N Stefan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Plasma adiponectin levels are not associated with fat oxidation in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 10:1016-20. 2002
  2. ncbi request reprint A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance
    Otto Tschritter
    Medizinische Universitatsklinik, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 91:654-8. 2006
  3. doi request reprint Identification and characterization of metabolically benign obesity in humans
    Norbert Stefan
    Department of Internal Medicine IV, University of Tubingen, D 72076 Tubingen, Germany
    Arch Intern Med 168:1609-16. 2008
  4. ncbi request reprint Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1884-8. 2002
  5. ncbi request reprint Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Am J Physiol Endocrinol Metab 284:E1156-61. 2003
  6. ncbi request reprint Plasma adiponectin concentrations in children: relationships with obesity and insulinemia
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 87:4652-6. 2002
  7. ncbi request reprint The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Int J Obes Relat Metab Disord 26:1629-32. 2002
  8. ncbi request reprint Exaggerated insulin secretion in Pima Indians and African-Americans but higher insulin resistance in Pima Indians compared to African-Americans and Caucasians
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabet Med 21:1090-5. 2004
  9. doi request reprint mRNA concentrations of MIF in subcutaneous abdominal adipose cells are associated with adipocyte size and insulin action
    J Koska
    Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health DHHS, Phoenix, AZ, USA
    Int J Obes (Lond) 33:842-50. 2009
  10. ncbi request reprint Adiponectin--its role in metabolism and beyond
    N Stefan
    Clinical Nutrition and Metabolism Section, NIDDK, NIH, Phoenix, Arizona 85016, USA
    Horm Metab Res 34:469-74. 2002

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Plasma adiponectin levels are not associated with fat oxidation in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 10:1016-20. 2002
    ..To test the hypothesis that low adiponectin is associated with low fat oxidation in humans...
  2. ncbi request reprint A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance
    Otto Tschritter
    Medizinische Universitatsklinik, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 91:654-8. 2006
    ..The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed in a variety of tissues including liver and skeletal muscle. In animal models, knockout of Kv1.3 has been found to improve insulin sensitivity and glucose tolerance...
  3. doi request reprint Identification and characterization of metabolically benign obesity in humans
    Norbert Stefan
    Department of Internal Medicine IV, University of Tubingen, D 72076 Tubingen, Germany
    Arch Intern Med 168:1609-16. 2008
    ..Conversely, even in obesity, a metabolically benign fat distribution phenotype may exist...
  4. ncbi request reprint Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1884-8. 2002
    ..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans...
  5. ncbi request reprint Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Am J Physiol Endocrinol Metab 284:E1156-61. 2003
    ..However, in subjects who have progressed to a state of IGT, chronically elevated NEFA seem to have a deleterious effect on insulin-secretory capacity...
  6. ncbi request reprint Plasma adiponectin concentrations in children: relationships with obesity and insulinemia
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 87:4652-6. 2002
    ....
  7. ncbi request reprint The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Int J Obes Relat Metab Disord 26:1629-32. 2002
    ..These findings are consistent with a role of the Gln223Arg polymorphism in reducing peripheral and central leptin binding to the LEPR in humans. However, these effects do not seem to have a major impact on adiposity in this population...
  8. ncbi request reprint Exaggerated insulin secretion in Pima Indians and African-Americans but higher insulin resistance in Pima Indians compared to African-Americans and Caucasians
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabet Med 21:1090-5. 2004
    ....
  9. doi request reprint mRNA concentrations of MIF in subcutaneous abdominal adipose cells are associated with adipocyte size and insulin action
    J Koska
    Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health DHHS, Phoenix, AZ, USA
    Int J Obes (Lond) 33:842-50. 2009
    ..To determine whether the mRNA concentrations of inflammation response genes in isolated adipocytes and in cultured preadipocytes are related to adipocyte size and in vivo insulin action in obese individuals...
