Elena E Solomou

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia
    Elena E Solomou
    Hematology Branch, National Heart, Lung, and Blood Institute NIH, Bldg 10, CRC, Rm 3E5216, 10 Center Drive, Bethesda, MD 20892, USA
    Blood 107:3983-91. 2006
  2. pmc Perforin gene mutations in patients with acquired aplastic anemia
    Elena E Solomou
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Blood 109:5234-7. 2007
  3. pmc Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia
    Elena E Solomou
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 110:1603-6. 2007
  4. ncbi request reprint Decreased TCR zeta-chain expression in T cells from patients with acquired aplastic anaemia
    Elena E Solomou
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Haematol 138:72-6. 2007
  5. pmc Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro
    Xingmin Feng
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 111:3675-83. 2008
  6. ncbi request reprint Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain
    Yuang Taung Juang
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 168:2865-71. 2002
  7. pmc CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins
    Elaine M Sloand
    National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
    Blood 109:2399-405. 2007
  8. pmc Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
    Yuang Taung Juang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Clin Invest 115:996-1005. 2005
  9. ncbi request reprint Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity
    Thomas M Herndon
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Clin Immunol 103:145-53. 2002

Detail Information

Publications9

  1. pmc T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia
    Elena E Solomou
    Hematology Branch, National Heart, Lung, and Blood Institute NIH, Bldg 10, CRC, Rm 3E5216, 10 Center Drive, Bethesda, MD 20892, USA
    Blood 107:3983-91. 2006
    ..Blocking the transcription of the IFN-gamma gene with kinase inhibitors might lead to the development of novel therapeutic agents for patients with aplastic anemia and other autoimmune diseases...
  2. pmc Perforin gene mutations in patients with acquired aplastic anemia
    Elena E Solomou
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Blood 109:5234-7. 2007
    ..Our data suggest that PRF1 genetic alterations help explain the aberrant proliferation and activation of cytotoxic T cells and may represent genetic risk factors for bone marrow failure...
  3. pmc Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia
    Elena E Solomou
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 110:1603-6. 2007
    ..Our findings indicate that decreased NFAT1 could explain low FOXP3 expression and diminished Treg frequency in aplastic anemia. Treg defects are now implicated in autoimmune marrow failure...
  4. ncbi request reprint Decreased TCR zeta-chain expression in T cells from patients with acquired aplastic anaemia
    Elena E Solomou
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Haematol 138:72-6. 2007
    ..We concluded that TCR zeta-chain expression was decreased in the majority of patients with aplastic anaemia, regardless of disease activity or treatment status...
  5. pmc Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro
    Xingmin Feng
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 111:3675-83. 2008
    ..The therapeutic effects of rATG may occur not only because of lymphocyte depletion but also enhanced Treg cell number and function...
  6. ncbi request reprint Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain
    Yuang Taung Juang
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 168:2865-71. 2002
    ..In conclusion, different forms of Elf-1 are the products of posttranslational modifications that determine its subcellular localization, activity, and metabolic degradation...
  7. pmc CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins
    Elaine M Sloand
    National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
    Blood 109:2399-405. 2007
    ..Knock-down of survivin by siRNA resulted in preferential loss of trisomy 8 cells. These results suggest that trisomy 8 cells undergo incomplete apoptosis and are nonetheless capable of colony formation and growth...
  8. pmc Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
    Yuang Taung Juang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Clin Invest 115:996-1005. 2005
    ....
  9. ncbi request reprint Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity
    Thomas M Herndon
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Clin Immunol 103:145-53. 2002
    ....