Research Topics
Genomes and GenesSpecies | Rachael Z Stolzenberg-SolomonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Meat and meat-mutagen intake and pancreatic cancer risk in the NIH-AARP cohortRachael Z Stolzenberg-Solomon
National Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health Human Services, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 16:2664-75. 2007..006) increased risk in men and women combined. These findings support the hypothesis that meat intake, particularly meat cooked at high temperatures and associated mutagens, may play a role in pancreatic cancer development...
Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, ChinaRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
Cancer Epidemiol Biomarkers Prev 12:1222-6. 2003..59; 95% CI, 1.04-2.42). No association was observed for GCA. Our results suggest that the MTHFR C677T and MTRR A66G polymorphisms influence the risk of ESCC and GCA in this population...
Effects of a low fat, high fiber-carbohydrate diet on components of the IGF axis measured in plasma: a controlled feeding study in menRachael Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7232, USA
Cancer Epidemiol Biomarkers Prev 13:1086-7. 2004
Insulin-like growth factor (IGF)-1, IGF-binding protein-3, and pancreatic cancer in male smokersRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 13:438-44. 2004..Our results do not support the hypothesis that serum IGF-1 and IGFBP-3 concentrations are associated with pancreatic cancer risk among male smokers. Further studies are necessary to evaluate these associations in other populations...
A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokersRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health Human Services, Rockville, Maryland 20852, USA
Cancer Res 66:10213-9. 2006..Our results are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer...
Serum vitamin D and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian screening trialRachael Z Stolzenberg-Solomon
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, NIH, Rockville, Maryland 20852, USA
Cancer Res 69:1439-47. 2009..015). We did not confirm the previous strong positive association between 25(OH)D and pancreatic cancer; however, the increased risk among participants with low residential UVB exposure is similar...
Vitamin E intake, alpha-tocopherol status, and pancreatic cancer in a cohort of male smokersRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health Human Services, Rockville, MD, USA
Am J Clin Nutr 89:584-91. 2009..Evidence indicates that vitamin E has anticarcinogenic properties for gastrointestinal cancers; however, few studies have examined this with respect to exocrine pancreatic cancer...
Insulin, glucose, insulin resistance, and pancreatic cancer in male smokersRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20852, USA
JAMA 294:2872-8. 2005..Obesity, diabetes mellitus, and glucose intolerance have been associated with increased pancreatic cancer risk; however, prediagnostic serum insulin concentration has not been evaluated as a predictor of this malignancy...
Vitamin D and pancreatic cancerRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health Human Services, Rockville, MD, USA
Ann Epidemiol 19:89-95. 2009..More research is needed, particularly examination of pre-diagnostic vitamin D status and risk of pancreatic cancer, prior to conclusions for vitamin D's potential role in the etiology of this highly fatal cancer...
Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 320, Rockville, MD 20852, USA
Am J Clin Nutr 83:895-904. 2006..Several epidemiologic studies suggest that higher folate intakes are associated with lower breast cancer risk, particularly in women with moderate alcohol consumption...
Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health CohortRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Am J Epidemiol 167:586-97. 2008..53, 95% CI: 1.13, 5.65; p(trend) = 0.04) in women but not men. The authors observed no association with physical activity. Their results suggest a positive association between adiposity and pancreatic cancer...
Tooth loss, pancreatic cancer, and Helicobacter pyloriRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Clin Nutr 78:176-81. 2003..In addition, Helicobacter pylori has been found in dental plaque and has been associated with periodontal disease and pancreatic cancer...
Prediagnostic adiponectin concentrations and pancreatic cancer risk in male smokersRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Suite 320, Bethesda, MD 20852, USA
Am J Epidemiol 168:1047-55. 2008..lowest, odds ratio = 0.55, 95% confidence interval: 0.31, 0.98; P-trend = 0.03). These results support the hypothesis that higher adiponectin concentrations may be inversely associated with the development of pancreatic cancer...
Helicobacter pylori seropositivity as a risk factor for pancreatic cancerR Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics and Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA
J Natl Cancer Inst 93:937-41. 2001....
