Wolfgang H Sommer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint DNA microarrays and expression profiling in drug abuse research
    Peter J Gebicke-Haerter
    Addict Biol 10:1-3. 2005
  2. pmc Neuroplasticity in brain reward circuitry following a history of ethanol dependence
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA NIH, Bethesda, MD 20892 1108, USA
    Eur J Neurosci 27:1912-22. 2008
  3. ncbi request reprint Plasticity and impact of the central renin-angiotensin system during development of ethanol dependence
    W H Sommer
    Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bldg 10, CRC, Bethesda, MD, 20892 1108, USA
    J Mol Med (Berl) 85:1089-97. 2007
  4. pmc Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1108, USA
    J Mol Med (Berl) 86:723-8. 2008
  5. doi request reprint Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIH NIAAA, Bethesda, MD, USA
    Int J Neuropsychopharmacol 13:583-93. 2010
  6. doi request reprint Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 208:417-26. 2010
  7. pmc Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Inst on Alcohol Abuse and Alcoholism, National Inst of Health, Bethesda, MD, United States
    Neurosci Biobehav Rev 35:334-44. 2010
  8. pmc Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors
    Karl Björk
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Addict Biol 15:299-303. 2010
  9. pmc Acute ethanol challenge inhibits glycogen synthase kinase-3beta in the rat prefrontal cortex
    Olga Neznanova
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA
    Int J Neuropsychopharmacol 12:275-80. 2009
  10. pmc Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, USA
    Hum Mutat 31:E1594-608. 2010

Detail Information

Publications18

  1. ncbi request reprint DNA microarrays and expression profiling in drug abuse research
    Peter J Gebicke-Haerter
    Addict Biol 10:1-3. 2005
  2. pmc Neuroplasticity in brain reward circuitry following a history of ethanol dependence
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA NIH, Bethesda, MD 20892 1108, USA
    Eur J Neurosci 27:1912-22. 2008
    ..These two neuroadaptations could act in concert to facilitate progression into ethanol dependence...
  3. ncbi request reprint Plasticity and impact of the central renin-angiotensin system during development of ethanol dependence
    W H Sommer
    Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bldg 10, CRC, Bethesda, MD, 20892 1108, USA
    J Mol Med (Berl) 85:1089-97. 2007
    ....
  4. pmc Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1108, USA
    J Mol Med (Berl) 86:723-8. 2008
    ....
  5. doi request reprint Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIH NIAAA, Bethesda, MD, USA
    Int J Neuropsychopharmacol 13:583-93. 2010
    ..While suppression of hippocampal neurogenesis by alcohol dependence is transient, the suppression in the forebrain SVZ appears long-lasting...
  6. doi request reprint Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 208:417-26. 2010
    ..Here, we examined whether neuropeptide Y (NPY), an endogenous anti-stress mediator, blocks reinstatement of alcohol-seeking induced by the pharmacological stressor yohimbine...
  7. pmc Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Inst on Alcohol Abuse and Alcoholism, National Inst of Health, Bethesda, MD, United States
    Neurosci Biobehav Rev 35:334-44. 2010
    ....
  8. pmc Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors
    Karl Björk
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Addict Biol 15:299-303. 2010
    ..One of these is D2-dependent, while the other is not. These findings illustrate that pharmacology of ethanol reward is likely more complex than that for other addictive drugs...
  9. pmc Acute ethanol challenge inhibits glycogen synthase kinase-3beta in the rat prefrontal cortex
    Olga Neznanova
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA
    Int J Neuropsychopharmacol 12:275-80. 2009
    ..Together, these results identify candidate pathways for mediating high ethanol preference and emphasize the importance of the mPFC in controlling this behaviour...
  10. pmc Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, USA
    Hum Mutat 31:E1594-608. 2010
    ..Our results show the importance of rs16147:T>C for regulation of NPY gene expression and brain function...
  11. pmc Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques
    Stephen G Lindell
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Arch Gen Psychiatry 67:423-31. 2010
    ..In humans, low NPY expression predicts amygdala response and emotional reactivity. Genetic variation that affects the NPY system could moderate stress resilience and susceptibility to alcohol dependence...
  12. ncbi request reprint Gene discovery in neuropharmacological and behavioral studies using Affymetrix microarray data
    Mark Reimers
    Laboratory of Molecular Pharmacology, NCI, National Institutes of Health, Bethesda, USA
    Methods 37:219-28. 2005
    ..We also describe in detail the pre-processing methods we have found useful for Affymetrix data. Finally, we summarize the statistical literature and describe some pitfalls in the post-processing analysis...
  13. doi request reprint Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA
    J Psychopharmacol 25:1378-87. 2011
    ..These results indicate that the tropic hypothesis of depression has limitations and emphasize the need for validated disease models of depression to assess potential treatment targets...
  14. ncbi request reprint Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Neuropsychopharmacology 32:117-26. 2007
    ..These results show for the first time that impaired FAAH function may confer a phenotype of high voluntary alcohol intake, and point to a FAAH both as a potential susceptibility factor and a therapeutic target...
  15. ncbi request reprint Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, Maryland 20892 1108, USA
    Biol Psychiatry 63:139-45. 2008
    ..A history of alcohol dependence recruits increased voluntary alcohol intake and sensitivity to stress. Corticotropin-releasing hormone (CRH) has been implicated in this transition, but underlying molecular mechanisms remain unclear...
  16. doi request reprint The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus
    Smitha Sreedharan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    FEBS J 278:4881-94. 2011
    ..This report provides the first detailed characterization of the evolution, expression and primary functional properties of the Gpr153 gene...
  17. ncbi request reprint Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA NIH, Bethesda, MD 20892 1108, USA
    Addict Biol 12:30-4. 2007
    ....
  18. doi request reprint Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat
    Daina Economidou
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino MC, Italy
    Biol Psychiatry 64:211-8. 2008
    ....