William G Stetler-Stevenson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Dietary intake of a plant phospholipid/lipid conjugate reduces lung cancer growth and tumor angiogenesis
    Laurie A Shuman Moss
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20895, USA
    Carcinogenesis 35:1556-63. 2014
  2. pmc TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells
    Seo Jin Lee
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Lab Invest 90:374-82. 2010
  3. pmc Overexpression of tissue inhibitors of metalloproteinase 2 up-regulates NF-kappaB activity in melanoma cells
    Jun Sun
    Department of Medicine, Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Mol Signal 4:4. 2009
  4. pmc Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities
    William G Stetler-Stevenson
    Extracellular Matrix Pathology Section, Cell and Cancer Biology Branch, Vascular Biology Faculty, Center for Cancer Research, National Cancer Institute NCI, NIH, Advanced Technology Center, Bethesda, MD 20892 4605, USA
    Sci Signal 1:re6. 2008
  5. pmc The tumor microenvironment: regulation by MMP-independent effects of tissue inhibitor of metalloproteinases-2
    William G Stetler-Stevenson
    Cell and Cancer Biology Branch, NCI, NIH, Bethesda, MD, 20892 1500, USA
    Cancer Metastasis Rev 27:57-66. 2008
  6. ncbi request reprint TIMP-2: an endogenous inhibitor of angiogenesis
    William G Stetler-Stevenson
    Cell and Cancer Biology Branch, Vascular Biology Faculty, CCR, NCI, NIH, Bldg 10, Room 2A33, MSC 1500, 10 Center Dr, Bethesda, MD 20892 1500, USA
    Trends Mol Med 11:97-103. 2005
  7. ncbi request reprint Proteases in invasion: matrix metalloproteinases
    W G Stetler-Stevenson
    Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Cancer Biol 11:143-52. 2001
  8. ncbi request reprint The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis
    W G Stetler-Stevenson
    Extracellular Matrix Pathology Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland 20892 1500, USA
    Surg Oncol Clin N Am 10:383-92, x. 2001
  9. ncbi request reprint TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism
    Dong Wan Seo
    National Cancer Institute, Center for Cancer Research, Vascular Biology Faculty and Laboratory of Pathology, Extracellular Matrix Pathology Section, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 114:171-80. 2003
  10. pmc TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells
    Dimitra Bourboulia
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD, USA
    Oncotarget 4:163-73. 2013

Detail Information

Publications41

  1. ncbi request reprint Dietary intake of a plant phospholipid/lipid conjugate reduces lung cancer growth and tumor angiogenesis
    Laurie A Shuman Moss
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20895, USA
    Carcinogenesis 35:1556-63. 2014
    ..9-fold and 10.9-fold, respectively, compared with vehicle control. These findings lead us to propose using this plant phosolipid/lipid conjugate as a dietary supplement that may be useful in cancer prevention. ..
  2. pmc TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells
    Seo Jin Lee
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Lab Invest 90:374-82. 2010
    ....
  3. pmc Overexpression of tissue inhibitors of metalloproteinase 2 up-regulates NF-kappaB activity in melanoma cells
    Jun Sun
    Department of Medicine, Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Mol Signal 4:4. 2009
    ..abstract:..
  4. pmc Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities
    William G Stetler-Stevenson
    Extracellular Matrix Pathology Section, Cell and Cancer Biology Branch, Vascular Biology Faculty, Center for Cancer Research, National Cancer Institute NCI, NIH, Advanced Technology Center, Bethesda, MD 20892 4605, USA
    Sci Signal 1:re6. 2008
    ..The emerging concept is that TIMPs function in a contextual fashion so that the mechanism of action depends on the tissue microenvironment...
  5. pmc The tumor microenvironment: regulation by MMP-independent effects of tissue inhibitor of metalloproteinases-2
    William G Stetler-Stevenson
    Cell and Cancer Biology Branch, NCI, NIH, Bethesda, MD, 20892 1500, USA
    Cancer Metastasis Rev 27:57-66. 2008
    ..These new findings are discussed in terms of a model of TIMP-2 regulation of cellular functions in the tumor microenvironment...
