Stephen Spellman

Summary

Affiliation: National Marrow Donor Program
Country: USA

Publications

  1. ncbi request reprint State of the art review: HLA matching and outcome of unrelated donor umbilical cord blood transplants
    Naynesh Kamani
    Biol Blood Marrow Transplant 14:1-6. 2008
  2. doi request reprint Advances in the selection of HLA-compatible donors: refinements in HLA typing and matching over the first 20 years of the National Marrow Donor Program Registry
    Stephen Spellman
    National Marrow Donor Program, Minneapolis, Minnesota 55413, USA
    Biol Blood Marrow Transplant 14:37-44. 2008
  3. pmc Scoring HLA class I mismatches by HistoCheck does not predict clinical outcome in unrelated hematopoietic stem cell transplantation
    Stephen Spellman
    Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota 55413, USA
    Biol Blood Marrow Transplant 18:739-46. 2012
  4. pmc Effects of mismatching for minor histocompatibility antigens on clinical outcomes in HLA-matched, unrelated hematopoietic stem cell transplants
    Stephen Spellman
    National Marrow Donor Program, Minneapolis, MN 55413, USA
    Biol Blood Marrow Transplant 15:856-63. 2009
  5. pmc The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure
    Stephen Spellman
    National Marrow Donor Program, Minneapolis, MN 55413, USA
    Blood 115:2704-8. 2010
  6. doi request reprint Guidelines for the development and validation of new potency assays for the evaluation of umbilical cord blood
    Stephen Spellman
    Center for International Blood and Marrow Transplantation Research, Minneapolis, Minnesota 55413, USA
    Cytotherapy 13:848-55. 2011
  7. pmc Sibling versus unrelated donor allogeneic hematopoietic cell transplantation for chronic myelogenous leukemia: refined HLA matching reveals more graft-versus-host disease but not less relapse
    Daniel J Weisdorf
    University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 15:1475-8. 2009
  8. pmc Classification of HLA-matching for retrospective analysis of unrelated donor transplantation: revised definitions to predict survival
    Daniel Weisdorf
    University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:748-58. 2008
  9. pmc Effect of donor-recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis
    Mary Eapen
    Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Lancet Oncol 12:1214-21. 2011
  10. pmc Unrelated donor hematopoietic cell transplantation: factors associated with a better HLA match
    Jason Dehn
    National Marrow Donor Program, Minneapolis, Minnesota 55413 1753, USA
    Biol Blood Marrow Transplant 14:1334-40. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint State of the art review: HLA matching and outcome of unrelated donor umbilical cord blood transplants
    Naynesh Kamani
    Biol Blood Marrow Transplant 14:1-6. 2008
  2. doi request reprint Advances in the selection of HLA-compatible donors: refinements in HLA typing and matching over the first 20 years of the National Marrow Donor Program Registry
    Stephen Spellman
    National Marrow Donor Program, Minneapolis, Minnesota 55413, USA
    Biol Blood Marrow Transplant 14:37-44. 2008
  3. pmc Scoring HLA class I mismatches by HistoCheck does not predict clinical outcome in unrelated hematopoietic stem cell transplantation
    Stephen Spellman
    Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota 55413, USA
    Biol Blood Marrow Transplant 18:739-46. 2012
    ..The dataset used in this study is available to evaluate new algorithms proposed for donor selection...
  4. pmc Effects of mismatching for minor histocompatibility antigens on clinical outcomes in HLA-matched, unrelated hematopoietic stem cell transplants
    Stephen Spellman
    National Marrow Donor Program, Minneapolis, MN 55413, USA
    Biol Blood Marrow Transplant 15:856-63. 2009
    ..Based on these data, we conclude that mHAg incompatibility at HA-1, HA-2, HA-3, HA-8, HB-1, and CD31 has no detectable effect on the outcome of HLA matched unrelated donor HSCT...
  5. pmc The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure
    Stephen Spellman
    National Marrow Donor Program, Minneapolis, MN 55413, USA
    Blood 115:2704-8. 2010
    ..57-infinity; P < .001). These results indicate that the presence of pretransplantation DSAs in recipients of unrelated donor HCT is associated with failed engraftment and should be considered in HCT donor selection...
  6. doi request reprint Guidelines for the development and validation of new potency assays for the evaluation of umbilical cord blood
    Stephen Spellman
    Center for International Blood and Marrow Transplantation Research, Minneapolis, Minnesota 55413, USA
    Cytotherapy 13:848-55. 2011
    ....
  7. pmc Sibling versus unrelated donor allogeneic hematopoietic cell transplantation for chronic myelogenous leukemia: refined HLA matching reveals more graft-versus-host disease but not less relapse
