Research Topics
Genomes and Genes
| William G Stetler-StevensonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Overexpression of tissue inhibitors of metalloproteinase 2 up-regulates NF-kappaB activity in melanoma cellsJun Sun
Department of Medicine, Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Mol Signal 4:4. 2009..abstract:..
TIMP-2: an endogenous inhibitor of angiogenesisWilliam G Stetler-Stevenson
Cell and Cancer Biology Branch, Vascular Biology Faculty, CCR, NCI, NIH, Bldg 10, Room 2A33, MSC 1500, 10 Center Dr, Bethesda, MD 20892 1500, USA
Trends Mol Med 11:97-103. 2005..These new findings are integrated in a comprehensive model of TIMP-2 function in tissue homeostasis...- The tumor microenvironment: regulation by MMP-independent effects of tissue inhibitor of metalloproteinases-2William G Stetler-Stevenson
Cell and Cancer Biology Branch, NCI, NIH, Bethesda, MD, 20892 1500, USA
Cancer Metastasis Rev 27:57-66. 2008..These new findings are discussed in terms of a model of TIMP-2 regulation of cellular functions in the tumor microenvironment... - Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activitiesWilliam G Stetler-Stevenson
Extracellular Matrix Pathology Section, Cell and Cancer Biology Branch, Vascular Biology Faculty, Center for Cancer Research, National Cancer Institute NCI, NIH, Advanced Technology Center, Bethesda, MD 20892 4605, USA
Sci Signal 1:re6. 2008..The emerging concept is that TIMPs function in a contextual fashion so that the mechanism of action depends on the tissue microenvironment... - Proteases in invasion: matrix metalloproteinasesW G Stetler-Stevenson
Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Semin Cancer Biol 11:143-52. 2001.... - The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesisW G Stetler-Stevenson
Extracellular Matrix Pathology Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland 20892 1500, USA
Surg Oncol Clin N Am 10:383-92, x. 2001..This article discusses the matrix metalloproteinase family, the regulation of matrix metalloproteinase activity, and the functions of matrix metalloproteinases in tumor progression... - TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanismDong Wan Seo
National Cancer Institute, Center for Cancer Research, Vascular Biology Faculty and Laboratory of Pathology, Extracellular Matrix Pathology Section, National Institutes of Health, Bethesda, MD 20892, USA
Cell 114:171-80. 2003..Our findings establish an unexpected, MMP-independent mechanism for TIMP-2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo... - The effects of adrenomedullin overexpression in breast tumor cellsAlfredo Martinez
Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Natl Cancer Inst 94:1226-37. 2002..Several reports have indicated that adrenomedullin may be involved in tumor survival, but this has not been directly shown. Here we evaluate the in vitro and in vivo effects of adrenomedullin overexpression in human breast cancer cells... - Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cellsDong Wan Seo
Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 1500, USA
J Biol Chem 281:3711-21. 2006.... - Proadrenomedullin NH2-terminal 20 peptide is a potent angiogenic factor, and its inhibition results in reduction of tumor growthAlfredo Martinez
Cell and Cancer Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 64:6489-94. 2004..Together, our data demonstrate PAMP to be an extremely potent angiogenic factor and implicate this peptide as an attractive molecular target for angiogenesis-based antitumor therapy... - Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cellsAki Iwai
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Cell Cycle 11:3649-55. 2012.... - Role of human cripto-1 in tumor angiogenesisCaterina Bianco
Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Natl Cancer Inst 97:132-41. 2005..66 vessels per field and Neo-transfected cells = 2.33 vessels per field; difference = 2.33 vessels per field, 95% CI = 1.2 to 2.8; P = .004). CONCLUSION: CR-1 appears to have an important role in the multistep process of angiogenesis... - Tissue inhibitor of metalloproteinase 1 (TIMP-1) promotes plasmablastic differentiation of a Burkitt lymphoma cell line: implications in the pathogenesis of plasmacytic/plasmablastic tumorsLiliana Guedez
Cell and Cancer Biology Branch and Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Blood 105:1660-8. 2005..These findings strongly support TIMP-1 as an important factor in the pathogenesis of plasmacytic/plasmablastic tumors... - CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cellsTao Wang
