C L Sommers

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways
    Connie L Sommers
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Bioessays 26:61-7. 2004
  2. ncbi request reprint The role of cadherin-mediated adhesion in breast cancer
    C L Sommers
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda, Maryland, USA
    J Mammary Gland Biol Neoplasia 1:219-29. 1996
  3. pmc Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development
    C L Sommers
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:135-42. 2001
  4. pmc A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection
    C L Sommers
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 190:1427-38. 1999
  5. pmc Function of CD3 epsilon-mediated signals in T cell development
    C L Sommers
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 192:913-19. 2000
  6. pmc Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire
    E W Shores
    Division of Hematologic Products, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Exp Med 185:893-900. 1997
  7. ncbi request reprint Essential role of LAT in T cell development
    W Zhang
    Section on Lymphocyte Signaling, Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 10:323-32. 1999
  8. ncbi request reprint Fine tuning of TCR signaling by CD5
    H S Azzam
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:5464-72. 2001
  9. ncbi request reprint LAT is essential for Fc(epsilon)RI-mediated mast cell activation
    S Saitoh
    Laboratory of Cellular and Molecular Biology, Division of Basic Science, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 12:525-35. 2000
  10. pmc Specific requirement for CD3epsilon in T cell development
    J B DeJarnette
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:14909-14. 1998

Collaborators

Detail Information

Publications14

  1. ncbi request reprint LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways
    Connie L Sommers
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Bioessays 26:61-7. 2004
    ..These studies suggest that similar levels of control may be found in other systems where adapter molecules are known to have important functions...
  2. ncbi request reprint The role of cadherin-mediated adhesion in breast cancer
    C L Sommers
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda, Maryland, USA
    J Mammary Gland Biol Neoplasia 1:219-29. 1996
    ..The collective effect of these molecules on the adhesive phenotype of breast cancer cells may be one determinant of metastatic potential...
  3. pmc Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development
    C L Sommers
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:135-42. 2001
    ..These results demonstrate that the distal four tyrosine residues of LAT are essential for preTCR signaling and T cell development in vivo...
  4. pmc A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection
    C L Sommers
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 190:1427-38. 1999
    ..These results identify a role for Txk in TCR signal transduction, T cell development, and selection and suggest that the Tec family kinases Itk and Txk perform analogous functions...
  5. pmc Function of CD3 epsilon-mediated signals in T cell development
    C L Sommers
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 192:913-19. 2000
    ..Unexpectedly, analysis of TCR-transgenic/CD3 epsilon-mutant mice reveals a potential role for CD3 epsilon signals in T cell survival...
  6. pmc Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire
    E W Shores
    Division of Hematologic Products, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Exp Med 185:893-900. 1997
    ..These results reveal a role for multiple TCR ITAMs in thymocyte selection and identify a function for TCR signal amplification in formation of the T cell repertoire...
  7. ncbi request reprint Essential role of LAT in T cell development
    W Zhang
    Section on Lymphocyte Signaling, Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 10:323-32. 1999
    ..Intrathymic development was blocked within the CD4- CD8- stage. No gross abnormality of NK or platelet function was observed. LAT is thus critical to both T cell activation and development...
  8. ncbi request reprint Fine tuning of TCR signaling by CD5
    H S Azzam
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:5464-72. 2001
    ..Together, these results indicate that inducible regulation of CD5 surface expression during thymocyte selection functions to fine tune the TCR signaling response...
  9. ncbi request reprint LAT is essential for Fc(epsilon)RI-mediated mast cell activation
    S Saitoh
    Laboratory of Cellular and Molecular Biology, Division of Basic Science, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 12:525-35. 2000
    ..These results show that LAT plays a critical role in Fc(epsilon)RI-mediated signaling in mast cells...
  10. pmc Specific requirement for CD3epsilon in T cell development
    J B DeJarnette
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:14909-14. 1998
    ..These results identify an essential role for CD3epsilon in T cell development not shared by the CD3gamma, CD3delta, or zeta-family proteins and provide further evidence that PGK-NEO can influence the expression of genes in its proximity...
  11. pmc T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma)
    E W Shores
    Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
    J Exp Med 187:1093-101. 1998
    ..A possible function for the differential expression of zeta family proteins may be to impart distinctive signaling properties to TCR complexes expressed on specific T cell populations...
  12. ncbi request reprint Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow
    K Huang
    Laboratory of Mammalian Genes and Development, NICHD, NIH, Bethesda, Maryland 20892, USA
    Oncogene 13:1567-73. 1996
    ..The high level expression of PTP-K1 mRNA in bone marrow suggests that PTP-K1 may be involved in signal transduction in growth and differentiation of hematopoietic cells...
  13. ncbi request reprint Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells
    C L Sommers
    Medical Breast Cancer Section, National Cancer Institute, Bethesda, Maryland 20892
    Cancer Res 49:4258-63. 1989
    ..Analysis of several other kinds of epithelial carcinoma cell lines showed only rare examples of vimentin expression...
  14. pmc RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation
    K Rajagopal
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    J Exp Med 190:1657-68. 1999
    ..These data suggest that RIBP plays an important role in TCR-mediated signal transduction pathways and that its binding to Itk and Rlk/Txk may regulate T cell differentiation...