892, USA
    Chem Senses 37:455-61. 2012
    ..Together, these results suggest that, although nonpheromonal host plant odors activate broadly distributed responses, they may be linked to attractive behaviors mainly through specific wiring in the brain...
  9. ncbi Olfactory coding: giant inhibitory neuron governs sparse odor codes
    Nitin Gupta
    National Institutes of Health, National Institute of Child Health and Human Development, Building 35, 35 Lincoln Drive, Rm 3A 102, msc 3715, Bethesda, MD 20892, USA
    Curr Biol 21:R504-6. 2011
    ..Electrophysiological investigations in locusts have revealed that the sparseness of odor representations, in the brain region expected to mediate olfactory learning, is shaped by a unique inhibitory neuron...
  10. ncbi Functional analysis of a higher olfactory center, the lateral horn
    Nitin Gupta
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 32:8138-48. 2012
    ..Our results rather point to three other possible roles of LHNs: extracting general stimulus features such as odor intensity; mediating bilateral integration of sensory information; and integrating multimodal sensory stimuli...
  11. ncbi Bilateral olfaction: two is better than one for navigation
    Baranidharan Raman
    National Institute of Child Health and Human Development, NIH, Lincoln Drive, Bethesda, MD 20892, USA
    Genome Biol 9:212. 2008
    ....
  12. ncbi Insect olfactory coding and memory at multiple timescales
    Nitin Gupta
    NIH NICHD, Bethesda, MD 20892, USA
    Curr Opin Neurobiol 21:768-73. 2011
    ..Our sampling of the olfactory system emphasizes the diversity of memories, and the importance of understanding these memories in the context of computations performed by different parts of a sensory system...
  13. ncbi Olfactory coding: non-linear amplification separates smells
    Baranidharan Raman
    National Institutes of Health, National Institute of Child Health and Human Development, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
    Curr Biol 18:R29-32. 2008
    ....
  14. ncbi Odor-evoked neural oscillations in Drosophila are mediated by widely branching interneurons
    Nobuaki K Tanaka
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:8595-603. 2009
    ..We found only the more widely branching population of LNs is necessary for generating odor-elicited oscillations...
  15. ncbi Olfactory coding: a plastic approach to timing precision
    Rebecca L Vislay Meltzer
    National Institutes of Health, National Institute of Child Health and Human Development, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
    Curr Biol 17:R797-9. 2007
    ..Spike-timing dependent plasticity has been associated with neural development, learning, and memory. Recently, this mechanism was found to stabilize spike timing relationships across populations of neurons in the locust olfactory system...
  16. ncbi Olfactory coding: inhibition reshapes odor responses
    Mark Stopfer
    Laboratory of Cellular and Synaptic Neurophysiology, NICHD, Porter Neuroscience Research Center, Building 35, Room 3A-102, 35 Convent Drive, MSC 3712, Bethesda, Maryland, USA
    Curr Biol 15:R996-8. 2005
    ..Olfactory information is dramatically restructured as it makes its way through the brain. Recent work using a remarkable experimental preparation has revealed how this transformation is achieved...
  17. ncbi Encoding a temporally structured stimulus with a temporally structured neural representation
    Stacey L Brown
    National Institute of Child Health and Human Development, US National Institutes of Health, Building 35, Room 3A 102, Bethesda, Maryland 20892, USA
    Nat Neurosci 8:1568-76. 2005
    ..Thus, ensemble-based spatiotemporal coding could disambiguate complex and potentially confounding temporally structured sensory stimuli and thereby provide an invariant response to a stimulus presented in various ways...
  18. ncbi Fast odor learning improves reliability of odor responses in the locust antennal lobe
    Maxim Bazhenov
    The Salk Institute for Biological Studies, Computational Neurobiology Laboratory, La Jolla, California 92037, USA
    Neuron 46:483-92. 2005
    ..Thus, our study suggests that fast olfactory learning results from stimulus-specific, activity-dependent synaptic facilitation and may improve the signal-to-noise ratio for repeatedly encountered odor stimuli...
  19. ncbi Adaptive regulation of sparseness by feedforward inhibition
    Collins Assisi
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 10:1176-84. 2007
    ..This simple adaptive mechanism could maintain the sparseness of sensory representations across wide ranges of stimulus conditions...
  20. ncbi Synaptic learning rules and sparse coding in a model sensory system
    Luca A Finelli
    Computational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS Comput Biol 4:e1000062. 2008
    ....
  21. ncbi Intensity versus identity coding in an olfactory system
    Mark Stopfer
    California Institute of Technology, Division of Biology, Computation and Neural Systems Program, Pasadena, CA 91125, USA
    Neuron 39:991-1004. 2003
    ..The tuning of KCs to identity and concentration and the patterning of their responses are consistent with piecewise decoding of their PN inputs over oscillation-cycle length epochs...