C Y Spong

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome
    C Y Spong
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Pharmacol Exp Ther 297:774-9. 2001
  2. doi request reprint Reversal of alcohol-induced learning deficits in the young adult in a model of fetal alcohol syndrome
    Maddalena Incerti
    Unit on Perinatal and Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 0925, USA
    Obstet Gynecol 115:350-6. 2010
  3. ncbi request reprint Preterm premature rupture of the fetal membranes complicated by oligohydramnios
    C Y Spong
    Pregnancy and Perinatology Branch, Center for Research for Mothers and Children, NICHD, National Institutes of Health, Bethesda, Maryland, USA
    Clin Perinatol 28:753-9, vi. 2001
  4. ncbi request reprint Management of isoimmunization in the presence of multiple maternal antibodies
    C Y Spong
    Department of Obstetrics and Gynecology, Georgetown University, Washington DC, USA
    Am J Obstet Gynecol 185:481-4. 2001
  5. ncbi request reprint Maternal estrogen receptor-beta expression during mouse gestation
    C Y Spong
    Section on Developmental and Molecular Pharmacology, LDN, NICHD, NIH, Bethesda, Maryland 20892, USA
    Am J Reprod Immunol 44:249-52. 2000
  6. ncbi request reprint Vasoactive intestinal peptide mRNA and immunoreactivity are decreased in fetal alcohol syndrome model
    Catherine Y Spong
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, NICHD, NIH, Building 49, Room 5A 38, MSC 4480, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Regul Pept 108:143-7. 2002
  7. doi request reprint What is new in maternal-fetal medicine?: best articles from the past year
    Catherine Y Spong
    Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Obstet Gynecol 119:168-70. 2012
  8. ncbi request reprint Protective peptides derived from novel glial proteins
    D E Brenneman
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, National Institute on Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Soc Trans 28:452-5. 2000
  9. ncbi request reprint Levels of interleukin-6 in second-trimester amniotic fluid are not predictive of adverse neonatal outcome
    D Hasson
    Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC 20007, USA
    J Matern Fetal Med 10:35-9. 2001
  10. ncbi request reprint Chemokines released from astroglia by vasoactive intestinal peptide. Mechanism of neuroprotection from HIV envelope protein toxicity
    D E Brenneman
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 921:109-14. 2000

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome
    C Y Spong
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Pharmacol Exp Ther 297:774-9. 2001
    ....
  2. doi request reprint Reversal of alcohol-induced learning deficits in the young adult in a model of fetal alcohol syndrome
    Maddalena Incerti
    Unit on Perinatal and Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 0925, USA
    Obstet Gynecol 115:350-6. 2010
    ....
  3. ncbi request reprint Preterm premature rupture of the fetal membranes complicated by oligohydramnios
    C Y Spong
    Pregnancy and Perinatology Branch, Center for Research for Mothers and Children, NICHD, National Institutes of Health, Bethesda, Maryland, USA
    Clin Perinatol 28:753-9, vi. 2001
    ..In this article the role of amniotic fluid in fetal development, especially lung development, is reviewed; complications resulting from oligohydramnios are outlined; and the evaluated therapeutics and management schemes are delineated...
  4. ncbi request reprint Management of isoimmunization in the presence of multiple maternal antibodies
    C Y Spong
    Department of Obstetrics and Gynecology, Georgetown University, Washington DC, USA
    Am J Obstet Gynecol 185:481-4. 2001
    ....
  5. ncbi request reprint Maternal estrogen receptor-beta expression during mouse gestation
    C Y Spong
    Section on Developmental and Molecular Pharmacology, LDN, NICHD, NIH, Bethesda, Maryland 20892, USA
    Am J Reprod Immunol 44:249-52. 2000
    ..The objective of this study was to evaluate the expression of ER-beta during pregnancy...
  6. ncbi request reprint Vasoactive intestinal peptide mRNA and immunoreactivity are decreased in fetal alcohol syndrome model
    Catherine Y Spong
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, NICHD, NIH, Building 49, Room 5A 38, MSC 4480, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Regul Pept 108:143-7. 2002
    ..This alcohol-induced loss of a recognized regulator of embryonic growth and differentiation may contribute to the sequelae of toxicity observed in fetal alcohol syndrome...
  7. doi request reprint What is new in maternal-fetal medicine?: best articles from the past year
    Catherine Y Spong
    Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Obstet Gynecol 119:168-70. 2012
    ..Spong discusses six recent publications, and each is concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in Box 1 on this page, along with direct links to the abstracts...
  8. ncbi request reprint Protective peptides derived from novel glial proteins
    D E Brenneman
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, National Institute on Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Soc Trans 28:452-5. 2000
    ..These peptides, both as individual agents and in combination, have promise as possible protective agents in the treatment of human neurodegenerative disease and in pathologies involving oxidative stress...