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bldg 10, Rm 3B 43, Bethesda, MD 20892, USA
Blood 105:2836-44. 2005..Integrin alpha5beta1 is the first high-affinity cellular counterreceptor that has been identified for a member within this family of adhesion receptors... - Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2Christine E Horak
Women s Cancer Section, Laboratory of Molecular Pharmacology, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
Cancer Res 67:7238-46. 2007..These data suggest that Nm23-H1 suppresses metastasis, at least in part, through down-regulation of EDG2 expression... - An integrin-binding N-terminal peptide region of TIMP-2 retains potent angio-inhibitory and anti-tumorigenic activity in vivoDong Wan Seo
Radiation Oncology Branch, Advanced Technology Center, Center for Cancer Research, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, MD 20892, USA
Peptides 32:1840-8. 2011..Our findings demonstrate that the integrin binding, tumor growth suppressor and in vivo angio-inhibitory activities of TIMP-2 are intimately associated within a unique sequence/structural loop (B-C loop)... - Quantitative assessment of angiogenic responses by the directed in vivo angiogenesis assayLiliana Guedez
Extracellular Matrix Section, Laboratory of Pathology, and the Vascular Biology Faculty, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD20892, USA
Am J Pathol 162:1431-9. 2003..These results support DIVAA as an assay to compare potencies of angiogenic factors or inhibitors, and for profiling molecular markers of angiogenesis in vivo... - TIMP-2 targets tumor-associated myeloid suppressor cells with effects in cancer immune dysfunction and angiogenesisLiliana Guedez
Extracellular Matrix Pathology Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
J Immunother 35:502-12. 2012..Therefore, this study supports TIMP-2 as a negative regulator of MDSCs with important implications for the immunotherapy and/or antiangiogenic treatment of NSCLC... - Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesionDimitra Bourboulia
Radiation Oncology Branch, Center for Cancer Research, NCI NIH, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
Semin Cancer Biol 20:161-8. 2010..In this review, we describe and discuss data that support the important role of MMPs and TIMPs in cancer cell adhesion and tumor progression... - Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-betaChristina H Stuelten
Laboratory of Cell Regulation and Carcinogenesis, CCR, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Sci 118:2143-53. 2005..Together, our results indicate that MMP-9 levels in tumor fibroblasts are regulated by a complex tumor-stroma cross-talk, involving multiple ligands and cellular signaling pathways... - Endogenous angiogenesis inhibitor blocks tumor growth via direct and indirect effects on tumor microenvironmentDimitra Bourboulia
Extracellular Matrix Pathology Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, The National Institutes of Health, Advanced Technology Center, Bethesda, Maryland, USA
Am J Pathol 179:2589-600. 2011..We conclude that TIMP-2-mediated inhibition of tumor growth occurs, at least in part, independently of MMP inhibition, and is a consequence of both direct effects of TIMP-2 on tumor cells and modulation of the tumor microenvironment... - TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cellsDimitra Bourboulia
Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD, USA
Oncotarget 4:166-76. 2013..In conclusion, we show that TIMP-2 promotes an anti-tumoral transcriptional profile in vitro and in vivo, including upregulation of E-cadherin, in A549 lung cancer cells... - Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECKJunseo Oh
National Cancer Institute, Center for Cancer Research, Cell and Cancer Biology Branch, Bethesda, Maryland, USA
Cancer Res 64:9062-9. 2004..Secondly, TIMP-2 can disrupt VEGF signaling required for initiation of hMVEC migration. Third, TIMP-2 can enhance expression of RECK via Rap1 signaling resulting in an indirect, time-dependent inhibition of endothelial cell migration... - Modulation of tumor-host interactions, angiogenesis, and tumor growth by tissue inhibitor of metalloproteinase 2 via a novel mechanismAndrew L Feldman
Metabolism Section, Surgery Branch, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 64:4481-6. 2004..Phosphatase activity appears important in regulating tumor angiogenesis, offering a promising direction for the identification of novel molecular targets and antiangiogenic compounds for the treatment of cancer... - Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone functionMehdi Mollapour