Prospective study of diet and pancreatic cancer in male smokersRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
Am J Epidemiol 155:783-92. 2002..03 (p trend = 0.02), respectively). These results support the hypothesis that a high intake of saturated fat may increase the risk of pancreatic cancer in smokers, while greater intakes of energy and carbohydrate may reduce the risk...
Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older populationR Z Stolzenberg-Solomon
Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
Am J Clin Nutr 69:467-75. 1999..Previous studies identified suboptimal nutritional status and dietary intake of folate, vitamin B-6, and vitamin B-12 as determinants of elevated tHcy...
A prospective study of medical conditions, anthropometry, physical activity, and pancreatic cancer in male smokers (Finland)Rachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7026, USA
Cancer Causes Control 13:417-26. 2002..To examine the association between several medical conditions, anthropometric measurements, occupational and leisure physical activity, and pancreatic cancer in a cohort of male Finnish smokers...
Dietary and other methyl-group availability factors and pancreatic cancer risk in a cohort of male smokersR Z Stolzenberg-Solomon
Cancer Prevention Studies Branch, Division of Clinical Science, National Cancer Institute, Bethesda, MD 20892, USA
Am J Epidemiol 153:680-7. 2001..10, 3.03; p-trend = 0.05). These results support the hypothesis that dietary folate intake is inversely associated with the risk of pancreatic cancer and confirm the risk associated with greater cigarette smoking...
Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokersR Z Stolzenberg-Solomon
Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA
J Natl Cancer Inst 91:535-41. 1999..Whether biochemical indicators of methyl-group availability are associated with exocrine pancreatic cancer risk was the focus of this investigation...
Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer CancersKathy J Helzlsouer
Mercy Medical Center, Baltimore, MD 21202, USA
Am J Epidemiol 172:4-9. 2010..The results of this study have application for the planning and conduct of intervention trials, especially in determining potential risks...
Tooth loss is associated with increased risk of gastric non-cardia adenocarcinoma in a cohort of Finnish smokersChristian C Abnet
Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Scand J Gastroenterol 40:681-7. 2005..pylori seropositivity...
Available carbohydrates, glycemic load, and pancreatic cancer: is there a link?Cari L Meinhold
National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Am J Epidemiol 171:1174-82. 2010..Rather than being causal, the short-term increase in pancreatic cancer risk associated with high available carbohydrate and low fat intake may be capturing dietary changes associated with subclinical disease...
Serum C-reactive protein and risk of pancreatic cancer in two nested, case-control studiesJason B Douglas
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
Cancer Epidemiol Biomarkers Prev 20:359-69. 2011..Many epidemiologic studies have examined the association between C-reactive protein (CRP) and risk of cancer with inconsistent results...
Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer CancersLisa Gallicchio
Mercy Medical Center, Baltimore, Maryland 21202, USA
Am J Epidemiol 172:10-20. 2010..This consortium approach permits estimation of the association between 25(OH)D and several rarer cancers with high accuracy and precision across a wide range of 25(OH)D concentrations...
Evidence that serum levels of the soluble receptor for advanced glycation end products are inversely associated with pancreatic cancer risk: a prospective studyLi Jiao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Cancer Res 71:3582-9. 2011..46 (0.23-0.73), P(trend) = 0.002]. Further adjustment for glucose or insulin levels did not change the observed associations. Our findings suggest that sRAGE is inversely associated with pancreatic cancer risk among Finnish male smokers...
Advanced glycation end products, soluble receptor for advanced glycation end products, and risk of colorectal cancerLi Jiao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 20:1430-8. 2011..AGEs induce oxidative stress and inflammation via the receptor for AGEs (RAGE) and soluble RAGE (sRAGE) can neutralize the effects mediated by RAGE-ligand engagement...
Alcohol use and risk of pancreatic cancer: the NIH-AARP Diet and Health StudyLi Jiao
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Am J Epidemiol 169:1043-51. 2009..41, 95% CI: 1.01, 2.00). These findings suggest a moderately increased pancreatic cancer risk with heavy alcohol use, particularly liquor; however, residual confounding by cigarette smoking cannot be completely excluded...
