Byoung Joon Song
Affiliation: National Institutes of Health
- Choi Y, Abdelmegeed M, Song B. Preventive effects of indole-3-carbinol against alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms: Role of gut-liver-adipose tissue axis. J Nutr Biochem. 2018;55:12-25 pubmed publisher..Therefore, I3C may also have a high potential for translational research in treating or preventing other types of hepatic injury associated with oxidative stress and inflammation. ..
- Cho Y, Yu L, Abdelmegeed M, Yoo S, Song B. Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury. J Hepatol. 2018;69:142-153 pubmed publisher..These results provide insight into the molecular mechanisms of alcohol-induced inflammatory liver disease. ..
- Choi Y, Abdelmegeed M, Song B. Preventive effects of dietary walnuts on high-fat-induced hepatic fat accumulation, oxidative stress and apoptosis in mice. J Nutr Biochem. 2016;38:70-80 pubmed publisher..The beneficial effects of dietary walnut likely result, at least partially, from its antioxidant ingredients and attenuating HFD-induced hepatic steatosis, nitroxidative stress and apoptosis. ..
- Choi Y, Abdelmegeed M, Song B. Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress. Food Chem Toxicol. 2017;103:111-121 pubmed publisher..5-fold, respectively), were observed in HFRD-fed mice. Thus, HFRD exposure increased hepatic steatosis accompanied by oxidative stress and inflammation, leading to hepatocyte apoptosis. ..
- Abdelmegeed M, Choi Y, Ha S, Song B. Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress. Food Chem Toxicol. 2017;109:48-59 pubmed publisher..Thus, CYP2E1 is important in causing aging-related kidney damage most likely through increasing nitroxidative stress and that CYP2E1 could be a potential target in preventing aging-related kidney diseases. ..