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Mol Cell 37:333-43. 2010.... - Matrix metalloproteinases: changing roles in tumor progression and metastasisLaurie A Shuman Moss
Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Am J Pathol 181:1895-9. 2012..This review attempts to summarize the contribution of AJP to some of the key changes that have led to the evolution of this field... - Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilatorAlfredo Martinez
Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Biochem J 383:413-8. 2004..The present study defines a new mechanism through which MMP-2 may regulate blood pressure by simultaneously eliminating a vasodilator and generating a vasoconstrictor... - TIMP-2 promotes cell spreading and adhesion via upregulation of Rap1 signalingHyeujin Chang
Laboratory of Cellular Oncology, Korea University Graduate School of Medicine, Ansan, Gyeonggi do 425 707, Republic of Korea
Biochem Biophys Res Commun 345:1201-6. 2006.... - Glucose-induced changes in integrins and matrix-related functions in cultured human glomerular epithelial cellsParaskevi V Kitsiou
Institute of Biology, National Center for Scientific Research Demokritos, 15310 Agia Paraskevi, Athens, Greece
Am J Physiol Renal Physiol 284:F671-9. 2003..Finally, tissue inhibitor of metalloproteinase-2, the specific inhibitor of MMP-2, was upregulated in high glucose and could contribute to matrix accumulation. These changes could help explain basement membrane thickening in diabetes... - Pro-matrix metalloproteinase-2 transfection increases orthotopic primary growth and experimental metastasis of MDA-MB-231 human breast cancer cells in nude miceAngus M Tester
Victorian Breast Cancer Research Consortium VBCRC Invasion and Metastasis Unit, St Vincent s Institute of Medical Research, Department of Surgery, University of Melbourne, Australia
Cancer Res 64:652-8. 2004..MMP-2 may be a useful target for breast cancer therapy when refinement of MMP inhibitors provides for MMP-specific agents... - TIMP1 induces CD44 expression and the activation and nuclear translocation of SHP1 during the late centrocyte/post-germinal center B cell differentiationYoung Sik Kim
Department of Pathology, Korea University Ansan Hospital, 516 Gojan 1 dong, Danwon gu, Gyeonggi Do, Ansan 425 707, Republic of Korea
Cancer Lett 269:37-45. 2008..These results suggest that TIMP1 functions as a differentiating and survival factor of GC B cells by modulating CD44 and SHP1 in the late centrocyte/post-GC stage, regardless of EBV infection... - Hematopoiesis in mice is extremely resilient to wide variation in TIMP/MMP balancePeter Haviernik
Department of Medicine, Division of Hematology Oncology, Case Western Reserve University, Cleveland, OH 44106, USA
Blood Cells Mol Dis 41:179-87. 2008..An important corollary of these studies is that specific modulation using MMP inhibitors for cancer or immunologic therapy is unlikely to have adverse hematopoietic side effects... 
TGF-beta signaling preserves RECK expression in activated pancreatic stellate cellsHongsik Lee
Department of Internal Medicine, Ansan Korea University Hospital, Ansan, Gyeonggi Do, Korea
J Cell Biochem 104:1065-74. 2008....- Tissue inhibitor of matrix metalloproteinase-1 overexpression in M1 myeloblasts impairs IL-6-induced differentiationPeter Haviernik
Hematopoiesis Department, American Red Cross, Jerome H Holland Laboratory for the Biomedical Sciences, Rockville, MD 20855, USA
Oncogene 23:9212-9. 2004..Intrinsic TIMP-1 expression in myeloid leukemia cells might thus impact upon survival or differentiation... - Proximal tubular epithelial cell integrins respond to high glucose by altered cell-matrix interactions and differentially regulate matrixin expressionPanagiotis M Karamessinis
Institute of Biology, National Center for Scientific Research Demokritos, Athens, Greece
Lab Invest 82:1081-93. 2002..The above data implicate integrins of proximal tubular epithelial cells in the regulation of MMPs and in the development of TBM thickening in diabetic nephropathy... - Immunohistochemical study of endothelin-1 and matrix metalloproteinases in plexogenic pulmonary arteriopathyKazuhiro Matsui
Department of Pathology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
Pathol Res Pract 198:403-12. 2002..These changes may play important roles in the remodeling of arterial structures, particularly of basement membranes, in this disorder...