    Daniel J Weisdorf
    University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 15:1475-8. 2009
    ..In this analysis, greater histoincompatibility can augment GVHD, but does not improve protection against relapse; thus the best donor remains the most closely matched donor...
  8. pmc Classification of HLA-matching for retrospective analysis of unrelated donor transplantation: revised definitions to predict survival
    Daniel Weisdorf
    University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:748-58. 2008
    ..This improved categorization of HLA matching status allows adjustment for donor-recipient HLA compatibility, and can standardize interpretations of prior URD HCT experience...
  9. pmc Effect of donor-recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis
    Mary Eapen
    Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Lancet Oncol 12:1214-21. 2011
    ..The selection algorithm for umbilical-cord blood units generally considers intermediate resolution HLA typing at A and B and allele-level typing at DRB1. We aimed to establish the relative importance of additional matching at HLA C...
  10. pmc Unrelated donor hematopoietic cell transplantation: factors associated with a better HLA match
    Jason Dehn
    National Marrow Donor Program, Minneapolis, Minnesota 55413 1753, USA
    Biol Blood Marrow Transplant 14:1334-40. 2008
    ....
  11. pmc Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia
    Sarah Cooley
    Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 116:2411-9. 2010
    ..Adopting this practice could result in superior disease-free survival for patients with AML...
  12. pmc Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals
    Cynthia Vierra-Green
    Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota, USA
    PLoS ONE 7:e47491. 2012
    ..These high-resolution, high-quality haplotypes extend our basic knowledge of the KIR gene system and may be used to support clinical studies beyond single gene analysis...
  13. pmc A combined DPA1~DPB1 amino acid epitope is the primary unit of selection on the HLA-DP heterodimer
    Jill A Hollenbach
    National Marrow Donor Program, Minneapolis, MN, USA
    Immunogenetics 64:559-69. 2012
    ..These findings further support the notion that allele-level associations in disease and transplantation may not be the most important unit of analysis, and that they should be considered instead in the molecular context...
  14. doi request reprint Awareness and acceptance of public cord blood banking among practicing obstetricians in the United States
    Tim Walker
    National Marrow Donor Program NMDP and Center for International Blood and Marrow Transplant Research CIBMTR, Minneapolis, Minnesota 55413, USA
    Transfusion 52:787-93. 2012
    ....
  15. pmc KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation
    Sarah Cooley
    Division of Hematology Oncology and Transplantation, University of Minnesota Cancer Center, University of Minnesota, National Marrow Donor Program, MMC 806, Harvard St at E River Rd, Minneapolis, MN 55455, USA
    Blood 106:4370-6. 2005
    ..These results support the notion that T cells in the graft affect NK cell reconstitution in vivo. Understanding these mechanisms may result in strategies to improve clinical outcomes from unrelated HCT...
  16. doi request reprint National marrow donor program HLA matching guidelines for unrelated adult donor hematopoietic cell transplants
    Robert A Bray
    Department of Pathology, Emory University, Atlanta, Georgia, USA
    Biol Blood Marrow Transplant 14:45-53. 2008
  17. ncbi request reprint High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation
    Stephanie J Lee
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 110:4576-83. 2007
    ..High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of survival...
  18. pmc Mapping MHC-resident transplantation determinants
    Mari Malkki
    The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biol Blood Marrow Transplant 13:986-95. 2007
    ..67; 95% confidence interval, 0.45-0.98; P=.04). These results suggest that Msats may be informative for mapping MHC-resident genetic variation of clinical importance in HCT...
  19. pmc HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation
    Judith A Wade
    Department of Surgery, University of Toronto, Ontario, Canada
    Blood 109:4064-70. 2007
    ..001). For patients without an HLA match, the selection of a CREG-compatible donor as tested does not improve outcome...
  20. ncbi request reprint A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs
    Carolyn Katovich Hurley
    Department of Oncology, Georgetown University, Washington, DC, USA
    Hum Immunol 68:30-40. 2007
    ....