Krisztian Stadler

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis
    Krisztian Stadler
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Physiol Endocrinol Metab 295:E456-62. 2008
  2. pmc Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes
    Krisztian Stadler
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233 MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:866-74. 2008
  3. pmc Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation
    Maria B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Diabetes 61:586-96. 2012
  4. pmc Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis
    Saurabh Chatterjee
    Free Radical Metabolism Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 183:4055-66. 2009
  5. pmc Ceruloplasmin (ferroxidase) oxidizes hydroxylamine probes: deceptive implications for free radical detection
    Douglas Ganini
    Free Radical Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 53:1514-21. 2012
  6. doi request reprint NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses
    Danielle Duma
    Laboratory of Signal Transduction, Institute of Environmental Health Sciences, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC, USA
    Eur J Pharmacol 668:285-92. 2011
  7. pmc Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin
    Kozo Nakai
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 01, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 103:4616-21. 2006
  8. pmc Direct magnetic resonance evidence for peroxymonocarbonate involvement in the cu,zn-superoxide dismutase peroxidase catalytic cycle
    Marcelo G Bonini
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC, USA
    J Biol Chem 284:14618-27. 2009
  9. pmc Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation
    Marcelo G Bonini
    Laboratories of Pharmacology and Chemistry and Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 105:8569-74. 2008
  10. pmc Biomarkers of Oxidative Stress Study IV: ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid
    Maria B Kadiiska
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 51:1636-42. 2011

Detail Information

Publications10

  1. pmc Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis
    Krisztian Stadler
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Physiol Endocrinol Metab 295:E456-62. 2008
    ..Taken together, our data demonstrate that acetone administration, a model of ketosis, can lead to protein oxidation and lipid peroxidation through a free radical-dependent mechanism driven mainly by iNOS overexpression...
  2. pmc Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes
    Krisztian Stadler
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233 MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:866-74. 2008
    ..Taken together, our studies support inducible nitric oxide synthase as a significant source of EPR-detectable reactive intermediates, which leads to lipid peroxidation and may contribute to disease progression as well...
  3. pmc Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation
    Maria B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Diabetes 61:586-96. 2012
    ..Our results suggest that hepatic iNOS expression may underlie the accumulation of lipid end products and that reducing the accumulation of toxic lipid metabolites contributes to a better redox status in insulin-sensitive tissues...
  4. pmc Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis
    Saurabh Chatterjee
    Free Radical Metabolism Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 183:4055-66. 2009
    ..These results open up new avenues for the investigation of several enzymes involved in inflammation and their site-specific oxidative modifications by protein-protein interactions as well as their role in sepsis...
  5. pmc Ceruloplasmin (ferroxidase) oxidizes hydroxylamine probes: deceptive implications for free radical detection
    Douglas Ganini
    Free Radical Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 53:1514-21. 2012
    ..In conclusion, we show that the ferroxidase activity of ceruloplasmin is a possible biological source of artifacts in the cyclic hydroxylamine-oxidation assay used for reactive oxygen species detection and quantification...
  6. doi request reprint NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses
    Danielle Duma
    Laboratory of Signal Transduction, Institute of Environmental Health Sciences, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC, USA
    Eur J Pharmacol 668:285-92. 2011
    ....
  7. pmc Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin
    Kozo Nakai
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 01, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 103:4616-21. 2006
    ..Our results imply that both iNOS and XO, but neither NADPH oxidase nor ferric iron, work synergistically to form lipid radical and nitrotyrosine early in the skin inflammation caused by LPS...
  8. pmc Direct magnetic resonance evidence for peroxymonocarbonate involvement in the cu,zn-superoxide dismutase peroxidase catalytic cycle
    Marcelo G Bonini
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC, USA
    J Biol Chem 284:14618-27. 2009
    ..The results gathered herein indicate that peroxymonocarbonate (HOOCO(2)(-)) is a key intermediate in the SOD1 peroxidase cycle and identify this species as the precursor of carbonate radical anions...
  9. pmc Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation
    Marcelo G Bonini
    Laboratories of Pharmacology and Chemistry and Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 105:8569-74. 2008
    ..Our studies in cell cultures, isolated vessels, and whole animals identified endothelial NOS activation as a fundamental requirement for nitroglycerin action at pharmacologically relevant concentrations in WT animals...
  10. pmc Biomarkers of Oxidative Stress Study IV: ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid
    Maria B Kadiiska
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 51:1636-42. 2011
    ..We conclude that measurements of antioxidants in plasma are not sensitive biomarkers for oxidative damage induced by ozone and are not a useful choice for the assessment of oxidative damage by ozone in vivo...