  10. ncbi request reprint Adiponectin--its role in metabolism and beyond
    N Stefan
    Clinical Nutrition and Metabolism Section, NIDDK, NIH, Phoenix, Arizona 85016, USA
    Horm Metab Res 34:469-74. 2002
    ..This suggests that adiponectin may reflect PPAR-gamma activity in vivo. Finally, reversal or alleviation of hypoadiponectinemia may represent a target for development of drugs improving insulin sensitivity and glucose tolerance...
  11. ncbi request reprint New imaging techniques of fat, muscle and liver within the context of determining insulin sensitivity
    Norbert Stefan
    Department of Internal Medicine, University of Tubingen, Tubingen, Germany
    Horm Res 64:38-44. 2005
    ..This may allow a search for new candidate genes for type 2 diabetes mellitus and identify, at an early stage, individuals at risk for decline in insulin sensitivity...
  12. ncbi request reprint The -8503 G/A polymorphism of the adiponectin receptor 1 gene is associated with insulin sensitivity dependent on adiposity
    Konstantinos Kantartzis
    Diabetes Care 29:464. 2006
  13. ncbi request reprint Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans
    Norbert Stefan
    Department of Internal Medicine, University of Tubingen, Germany
    Diabetes Care 29:853-7. 2006
    ..Therefore, we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only be associated with insulin resistance but also with fat accumulation in the liver...
  14. ncbi request reprint Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1
    Anita M Hennige
    University of Tuebingen, Department of Internal Medicine IV, Tuebingen D 72076, Germany
    FASEB J 20:1206-8. 2006
    ..In summary, these data suggest that phosphorylation of Ser-318 in Irs1 mediates the inhibitory signal of leptin on the insulin-signaling cascade in obese subjects...
  15. ncbi request reprint The relationships of plasma adiponectin with a favorable lipid profile, decreased inflammation, and less ectopic fat accumulation depend on adiposity
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry, and Clinical Chemistry, Eberhard Karls University of Tubingen, Tubingen, Germany
    Clin Chem 52:1934-42. 2006
    ..Adiposity may also affect the relationship of adiponectin concentrations with serum lipid profile; markers of inflammation, atherosclerosis, and endothelial function; and ectopic fat accumulation...
  16. ncbi request reprint Upstream transcription factor 1 gene polymorphisms are associated with high antilipolytic insulin sensitivity and show gene-gene interactions
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Medicine and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    J Mol Med (Berl) 85:55-61. 2007
    ..01). In conclusion, subjects carrying the T allele of SNP usf1s1 and the A allele of SNP usf1s2 have a higher antilipolytic insulin sensitivity. Moreover, both SNPs may interact with the -514C > T SNP in LIPC to determine liver fat...
  17. ncbi request reprint High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans
    Norbert Stefan
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, D 72076 Tubingen, Germany
    Diabetes Care 30:1173-8. 2007
    ..To determine which fat compartments are associated with elevated RBP4 levels in humans, we measured circulating RBP4 in 75 healthy subjects and used state-of-the-art measurements of body fat distribution...
  18. ncbi request reprint High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention
    Claus Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Obesity (Silver Spring) 15:531-8. 2007
    ..We studied changes in these two fat depots during weight loss and analyzed whether VAT and LF at baseline predict the response to lifestyle intervention...
  19. ncbi request reprint Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    Norbert Stefan
    Department of Internal Medicine, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 92:1827-33. 2007
    ..Peroxisome proliferator-activated receptor (PPAR)-delta (gene PPARD) and PPARgamma coactivator 1alpha (gene PPARGC1A) are determinants of mitochondrial function in animals and in vitro...
  20. doi request reprint Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University of Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 16:1969-72. 2008
    ..In conclusion, despite an association with BMI and whole body fat distribution, variation in the FTO locus has no effect on the success of a lifestyle intervention program...
  21. ncbi request reprint A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
    Harald Staiger
    Internal Medicine IV, Medical Clinic Tübingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 57:514-7. 2008
    ..Based on HHEX's function during embryonic development of the ventral pancreas in mice, we investigated whether these SNPs affect beta-cell function in humans...