  9. ncbi request reprint Levels of interleukin-6 in second-trimester amniotic fluid are not predictive of adverse neonatal outcome
    D Hasson
    Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC 20007, USA
    J Matern Fetal Med 10:35-9. 2001
    ..OBJECTIVE: Elevation of interleukin (IL)-6 in the amniotic fluid (AF) during the second trimester is associated with increased risk of preterm deliver..
  10. ncbi request reprint Chemokines released from astroglia by vasoactive intestinal peptide. Mechanism of neuroprotection from HIV envelope protein toxicity
    D E Brenneman
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 921:109-14. 2000
    ..Our studies further imply that in a developing system, stimulation with a MIP-1 alpha like substance is necessary for neuronal survival and interference with this action results in neuronal cell death...
  11. ncbi request reprint Optimization of cytokine stability in stored amniotic fluid
    A E Porter
    Department of Obstetrics and Gynecology, Georgetown University, Washington, DC, USA
    Am J Obstet Gynecol 185:459-62. 2001
    ..05). CONCLUSIONS: Degradation of cytokines occurs when amniotic fluid samples are stored for prolonged periods at temperatures greater than -80 degrees C. The addition of a protease inhibitor helps stem the degradation of some cytokines...
  12. ncbi request reprint Maternal regulation of embryonic growth: the role of vasoactive intestinal peptide
    C Y Spong
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 140:917-24. 1999
    ..These findings suggest that maternal lymphocytes are the source of VIP's regulating early postimplantation embryonic growth...
  13. ncbi request reprint Novel peptides prevent alcohol-induced spatial learning deficits and proinflammatory cytokine release in a mouse model of fetal alcohol syndrome
    Joy Vink
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Obstet Gynecol 193:825-9. 2005
    ....
  14. ncbi request reprint Biophysical profile in predicting acute ascending infection in preterm rupture of membranes before 32 weeks
    A Ghidini
    Department of Obstetrics and Gynecology, Georgetown University Medical Center, Washington, DC 20007, USA
    Obstet Gynecol 96:201-6. 2000
    ....
  15. ncbi request reprint Prevention of alcohol-induced developmental delays and learning abnormalities in a model of fetal alcohol syndrome
    M Endres
    Unit on Perinatal and Developmental Neurobiology, National Insitute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 0925, USA
    Am J Obstet Gynecol 193:1028-34. 2005
    ..The objective of this work was to evaluate whether activity-dependent neurotrophic factor-12 could prevent alcohol-induced damage in a model of fetal alcohol syndrome...
  16. ncbi request reprint Prevention of alcohol-induced learning deficits in fetal alcohol syndrome mediated through NMDA and GABA receptors
    Laura Toso
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child and Human Development, National Institutes of Health, Bethesda, MD 20892 0925, USA
    Am J Obstet Gynecol 194:681-6. 2006
    ..Vasoactive intestinal peptide (VIP)-related peptides prevented the learning deficit in the offspring in a model for fetal alcohol syndrome. We evaluated whether the mechanism of the peptide protection included NR2B, NR2A, and GABAAalpha5...
  17. ncbi request reprint Differential expression of c-fos in a mouse model of fetal alcohol syndrome
    Sarah H Poggi
    Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC, USA
    Am J Obstet Gynecol 189:786-9. 2003
    ..Our objective was to identify signal transduction pathways expressed in a model of FAS and to quantify expression of c-fos, a gene in the stress signal pathway...
  18. ncbi request reprint Neuroprotective peptides prevent some alcohol-induced alteration in gamma-aminobutyric acid A-beta3, which plays a role in cleft lip and palate and learning in fetal alcohol syndrome
    Laura Toso
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 196:259.e1-5. 2007
    ..The gamma-aminobutyric acid A (GABA) receptor subunit GABAbeta3 plays a critical role for nervous system and palate development. Our objective was to determine whether the neuropeptides prevented alcohol-induced damage through GABAbeta3...
  19. pmc Protection against prenatal alcohol-induced damage
    Catherine Y Spong
    Pregnancy and Perinatology Branch, The National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Med 3:e196. 2006
  20. pmc Altered expression of KIF17, a kinesin motor protein associated with NR2B trafficking, may mediate learning deficits in a Down syndrome mouse model
    Robin Roberson
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20895, USA
    Am J Obstet Gynecol 198:313.e1-4. 2008
    ..Down regulation of KIF17 reflects up-regulation of less plastic NR2A subunit. We evaluated NR2B, NR2A, and KIF17 in Ts65Dn and control mice...
  21. ncbi request reprint Prediction and prevention of recurrent spontaneous preterm birth
    Catherine Y Spong
    Pregnancy and Perinatology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Bethesda, MD 20892, USA
    Obstet Gynecol 110:405-15. 2007
    ..Results from the ongoing trials of cerclage as an interventional therapy and omega-3 fatty acid supplementation as a preventive therapy will provide additional knowledge for the optimal management of these high-risk women...
