Research Topics
| D SolomonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trialD Solomon
Breast and Gynecologic Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Natl Cancer Inst 93:293-9. 2001..Effective colposcopy triage strategies are needed to identify the minority of women who have clinically significant disease while avoiding excessive follow-up evaluation for others...
The 2001 Bethesda System: terminology for reporting results of cervical cytologyDiane Solomon
EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA
JAMA 287:2114-9. 2002..A primary objective was to develop a new approach to broaden participation in the consensus process...
ASCUS LSIL Triage Study (ALTS) conclusions reaffirmed: response to a November 2001 commentaryDiane Solomon
Division of Cancer Prevention, National Cancer Institute, Maryland, USA
Obstet Gynecol 99:671-4. 2002
Update on cervical screeningDiane Solomon
National Cancer Institute, Division of Cancer Prevention, National Institute of Health, 6130 Executive Blvd, EPN 2130, Rockville, MD 20852, USA
Gynecol Oncol 99:S13. 2005
Qualification of ASCUS. A comparison of equivocal LSIL and equivocal HSIL cervical cytology in the ASCUS LSIL Triage StudyM E Sherman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 7080, Rockville, MD 20852-7374, USA
Am J Clin Pathol 116:386-94. 2001..ASCUS-H is an uncommon interpretation that derives clinical usefulness from its high positive predictive value for lesions CIN 2 or worse...
Long-term persistence of prevalently detected human papillomavirus infections in the absence of detectable cervical precancer and cancerPhilip E Castle
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7234, USA
J Infect Dis 203:814-22. 2011..Detailed descriptions of long-term persistence of human papillomavirus (HPV) in the absence of cervical precancer are lacking...
Diagnostic utility of endocervical curettage in women undergoing colposcopy for equivocal or low-grade cytologic abnormalitiesDiane Solomon
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Obstet Gynecol 110:288-95. 2007....
2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
J Low Genit Tract Dis 11:223-39. 2007..To provide updated consensus guidelines for the management of women with cervical intraepithelial neoplasia (CIN) or adenocarcinoma in situ (AIS)...
2006 consensus guidelines for the management of women with abnormal cervical screening testsThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
J Low Genit Tract Dis 11:201-22. 2007..To provide revised evidence-based consensus guidelines for managing women with abnormal cervical cancer screening test results...
Risk assessment to guide the prevention of cervical cancerPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7234, USA
Am J Obstet Gynecol 197:356.e1-6. 2007....
Risk of precancer and follow-up management strategies for women with human papillomavirus-negative atypical squamous cells of undetermined significanceMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
Obstet Gynecol 109:1325-31. 2007....
2006 consensus guidelines for the management of women with abnormal cervical cancer screening testsThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Am J Obstet Gynecol 197:346-55. 2007..The 2004 Interim Guidance for HPV testing as an adjunct to cervical cytology for screening in women 30 years of age and older was formally adopted with only very minor modifications...
2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Am J Obstet Gynecol 197:340-5. 2007..Moreover, management recommendations for women with biopsy-confirmed adenocarcinoma in situ are now included...
Workshop on imaging science development for cancer prevention and preemptionGary J Kelloff
NIH NCI DCTD, Cancer Imaging Program, Bethesda, MD, USA
Cancer Biomark 3:1-33. 2007..Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer...
Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection: a randomized trialAllan Hildesheim
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
JAMA 298:743-53. 2007..Viruslike particle human papillomavirus (HPV) vaccines were designed to prevent HPV infection and development of cervical precancers and cancer. Women with oncogenic HPV infections might consider vaccination as therapy...
CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samplesJoseph D Carreon
Division of Cancer Epidemiology and Genetics, The National Cancer Institute, National Institutes of Health, Department of Health and Human Services Rockville, Maryland 20852, USA
Int J Gynecol Pathol 26:441-6. 2007..The CIN3 is a substantially more reproducible diagnosis that can be validated more frequently with HPV tests and cytological interpretations than CIN2...
Cervical cancer prevention--cervical screening: science in evolutionMahboobeh Safaeian
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Rockville, MD 20852, USA
Obstet Gynecol Clin North Am 34:739-60, ix. 2007..This article describes the traditional methods of screening for cervical cancer and innovative methods that might help overcome financial and cultural barriers to more widespread screening...