Mitochondrial DNA copy number and pancreatic cancer in the alpha-tocopherol beta-carotene cancer prevention studyShannon M Lynch
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
Cancer Prev Res (Phila) 4:1912-9. 2011..14, 95% CI = 0.53-2.45, continuous OR = 1.05, 95% CI = 0.93-1.18). Our results support the hypothesis that mtDNA copy number is associated with pancreatic cancer and could possibly serve as a biomarker for pancreatic cancer development...
Flavonoid intake and risk of pancreatic cancer in male smokers (Finland)Gerd Bobe
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Boulevard, Room 3022, Rockville, MD 20852 7232, USA
Cancer Epidemiol Biomarkers Prev 17:553-62. 2008..Our data suggest that a flavonoid-rich diet may decrease pancreatic cancer risk in male smokers not consuming supplemental alpha-tocopherol and/or beta-carotene...
A prospective study of physical activity and the risk of pancreatic cancer among women (United States)Brook A Calton
Division of Cancer Epidemiology and Genetics, NCI NIH, Rockville, MD, USA
BMC Cancer 8:63. 2008..Several epidemiologic studies have examined the association between physical activity and pancreatic cancer risk; however, the results of these studies are not consistent...
Pancreatic cancer and exposure to dietary nitrate and nitrite in the NIH-AARP Diet and Health StudyBriseis Aschebrook-Kilfoy
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
Am J Epidemiol 174:305-15. 2011..These results provide modest evidence that processed meat sources of dietary nitrate and nitrite may be associated with pancreatic cancer among men and provide no support for the hypothesis in women...
Predictors of fasting serum insulin and glucose and the risk of pancreatic cancer in smokersCari L Meinhold
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, 6120 Executive Blvd, Rockville, MD 20852, USA
Cancer Causes Control 20:681-90. 2009..A history of type 2 diabetes is one of few consistent risk factors for pancreatic cancer. Potentially modifiable factors related to fasting insulin and glucose concentrations may influence pancreatic cancer risk...
Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer CancersRachael Z Stolzenberg-Solomon
National Cancer Institute, Bethesda, Maryland 20852, USA
Am J Epidemiol 172:81-93. 2010..12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered...
Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health studyAnne C M Thiebaut
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
J Natl Cancer Inst 101:1001-11. 2009..Previous research relating dietary fat, a modifiable risk factor, to pancreatic cancer has been inconclusive...
Atrophic gastritis and the risk of incident colorectal cancerAdeyinka O Laiyemo
Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD, USA
Cancer Causes Control 21:163-70. 2010..We prospectively examined the association of atrophic gastritis, a pre-malignant condition for gastric cancer and long-term sequelae common to many exposure factors, and the risk of incident CRC...
Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohortsLi Jiao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Cancer Causes Control 21:1305-14. 2010..To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes...
Folate intake, post-folic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialBrietta M Oaks
Nutritional Epidemiology Branch, the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Am J Clin Nutr 91:449-55. 2010..Folate plays a critical role in DNA methylation, synthesis, and repair. Several epidemiologic studies suggest that higher folate intake is associated with decreased pancreatic cancer risk...
Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort studyAdeyinka O Laiyemo
Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
Cancer Epidemiol 33:368-73. 2009..We hypothesized that low SPGI level may be associated with an increased risk of pancreatic cancer and be a useful biomarker for the disease...
Serum creatinine and prostate cancer risk in a prospective studyStephanie J Weinstein
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 18:2643-9. 2009..We evaluated whether serum creatinine concentration was associated with risk of developing prostate cancer in a prospective cohort of male smokers...
Intakes of red meat, processed meat, and meat mutagens increase lung cancer riskTram Kim Lam
Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, NIH, Department of Health and Human Services, corrected Bethesda, Maryland 20892 7236, USA
Cancer Res 69:932-9. 2009..In summary, red meat, processed meat, and meat mutagens were independently associated with increased risk of lung cancer...
Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)Eric J Jacobs
Department of Epidemiology, American Cancer Society, Atlanta, GA, USA
Int J Cancer 127:1421-8. 2010..47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study...
Meat and meat-related compounds and risk of prostate cancer in a large prospective cohort study in the United StatesRashmi Sinha
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Am J Epidemiol 170:1165-77. 2009..There were no clear associations for fatal prostate cancer. Red and processed meat may be positively associated with prostate cancer via mechanisms involving heme iron, nitrite/nitrate, grilling/barbecuing, and benzo[a]pyrene...