  22. pmc Understanding the mechanism of learning enhancement: NMDA and GABA receptor expression
    Laura Toso
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Obstet Gynecol 197:267.e1-4. 2007
    ..Our objective was to test whether NMDA and GABA receptors contribute to the learning enhancement that is induced by the peptides after adult administration...
  23. ncbi request reprint Risk of uterine rupture and adverse perinatal outcome at term after cesarean delivery
    Catherine Y Spong
    National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Obstet Gynecol 110:801-7. 2007
    ....
  24. doi request reprint Prevention of the alcohol-induced changes in brain-derived neurotrophic factor expression using neuroprotective peptides in a model of fetal alcohol syndrome
    Maddalena Incerti
    Unit on Perinatal and Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, USA
    Am J Obstet Gynecol 202:457.e1-4. 2010
    ....
  25. pmc Alterations in phosphorylated cyclic adenosine monophosphate response element of binding protein activity: a pathway for fetal alcohol syndrome-related neurotoxicity
    Robin Roberson
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20895, USA
    Am J Obstet Gynecol 200:193.e1-5. 2009
    ..In adult (FAS) mice, we measured phosphorylated cyclic adenosine monophosphate response element of binding protein (pCREB) staining in hippocampal subregions to evaluate a possible mechanism underlying FAS learning deficits...
  26. doi request reprint Prenatal NAP+SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and gamma-aminobutyric acid receptors
    Joy Vink
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Obstet Gynecol 200:524.e1-4. 2009
    ..We investigated whether this finding involves N-methyl-D-aspartic acid and gamma-aminobutyric acid (GABA) receptor subunits...
  27. pmc Antenatal testing-a reevaluation: executive summary of a Eunice Kennedy Shriver National Institute of Child Health and Human Development workshop
    Caroline Signore
    Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Obstet Gynecol 113:687-701. 2009
    ..Finally, a synthesis of recommendations for further research compiled from three breakout workgroups is presented...
  28. ncbi request reprint The role of activity-dependent neuroprotective protein in a mouse model of fetal alcohol syndrome
    Sarah H Poggi
    Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC, USA
    Am J Obstet Gynecol 189:790-3. 2003
    ..Our objective was to characterize ADNP in this model to relate this protein to the mechanisms of damage and peptide neuroprotection...
  29. ncbi request reprint Protective peptides that are orally active and mechanistically nonchiral
    Douglas E Brenneman
    Section of Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    J Pharmacol Exp Ther 309:1190-7. 2004
    ..These studies suggest therapeutic potential for the combined administration of neuroprotective peptides that can act through a mechanism independent of chiral recognition...
  30. ncbi request reprint VIP and D-ala-peptide T-amide release chemokines which prevent HIV-1 GP120-induced neuronal death
    D E Brenneman
    Section on Developmental and Molecular Pharmacology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res 838:27-36. 1999
    ..Furthermore, neuroprotection produced by chemokines is dependent on both the type of chemokine and the variant structure of gp120 and may be relevant to drug strategies for the treatment of AIDS dementia...
  31. ncbi request reprint Amniotic fluid index in the uncomplicated term pregnancy. Prediction of outcome
    M Rainford
    Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, USA
    J Reprod Med 46:589-92. 2001
    ..CONCLUSION: In the uncomplicated pregnancy at term, an amniotic fluid index < or = 5 cm increases the incidence of labor induction but does not appear to affect the rate of operative delivery for abnormal fetal heart rate tracings...
  32. pmc Timing of elective repeat cesarean delivery at term and neonatal outcomes
    Alan T N Tita
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Alabama at Birmingham, 619 19th St South, Birmingham, AL 35249, USA
    N Engl J Med 360:111-20. 2009
    ..We assessed associations between elective cesarean delivery at term (37 weeks of gestation or longer) but before 39 weeks of gestation and neonatal outcomes...
  33. pmc Prevention of developmental delays in a Down syndrome mouse model
    Laura Toso
    Unit on Perinatal and Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child and Human Development, National Institutes of Health, Bethesda, Maryland 20852, USA
    Obstet Gynecol 112:1242-51. 2008
    ....
  34. ncbi request reprint Prenatal alcohol exposure alters GABA(A)alpha5 expression: a mechanism of alcohol-induced learning dysfunction
    Laura Toso
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child and Human Development, National Institute of Health, Bethesda, MD 20892 0925, USA
    Am J Obstet Gynecol 195:522-7. 2006
    ..We were interested to evaluate alcohol's effect on GABA(A)alpha5 expression to further understand alcohol-induced learning dysfunction...
  35. doi request reprint Treatment with neuropeptides attenuates c-fos expression in a mouse model of fetal alcohol syndrome
    Maddalena Incerti
    Unit on Perinatal and Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland 20892 0925, USA
    Am J Perinatol 27:743-8. 2010
    ..There was no difference in C-FOS expression in the cortex. Adult treatment with NAP + SAL restored the down-regulation of C-FOS expression in hippocampus attenuating the alcohol-induced alteration of the stress-signal pathway...
