Research Topics
Genomes and GenesSpecies | Elena E SolomouSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemiaElena E Solomou
Hematology Branch, National Heart, Lung, and Blood Institute NIH, Bldg 10, CRC, Rm 3E5216, 10 Center Drive, Bethesda, MD 20892, USA
Blood 107:3983-91. 2006..Blocking the transcription of the IFN-gamma gene with kinase inhibitors might lead to the development of novel therapeutic agents for patients with aplastic anemia and other autoimmune diseases...- Perforin gene mutations in patients with acquired aplastic anemiaElena E Solomou
Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
Blood 109:5234-7. 2007..Our data suggest that PRF1 genetic alterations help explain the aberrant proliferation and activation of cytotoxic T cells and may represent genetic risk factors for bone marrow failure... - Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemiaElena E Solomou
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 110:1603-6. 2007..Our findings indicate that decreased NFAT1 could explain low FOXP3 expression and diminished Treg frequency in aplastic anemia. Treg defects are now implicated in autoimmune marrow failure... 
Decreased TCR zeta-chain expression in T cells from patients with acquired aplastic anaemiaElena E Solomou
Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Br J Haematol 138:72-6. 2007..We concluded that TCR zeta-chain expression was decreased in the majority of patients with aplastic anaemia, regardless of disease activity or treatment status...- Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitroXingmin Feng
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 111:3675-83. 2008..The therapeutic effects of rATG may occur not only because of lymphocyte depletion but also enhanced Treg cell number and function... - Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chainYuang Taung Juang
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Immunol 168:2865-71. 2002..In conclusion, different forms of Elf-1 are the products of posttranslational modifications that determine its subcellular localization, activity, and metabolic degradation... - CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteinsElaine M Sloand
National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
Blood 109:2399-405. 2007..Knock-down of survivin by siRNA resulted in preferential loss of trisomy 8 cells. These results suggest that trisomy 8 cells undergo incomplete apoptosis and are nonetheless capable of colony formation and growth... - Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIVYuang Taung Juang
Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
J Clin Invest 115:996-1005. 2005.... - Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activityThomas M Herndon
Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
Clin Immunol 103:145-53. 2002....