Raman Sood

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization
    R Sood
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Building 36, Room 3D05, 9000 Rockville Pike, Bethesda, MD, USA
    Biochim Biophys Acta 1491:285-8. 2000
  2. ncbi request reprint Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus
    R Sood
    Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Genomics 73:211-22. 2001
  3. ncbi request reprint Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region
    Raman Sood
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genomics 82:153-61. 2003
  4. pmc Unique alterations of an ultraconserved non-coding element in the 3'UTR of ZIC2 in holoprosencephaly
    Erich Roessler
    Medical Genetics Branch, National Human Genome Research Institute NHGRI, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e39026. 2012
  5. pmc Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis
    Rivka A Rachel
    Neurobiology Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 122:1233-45. 2012
  6. pmc Knockdown of Bardet-Biedl syndrome gene BBS9/PTHB1 leads to cilia defects
    Shobi Veleri
    Neurobiology Neurodegeneration and Repair Laboratory N NRL, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e34389. 2012
  7. ncbi request reprint Identification of six novel genes by experimental validation of GeneMachine predicted genes
    Izabela Makalowska
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Gene 284:203-13. 2002
  8. pmc Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation
    Raman Sood
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 115:2806-9. 2010
  9. pmc A congenital neutrophil defect syndrome associated with mutations in VPS45
    Thierry Vilboux
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 369:54-65. 2013
  10. pmc Incomplete splicing, cell division defects, and hematopoietic blockage in dhx8 mutant zebrafish
    Milton A English
    Oncogenesis and Development Section, National Human Genome Research Institute NIH, Bethesda, MD 20892, USA
    Dev Dyn 241:879-89. 2012