  36. ncbi request reprint Stillbirth in obstetric practice: report of survey findings
    C Y Spong
    Pregnancy and Perinatology Branch, NICHD, NIH, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 14:39-44. 2003
    ..Despite the large burden, little information is available to offer patients regarding etiology, treatment or prevention for a subsequent pregnancy...
  37. ncbi request reprint Severe meconium aspiration syndrome is not caused by aspiration of meconium
    A Ghidini
    Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC 20007, USA
    Am J Obstet Gynecol 185:931-8. 2001
    ....
  38. ncbi request reprint A planned randomized clinical trial of treatment for mild gestational diabetes mellitus
    M B Landon
    The Maternal Fetal Medicine Units Network, The National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 11:226-31. 2002
    ..A planned study is described which will determine whether a benefit exists for the treatment of mild carbohydrate intolerance during pregnancy...
  39. ncbi request reprint Randomized controlled trial of 50 and 100 mcg of misoprostol for induction of labor at term
    A Ghidini
    Department of Obstetrics and Gynecology, Inova Alexandria Hospital, Virginia 22304, USA
    Arch Gynecol Obstet 265:128-30. 2001
    ..05, beta=0.80). Similarly, rates of 5-minute Apgar scores <7 (4% vs 3%, p=1.0), and of meconium passage (17% vs 25%, p=0.73) were not significantly different between the two groups...
  40. pmc The frequency and complication rates of hysterectomy accompanying cesarean delivery
    Cynthia S Shellhaas
    Department of Obstetrics and Gynecology, Ohio State University, Columbus, 43210, USA
    Obstet Gynecol 114:224-9. 2009
    ..To estimate the frequency, indications, and complications of cesarean hysterectomy...
  41. pmc Failed operative vaginal delivery
    James M Alexander
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Obstet Gynecol 114:1017-22. 2009
    ..To compare maternal and neonatal outcomes in women undergoing second-stage cesarean delivery after a trial of operative vaginal delivery with those in women undergoing second-stage cesarean delivery without such an attempt...
  42. ncbi request reprint Risk of uterine rupture with a trial of labor in women with multiple and single prior cesarean delivery
    Mark B Landon
    Department of Obstetrics and Gynecology, Ohio State University, Columbus, Ohio, USA
    Obstet Gynecol 108:12-20. 2006
    ..To determine whether the risk for uterine rupture is increased in women attempting vaginal birth after multiple cesarean deliveries...
  43. ncbi request reprint Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women
    Israel Hendler
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Hutzel Hospital Wayne State University, Detroit, Michigan 48201, USA
    Obstet Gynecol 108:77-82. 2006
    ..To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women...
  44. pmc A multicenter, randomized trial of treatment for mild gestational diabetes
    Mark B Landon
    Department of Obstetrics and Gynecology, Ohio State University, Columbus, USA
    N Engl J Med 361:1339-48. 2009
    ..It is uncertain whether treatment of mild gestational diabetes mellitus improves pregnancy outcomes...
  45. ncbi request reprint N-methyl-D-aspartate subunit expression during mouse development altered by in utero alcohol exposure
    Laura Toso
    NICHD, National Institutes of Health, Bethesda, MD 20892 0925, USA
    Am J Obstet Gynecol 193:1534-9. 2005
    ..To understand the mechanism of learning deficits in FAS, we evaluated NR2B and NR2A expression in embryonic and adult mice...
  46. ncbi request reprint Progesterone for prevention of recurrent preterm birth: impact of gestational age at previous delivery
    Catherine Y Spong
    National Institute of Child Health and Human Development, Bethesda, MD, USA
    Am J Obstet Gynecol 193:1127-31. 2005
    ..We hypothesized that treatment with 17-OHP caproate is more effective in prolonging pregnancy depending on the gestational age of the earliest previous preterm birth (20-27.9, 28-33.9 vs 34-36.9 weeks)...
  47. ncbi request reprint Fetal growth after preterm premature rupture of membranes: is it related to amniotic fluid volume?
    Shad H Deering
    Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC, USA
    J Matern Fetal Neonatal Med 20:397-400. 2007
    ..It is unknown whether impairment of fetal growth is mediated through external compression from decreased amniotic fluid volume or (an)other mechanism(s)...
  48. ncbi request reprint Learning enhancement with neuropeptides
    Laura Toso
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD, USA
    Am J Obstet Gynecol 194:1153-8; discussion 1158-9. 2006
    ..The current studies were undertaken to evaluate whether these peptides could enhance performance in a learning and memory paradigm when administered either prenatally or to aged mice...