  6. ncbi request reprint TIMP-2: an endogenous inhibitor of angiogenesis
    William G Stetler-Stevenson
    Cell and Cancer Biology Branch, Vascular Biology Faculty, CCR, NCI, NIH, Bldg 10, Room 2A33, MSC 1500, 10 Center Dr, Bethesda, MD 20892 1500, USA
    Trends Mol Med 11:97-103. 2005
    ..These new findings are integrated in a comprehensive model of TIMP-2 function in tissue homeostasis...
  7. ncbi request reprint Proteases in invasion: matrix metalloproteinases
    W G Stetler-Stevenson
    Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Cancer Biol 11:143-52. 2001
    ....
  8. ncbi request reprint The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis
    W G Stetler-Stevenson
    Extracellular Matrix Pathology Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland 20892 1500, USA
    Surg Oncol Clin N Am 10:383-92, x. 2001
    ..This article discusses the matrix metalloproteinase family, the regulation of matrix metalloproteinase activity, and the functions of matrix metalloproteinases in tumor progression...
  9. ncbi request reprint TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism
    Dong Wan Seo
    National Cancer Institute, Center for Cancer Research, Vascular Biology Faculty and Laboratory of Pathology, Extracellular Matrix Pathology Section, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 114:171-80. 2003
    ..Our findings establish an unexpected, MMP-independent mechanism for TIMP-2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo...
  10. pmc TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells
    Dimitra Bourboulia
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD, USA
    Oncotarget 4:163-73. 2013
    ..In conclusion, we show that TIMP-2 promotes an anti-tumoral transcriptional profile in vitro and in vivo, including upregulation of E-cadherin, in A549 lung cancer cells. ..
  11. pmc Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
    Dong Wan Seo
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 1500, USA
    J Biol Chem 281:3711-21. 2006
    ....
  12. ncbi request reprint The effects of adrenomedullin overexpression in breast tumor cells
    Alfredo Martinez
    Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Natl Cancer Inst 94:1226-37. 2002
    ..Several reports have indicated that adrenomedullin may be involved in tumor survival, but this has not been directly shown. Here we evaluate the in vitro and in vivo effects of adrenomedullin overexpression in human breast cancer cells...
  13. ncbi request reprint Proadrenomedullin NH2-terminal 20 peptide is a potent angiogenic factor, and its inhibition results in reduction of tumor growth
    Alfredo Martinez
    Cell and Cancer Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 64:6489-94. 2004
    ..Together, our data demonstrate PAMP to be an extremely potent angiogenic factor and implicate this peptide as an attractive molecular target for angiogenesis-based antitumor therapy...
  14. ncbi request reprint TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells
    Dimitra Bourboulia
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD, USA
    Oncotarget 4:166-76. 2013
    ..In conclusion, we show that TIMP-2 promotes an anti-tumoral transcriptional profile in vitro and in vivo, including upregulation of E-cadherin, in A549 lung cancer cells...
  15. pmc Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells
    Aki Iwai
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Cell Cycle 11:3649-55. 2012
    ....
  16. ncbi request reprint Tissue inhibitor of metalloproteinase 1 (TIMP-1) promotes plasmablastic differentiation of a Burkitt lymphoma cell line: implications in the pathogenesis of plasmacytic/plasmablastic tumors
    Liliana Guedez
    Cell and Cancer Biology Branch and Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 105:1660-8. 2005
    ..These findings strongly support TIMP-1 as an important factor in the pathogenesis of plasmacytic/plasmablastic tumors...
  17. ncbi request reprint Role of human cripto-1 in tumor angiogenesis
    Caterina Bianco
    Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 97:132-41. 2005
    ..Human cripto-1 (CR-1) promotes cell transformation and increases migration and invasion of various mouse and human epithelial cell lines. We investigated whether CR-1 also stimulates angiogenesis...
  18. ncbi request reprint CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells
    Tao Wang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bldg 10, Rm 3B 43, Bethesda, MD 20892, USA
    Blood 105:2836-44. 2005
    ..Integrin alpha5beta1 is the first high-affinity cellular counterreceptor that has been identified for a member within this family of adhesion receptors...
  19. pmc Quantitative assessment of angiogenic responses by the directed in vivo angiogenesis assay
    Liliana Guedez
    Extracellular Matrix Section, Laboratory of Pathology, and the Vascular Biology Faculty, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD20892, USA
    Am J Pathol 162:1431-9. 2003
    ..These results support DIVAA as an assay to compare potencies of angiogenic factors or inhibitors, and for profiling molecular markers of angiogenesis in vivo...