Risk assessment to guide the prevention of cervical cancerPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7234, USA
J Low Genit Tract Dis 12:1-7. 2008....
Human papillomavirus infection and the primary and secondary prevention of cervical cancerDouglas R Lowy
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Cancer 113:1980-93. 2008..The manner in which vaccination and screening programs are integrated will need to be considered carefully so that they are efficient in reducing the overall incidence of cervical cancer...
Factors influencing histologic confirmation of high-grade squamous intraepithelial lesion cytologyPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Obstet Gynecol 112:637-45. 2008..To examine the predictors of histologic confirmation of high-grade squamous intraepithelial lesion (HSIL) cytology occurring in follow-up of young women originally referred into a trial because of less severe cytology...
Rationale and design of a community-based double-blind randomized clinical trial of an HPV 16 and 18 vaccine in Guanacaste, Costa RicaRolando Herrero
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 300 Oeste del ICE, Piso 7, Sabana Norte, San Jose, Costa Rica
Vaccine 26:4795-808. 2008..4% agreement for all types, kappa 0.59). Follow up will continue with yearly or more frequent examinations for at least 4 years for each participant...
Human papillomavirus genotype specificity of hybrid capture 2Philip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5030, EPS MSC 7234, Bethesda, MD 20892 7234, USA
J Clin Microbiol 46:2595-604. 2008..In conclusion, hc2 cross-reacts with certain untargeted, noncarcinogenic HPV genotypes that are phylogenetically related to the targeted genotypes, but the degree of cross-reactivity may be less than previously reported...
Impact of 6-month frozen storage of cervical specimens in alkaline buffer conditions on human papillomavirus genotypingBrandon J LaMere
Regional Laboratory, Kaiser Permanente Northern California, Berkley, CA, USA
J Virol Methods 151:298-300. 2008..Six-month frozen storage of cervical specimens at alkaline pH had little impact on testing for HPV genotypes among hc2-positive women using this HPV genotyping method...
Can HPV-16 genotyping provide a benchmark for cervical biopsy specimen interpretation?Mary T Galgano
Robert E Fechner Laboratory of Surgical Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
Am J Clin Pathol 130:65-70. 2008..Thus the HPV-16 fraction was not found to be broadly useful as a quality assurance metric for biopsy diagnosis in this analysis...
Comparison of linear array and line blot assay for detection of human papillomavirus and diagnosis of cervical precancer and cancer in the atypical squamous cell of undetermined significance and low-grade squamous intraepithelial lesion triage studyPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5004, EPS MSC 7234, Bethesda, MD 20892 7234, USA
J Clin Microbiol 46:109-17. 2008..In conclusion, we found LA to be a promising assay for the detection of HPV genotypes and carcinogenic HPV, and it may be clinically useful for the detection of cervical precancer and cancer in women with equivocal cytology...
A comparison of linear array and hybrid capture 2 for detection of carcinogenic human papillomavirus and cervical precancer in ASCUS-LSIL triage studyPatti E Gravitt
Department of Epidemiology and Molecular Microbiology, Johns Hopkins University, Baltimore, Maryland, USA
Cancer Epidemiol Biomarkers Prev 17:1248-54. 2008..We were interested in comparing the performance of Linear Array (LA; Roche Molecular Systems) to Hybrid Capture 2 (hc2; Digene) for the detection of carcinogenic human papillomavirus (HPV) and cervical precancer...
Epidemiology of genital Chlamydia trachomatis infection among young women in Costa RicaCarolina Porras
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, San Jose, Costa Rica
Sex Transm Dis 35:461-8. 2008..To investigate Chlamydia trachomatis (Ct) epidemiology among 5829 women 18 to 25 years old, in Costa Rica...
An analysis of high-risk human papillomavirus DNA-negative cervical precancers in the ASCUS-LSIL Triage Study (ALTS)Philip E Castle
Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Obstet Gynecol 111:847-56. 2008....
Rapid clearance of human papillomavirus and implications for clinical focus on persistent infectionsAna Cecilia Rodriguez
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Rm 5032, Rockville, MD 20852, USA
J Natl Cancer Inst 100:513-7. 2008..These findings suggest that the medical community should emphasize persistence of cervical HPV infection, not single-time detection of HPV, in management strategies and health messages...
