Prakash Srinivasan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito
    Prakash Srinivasan
    Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD 20852, USA
    Cell Microbiol 10:1304-12. 2008
  2. ncbi request reprint Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research and
    Proc Natl Acad Sci U S A 111:10311-6. 2014
  3. pmc Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20852, USA
    Nat Commun 4:2261. 2013
  4. pmc Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:13275-80. 2011
  5. pmc Distinct roles of Plasmodium rhomboid 1 in parasite development and malaria pathogenesis
    Prakash Srinivasan
    Department of Molecular Microbiology, ImmunologyJohns Hopkins School of Public Health, Baltimore, Maryland, United States of America
    PLoS Pathog 5:e1000262. 2009
  6. pmc Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P
    Michael Waisberg
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 109:5429-34. 2012
  7. pmc Malaria parasites tolerate a broad range of ionic environments and do not require host cation remodelling
    Ajay D Pillai
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Mol Microbiol 88:20-34. 2013
  8. ncbi request reprint Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges
    Michael A Riehle
    Johns Hopkins University, Bloomberg School of Public Health, Dept of Molecular Microbiology and Immunology, 615 N Wolfe St, Baltimore, MD 21205 2179, USA
    J Exp Biol 206:3809-16. 2003
  9. pmc Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria
    Ivo M B Francischetti
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 32:786-98. 2012
  10. pmc Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay
    Harold Obiakor
    Laboratory of Malaria Immunology and Vaccinology, NIAID NIH, Rockville, MD, USA
    Clin Vaccine Immunol 20:433-42. 2013

Collaborators

Detail Information

Publications15

  1. doi request reprint PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito
    Prakash Srinivasan
    Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD 20852, USA
    Cell Microbiol 10:1304-12. 2008
    ..As a result, mosquitoes infected with PbCap380(-) parasites do not transmit malaria. Targeting of the oocyst capsule may provide a new strategy for malaria control...
  2. ncbi request reprint Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research and
    Proc Natl Acad Sci U S A 111:10311-6. 2014
    ..Our results suggest that AMA1 subunit vaccines may be highly effective when presented to the immune system as an invasion complex with RON2. ..
  3. pmc Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20852, USA
    Nat Commun 4:2261. 2013
    ..This study uncovers a strategy that will allow for highly effective combination therapies alongside existing antimalarial drugs. ..
  4. pmc Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:13275-80. 2011
    ..Collectively, these results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plasmodium merozoites to RBC invasion and point to RON2 as a potential vaccine candidate...
  5. pmc Distinct roles of Plasmodium rhomboid 1 in parasite development and malaria pathogenesis
    Prakash Srinivasan
    Department of Molecular Microbiology, ImmunologyJohns Hopkins School of Public Health, Baltimore, Maryland, United States of America
    PLoS Pathog 5:e1000262. 2009
    ..The results indicate that P. berghei Rhomboid 1 plays a nonessential but important role during parasite development and identify rhomboid proteases as potential targets for disease control...
  6. pmc Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P
    Michael Waisberg
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 109:5429-34. 2012
    ....
  7. pmc Malaria parasites tolerate a broad range of ionic environments and do not require host cation remodelling
    Ajay D Pillai
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Mol Microbiol 88:20-34. 2013
    ..These findings provide insights into transmembrane signalling in malaria and reveal fundamental differences between host and parasite ionic requirements...
  8. ncbi request reprint Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges
    Michael A Riehle
    Johns Hopkins University, Bloomberg School of Public Health, Dept of Molecular Microbiology and Immunology, 615 N Wolfe St, Baltimore, MD 21205 2179, USA
    J Exp Biol 206:3809-16. 2003
    ....
  9. pmc Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria
    Ivo M B Francischetti
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 32:786-98. 2012
    ..DF was investigated here as a drug to treat cerebral malaria...
  10. pmc Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay
    Harold Obiakor
    Laboratory of Malaria Immunology and Vaccinology, NIAID NIH, Rockville, MD, USA
    Clin Vaccine Immunol 20:433-42. 2013
    ....
  11. pmc Dendritic cells and hepatocytes use distinct pathways to process protective antigen from plasmodium in vivo
    Ian A Cockburn
    Johns Hopkins Malaria Research Institute and Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 7:e1001318. 2011
    ..Together, these results indicate that the presentation of epitopes to CD8+ T cells follows distinct pathways in DCs when the immune response is induced and in hepatocytes during the effector phase...
  12. ncbi request reprint Molecular strategies to study Plasmodium-mosquito interactions
    Anil Ghosh
    Case Western Reserve University, Department of Genetics, 10900 Euclid Avenue, Cleveland, Ohio 44106 4955, USA
    Trends Parasitol 19:94-101. 2003
    ..This article reviews recent achievements and introduces some promising new technologies and approaches for studying host-parasite interactions...
  13. ncbi request reprint Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions
    Xiaojin Xu
    Department of Biological Sciences, Imperial College, London SW7 2AZ, UK
    Mol Biochem Parasitol 142:76-87. 2005
    ..Intriguing transcription patterns for highly variable Plasmodium surface antigens may indicate parasite strategies to avoid recognition by the mosquito's immune surveillance system...
  14. ncbi request reprint Analysis of the Plasmodium and Anopheles transcriptional repertoire during ookinete development and midgut invasion
    Eappen G Abraham
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 279:5573-80. 2004
    ..Kafatos, F. C., Adams, J. H., and Jacobs-Lorena, M. (2004) J. Biol. Chem. 279, 5581-5587) provide the foundation for further analysis of Plasmodium differentiation in the mosquito and of mosquito responses to the parasite...
  15. ncbi request reprint Analysis of the Plasmodium and Anopheles transcriptomes during oocyst differentiation
    Prakash Srinivasan
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 279:5581-7. 2004
    ..Kafatos, F. C., Dimopoulos, G., & Jacobs-Lorena, M. (2003) J. Biol. Chem. 279, 5573-5580) provide the foundation for studies seeking to understand at the molecular level Plasmodium development and its interactions with the mosquito...