  20. ncbi request reprint Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2
    Christine E Horak
    Women s Cancer Section, Laboratory of Molecular Pharmacology, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Cancer Res 67:7238-46. 2007
    ..These data suggest that Nm23-H1 suppresses metastasis, at least in part, through down-regulation of EDG2 expression...
  21. pmc Endogenous angiogenesis inhibitor blocks tumor growth via direct and indirect effects on tumor microenvironment
    Dimitra Bourboulia
    Extracellular Matrix Pathology Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, The National Institutes of Health, Advanced Technology Center, Bethesda, Maryland, USA
    Am J Pathol 179:2589-600. 2011
    ..We conclude that TIMP-2-mediated inhibition of tumor growth occurs, at least in part, independently of MMP inhibition, and is a consequence of both direct effects of TIMP-2 on tumor cells and modulation of the tumor microenvironment...
  22. pmc An integrin-binding N-terminal peptide region of TIMP-2 retains potent angio-inhibitory and anti-tumorigenic activity in vivo
    Dong Wan Seo
    Radiation Oncology Branch, Advanced Technology Center, Center for Cancer Research, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, MD 20892, USA
    Peptides 32:1840-8. 2011
    ..Our findings demonstrate that the integrin binding, tumor growth suppressor and in vivo angio-inhibitory activities of TIMP-2 are intimately associated within a unique sequence/structural loop (B-C loop)...
  23. pmc Matrix metalloproteinases: changing roles in tumor progression and metastasis
    Laurie A Shuman Moss
    Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Am J Pathol 181:1895-9. 2012
    ..This review attempts to summarize the contribution of AJP to some of the key changes that have led to the evolution of this field...
  24. pmc TIMP-2 targets tumor-associated myeloid suppressor cells with effects in cancer immune dysfunction and angiogenesis
    Liliana Guedez
    Extracellular Matrix Pathology Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunother 35:502-12. 2012
    ..Therefore, this study supports TIMP-2 as a negative regulator of MDSCs with important implications for the immunotherapy and/or antiangiogenic treatment of NSCLC...
  25. ncbi request reprint Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta
    Christina H Stuelten
    Laboratory of Cell Regulation and Carcinogenesis, CCR, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 118:2143-53. 2005
    ..Together, our results indicate that MMP-9 levels in tumor fibroblasts are regulated by a complex tumor-stroma cross-talk, involving multiple ligands and cellular signaling pathways...
  26. pmc Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
    Dimitra Bourboulia
    Radiation Oncology Branch, Center for Cancer Research, NCI NIH, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Semin Cancer Biol 20:161-8. 2010
    ..In this review, we describe and discuss data that support the important role of MMPs and TIMPs in cancer cell adhesion and tumor progression...
  27. doi request reprint Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors
    Mehdi Mollapour
    Department of Urology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA Cancer Research Institute, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA Electronic address
    Mol Cell 53:317-29. 2014
    ....
  28. ncbi request reprint Modulation of tumor-host interactions, angiogenesis, and tumor growth by tissue inhibitor of metalloproteinase 2 via a novel mechanism
    Andrew L Feldman
    Metabolism Section, Surgery Branch, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 64:4481-6. 2004
    ..Phosphatase activity appears important in regulating tumor angiogenesis, offering a promising direction for the identification of novel molecular targets and antiangiogenic compounds for the treatment of cancer...
  29. ncbi request reprint Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK
    Junseo Oh
    National Cancer Institute, Center for Cancer Research, Cell and Cancer Biology Branch, Bethesda, Maryland, USA
    Cancer Res 64:9062-9. 2004
    ..Secondly, TIMP-2 can disrupt VEGF signaling required for initiation of hMVEC migration. Third, TIMP-2 can enhance expression of RECK via Rap1 signaling resulting in an indirect, time-dependent inhibition of endothelial cell migration...
  30. pmc Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene
    Adewole Adamson
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    PLoS ONE 8:e59367. 2013
    ..Finally, we demonstrate that when restricted to T cells, expression of TIMP1 promotes neuropathology in experimental allergic encephalomyelitis...
  31. pmc Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function
    Mehdi Mollapour
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cell 37:333-43. 2010
    ....