Detail Information

Publications29

  1. ncbi request reprint The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization
    R Sood
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Building 36, Room 3D05, 9000 Rockville Pike, Bethesda, MD, USA
    Biochim Biophys Acta 1491:285-8. 2000
    ..Northern blot analysis shows that human RGL is expressed in a wide variety of tissues with strong expression being seen in the heart, brain, kidney, spleen and testis...
  2. ncbi request reprint Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus
    R Sood
    Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Genomics 73:211-22. 2001
    ..Overall, data on 13 novel transcripts and the human RGS8 gene (homologue of the rat RGS8 gene) are presented in this paper. Ten of the 13 novel transcripts are expressed in prostate tissue and represent positional candidates for HPC1...
  3. ncbi request reprint Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region
    Raman Sood
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genomics 82:153-61. 2003
    ..We have identified one truncating and three missense mutations, thus suggesting SHPRH as a possible candidate for the tumor suppressor gene...
  4. pmc Unique alterations of an ultraconserved non-coding element in the 3'UTR of ZIC2 in holoprosencephaly
    Erich Roessler
    Medical Genetics Branch, National Human Genome Research Institute NHGRI, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e39026. 2012
    ..These findings support a general recommendation that the identification and analysis of key ultraconserved elements should be incorporated into the genetic risk assessment of holoprosencephaly cases...
  5. pmc Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis
    Rivka A Rachel
    Neurobiology Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 122:1233-45. 2012
    ..Amelioration of the sensory phenotypes caused by specific mutations in one protein by removal of an interacting domain/protein suggests a possible novel approach for treating human ciliopathies...
  6. pmc Knockdown of Bardet-Biedl syndrome gene BBS9/PTHB1 leads to cilia defects
    Shobi Veleri
    Neurobiology Neurodegeneration and Repair Laboratory N NRL, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e34389. 2012
    ..Consistent with these findings, knockdown of Bbs9 in mouse IMCD3 cells results in the absence of cilia. Our studies suggest a key conserved role of BBS9 in biogenesis and/or function of cilia in zebrafish and mammals...
  7. ncbi request reprint Identification of six novel genes by experimental validation of GeneMachine predicted genes
    Izabela Makalowska
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Gene 284:203-13. 2002
    ..Our studies support the feasibility of identifying novel genes from regions of interest using draft human genome sequence...
  8. pmc Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation
    Raman Sood
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 115:2806-9. 2010
    ..Overall, our data suggest that in zebrafish adult HSCs can be formed without an intact runx1...
  9. pmc A congenital neutrophil defect syndrome associated with mutations in VPS45
    Thierry Vilboux
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 369:54-65. 2013
    ..Genetically determined neutrophil disorders confer a predisposition to severe infections and reveal novel mechanisms that control vesicular trafficking, hematopoiesis, and innate immunity...
  10. pmc Incomplete splicing, cell division defects, and hematopoietic blockage in dhx8 mutant zebrafish
    Milton A English
    Oncogenesis and Development Section, National Human Genome Research Institute NIH, Bethesda, MD 20892, USA
    Dev Dyn 241:879-89. 2012
    ..To identify novel genes involved in early hematopoiesis, we conducted an ENU (N-ethyl-N-nitrosourea) mutagenesis screen in zebrafish. The mummy (mmy) line was investigated because of its multiple hematopoietic defects...
  11. pmc Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish
    Christiane L Belele
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 114:5162-72. 2009
    ..Our findings suggest that the impact of Gata1 on hematopoiesis correlates with its DNA-binding ability and that primitive hematopoiesis is more sensitive to reduction in Gata1 function than definitive hematopoiesis...
  12. ncbi request reprint Methods for reverse genetic screening in zebrafish by resequencing and TILLING
    Raman Sood
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Methods 39:220-7. 2006
    ..Amplicons with fewer common SNPs are ideal for TILLING whereas amplicons with multiple SNPs and in/del polymorphisms are best suited for sequencing followed by analysis with SNPdetector...
  13. pmc Efficient methods for targeted mutagenesis in zebrafish using zinc-finger nucleases: data from targeting of nine genes using CompoZr or CoDA ZFNs
    Raman Sood
    Zebrafish Core Facility, Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    PLoS ONE 8:e57239. 2013
    ..This work provides high throughput protocols for efficient generation of zebrafish mutants using ZFNs and TALENs...
  14. pmc Variation of BMP3 contributes to dog breed skull diversity
    Jeffrey J Schoenebeck
    Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002849. 2012
    ..Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait...
  15. pmc Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination
    Akira Motegi
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 175:703-8. 2006
    ..Therefore, the yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress...
  16. pmc Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
    Bo Gao
    National Human Genome Research Institute, Bethesda, MD 20892, USA
    Dev Cell 20:163-76. 2011
    ..Our studies have provided new insight to Robinow syndrome, Brachydactyly Type B1, and spinal bifida which are caused by mutations in human ROR2, WNT5A, or VANGL...
  17. pmc Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction
    Lea Cunningham
    Oncogenesis and Development Section, National Institute of Allergy and Infectious Diseases, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:14592-7. 2012
    ..Our data thus confirmed that RUNX1-CBFβ interaction can be targeted for leukemia treatment and we have identified a promising lead compound for this purpose...
  18. ncbi request reprint Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia
    Pamela M Pollock
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 34:108-12. 2003
    ..This study provides compelling evidence for the importance of metabotropic glutamate signaling in melanocytic neoplasia...
  19. pmc A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3
    Wuhong Pei
    Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Development 137:2587-96. 2010
    ..In summary, this paper introduces a faithful Costeff Syndrome model and demonstrates a requirement for mitochondrial OPA3 to limit HMG-CoA-derived MGC and protect the electron transport chain against inhibitory compounds...
  20. pmc Localization of a novel melanoma susceptibility locus to 1p22
    Elizabeth Gillanders
    Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, MD
    Am J Hum Genet 73:301-13. 2003
    ..43, was obtained at D1S2779 and occurred when the 15 families with the earliest ages at onset were included. These data provide significant evidence of a novel susceptibility gene for CMM located within chromosome band 1p22...
  21. pmc brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis
    Heather R Shive
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:19350-5. 2010
    ..These studies reveal critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues...
  22. pmc Novel insights into the genetic controls of primitive and definitive hematopoiesis from zebrafish models
    Raman Sood
    Oncogenesis and Development Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Adv Hematol 2012:830703. 2012
    ....
  23. ncbi request reprint Physical and transcript map of the hereditary prostate cancer region at xq27
    Dietrich A Stephan
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genomics 79:41-50. 2002
    ..These transcriptional units represent candidate genes for HPCX and multiple other hereditary diseases at Xq26.3-q27.3...
  24. ncbi request reprint Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat
    David E Dobbins
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Biochem Biophys Res Commun 294:1114-20. 2002
    ..These data suggest that osteopetrosis develops in tl/tl rats because they cannot produce functional mCsf, a growth factor required for osteoclast differentiation and activation...
  25. pmc Transient knockdown and overexpression reveal a developmental role for the zebrafish enosf1b gene
    Steve Finckbeiner
    Oncogenesis and Development Section, National Human Genome Research Institute, 49 Convent Drive, Bethesda MD, 20892, USA
    Cell Biosci 1:32. 2011
    ..abstract:..
  26. pmc SNPdetector: a software tool for sensitive and accurate SNP detection
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Comput Biol 1:e53. 2005
    ..SNPdetector runs on Unix/Linux platform and is available publicly (http://lpg.nci.nih.gov)...
  27. ncbi request reprint A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region
    Agnes B Baffoe-Bonnie
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Hum Genet 117:307-16. 2005
    ..Fine mapping efforts included the genotyping of four additional markers D3S2390, bG82i1.9, bG82i1.1, bG82i1.0 and four single nucleotide polymorphisms (SNPs) to augment the original markers around DXS1205...
  28. ncbi request reprint Identification and characterization of mouse Rab32 by mRNA and protein expression analysis
    Karine A Cohen-Solal
    Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Biochim Biophys Acta 1651:68-75. 2003
    ..Based on these data, we propose the inclusion of Rab32 to the so-called melanocyte/platelet family of Rab proteins...
  29. ncbi request reprint Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval
    Graeme J Walker
    Human Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Genes Chromosomes Cancer 41:56-64. 2004
    ....