Rosanne Spolski

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Interleukin-21: basic biology and implications for cancer and autoimmunity
    Rosanne Spolski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1674, USA
    Annu Rev Immunol 26:57-79. 2008
  2. pmc IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
    Christian S Hinrichs
    National Cancer Institute, Surgery Branch, National Institutes of Health, Bethesda, MD 20892 1502, USA
    Blood 111:5326-33. 2008
  3. pmc Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
    Rong Zeng
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:139-48. 2005
  4. pmc A role for TSLP in the development of inflammation in an asthma model
    Amin Al-Shami
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:829-39. 2005
  5. pmc T-cell development and function are modulated by dual specificity phosphatase DUSP5
    Panu E Kovanen
    Laboratory of Molecular Immunology, NHLBI, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:17362-9. 2008
  6. pmc IL-21 mediates suppressive effects via its induction of IL-10
    Rosanne Spolski
    Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:2859-67. 2009
  7. pmc Critical role for Rsk2 in T-lymphocyte activation
    Jian Xin Lin
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 111:525-33. 2008
  8. ncbi request reprint Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Immunol 173:5361-71. 2004
  9. pmc The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells
    Chi Keung Wan
    Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Immunity 38:514-27. 2013
  10. pmc Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma
    John A Kelly
    Laboratory of Molecular Immunology, National Heart and Blood Institute, National Cancer Institute, Bethesda, MD 20892 1674, USA
    J Exp Med 198:79-89. 2003

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Interleukin-21: basic biology and implications for cancer and autoimmunity
    Rosanne Spolski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1674, USA
    Annu Rev Immunol 26:57-79. 2008
    ..The key to harnessing the power of IL-21 will depend on better understanding its range of biological actions, its mechanism of action, and the molecular basis of regulation of expression of IL-21 and its receptor...
  2. pmc IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
    Christian S Hinrichs
    National Cancer Institute, Surgery Branch, National Institutes of Health, Bethesda, MD 20892 1502, USA
    Blood 111:5326-33. 2008
    ..Thus, the efficacy of CD8(+) T cells for adoptive immunotherapy can be influenced by opposing differentiation programs conferred by IL-2 and IL-21, a finding with important implications for the development of cellular cancer therapies...
  3. pmc Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
    Rong Zeng
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:139-48. 2005
    ..Thus, our studies reveal that IL-21 potently regulates CD8+ T cell expansion and effector function, primarily in a synergistic context with IL-15...
  4. pmc A role for TSLP in the development of inflammation in an asthma model
    Amin Al-Shami
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:829-39. 2005
    ..This underscores an important role for this cytokine in the development of inflammatory and/or allergic responses in vivo...
  5. pmc T-cell development and function are modulated by dual specificity phosphatase DUSP5
    Panu E Kovanen
    Laboratory of Molecular Immunology, NHLBI, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:17362-9. 2008
    ..Thus, proper regulation of DUSP5 activity is critical for normal immune system development, IL-2 actions, and tolerance...
  6. pmc IL-21 mediates suppressive effects via its induction of IL-10
    Rosanne Spolski
    Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:2859-67. 2009
    ..Overall, our data indicate that IL-21 regulates immune responses at least in part by inducing IL-10 and reveal unanticipated immunosuppressive actions for this cytokine...
  7. pmc Critical role for Rsk2 in T-lymphocyte activation
    Jian Xin Lin
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 111:525-33. 2008
    ..These results indicate an essential nonredundant role of Rsk2 in T-cell activation...
  8. ncbi request reprint Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Immunol 173:5361-71. 2004
    ..Finally, BXSB-Yaa mice, which develop a systemic lupus erythematosus-like disease, have greatly elevated IL-21, suggesting a role for IL-21 in the development of autoimmune disease...
  9. pmc The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells
    Chi Keung Wan
    Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Immunity 38:514-27. 2013
    ..Thus, IL-21 and GM-CSF exhibit cross-regulatory actions on gene regulation and apoptosis, regulating cDC numbers and thereby the magnitude of the immune response...
  10. pmc Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma
    John A Kelly
    Laboratory of Molecular Immunology, National Heart and Blood Institute, National Cancer Institute, Bethesda, MD 20892 1674, USA
    J Exp Med 198:79-89. 2003
    ..These data demonstrate the oncogenic potential of dysregulated expression of a STAT protein that is not constitutively activated, and that TCR stimulation can contribute to this process...
  11. ncbi request reprint Measurement of interleukin-21
    Rong Zeng
    National Institutes of Health, Bethesda, Maryland, USA
    Curr Protoc Immunol . 2007
    ..Finally, a method to assess IL-21-induced tyrosine phosphorylation of Stat3 in splenic CD8(+) T cells using a flow cytometry-based analysis is described...
  12. pmc A role for thymic stromal lymphopoietin in CD4(+) T cell development
    Amin Al-Shami
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 200:159-68. 2004
    ..Thus, as compared with other known cytokines, TSLP is distinctive in exhibiting a lineage preference for the expansion and survival of CD4(+) T cells...
  13. ncbi request reprint IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
    ..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses...
  14. pmc Thymic stromal lymphopoietin is produced by dendritic cells
    Mohit Kashyap
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:1207-11. 2011
    ..These data suggested that DCs not only respond to TSLP but also are a source of TSLP during pathogen and/or allergen encounter...