  32. pmc Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator
    Alfredo Martinez
    Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem J 383:413-8. 2004
    ..The present study defines a new mechanism through which MMP-2 may regulate blood pressure by simultaneously eliminating a vasodilator and generating a vasoconstrictor...
  33. pmc TIMP1 induces CD44 expression and the activation and nuclear translocation of SHP1 during the late centrocyte/post-germinal center B cell differentiation
    Young Sik Kim
    Department of Pathology, Korea University Ansan Hospital, 516 Gojan 1 dong, Danwon gu, Gyeonggi Do, Ansan 425 707, Republic of Korea
    Cancer Lett 269:37-45. 2008
    ..These results suggest that TIMP1 functions as a differentiating and survival factor of GC B cells by modulating CD44 and SHP1 in the late centrocyte/post-GC stage, regardless of EBV infection...
  34. ncbi request reprint Pro-matrix metalloproteinase-2 transfection increases orthotopic primary growth and experimental metastasis of MDA-MB-231 human breast cancer cells in nude mice
    Angus M Tester
    Victorian Breast Cancer Research Consortium VBCRC Invasion and Metastasis Unit, St Vincent s Institute of Medical Research, Department of Surgery, University of Melbourne, Australia
    Cancer Res 64:652-8. 2004
    ..MMP-2 may be a useful target for breast cancer therapy when refinement of MMP inhibitors provides for MMP-specific agents...
  35. ncbi request reprint Glucose-induced changes in integrins and matrix-related functions in cultured human glomerular epithelial cells
    Paraskevi V Kitsiou
    Institute of Biology, National Center for Scientific Research Demokritos, 15310 Agia Paraskevi, Athens, Greece
    Am J Physiol Renal Physiol 284:F671-9. 2003
    ..Finally, tissue inhibitor of metalloproteinase-2, the specific inhibitor of MMP-2, was upregulated in high glucose and could contribute to matrix accumulation. These changes could help explain basement membrane thickening in diabetes...
  36. ncbi request reprint Tissue inhibitor of matrix metalloproteinase-1 overexpression in M1 myeloblasts impairs IL-6-induced differentiation
    Peter Haviernik
    Hematopoiesis Department, American Red Cross, Jerome H Holland Laboratory for the Biomedical Sciences, Rockville, MD 20855, USA
    Oncogene 23:9212-9. 2004
    ..Intrinsic TIMP-1 expression in myeloid leukemia cells might thus impact upon survival or differentiation...
  37. ncbi request reprint TIMP-2 promotes cell spreading and adhesion via upregulation of Rap1 signaling
    Hyeujin Chang
    Laboratory of Cellular Oncology, Korea University Graduate School of Medicine, Ansan, Gyeonggi do 425 707, Republic of Korea
    Biochem Biophys Res Commun 345:1201-6. 2006
    ....
  38. doi request reprint TGF-beta signaling preserves RECK expression in activated pancreatic stellate cells
    Hongsik Lee
    Department of Internal Medicine, Ansan Korea University Hospital, Ansan, Gyeonggi Do, Korea
    J Cell Biochem 104:1065-74. 2008
    ....
  39. pmc Hematopoiesis in mice is extremely resilient to wide variation in TIMP/MMP balance
    Peter Haviernik
    Department of Medicine, Division of Hematology Oncology, Case Western Reserve University, Cleveland, OH 44106, USA
    Blood Cells Mol Dis 41:179-87. 2008
    ..An important corollary of these studies is that specific modulation using MMP inhibitors for cancer or immunologic therapy is unlikely to have adverse hematopoietic side effects...
  40. ncbi request reprint Proximal tubular epithelial cell integrins respond to high glucose by altered cell-matrix interactions and differentially regulate matrixin expression
    Panagiotis M Karamessinis
    Institute of Biology, National Center for Scientific Research Demokritos, Athens, Greece
    Lab Invest 82:1081-93. 2002
    ..The above data implicate integrins of proximal tubular epithelial cells in the regulation of MMPs and in the development of TBM thickening in diabetic nephropathy...
  41. ncbi request reprint Immunohistochemical study of endothelin-1 and matrix metalloproteinases in plexogenic pulmonary arteriopathy
    Kazuhiro Matsui
    Department of Pathology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Pathol Res Pract 198:403-12. 2002
    ..These changes may play important roles in the remodeling of arterial structures, particularly of basement membranes, in this disorder...