Byoung Joon Song


Affiliation: National Institutes of Health
Country: USA


  1. Abdelmegeed M, Banerjee A, Jang S, Yoo S, Yun J, Gonzalez F, et al. CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis. Free Radic Biol Med. 2013;65:1238-1245 pubmed publisher
  2. Cho Y, Song B. Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress. Redox Biol. 2018;18:266-278 pubmed publisher
    ..These results showed for the first time that POM can prevent alcohol-induced gut leakiness and inflammatory liver injury by suppressing oxidative and nitrative stress. ..
  3. Song B, Moon K, Upreti V, Eddington N, Lee I. Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage. Curr Pharm Biotechnol. 2010;11:434-43 pubmed
  4. Song B, Abdelmegeed M, Henderson L, Yoo S, Wan J, Purohit V, et al. Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic fatty liver disease. Oxid Med Cell Longev. 2013;2013:781050 pubmed publisher
    ..Finally, we discuss various applications of this method in studying oxidatively modified mitochondrial proteins in extrahepatic tissues or different subcellular organelles and translational research. ..
  5. Yun J, Son M, Abdelmegeed M, Banerjee A, Morgan T, Yoo S, et al. Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1α-dependent apoptosis pathway in mice and humans. Free Radic Biol Med. 2014;77:183-94 pubmed publisher
    ..Thus binge alcohol promotes acute liver injury in mice and humans at least partly through a CYP2E1-HIF-1α-dependent apoptosis pathway. ..
  6. Song B, Abdelmegeed M, Yoo S, Kim B, Jo S, Jo I, et al. Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications. J Proteomics. 2011;74:2691-702 pubmed publisher
  7. Song B, Akbar M, Jo I, Hardwick J, Abdelmegeed M. Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease. Adv Pharmacol. 2015;74:303-72 pubmed publisher
    ..We also discuss translational research opportunities with natural and/or synthetic antioxidants, which can prevent or delay the onset of inflammation and liver disease. ..
  8. Jang S, Yu L, Abdelmegeed M, Gao Y, Banerjee A, Song B. Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. Redox Biol. 2015;6:552-64 pubmed publisher
    ..These data provide a novel mechanism by which JNK, rapidly activated by CCl4, promotes mitochondrial dysfunction and acute hepatotoxicity through robust phosphorylation of numerous mitochondrial proteins. ..
  9. Abdelmegeed M, Choi Y, Ha S, Song B. Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress. Free Radic Biol Med. 2016;91:188-202 pubmed publisher

More Information


  1. Choi Y, Abdelmegeed M, Akbar M, Song B. Dietary walnut reduces hepatic triglyceride content in high-fat-fed mice via modulation of hepatic fatty acid metabolism and adipose tissue inflammation. J Nutr Biochem. 2016;30:116-25 pubmed publisher
  2. Choi Y, Abdelmegeed M, Song B. Preventive effects of indole-3-carbinol against alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms: Role of gut-liver-adipose tissue axis. J Nutr Biochem. 2018;55:12-25 pubmed publisher
    ..Therefore, I3C may also have a high potential for translational research in treating or preventing other types of hepatic injury associated with oxidative stress and inflammation. ..
  3. Cho Y, Yu L, Abdelmegeed M, Yoo S, Song B. Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury. J Hepatol. 2018;69:142-153 pubmed publisher
    ..These results provide insight into the molecular mechanisms of alcohol-induced inflammatory liver disease. ..
  4. Hur W, Lee J, Kim S, Kim J, Bae S, Kim M, et al. Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway. Int J Biochem Cell Biol. 2015;64:265-76 pubmed publisher
  5. Choi Y, Abdelmegeed M, Song B. Preventive effects of dietary walnuts on high-fat-induced hepatic fat accumulation, oxidative stress and apoptosis in mice. J Nutr Biochem. 2016;38:70-80 pubmed publisher
    ..The beneficial effects of dietary walnut likely result, at least partially, from its antioxidant ingredients and attenuating HFD-induced hepatic steatosis, nitroxidative stress and apoptosis. ..
  6. Choi Y, Abdelmegeed M, Song B. Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress. Food Chem Toxicol. 2017;103:111-121 pubmed publisher
    ..5-fold, respectively), were observed in HFRD-fed mice. Thus, HFRD exposure increased hepatic steatosis accompanied by oxidative stress and inflammation, leading to hepatocyte apoptosis. ..
  7. Abdelmegeed M, Choi Y, Ha S, Song B. Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress. Food Chem Toxicol. 2017;109:48-59 pubmed publisher
    ..Thus, CYP2E1 is important in causing aging-related kidney damage most likely through increasing nitroxidative stress and that CYP2E1 could be a potential target in preventing aging-related kidney diseases. ..