Fat, fiber, fruits, vegetables, and risk of colorectal adenomasAleyamma Mathew
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Int J Cancer 108:287-92. 2004..Increased intake of dietary fiber was associated with a moderately decreased risk of adenomas...
Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortiumJoanne W Elena
Division of Cancer Control and Population Science, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Causes Control 24:13-25. 2013..This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan)...
Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortiumShannon M Lynch
National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
Am J Epidemiol 170:403-13. 2009..This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis...
Impact of circulating vitamin D binding protein levels on the association between 25-hydroxyvitamin D and pancreatic cancer risk: a nested case-control studyStephanie J Weinstein
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20982, USA
Cancer Res 72:1190-8. 2012..Simultaneous examination of DBP and 25(OH)D may be important in determining the association of vitamin D with cancer risk...
Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trialJason B Douglas
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
Cancer Epidemiol Biomarkers Prev 19:2298-306. 2010..Increased IGF-II and decreased IGF binding protein (IGFBP)-3 serum concentrations have been linked to a number of other cancers...
A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer riskJeanine M Genkinger
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Int J Cancer 129:1708-17. 2011..03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer...
Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic womenUnhee Lim
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA
Gastroenterology 134:47-55. 2008..We examined genomic methylation of leukocyte DNA in relation to colorectal adenoma (CRA) among asymptomatic women (40-79 years of age) participating in a multicenter colonoscopy screening study (CONCeRN Study, 2000-2002)...
Leukocyte polycyclic aromatic hydrocarbon-DNA adduct formation and colorectal adenomaMarc J Gunter
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Division of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 28:1426-9. 2007..8 (95% CI, 1.2-6.5; P(trend) = 0.048) for risk of colorectal adenoma. These data support a link between PAH exposure and colorectal adenoma...
Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokersMargaret E Wright
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
Am J Epidemiol 160:68-76. 2004..14), 0.91 (95% CI: 0.79, 1.05), 0.79 (95% CI: 0.68, 0.92), and 0.84 (95% CI: 0.72, 0.98) (p for trend = 0.002). These findings support the hypothesis that a combination of dietary antioxidants reduces lung cancer risk in male smokers...
Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis CNeal D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Hepatology 50:1360-9. 2009..Tea intake was not associated with outcomes. CONCLUSION: In a large prospective study of participants with advanced hepatitis C-related liver disease, regular coffee consumption was associated with lower rates of disease progression...
A correlation study of organochlorine levels in serum, breast adipose tissue, and gluteal adipose tissue among breast cancer cases in IndiaJennifer A Rusiecki
Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, EPS 8111, Bethesda, MD 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 14:1113-24. 2005..However, such measurements are a combination of both recent exposures and past exposures, which have metabolized slowly and may still persist. Therefore, investigators should use caution when assigning a level as lifetime body burden...
Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control studyMarc J Gunter
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, EPS, 6120 Executive Boulevard, Rockville, MD 20852, USA
Carcinogenesis 26:637-42. 2005..49 (95% CI, 0.28-0.85)]. We did not identify any association with consumption of individual HCAs and colorectal adenoma risk. These results support the hypothesis that BP contributes to colorectal carcinogenesis...
Meat and meat-mutagen intake and risk of non-Hodgkin lymphoma: results from a NCI-SEER case-control studyAmanda J Cross
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
Carcinogenesis 27:293-7. 2006..39 (0.22-0.70); P trend = 0.004]. Overall, our study suggests that consumption of meat, whether or not it is well-done, does not increase the risk of NHL. Furthermore, neither HCAs nor B[a]P from meat increase the risk of NHL...
A prospective study of meat, cooking methods, meat mutagens, heme iron, and lung cancer risksNatasa Tasevska
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7242, USA
Am J Clin Nutr 89:1884-94. 2009..Red and processed meat consumption may play a role in lung cancer pathogenesis because of these meats' fat and carcinogen content...