  49. ncbi request reprint Gender differences in amniotic fluid cytokine levels
    S H Poggi
    Department of Obstetrics and Gynecology, Georgetown University Hospital, 3800 Reservoir Road, Washington, DC 20007, USA
    J Matern Fetal Neonatal Med 15:367-71. 2004
    ..We investigated whether fetal gender affects amniotic fluid levels of the inflammatory cytokines interleukin (IL)-6 and IL-10 and the pro-angiogenesis cytokine angiogenin...
  50. ncbi request reprint Single versus weekly courses of antenatal corticosteroids: evaluation of safety and efficacy
    Ronald J Wapner
    Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA, USA
    Am J Obstet Gynecol 195:633-42. 2006
    ..The purpose of this study was to determine if weekly corticosteroids improve neonatal outcome without undue harm...
  51. ncbi request reprint A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twins
    Dwight J Rouse
    Department of Obstetrics and Gynecology, Center for Women s Reproductive Health, University of Alabama at Birmingham, Birmingham 35249 7333, USA
    N Engl J Med 357:454-61. 2007
    ..In singleton gestations, 17 alpha-hydroxyprogesterone caproate (17P) has been shown to reduce the rate of recurrent preterm birth. This study was undertaken to evaluate whether 17P would reduce the rate of preterm birth in twin gestations...
  52. pmc Cesarean delivery for the second twin
    James M Alexander
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235 9032, USA
    Obstet Gynecol 112:748-52. 2008
    ..To examine maternal and infant outcomes after a vaginal delivery of twin A and a cesarean delivery of twin B, and to identify whether the second twin experienced increased short-term morbidity as part of a combined route of delivery...
  53. ncbi request reprint Complications of anesthesia for cesarean delivery
    Steven L Bloom
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 106:281-7. 2005
    ....
  54. ncbi request reprint Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy
    Brian M Casey
    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 109:1129-35. 2007
    ..To establish pregnancy-specific free thyroxine thresholds and to assess perinatal effects associated with isolated maternal hypothyroxinemia identified in the first half of pregnancy...
  55. pmc Antiphospholipid antibodies and pregnancy outcomes in women heterozygous for factor V Leiden
    Tracy Manuck
    Department of Obstetrics and Gynecology, University of Utah, 30N 1900E, Room 2B200, Salt Lake City, UT 84132, USA
    J Reprod Immunol 85:180-5. 2010
    ..Among FVL carriers, the presence of antiphospholipid antibodies does not appear to contribute to adverse pregnancy outcome...
  56. ncbi request reprint Role of lamellar body count for the prediction of neonatal respiratory distress syndrome in non-diabetic pregnant women
    Alessandro Ghidini
    Department of Obstetrics and Gynecology, Georgetown University Hospital, 3PHC 3800 Reservoir Road, N W, Washington, DC 20007, USA
    Arch Gynecol Obstet 271:325-8. 2005
    ..Lamellar body count is a new and fast technique to establish the presence of fetal lung maturity. We have assessed the predictive ability of lamellar body count for neonatal respiratory distress syndrome (RDS) in a non-diabetic population...
  57. ncbi request reprint The Maternal-Fetal Medicine Units Cesarean Registry: safety and efficacy of a trial of labor in preterm pregnancy after a prior cesarean delivery
    Celeste P Durnwald
    Department of Obstetrics and Gynecology, Ohio State University, Columbus, OH, USA
    Am J Obstet Gynecol 195:1119-26. 2006
    ....
  58. ncbi request reprint Amniotic fluid index and birth weight: is there a relationship in diabetics with poor glycemic control?
    Joy Y Vink
    Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC 20007, USA
    Am J Obstet Gynecol 195:848-50. 2006
    ..This study was undertaken to evaluate if the previously demonstrated relationship between macrosomia (> 4000 g) and polyhydramnios (> 25 cm) is linear across birth weights (BW) in diabetic patients with poor glycemic control...
  59. ncbi request reprint The Maternal-Fetal Medicine Units cesarean registry: chorioamnionitis at term and its duration-relationship to outcomes
    Dwight J Rouse
    Department of Obstetrics and Gynecology, Center for Research in Women s Health, University of Alabama at Birmingham, 35249 7333, USA
    Am J Obstet Gynecol 191:211-6. 2004
    ..The purpose of this study was to evaluate the relationship between chorioamnionitis and its duration to adverse maternal, fetal, and neonatal outcomes...
  60. ncbi request reprint Decision-to-incision times and maternal and infant outcomes
    Steven L Bloom
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Obstet Gynecol 108:6-11. 2006
    ....
  61. ncbi request reprint Does air travel affect pregnancy outcome?
    Mala Freeman
    Department of Obstetrics and Gynecology, Georgetown University Medical Center, 3800 Reservoir Road N W, Washington, D C 20007, USA
    Arch Gynecol Obstet 269:274-7. 2004
    ..Statistical analysis included Student's t-test, Mann-Whitney U test, chi square, Fisher's exact test where appropriate, and linear and logistic regression analysis, with p<0.05 considered significant...