The relationship of community biopsy-diagnosed cervical intraepithelial neoplasia grade 2 to the quality control pathology-reviewed diagnoses: an ALTS reportPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
Am J Clin Pathol 127:805-15. 2007....
Human papillomavirus type 16 infections and 2-year absolute risk of cervical precancer in women with equivocal or mild cytologic abnormalitiesPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7234, USA
J Natl Cancer Inst 97:1066-71. 2005....
Stability of archived liquid-based cervical cytologic specimensPhilip E Castle
The National Cancer Institute, Division of Cancer Epidemiology and Genetics, Rockville, Maryland 20892 7234, USA
Cancer 99:89-96. 2003..However, long-term DNA stability and cytologic stability of these biospecimens have not been evaluated...
Determinants of human papillomavirus-negative, low-grade squamous intraepithelial lesions in the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesions triage study (ALTS)Rosemary E Zuna
Pathology Department, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Cancer 105:253-62. 2005..Using the Atypical Squamous Cells of Undetermined Significance/LSIL Triage Study (ALTS) population, the authors evaluated the significance of HPV-negative LSIL...
The carcinogenicity of human papillomavirus types reflects viral evolutionMark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MA, USA
Virology 337:76-84. 2005..These results present several clear clues and research directions in our ongoing efforts to understand HPV carcinogenesis...
Does the interval between papanicolaou tests influence the quality of cytology?Jose Jeronimo
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892, USA
Cancer 105:133-8. 2005..It is commonly believed that the sensitivity of Papanicolaou (Pap) tests decreases with a short interval between cytology samplings. To the authors' knowledge, there is only limited evidence to support this belief...
A study of the impact of adding HPV types to cervical cancer screening and triage testsMark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7234, USA
J Natl Cancer Inst 97:147-50. 2005..The minimal increases in sensitivity and in negative predictive value achieved by adding HPV types to DNA tests must be weighed against the projected burden to thousands of women falsely labeled as being at high risk of cervical cancer...
Interlaboratory reliability of Hybrid Capture 2Philip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
Am J Clin Pathol 122:238-45. 2004..73); among those with equivocal or abnormal cytologic findings, kappa values were 0.80 or more. These data show that HC2 is a reliable test for detecting clinically relevant oncogenic HPV DNA...
Have we resolved how to triage equivocal cervical cytology?Diane Solomon
J Natl Cancer Inst 96:250-1. 2004
Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screeningThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404 P and S Building, 630 West 168th Street, New York, NY 10032, USA
Obstet Gynecol 103:304-9. 2004..If test results of either are abnormal, colposcopy should then be performed. This guidance should assist clinicians in utilizing HPV DNA testing in an effective manner, while minimizing unnecessary evaluations and treatments...
Findings to date from the ASCUS-LSIL Triage Study (ALTS)Mark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Arch Pathol Lab Med 127:946-9. 2003..Many additional analyses are underway...
Prospective follow-up suggests similar risk of subsequent cervical intraepithelial neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsyJ Thomas Cox
University of California, Santa Barbara, USA
Am J Obstet Gynecol 188:1406-12. 2003..This risk does not vary meaningfully by initial distinction of histologic CIN grade 1 from negative colposcopy and biopsy...
American Cancer Society guideline for the early detection of cervical neoplasia and cancerDebbie Saslow
Breast and Gynecologic Cancer, American Cancer Society, Atlanta, GA, USA
CA Cancer J Clin 52:342-62. 2002....
A comparison of a prototype PCR assay and hybrid capture 2 for detection of carcinogenic human papillomavirus DNA in women with equivocal or mildly abnormal papanicolaou smearsMark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7234, USA
Am J Clin Pathol 124:722-32. 2005..Smaller amounts of material used in PCR could have limited its sensitivity, but our results demonstrate the importance of optimization and standardization of PCR-based assays for clinical applications...
The expanded use of HPV testing in gynecologic practice per ASCCP-guided management requires the use of well-validated assaysMark H Stoler
Robert E. Fechner Laboratory of Surgical Pathology, University of Virginia Health System, Charlottesville, USA
Am J Clin Pathol 127:335-7. 2007
The natural history of human papillomavirus infection and cervical intraepithelial neoplasia among young women in the Guanacaste cohort shortly after initiation of sexual lifeAna Cecilia Rodriguez
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, Maryland 20859, USA
Sex Transm Dis 34:494-502. 2007..We wanted to explore early HPV natural history and CIN 3 prospectively...