Dietary fibre and colorectal adenoma in a colorectal cancer early detection programmeUlrike Peters
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, DHHS, MD 20892 7273, USA
Lancet 361:1491-5. 2003..Although dietary fibre has been reported to have no association with colorectal adenoma and cancer, in some studies this topic remains controversial...
Meat-related mutagens/carcinogens in the etiology of colorectal cancerAmanda J Cross
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Environ Mol Mutagen 44:44-55. 2004..Here, we review the current epidemiologic knowledge of meat-related mutagens, and evaluate the types of studies that may be required in the future to clarify the association between meat consumption and colorectal cancer...
Relative validity of a food frequency questionnaire with a meat-cooking and heterocyclic amine moduleMarie Cantwell
Nutrition Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
Cancer Epidemiol Biomarkers Prev 13:293-8. 2004..In conclusion, although the FFQ and meat module underestimated absolute MeIQx and PhIP intake, its ability to rank individuals according to intake was acceptable...
A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this associationAmanda J Cross
Nutritional Epidemiology Branch, Biostatistics Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Rockville, Maryland, USA
Cancer Res 70:2406-14. 2010..In conclusion, we found a positive association for red and processed meat intake and colorectal cancer; heme iron, nitrate/nitrite, and heterocyclic amines from meat may explain these associations...
No effect of meat, meat cooking preferences, meat mutagens or heme iron on lung cancer risk in the prostate, lung, colorectal and ovarian cancer screening trialNatasa Tasevska
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Int J Cancer 128:402-11. 2011..In this population, we found no association between meat type, cooking method, doneness level or intake of specific meat mutagens or heme iron and lung cancer risk...
Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomasNaoko Ishibe
Genetic Epidemioly Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA
Pharmacogenetics 12:145-50. 2002..Further study of larger populations is needed to confirm and extend these observations...
Highlights of the eighth international conference on carcinogenic/mutagenic N-substituted aryl compoundsElizabeth G Snyderwine
Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892 4258, USA
Mutat Res 506:1-8. 2002....
An epidemiologic approach to studying heterocyclic aminesRashmi Sinha
Nutritional Epidemiology Branch, Rm 7028, National Cancer Institute, 6120 Executive Boulevard, EPS 3024, Rockville, MD 20892, USA
Mutat Res 506:197-204. 2002..In this manuscript I will provide one approach to studying the relation of meat cooking-mutagens and cancer risk and will suggest the types of studies that may be required in the future to clarify these associations...
A cross-sectional investigation of regional patterns of diet and cardio-metabolic risk in IndiaCarrie R Daniel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
Nutr J 10:12. 2011..The role of diet in India's rapidly progressing chronic disease epidemic is unclear; moreover, diet may vary considerably across North-South regions...
Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohortNeal D Freedman
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, Rockville, MD 20852, USA
J Natl Cancer Inst 102:1354-65. 2010..Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations...
Meat and components of meat and the risk of bladder cancer in the NIH-AARP Diet and Health StudyLeah M Ferrucci
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
Cancer 116:4345-53. 2010..The authors comprehensively investigated the association between meat and meat components and bladder cancer...
Meat, fat, and their subtypes as risk factors for colorectal cancer in a prospective cohort of womenAndrew Flood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Am J Epidemiol 158:59-68. 2003..This study provided no evidence of an association between either meat or fat (or any of their subtypes) and colorectal cancer incidence, but the authors cannot rule out the possibility of a modest association...
Urinary mutagenicity and colorectal adenoma riskUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7273, USA
Cancer Epidemiol Biomarkers Prev 12:1253-6. 2003..2-13.9, comparing the highest with the lowest quintile). In our study population, diet may have contributed to mutagenic exposure, which was positively associated with colorectal adenoma risk...
Urinary mutagenesis and fried red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding studyUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892 7273, USA
Environ Mol Mutagen 43:53-74. 2004..The data from this study indicate that urinary mutagenicity correlates with mutagenic exposure from cooked meat and can potentially be used as a marker in etiological studies on cancer...
Dietary meat intake in relation to colorectal adenoma in asymptomatic womenLeah M Ferrucci
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Am J Gastroenterol 104:1231-40. 2009....