  22. ncbi request reprint Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals
    Juraj Koska
    Obesity and Diabetes Clinical Research Section, NIDDK NIH DHHS, Phoenix, AZ 85016, USA
    Am J Clin Nutr 87:295-302. 2008
    ....
  23. doi request reprint Genetic variation within the ANGPTL4 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus
    Harald Staiger
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, D 72076 Tubingen, Germany
    Metabolism 57:637-43. 2008
    ..We conclude that common genetic variation within the ANGPTL4 gene may not play a major role in the development of prediabetic phenotypes in our white population...
  24. doi request reprint Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
    Alena Stancakova
    Department of Medicine, University of Kuopio and University Hospital, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 93:1924-30. 2008
    ..CDKAL1 is a recently discovered susceptibility gene for type 2 diabetes...
  25. ncbi request reprint The association between plasma adiponectin and insulin sensitivity in humans depends on obesity
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Obes Res 13:1683-91. 2005
    ..However, it is possible that the contribution of adiponectin to insulin sensitivity is not equally strong over the whole range of obesity...
  26. ncbi request reprint Liver fat and insulin resistance are independently associated with the -514C>T polymorphism of the hepatic lipase gene
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Germany
    J Clin Endocrinol Metab 90:4238-43. 2005
    ..Liver fat predicts insulin resistance in humans. So far, there is not much information on genetic determinants of liver fat. Hepatic lipase is a liver-specific enzyme that regulates lipid metabolism...
  27. ncbi request reprint Increased insulin clearance in peroxisome proliferator-activated receptor gamma2 Pro12Ala
    Otto Tschritter
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Metabolism 52:778-83. 2003
    ..Because PPARgamma(2) is mainly expressed in adipose tissue, one of the main regulatory effects of the polymorphism may well be the more efficient suppression of (possibly intra-abdominal) lipolysis...
  28. ncbi request reprint Glucose allostasis
    Michael Stumvoll
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 52:903-9. 2003
    ..With increasing severity and over time, the allostatic load (increase in glycemia) may have pathological consequences, such as the development of type 2 diabetes...
  29. ncbi request reprint Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Room 5 41, Phoenix, AZ 85016, USA
    Diabetes 52:1544-50. 2003
    ....
  30. ncbi request reprint Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans
    Andreas Fritsche
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 51:S234-9. 2002
    ..The age effect on insulin secretion appears to be attributable at least in part to an impairment of proinsulin conversion to insulin...
  31. ncbi request reprint Plasma adiponectin and endogenous glucose production in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, Department of Health and Human Services, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes Care 26:3315-9. 2003
    ..Whereas associations of plasma adiponectin with muscle insulin sensitivity in humans have been examined, this has not been done for the liver...
  32. ncbi request reprint Regulation of synovial adipocytokines
    Norbert Stefan
    JAMA 291:694-5; author reply 695. 2004
  33. ncbi request reprint Parasympathetic blockade attenuates augmented pancreatic polypeptide but not insulin secretion in Pima Indians
    Barbora Vozarova de Courten
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 53:663-71. 2004
    ..However, the hyperinsulinemia of this population does not appear to be due to increased vagal input to pancreatic beta-cells...
  34. ncbi request reprint C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
    Obes Res 12:679-83. 2004
    ..We investigated whether this polymorphism contributed to the variability in obesity in our population from southern Germany and whether it was associated with insulin sensitivity of lipolysis and/or glucose disposal...
  35. ncbi request reprint Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjects
    Claus Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Diabetes Care 27:2726-9. 2004
  36. ncbi request reprint Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight
    Norbert Stefan
    The Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Metabolism 53:904-11. 2004
    ..We conclude that interaction of multiple defects may contribute to increased susceptibility to type 2 diabetes among individuals with LBW...
  37. ncbi request reprint Interaction effect between common polymorphisms in PPARgamma2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity
    Michael Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Mol Med (Berl) 80:33-8. 2002
    ..Allowing for gene-gene interaction effects may reveal novel information regarding metabolic effects of genetic variants...
