Research Topics
Genomes and Genes
| Raman SoodSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Methods for reverse genetic screening in zebrafish by resequencing and TILLINGRaman Sood
Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Methods 39:220-7. 2006..Amplicons with fewer common SNPs are ideal for TILLING whereas amplicons with multiple SNPs and in/del polymorphisms are best suited for sequencing followed by analysis with SNPdetector...
Knockdown of Bardet-Biedl syndrome gene BBS9/PTHB1 leads to cilia defectsShobi Veleri
Neurobiology Neurodegeneration and Repair Laboratory N NRL, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 7:e34389. 2012..Consistent with these findings, knockdown of Bbs9 in mouse IMCD3 cells results in the absence of cilia. Our studies suggest a key conserved role of BBS9 in biogenesis and/or function of cilia in zebrafish and mammals...- Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutationRaman Sood
Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 115:2806-9. 2010..Overall, our data suggest that in zebrafish adult HSCs can be formed without an intact runx1... - Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesisRivka A Rachel
Neurobiology Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 122:1233-45. 2012..Amelioration of the sensory phenotypes caused by specific mutations in one protein by removal of an interacting domain/protein suggests a possible novel approach for treating human ciliopathies... - Incomplete splicing, cell division defects, and hematopoietic blockage in dhx8 mutant zebrafishMilton A English
Oncogenesis and Development Section, National Human Genome Research Institute NIH, Bethesda, MD 20892, USA
Dev Dyn 241:879-89. 2012..To identify novel genes involved in early hematopoiesis, we conducted an ENU (N-ethyl-N-nitrosourea) mutagenesis screen in zebrafish. The mummy (mmy) line was investigated because of its multiple hematopoietic defects... - Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2Bo Gao
National Human Genome Research Institute, Bethesda, MD 20892, USA
Dev Cell 20:163-76. 2011..Our studies have provided new insight to Robinow syndrome, Brachydactyly Type B1, and spinal bifida which are caused by mutations in human ROR2, WNT5A, or VANGL... - Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 regionRaman Sood
Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Genomics 82:153-61. 2003..We have identified one truncating and three missense mutations, thus suggesting SHPRH as a possible candidate for the tumor suppressor gene... - Variation of BMP3 contributes to dog breed skull diversityJeffrey J Schoenebeck
Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
PLoS Genet 8:e1002849. 2012..Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait... - Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interactionLea Cunningham
Oncogenesis and Development Section, National Institute of Allergy and Infectious Diseases, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:14592-7. 2012..Our data thus confirmed that RUNX1-CBFβ interaction can be targeted for leukemia treatment and we have identified a promising lead compound for this purpose... - SNPdetector: a software tool for sensitive and accurate SNP detectionJinghui Zhang
Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Comput Biol 1:e53. 2005..SNPdetector runs on Unix/Linux platform and is available publicly (http://lpg.nci.nih.gov)... - A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3Wuhong Pei
Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Development 137:2587-96. 2010..In summary, this paper introduces a faithful Costeff Syndrome model and demonstrates a requirement for mitochondrial OPA3 to limit HMG-CoA-derived MGC and protect the electron transport chain against inhibitory compounds... - Identification of six novel genes by experimental validation of GeneMachine predicted genesIzabela Makalowska
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Gene 284:203-13. 2002..Our studies support the feasibility of identifying novel genes from regions of interest using draft human genome sequence... - Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafishChristiane L Belele
Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Blood 114:5162-72. 2009..Our findings suggest that the impact of Gata1 on hematopoiesis correlates with its DNA-binding ability and that primitive hematopoiesis is more sensitive to reduction in Gata1 function than definitive hematopoiesis... - Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitinationAkira Motegi
Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 175:703-8. 2006..Therefore, the yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress... - Novel insights into the genetic controls of primitive and definitive hematopoiesis from zebrafish modelsRaman Sood
Oncogenesis and Development Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Adv Hematol 2012:830703. 2012.... - Unique alterations of an ultraconserved non-coding element in the 3'UTR of ZIC2 in holoprosencephalyErich Roessler
Medical Genetics Branch, National Human Genome Research Institute NHGRI, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 7:e39026. 2012..These findings support a general recommendation that the identification and analysis of key ultraconserved elements should be incorporated into the genetic risk assessment of holoprosencephaly cases... - Transient knockdown and overexpression reveal a developmental role for the zebrafish enosf1b geneSteve Finckbeiner
Oncogenesis and Development Section, National Human Genome Research Institute, 49 Convent Drive, Bethesda MD, 20892, USA
Cell Biosci 1:32. 2011..abstract:.. - brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesisHeather R Shive
Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:19350-5. 2010..These studies reveal critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues... - Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasiaPamela M Pollock
Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 34:108-12. 2003..This study provides compelling evidence for the importance of metabotropic glutamate signaling in melanocytic neoplasia... - Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl ratDavid E Dobbins
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
Biochem Biophys Res Commun 294:1114-20. 2002..These data suggest that osteopetrosis develops in tl/tl rats because they cannot produce functional mCsf, a growth factor required for osteoclast differentiation and activation... - Physical and transcript map of the hereditary prostate cancer region at xq27Dietrich A Stephan
Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Genomics 79:41-50. 2002..These transcriptional units represent candidate genes for HPCX and multiple other hereditary diseases at Xq26.3-q27.3... - A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX regionAgnes B Baffoe-Bonnie
Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Hum Genet 117:307-16. 2005..This study represents the first report identifying a haplotype in the Xq27-28 region for an association between HPCX and X-linked prostate cancer with no-male-to-male transmission in the Finnish population... - Identification and characterization of mouse Rab32 by mRNA and protein expression analysisKarine A Cohen-Solal
Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Biochim Biophys Acta 1651:68-75. 2003..Based on these data, we propose the inclusion of Rab32 to the so-called melanocyte/platelet family of Rab proteins... - Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb intervalGraeme J Walker
Human Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Genes Chromosomes Cancer 41:56-64. 2004....