Meat intake and mortality: a prospective study of over half a million peopleRashmi Sinha
Division of Cancer Epidemiology and Genetics, National Cancer Institute Nutritional Epidemiology Branch, Rockville, MD 20852, USA
Arch Intern Med 169:562-71. 2009..High intakes of red or processed meat may increase the risk of mortality. Our objective was to determine the relations of red, white, and processed meat intakes to risk for total and cause-specific mortality...
Processed meat intake, CYP2A6 activity and risk of colorectal adenomaMary H Ward
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Carcinogenesis 28:1210-6. 2007..Our results suggest that nitrite and nitrate intake from processed meat intake increases the risk of colorectal adenoma after accounting for HCA and PAH...
Measurement of spices and seasonings in India: opportunities for cancer epidemiology and preventionLeah M Ferrucci
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Asian Pac J Cancer Prev 11:1621-9. 2010....
Inflammation-related gene polymorphisms and colorectal adenomaMarc J Gunter
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 15:1126-31. 2006..7; 95% CI, 0.3-1.5; P(interaction) = 0.01). These exploratory data provide evidence that polymorphic variation in genes that regulate inflammation could alter risk for colorectal adenoma...
Meat and meat mutagens and risk of prostate cancer in the Agricultural Health StudyStella Koutros
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8111, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 17:80-7. 2008..96-1.59) and 1.20 (95% CI, 0.93-1.55), respectively] when the highest quintile was compared with the lowest. In conclusion, well and very well done meat was associated with an increased risk for prostate cancer in this cohort...
A prospective study of serum C-reactive protein and colorectal cancer risk in menMarc J Gunter
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA
Cancer Res 66:2483-7. 2006..018). These results support the notion that chronic low-grade inflammation is a marker for increased risk of colorectal cancer...
Iron and colorectal cancer risk in the alpha-tocopherol, beta-carotene cancer prevention studyAmanda J Cross
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
Int J Cancer 118:3147-52. 2006..7, 95% CI = 1.4-15.1, p trend = 0.009). In summary, we found a significant inverse association between several serum iron indices and colon cancer risk...
A prospective study of red and processed meat intake in relation to cancer riskAmanda J Cross
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
PLoS Med 4:e325. 2007..We investigated whether red or processed meat intake increases cancer risk at a variety of sites...
Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancerStella Koutros
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA
Cancer Res 69:1877-84. 2009..The observed effect provides evidence to support the hypothesis that HCAs may act as promoters of malignant transformation by altering mitogenic signaling...
Development of a food frequency questionnaire module and databases for compounds in cooked and processed meatsRashmi Sinha
Nutrition Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7273, USA
Mol Nutr Food Res 49:648-55. 2005....
A prospective study of meat and meat mutagens and prostate cancer riskAmanda J Cross
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Res 65:11779-84. 2005..01-1.61). In conclusion, very well done meat was positively associated with prostate cancer risk. In addition, this study lends epidemiologic support to the animal studies, which have implicated PhIP as a prostate carcinogen...
Dietary benzo[a]pyrene intake and risk of colorectal adenomaRashmi Sinha
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
Cancer Epidemiol Biomarkers Prev 14:2030-4. 2005..21 (1.79-9.91) for the third quintile, 2.45 (0.98-6.12) for the fourth quintile, and 5.60 (2.20-14.20) for the fifth quintile (Ptrend=0.002). This study provides evidence that dietary BaP plays a role in colorectal adenoma etiology...
Meat, meat cooking methods and preservation, and risk for colorectal adenomaRashmi Sinha
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Res 65:8034-41. 2005..04; 95% CI, 0.90-1.19). Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma...
Dietary carotenoids, vegetables, and lung cancer risk in women: the Missouri women's health study (United States)Margaret E Wright
Department of Epidemiology, and Public Health, Yale University School of Medicine, New Haven, CT 05620-8034, USA
Cancer Causes Control 14:85-96. 2003..CONCLUSIONS: These results indicate that consumption of a wide variety of vegetables has a greater bearing on lung cancer risk in a population of smoking and nonsmoking women than intake of any specific carotenoid or total carotenoids...
Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
Opportunities for cancer epidemiology in developing countriesTanuja Rastogi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Rockville, Maryland 20852, USA
Nat Rev Cancer 4:909-17. 2004..What are the challenges and advantages to performing large epidemiological studies in developing nations?..