  62. ncbi request reprint Inflammatory-mediated model of cerebral palsy with developmental sequelae
    Laura Toso
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child and Human Development National Institute of Health, Bethesda, MD 20892 0925, USA
    Am J Obstet Gynecol 193:933-41. 2005
    ..Our objective was to develop an inflammatory model for CP based on chronic lipopolysaccharide (LPS) exposure with a recognizable phenotype in offspring...
  63. ncbi request reprint Trial of labor or repeat cesarean delivery in women with morbid obesity and previous cesarean delivery
    Judith U Hibbard
    Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois 60612, USA
    Obstet Gynecol 108:125-33. 2006
    ....
  64. pmc Vitamins C and E to prevent complications of pregnancy-associated hypertension
    James M Roberts
    Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, USA
    N Engl J Med 362:1282-91. 2010
    ..We assessed the effects of antioxidant supplementation with vitamins C and E, initiated early in pregnancy, on the risk of serious adverse maternal, fetal, and neonatal outcomes related to pregnancy-associated hypertension...
  65. pmc Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review
    Alan T N Tita
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Obstet Gynecol 113:675-82. 2009
    ..To review the current status of antibiotic prophylaxis for cesarean delivery, emerging strategies to enhance the effectiveness of antibiotic prophylaxis in reducing postcesarean infection, and the implications of the emerging practices...
  66. doi request reprint Maternal-Fetal Medicine Units Network cesarean registry: impact of shift change on cesarean complications
    Jennifer L Bailit
    Department of Obstetrics and Gynecology, Case Western Reserve University, Cleveland, OH, USA
    Am J Obstet Gynecol 198:173.e1-5. 2008
    ..This study was undertaken to evaluate the effect of change of shift for physicians and nurses on complications associated with cesarean delivery...
  67. ncbi request reprint Differential expression of embryonic and maternal activity-dependent neuroprotective protein during mouse development
    Sarah H Poggi
    Department of Obstetrics and Gynecology, 3PHC, Georgetown University Hospital, 3800 Reservoir Road, Washington, DC, USA
    Am J Obstet Gynecol 187:973-6. 2002
    ..The objective of this study was to characterize ADNP in mouse embryonic tissues throughout development...
  68. pmc Prediction of uterine rupture associated with attempted vaginal birth after cesarean delivery
    William A Grobman
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL, USA
    Am J Obstet Gynecol 199:30.e1-5. 2008
    ..The purpose of this study was to develop a model that predicts individual-specific risk of uterine rupture during an attempted vaginal birth after cesarean delivery...
  69. doi request reprint The 2008 National Institute of Child Health and Human Development workshop report on electronic fetal monitoring: update on definitions, interpretation, and research guidelines
    George A Macones
    Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Obstet Gynecol Neonatal Nurs 37:510-5. 2008
    ..A three-tier system for fetal heart rate tracing interpretation is also described. Lastly, prioritized topics for future research are provided...
  70. ncbi request reprint Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate
    Paul J Meis
    Department of Obstetrics and Gynecology, Wake Forest University, Winston Salem, NC 27157, USA
    N Engl J Med 348:2379-85. 2003
    ..The results of several small trials have suggested that 17 alpha-hydroxyprogesterone caproate (17P) may reduce the risk of preterm delivery...
  71. pmc Perioperative antibiotic prophylaxis for nonlaboring cesarean delivery
    Mara J Dinsmoor
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, USA
    Obstet Gynecol 114:752-6. 2009
    ..To estimate the efficacy of antibiotic prophylaxis at the time of nonlaboring cesarean delivery in reducing postpartum infection-related complications...
  72. pmc Absence of mitochondrial progesterone receptor polymorphisms in women with spontaneous preterm birth
    Tracy A Manuck
    Eunice Kennedy Shriver NICHD MFMU Network, Bethesda, MD, USA
    Reprod Sci 17:913-6. 2010
    ....
  73. doi request reprint Pregnancy outcomes in women with thyroid peroxidase antibodies
    Mina Abbassi-Ghanavati
    From the Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland
    Obstet Gynecol 116:381-6. 2010
    ....
  74. doi request reprint The 2008 National Institute of Child Health and Human Development workshop report on electronic fetal monitoring: update on definitions, interpretation, and research guidelines
    George A Macones
    Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Obstet Gynecol 112:661-6. 2008
    ..A three-tier system for fetal heart rate tracing interpretation is also described. Lastly, prioritized topics for future research are provided...
  75. ncbi request reprint Maternal morbidity associated with multiple repeat cesarean deliveries
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Obstet Gynecol 107:1226-32. 2006
    ..Our objective was to estimate the magnitude of increased maternal morbidity associated with increasing number of cesarean deliveries...
  76. ncbi request reprint The MFMU Cesarean Registry: uterine atony after primary cesarean delivery
    Dwight J Rouse
    Department of Obstetrics and Gynecology, Center for Research in Women s Health, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Obstet Gynecol 193:1056-60. 2005
    ..The purpose of this study was to define independent risk factors for uterine atony after primary cesarean delivery, and to assess their overall association with atony in the study cohort...