  15. pmc IL-21 and T follicular helper cells
    Rosanne Spolski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1674, USA
    Int Immunol 22:7-12. 2010
    ..Here, we review the role of IL-21 in the regulation of normal T(FH) development and function as well as in progression of autoimmune responses...
  16. pmc The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer
    Rosanne Spolski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1674, USA
    Curr Opin Immunol 20:295-301. 2008
    ..Moreover, IL-21 has potent anti-tumor effects and is implicated in the development of autoimmune diseases. Regulating IL-21 actions in vivo therefore has clinical potential for a range of diseases and is an area of active investigation...
  17. pmc The molecular basis of IL-21-mediated proliferation
    Rong Zeng
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Blood 109:4135-42. 2007
    ..Collectively, these data indicate the involvement of the Jak-STAT, MAPK, and PI3K pathways in IL-21 signaling...
  18. pmc Interleukin 21: a cytokine/cytokine receptor system that has come of age
    Warren J Leonard
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bldg 10, Rm 7B05, Bethesda, MD 20892 1674, USA
    J Leukoc Biol 84:348-56. 2008
    ..The ability to regulate and manipulate the actions of IL-21, therefore, has important implications for immunoregulation and the therapy of human disease...
  19. pmc IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
    Rosanne Spolski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 7B05, Bethesda, MD 20892 1674, USA
    Proc Natl Acad Sci U S A 105:14028-33. 2008
    ..Our studies establish a critical role for IL-21 in the development of type I diabetes in the NOD mouse, with obvious potential implications for type I diabetes in humans...
  20. ncbi request reprint A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2
    Jay H Bream
    Lymphocyte and Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health NIH, Bethesda, Maryland 20892 1820, USA
    J Biol Chem 279:41249-57. 2004
    ..These data led us to conclude that this distal region serves as both a target of chromatin remodeling in the IFNG locus as well as an IL-2-induced transcriptional enhancer that binds Stat5 proteins...
  21. pmc IL-21 promotes the pathologic immune response to pneumovirus infection
    Rosanne Spolski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:1924-32. 2012
    ....
  22. pmc Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity
    Christian S Hinrichs
    National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:17469-74. 2009
    ..These results indicate that insertion of genes that confer antitumor specificity into naïve rather than central memory CD8(+) T cells may allow superior efficacy upon adoptive transfer...
  23. ncbi request reprint In vivo antitumor activity of interleukin 21 mediated by natural killer cells
    Gang Wang
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Cancer Res 63:9016-22. 2003
    ..Our study suggests that IL-21 has significant antitumor activity and may have therapeutic potentials as an antitumor agent in the clinic...
  24. pmc BATF-JUN is critical for IRF4-mediated transcription in T cells
    Peng Li
    Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    Nature 490:543-6. 2012
    ..These findings reveal that IRF4 can signal via complexes containing ETS or AP1 motifs depending on the cellular context, thus indicating new approaches for modulating IRF4-dependent transcription...
  25. ncbi request reprint A role for Stat5 in CD8+ T cell homeostasis
    John Kelly
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:210-7. 2003
    ..Moreover, CD8+ memory T cells are substantially affected by Stat5 levels. These findings identify Stat5 proteins as critical signaling mediators used by cytokines to regulate CD8+ T cell homeostasis...
  26. pmc New insights into the regulation of T cells by gamma(c) family cytokines
    Yrina Rochman
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    Nat Rev Immunol 9:480-90. 2009
    ..This knowledge potentially allows for the therapeutic manipulation of immune responses for the treatment of cancer, autoimmunity, allergic diseases and immunodeficiency, as well as for vaccine development...
  27. ncbi request reprint The transcription factor GABP is a critical regulator of B lymphocyte development
    Hai Hui Xue
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    Immunity 26:421-31. 2007
    ..GABP could bind to the regulatory regions of Pax5 and Cd79a in vivo. Thus, GABP is a key regulator of B cell development, maturation, and function...
  28. ncbi request reprint Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation
    Warren J Leonard
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1674, USA
    Nat Rev Immunol 5:688-98. 2005
    ..Moreover, it has antitumour activity and might have a role in the development of autoimmunity, so these findings have implications for the treatment of cancer and autoimmune diseases...
  29. ncbi request reprint IL-21 is an immune activator that also mediates suppression via IL-10
    Rosanne Spolski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1674, USA
    Crit Rev Immunol 30:559-70. 2010
    ....
  30. pmc Cytokine mediators of Th17 function
    Rosanne Spolski
    Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethsda, MD, USA
    Eur J Immunol 39:658-61. 2009
    ..In this review, we discuss the current understanding of the specific functional characteristics and regulation of Th17 cytokines and clarify how they mediate the actions of Th17 cells...
  31. ncbi request reprint A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  32. ncbi request reprint IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  33. pmc Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor
    Martin Guimond
    Blood 111:969-70. 2008
  34. pmc Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP
    Renata Mazzucchelli
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute NCI, National Institutes of Health NIH, Frederick, MD, USA
    Blood 112:3283-92. 2008
    ....
  35. pmc A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling
    Katherine Bessette
    White River Junction Veteran s Association, White River Junction, VT, USA
    Blood 111:344-50. 2008
    ....
  36. pmc Defective B cell responses in the absence of SH2D1A
    Massimo Morra
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:4819-23. 2005
    ..Thus, both defective T and B cells exist in the absence of SH2D1A, which may explain the progressive dysgammaglobulinemia in a subset of X-linked lympho-proliferative disease patients without involvement of Epstein-Barr virus...