Cancer incidence rates among South Asians in four geographic regions: India, Singapore, UK and USTanuja Rastogi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
Int J Epidemiol 37:147-60. 2008..Examining such rates may provide us with insights into future aetiological research possibilities as well as screening and prevention...
Highly sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoringRao L Divi
National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA
Carcinogenesis 23:2043-9. 2002..95). Coded duplicate DNA samples from 15 individuals were assayed four times gave an inter-assay CV of 13.8%...
Dietary factors of one-carbon metabolism and prostate cancer riskStephanie J Weinstein
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA
Am J Clin Nutr 84:929-35. 2006..Vitamin B-6, vitamin B-12, methionine, and alcohol can influence folate-related metabolism...
Dietary carotenoids, serum beta-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort studyCrystal N Holick
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
Am J Epidemiol 156:536-47. 2002..These findings suggest that high fruit and vegetable consumption, particularly a diet rich in carotenoids, tomatoes, and tomato-based products, may reduce the risk of lung cancer...
Added sugar and sugar-sweetened foods and beverages and the risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health StudyYing Bao
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 88:431-40. 2008..Although it has been hypothesized that hyperglycemia, hyperinsulinemia, and insulin resistance are involved in the development of pancreatic cancer, results from epidemiologic studies of added sugar intake are inconclusive...
Serum high-density lipoprotein cholesterol and risk of non-hodgkin lymphomaUnhee Lim
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA
Cancer Res 67:5569-74. 2007..06). Our findings implicate HDL-C as a preclinical indicator of NHL and warrant further prospective investigations for its etiologic contribution...
A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokersKatherine Bowers
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Am J Epidemiol 164:652-64. 2006..58, 95% CI: 1.18, 2.10), but not rectal cancer. These results support the hypothesis that the significant association observed between IRS-defining metabolic abnormalities and colorectal cancer is determined primarily by adiposity...
Alcohol, smoking, and body size in relation to incident Hodgkin's and non-Hodgkin's lymphoma riskUnhee Lim
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Am J Epidemiol 166:697-708. 2007..19, 95% CI: 1.03, 1.38) were associated moderately with non-Hodgkin's lymphoma. These findings add to the evidence that lifestyle factors and relevant anthropometric characteristics play a role in lymphoma etiology...
Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancerLuke D Ratnasinghe
Center for Structural Genomics, NCTR, Food and Drug Administration, National Center for Toxicological Research FDA, 3900 NCTR Drive, Jefferson, Arkansas, AR 72079 9502, USA
Cancer Lett 216:157-64. 2004..In a nested case-cohort study that originated from two cancer prevention trials in Linxian, we examined the relationship between these cancers and two polymorphisms in the DNA repair gene XRCC1...
Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention TrialGwen Murphy
Cancer Prevention Fellowship Program, Office of Preventive Oncology, Bethesda, MD, USA
Cancer Causes Control 19:751-8. 2008..A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk...
Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC reviewStefania Boccia
Institute of Hygiene, Universita Cattolica del Sacro Cuore, Rome, Italy
Am J Epidemiol 167:505-16. 2008..05, 95% CI: 1.13, 3.72) versus high (OR = 0.95, 95% CI: 0.54, 1.67) folate levels. Overall, these findings support the hypothesis that folate plays a role in gastric carcinogenesis...
Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trialShih Chen Chang
Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Executive Plaza South, Suite 320, MSC7232, Bethesda, Maryland 20892 7232, USA
Cancer Epidemiol Biomarkers Prev 15:334-41. 2006..In addition, these three aspects of energy balance may act jointly in determining breast cancer risk...
Dietary factors of one-carbon metabolism in relation to non-Hodgkin lymphoma and multiple myeloma in a cohort of male smokersUnhee Lim
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 15:1109-14. 2006..Our results suggest that high intake of vitamin B12 among heavy smokers may be protective against NHL but warrant further studies, including among nonsmokers...
Null association between prostate cancer and serum folate, vitamin B(6), vitamin B(12), and homocysteineStephanie J Weinstein
Divison of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 12:1271-2. 2003