  38. ncbi request reprint Low plasma adiponectin concentrations do not predict weight gain in humans
    Barbora Vozarova
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:2964-7. 2002
    ..Therefore, the predictive effect of low plasma adiponectin concentrations on the development of type 2 diabetes seems to be mediated by factors other than increased adiposity...
  39. ncbi request reprint Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism
    Harald Staiger
    Department of Internal Medicine IV, Medical Clinic Tübingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 53:2195-201. 2004
    ..AdipoR1, but not AdipoR2, expression correlated with insulin secretion. The molecular nature of this link between muscle and beta-cells needs to be further clarified...
  40. ncbi request reprint High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1889-95. 2002
    ..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
  41. ncbi request reprint Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs
    Stephan Schiekofer
    Department of Medicine I, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
    Diabetes 52:621-33. 2003
    ....
  42. doi request reprint Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in/opposed-phase and spectral-spatial excitation techniques
    Nina F Schwenzer
    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University, Tubingen, Germany
    Invest Radiol 43:330-7. 2008
    ..Results of both approaches were compared, and influences of T1- and T2*-related corrections were assessed. The possibility of a correlation between pancreatic lipomatosis and liver steatosis was investigated...
  43. pmc Fetuin-A induces cytokine expression and suppresses adiponectin production
    Anita M Hennige
    Department of Internal Medicine, Division of Endocrinology, Nephrology, Vascular Disease and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    PLoS ONE 3:e1765. 2008
    ....
  44. doi request reprint Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study
    Claus Thamer
    Department of Endocrinology, Metabolism, Clinical Chemistry, Nephrology, and Angiology, Medical Clinic, Eberhard Karls University, 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 93:1497-500. 2008
    ..e. rs1053049, rs6902123, and rs2267668, affect the improvement of mitochondrial function, aerobic physical fitness, and insulin sensitivity by lifestyle intervention (LI)...
  45. ncbi request reprint The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individuals
    Kilian Rittig
    Department of Endocrinology, Diabetes, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Germany
    Atherosclerosis 198:338-46. 2008
    ..This might be due to reduced subendothelial inflammation, mediated by reduced transendothelial monocyte-migration ability...
  46. ncbi request reprint Fatty liver is independently associated with alterations in circulating HDL2 and HDL3 subfractions
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes Care 31:366-8. 2008
  47. ncbi request reprint Reduced adiponectin serum levels in smokers
    Claus Thamer
    Atherosclerosis 179:421-2. 2005
  48. ncbi request reprint Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes
    Peter Weyrich
    Department of Internal Medicine, Division of Diabetology, Endocrinology, Nephrology, Angiology and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    J Mol Med (Berl) 85:107-17. 2007
    ..This review summarizes the so far known genetic variations, which determine responders and nonresponders to a lifestyle intervention. In addition, general methodological approaches to study gene-lifestyle interactions are described...
  49. ncbi request reprint Adiponectin in youth: response to Bacha et al
    Norbert Stefan
    Diabetes Care 27:1519-20; author reply 1520-1. 2004
  50. ncbi request reprint Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy
    Jürgen Machann
    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Magn Reson Med 55:913-7. 2006
    ..Fat-selective images provide more spatial information about fat distribution, which makes this technique suitable for clinical imaging of patients with liver disease...
  51. ncbi request reprint Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells
    Harald Staiger
    Department of Endocrinology, Metabolism and Pathobiochemistry, Medical Clinic, Eberhard Karls University, Tubingen, Germany
    Diabetes 53:3209-16. 2004
    ..29, P < 0.05). We show here that the common plasma FFA palmitate induces high levels of IL-6 in CAECs. Furthermore, palmitate correlates with IL-6 in vivo. This points to a potential contribution of palmitate to vascular inflammation...
  52. ncbi request reprint Insulin resistance and congestive heart failure
    Norbert Stefan
    JAMA 294:2578; author reply 2578. 2005
  53. ncbi request reprint Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and nonobese subjects: response to Broch et al
    Norbert Stefan
    Diabetes Care 30:e91; author reply e92. 2007