The Bethesda Interobserver Reproducibility Study (BIRST): a web-based assessment of the Bethesda 2001 System for classifying cervical cytologyMark E Sherman
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7374, USA
Cancer 111:15-25. 2007..The Bethesda System (TBS) along with its companion atlas was updated in 2001 to improve standardization, clarity, and reproducibility of cervical cytology reporting...
Comparison of human papillomavirus distribution in cytologic subgroups of low-grade squamous intraepithelial lesionRosemary E Zuna
Pathology Department, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Cancer 108:288-97. 2006..In this study, the objective was to determine whether these 2 morphologic subcategories are characterized by differences in risk for CIN3 and/or HPV type distribution...
Predicting absolute risk of CIN3 during post-colposcopic follow-up: results from the ASCUS-LSIL Triage Study (ALTS)Joan L Walker
Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK, USA
Am J Obstet Gynecol 195:341-8. 2006..Using data from the ASCUS-LSIL Triage Study (ALTS) to inform clinical management, we calculated the absolute risk for developing CIN3 within 2 years of referral to an enrollment colposcopy...
Number of cervical biopsies and sensitivity of colposcopyJulia C Gage
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Obstet Gynecol 108:264-72. 2006..Although the sensitivity of the procedure does not differ significantly by type of medical training, it is greater when two or more biopsies are taken...
Human papillomavirus testing following loop electrosurgical excision procedure identifies women at risk for posttreatment cervical intraepithelial neoplasia grade 2 or 3 diseaseAimee R Kreimer
National Cancer Institute, NIH, 6130 Executive Boulevard, Bethesda, MD 20892 7333, USA
Cancer Epidemiol Biomarkers Prev 15:908-14. 2006....
Cervical cytology of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): characteristics and histologic outcomesMark E Sherman
Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
Cancer 108:298-305. 2006....
Cost-effectiveness analysis based on the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion Triage Study (ALTS)Shalini L Kulasingam
Department of Obstetrics and Gynecology, Duke University, Durham, NC, USA
J Natl Cancer Inst 98:92-100. 2006..We conducted a cost-effectiveness analysis of the ALTS trial to determine whether HPV DNA testing is a cost-effective alternative to immediate colposcopy or conservative management with up to three cytology examinations...
Evaluating the risk of cervical precancer with a combination of cytologic, virologic, and visual methodsSophia S Wang
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
Cancer Epidemiol Biomarkers Prev 14:2665-8. 2005..We conclude that the clear discrimination of cervical cancer risk provided by multiple test modalities is consistent with our understanding of cervical etiology related to HPV natural history...
Postcolposcopy management strategies for women referred with low-grade squamous intraepithelial lesions or human papillomavirus DNA-positive atypical squamous cells of undetermined significance: a two-year prospective studyRichard Guido
Magee-Womens Hospital of the University of Pittsburgh Health Care System, PA, USA
Am J Obstet Gynecol 188:1401-5. 2003..Baseline viral load and colposcopic impression were not helpful. CONCLUSION: The most efficient test for identifying women with CIN grade 2 or 3 after colposcopy might be an HPV test alone at 12 months...
Cervical cancer screening rates in the United States and the potential impact of implementation of screening guidelinesDiane Solomon
Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA
CA Cancer J Clin 57:105-11. 2007..Potentially, with more appropriate allocation of resources according to guidelines, all women could be screened and the total number of Pap tests reduced, despite projected increases in the population...
The distribution of neoplasia arising on the cervix: results from the ALTS trialRichard S Guido
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee Womens Hospital, Pittsburgh, PA, USA
Am J Obstet Gynecol 193:1331-7. 2005..This study was undertaken to evaluate the topographic distribution of precancerous intraepithelial lesions on the cervix...
Evaluation of systemic and mucosal anti-HPV16 and anti-HPV18 antibody responses from vaccinated womenTroy J Kemp
HPV Immunology Laboratory, SAIC Frederick Inc, NCI Frederick, Building 469, Room 120, Frederick, MD 21702, USA
Vaccine 26:3608-16. 2008....