  77. pmc Second-stage labor duration in nulliparous women: relationship to maternal and perinatal outcomes
    Dwight J Rouse
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Obstet Gynecol 201:357.e1-7. 2009
    ..The purpose of this study was to assess maternal and perinatal outcomes as a function of second-stage labor duration...
  78. ncbi request reprint Maternal and perinatal outcomes associated with a trial of labor after prior cesarean delivery
    Mark B Landon
    Department of Obstetrics and Gynecology at Ohio State University, College of Medicine and Public Health, Columbus 43210 1228, USA
    N Engl J Med 351:2581-9. 2004
    ..The absolute and relative risks associated with a trial of labor in women with a history of cesarean delivery, as compared with elective repeated cesarean delivery without labor, are uncertain...
  79. ncbi request reprint A neuroprotective peptide antagonizes fetal alcohol exposure-compromised brain growth
    Feng C Zhou
    Indiana University School of Medicine, Department of Anatomy and Cell Biology and Program in Medical Neurobiology, and IUPUI, Indianapolis, IN 46202, USA
    J Mol Neurosci 24:189-99. 2004
    ....
  80. doi request reprint Previous preterm cesarean delivery and risk of subsequent uterine rupture
    Anthony C Sciscione
    Department of Obstetrics and Gynecology at Christiana Care Health System, Newark, Delaware 19713, USA
    Obstet Gynecol 111:648-53. 2008
    ..To determine if women with a history of a previous preterm cesarean delivery experienced an increased risk of subsequent uterine rupture compared with women who had a previous nonclassic term cesarean delivery...
  81. pmc A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy
    Dwight J Rouse
    University of Alabama at Birmingham, Birmingham, USA
    N Engl J Med 359:895-905. 2008
    ..Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy...
  82. ncbi request reprint 2004 where do we go from here?--Summary of working group discussions on thyroid function and gestational outcomes
    Joseph G Hollowell
    Department of Pediatrics, University of Kansas Medical Center, Lawrence, KS 66049, USA
    Thyroid 15:72-6. 2005
    ..The group then identified research needs and gaps. The results of these discussions are outlined in the paper with recommended research strategies and public health action...
  83. ncbi request reprint Cesarean delivery on maternal request: obstetrician-gynecologists' knowledge, perception, and practice patterns
    Barbara A Bettes
    Department of Research, The American College of Obstetricians and Gynecologists, Washington, DC 20024, USA
    Obstet Gynecol 109:57-66. 2007
    ..To examine obstetrician-gynecologists' knowledge, opinions, and practice patterns related to cesarean delivery on maternal request...
  84. ncbi request reprint Risk of third-trimester amniocentesis: a case-control study
    Jonathan G Hodor
    Department of Obstetrics and Gynecology, Georgetown University Hospital, 3800 Reservoir Road NW, 3PHC, Washington, DC 20007, USA
    Am J Perinatol 23:177-80. 2006
    ..Amniocentesis in the third trimester is not associated with increased risk of urgent delivery, placental abruption, PROM, Apgar score at 5 minutes < 7, or perinatal death within 48 hours of the procedure...
  85. ncbi request reprint Fetal pulse oximetry and cesarean delivery
    Steven L Bloom
    University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    N Engl J Med 355:2195-202. 2006
    ..Knowledge of fetal oxygen saturation, as an adjunct to electronic fetal monitoring, may be associated with a significant change in the rate of cesarean deliveries or the infant's condition at birth...
  86. ncbi request reprint Blood transfusion and cesarean delivery
    Dwight J Rouse
    Department of Obstetrics, The University of Alabama at Birmingham, Birmingham, Alabama 35249 7333, USA
    Obstet Gynecol 108:891-7. 2006
    ..To evaluate risks for intraoperative or postoperative packed red blood cell transfusion in women who underwent cesarean delivery...
  87. ncbi request reprint The MFMU Cesarean Registry: impact of time of day on cesarean complications
    Jennifer L Bailit
    Department of Obstetrics and Gynecology, Case Western Reserve University, Cleveland, OH, USA
    Am J Obstet Gynecol 195:1132-7. 2006
    ..Studies suggest that sleep deprivation adversely affects performance. We hypothesized that cesarean delivery complications would be more frequent during the night shift (11 pm-7 am), and evaluated morbidities by delivery shift...
  88. ncbi request reprint The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus
    Donna Dizon-Townson
    National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network, Bethesda, Maryland, USA
    Obstet Gynecol 106:517-24. 2005
    ....
  89. ncbi request reprint Are women with recurrent spontaneous preterm births different from those without such history?
    Brian M Mercer
    Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH, USA
    Am J Obstet Gynecol 194:1176-84; discussion 1184-5. 2006
    ....
