Prakash Srinivasan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito
    Prakash Srinivasan
    Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD 20852, USA
    Cell Microbiol 10:1304-12. 2008
  2. ncbi Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:13275-80. 2011
  3. ncbi Distinct roles of Plasmodium rhomboid 1 in parasite development and malaria pathogenesis
    Prakash Srinivasan
    Department of Molecular Microbiology, ImmunologyJohns Hopkins School of Public Health, Baltimore, Maryland, United States of America
    PLoS Pathog 5:e1000262. 2009
  4. ncbi Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges
    Michael A Riehle
    Johns Hopkins University, Bloomberg School of Public Health, Dept of Molecular Microbiology and Immunology, 615 N. Wolfe St, Baltimore, MD 21205-2179, USA
    J Exp Biol 206:3809-16. 2003
  5. ncbi Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P
    Michael Waisberg
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 109:5429-34. 2012
  6. ncbi Dendritic cells and hepatocytes use distinct pathways to process protective antigen from plasmodium in vivo
    Ian A Cockburn
    Johns Hopkins Malaria Research Institute and Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 7:e1001318. 2011
  7. ncbi Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria
    Ivo M B Francischetti
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 32:786-98. 2012
  8. ncbi Molecular strategies to study Plasmodium-mosquito interactions
    Anil Ghosh
    Case Western Reserve University, Department of Genetics, 10900 Euclid Avenue, Cleveland, Ohio 44106-4955, USA
    Trends Parasitol 19:94-101. 2003
  9. ncbi Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions
    Xiaojin Xu
    Department of Biological Sciences, Imperial College, London SW7 2AZ, UK
    Mol Biochem Parasitol 142:76-87. 2005
  10. ncbi Analysis of the Plasmodium and Anopheles transcriptional repertoire during ookinete development and midgut invasion
    Eappen G Abraham
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 279:5573-80. 2004

Collaborators

Detail Information

Publications11

  1. ncbi PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito
    Prakash Srinivasan
    Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD 20852, USA
    Cell Microbiol 10:1304-12. 2008
    ..As a result, mosquitoes infected with PbCap380(-) parasites do not transmit malaria. Targeting of the oocyst capsule may provide a new strategy for malaria control...
  2. ncbi Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:13275-80. 2011
    ..Collectively, these results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plasmodium merozoites to RBC invasion and point to RON2 as a potential vaccine candidate...
  3. ncbi Distinct roles of Plasmodium rhomboid 1 in parasite development and malaria pathogenesis
    Prakash Srinivasan
    Department of Molecular Microbiology, ImmunologyJohns Hopkins School of Public Health, Baltimore, Maryland, United States of America
    PLoS Pathog 5:e1000262. 2009
    ..The results indicate that P. berghei Rhomboid 1 plays a nonessential but important role during parasite development and identify rhomboid proteases as potential targets for disease control...
  4. ncbi Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges
    Michael A Riehle
    Johns Hopkins University, Bloomberg School of Public Health, Dept of Molecular Microbiology and Immunology, 615 N. Wolfe St, Baltimore, MD 21205-2179, USA
    J Exp Biol 206:3809-16. 2003
    ....
  5. ncbi Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P
    Michael Waisberg
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 109:5429-34. 2012
    ....
  6. ncbi Dendritic cells and hepatocytes use distinct pathways to process protective antigen from plasmodium in vivo
    Ian A Cockburn
    Johns Hopkins Malaria Research Institute and Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 7:e1001318. 2011
    ..Together, these results indicate that the presentation of epitopes to CD8+ T cells follows distinct pathways in DCs when the immune response is induced and in hepatocytes during the effector phase...
  7. ncbi Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria
    Ivo M B Francischetti
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 32:786-98. 2012
    ..DF was investigated here as a drug to treat cerebral malaria...
  8. ncbi Molecular strategies to study Plasmodium-mosquito interactions
    Anil Ghosh
    Case Western Reserve University, Department of Genetics, 10900 Euclid Avenue, Cleveland, Ohio 44106-4955, USA
    Trends Parasitol 19:94-101. 2003
    ..This article reviews recent achievements and introduces some promising new technologies and approaches for studying host-parasite interactions...
  9. ncbi Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions
    Xiaojin Xu
    Department of Biological Sciences, Imperial College, London SW7 2AZ, UK
    Mol Biochem Parasitol 142:76-87. 2005
    ..Intriguing transcription patterns for highly variable Plasmodium surface antigens may indicate parasite strategies to avoid recognition by the mosquito's immune surveillance system...
  10. ncbi Analysis of the Plasmodium and Anopheles transcriptional repertoire during ookinete development and midgut invasion
    Eappen G Abraham
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 279:5573-80. 2004
    ..Kafatos, F. C., Adams, J. H., and Jacobs-Lorena, M. (2004) J. Biol. Chem. 279, 5581-5587) provide the foundation for further analysis of Plasmodium differentiation in the mosquito and of mosquito responses to the parasite...
  11. ncbi Analysis of the Plasmodium and Anopheles transcriptomes during oocyst differentiation
    Prakash Srinivasan
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 279:5581-7. 2004
    ..Kafatos, F. C., Dimopoulos, G., & Jacobs-Lorena, M. (2003) J. Biol. Chem. 279, 5573-5580) provide the foundation for studies seeking to understand at the molecular level Plasmodium development and its interactions with the mosquito...