  90. ncbi request reprint Comparison of maternal and infant outcomes from primary cesarean delivery during the second compared with first stage of labor
    James M Alexander
    Department of Obstetrics and Gynecology at the University of Texas Southwestern Medical Center, Dallas, Texas 75235 9032, USA
    Obstet Gynecol 109:917-21. 2007
    ..To compare maternal and neonatal outcomes when primary cesarean delivery is performed in the second stage of labor compared with the first stage...
  91. ncbi request reprint No phenotype associated with established lipopolysaccharide model for cerebral palsy
    Sarah H Poggi
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Obstet Gynecol 192:727-33. 2005
    ..To evaluate whether this histologic end point is associated with a CP phenotype, we reproduced a lipopolysaccharide (LPS) model for PVL, 1 and evaluated developmental, behavioral, and motor outcomes...
  92. ncbi request reprint Perioperative morbidity and mortality among human immunodeficiency virus infected women undergoing cesarean delivery
    Judette Louis
    Wayne State University, Detroit, MI, USA
    Obstet Gynecol 110:385-90. 2007
    ..To determine whether human immunodeficiency virus (HIV)-infected women have a higher rate of postcesarean morbidity and mortality compared with women without HIV infection...
  93. ncbi request reprint Recent developments in preventing recurrent preterm birth
    Catherine Y Spong
    Obstet Gynecol 101:1153-4. 2003
  94. doi request reprint Labor outcomes with increasing number of prior vaginal births after cesarean delivery
    Brian M Mercer
    Department of Obstetrics and Gynecology at Case Western Reserve University MetroHealth Medical Center, Cleveland, Ohio 44109 1989, USA
    Obstet Gynecol 111:285-91. 2008
    ..To estimate the success rates and risks of an attempted vaginal birth after cesarean delivery (VBAC) according to the number of prior successful VBACs...
  95. ncbi request reprint Peptide antagonists of ethanol inhibition of l1-mediated cell-cell adhesion
    Michael F Wilkemeyer
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Pharmacol Exp Ther 303:110-6. 2002
    ..These findings support the hypothesis that ethanol inhibition of L1 adhesion contributes to ethanol teratogenesis...
  96. ncbi request reprint Antenatal magnesium treatment and neonatal illness severity as measured by the Score for Neonatal Acute Physiology (SNAP)
    Shad H Deering
    Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC, USA
    J Matern Fetal Neonatal Med 17:151-5. 2005
    ..To determine if antepartum administration of magnesium sulfate affects the Score for Neonatal Acute Physiology (SNAP)...
  97. ncbi request reprint Pregnancy outcomes for women with placenta previa in relation to the number of prior cesarean deliveries
    William A Grobman
    Department of Obstetrics and Gynecology at Northwestern University, Chicago, Illinois, USA
    Obstet Gynecol 110:1249-55. 2007
    ..To estimate the association between the number of prior cesarean deliveries and pregnancy outcomes among women with placenta previa...
  98. ncbi request reprint The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Beneficial Effects of Antenatal Repeated Steroids study: impact of repeated doses of antenatal corticosteroids on placental growth and histologic findings
    Joram Sawady
    Department of Pathology, Metro Health Medical Center, Case Western Reserve University, Cleveland, OH, USA
    Am J Obstet Gynecol 197:281.e1-8. 2007
    ..In utero exposure to repeated doses of antenatal corticosteroids (ACSs) has been shown to reduce fetal growth. Our goal was to evaluate whether weekly betamethasone (R-ACS) alters placental growth and histologic findings...
  99. ncbi request reprint The Maternal-Fetal Medicine Unit cesarean registry: trial of labor with a twin gestation
    Michael W Varner
    Department of Obstetrics, University of Utah, Salt Lake City 84132, USA
    Am J Obstet Gynecol 193:135-40. 2005
    ..The purpose of this study was to identify the success rates and risks in women with a twin pregnancy who attempt a trial of labor after cesarean delivery...
  100. ncbi request reprint The MFMU Cesarean Registry: factors affecting the success of trial of labor after previous cesarean delivery
    Mark B Landon
    Department of Obstetrics and Gynecology at The Ohio State University College of Medicine and Public Health, Columbus, OH 43210 1228, USA
    Am J Obstet Gynecol 193:1016-23. 2005
    ..The purpose of this study was to determine which factors influence the likelihood of successful trial of labor (TOL) after 1 previous cesarean delivery (CD)...
  101. ncbi request reprint Lecithin/sphingomyelin ratio and lamellar body count. What values predict the presence of phosphatidylglycerol?
    Sarah H Poggi
    Departments of Obstetrics and Gynecology and of Pharmacology, Georgetown University Hospital, Washington, D C, USA
    J Reprod Med 48:330-4. 2003
    ..To assess which values of the lecithin/sphingomyelin (L/S) ratio and lamellar body count (LBC) optimally correspond to the presence of phosphatidylglycerol (PG)...