Marcello Solinas

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats
    Marcello Solinas
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Division of Intramural Research, National Institute of Health, Room 318, 5500 Nathan Shock Drive, Baltimore, MD, 21224, USA
    Psychopharmacology (Berl) 179:804-12. 2005
  2. ncbi request reprint Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systems
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA
    Neuropsychopharmacology 30:2035-45. 2005
  3. ncbi request reprint Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure
    Davide Quarta
    Preclinical Pharmacology, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 88:1151-8. 2004
  4. ncbi request reprint Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Front Biosci 13:2391-9. 2008
  5. ncbi request reprint Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation
    Davide Quarta
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 91:873-80. 2004
  6. ncbi request reprint Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats
    Zuzana Justinova
    Preclinical Pharmacology Section, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 307:977-86. 2003
  7. ncbi request reprint Previous exposure to THC alters the reinforcing efficacy and anxiety-related effects of cocaine in rats
    Leigh V Panlilio
    Department of Health and Human Services, Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropsychopharmacology 32:646-57. 2007
  8. ncbi request reprint Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in rats
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 30:2046-57. 2005
  9. ncbi request reprint Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 98:408-19. 2006
  10. ncbi request reprint Involvement of adenosine A1 receptors in the discriminative-stimulus effects of caffeine in rats
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, NIDA IRP, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 179:576-86. 2005

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats
    Marcello Solinas
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Division of Intramural Research, National Institute of Health, Room 318, 5500 Nathan Shock Drive, Baltimore, MD, 21224, USA
    Psychopharmacology (Berl) 179:804-12. 2005
    ..Many behavioral effects of delta-9-tetrahydrocannabinol (THC), including its discriminative-stimulus effects, are modulated by endogenous opioid systems...
  2. ncbi request reprint Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systems
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA
    Neuropsychopharmacology 30:2035-45. 2005
    ..These findings support the proposed therapeutic utility of cannabinoid agonists and antagonists in eating disorders...
  3. ncbi request reprint Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure
    Davide Quarta
    Preclinical Pharmacology, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 88:1151-8. 2004
    ..Development of tolerance to the dopamine-releasing effects of caffeine in the shell of the NAc may explain its weak addictive properties and atypical psychostimulant profile...
  4. ncbi request reprint Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Front Biosci 13:2391-9. 2008
    ..The analysis of the function of A1-A2A receptor heteromers during chronic treatment with caffeine gives new clues about the well-known phenomenon of tolerance to the psychostimulant effects of caffeine...
  5. ncbi request reprint Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation
    Davide Quarta
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 91:873-80. 2004
    ..Furthermore, these results underscore the role of A(1) vs. A(2A) receptor antagonism in the central effects of caffeine...
  6. ncbi request reprint Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats
    Zuzana Justinova
    Preclinical Pharmacology Section, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 307:977-86. 2003
    ..Therefore, adenosine A1 and A2A receptors appear to play important but differential roles in the modulation of the discriminative-stimulus effects of methamphetamine and cocaine...
  7. ncbi request reprint Previous exposure to THC alters the reinforcing efficacy and anxiety-related effects of cocaine in rats
    Leigh V Panlilio
    Department of Health and Human Services, Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropsychopharmacology 32:646-57. 2007
    ..This enhanced anxiogenic effect-which was verified in Experiment 3 using another model of anxiety, the light-dark test-may explain the reduced reinforcing value of cocaine observed in THC-exposed rats in Experiment 1...
  8. ncbi request reprint Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in rats
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 30:2046-57. 2005
    ....
  9. ncbi request reprint Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 98:408-19. 2006
    ..Thus, these results indicate that anandamide, through the activation of the mesolimbic dopaminergic system, participates in the signaling of brain reward processes...
  10. ncbi request reprint Involvement of adenosine A1 receptors in the discriminative-stimulus effects of caffeine in rats
    Marcello Solinas
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, NIDA IRP, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 179:576-86. 2005
    ..Caffeine is a non-selective adenosine receptor antagonist in vitro, but involvement of different adenosine receptor subtypes, particularly adenosine A1 and A 2A receptors, in the central effects of caffeine remains a matter of debate...
  11. ncbi request reprint Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release
    Davide Quarta
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 32:35-42. 2007
    ..These results reveal that striatal non-alpha(7) nicotinic acetylcholine receptors form part of heteromeric dopamine autoreceptor complexes that modulate dopamine release...
  12. pmc Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid
    Zuzana Justinova
    1 Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA 2 Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA 3
    Nat Neurosci 16:1652-61. 2013
    ..Despite a clear need, there are no medications approved for treatment of marijuana dependence. Modulation of KYNA offers a pharmacological strategy for achieving abstinence from marijuana and preventing relapse. ..
  13. ncbi request reprint Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration
    Marzena Karcz-Kubicha
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, NIDA, NIH, IRP, Department of Health and Human Services, Baltimore, MD, USA
    Neuropsychopharmacology 28:1281-91. 2003
    ....
  14. pmc Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors
    Carmen Mazzola
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore, Maryland 21224, USA
    Learn Mem 16:332-7. 2009
    ..These findings demonstrate novel mechanisms for memory enhancement by activation of PPAR-alpha, either directly by administering a PPAR-alpha agonist or indirectly by administering a FAAH inhibitor...
  15. pmc The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys
    Zuzana Justinova
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 25:5645-50. 2005
    ..These findings strongly suggest that release of endogenous cannabinoids is involved in brain reward processes and that activation of cannabinoid CB(1) receptors by anandamide could be part of the signaling of natural rewarding events...
  16. ncbi request reprint Two brain sites for cannabinoid reward
    Abraham Zangen
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:4901-7. 2006
    ..These findings link the sites of rewarding action of Delta9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of rewarding action...
  17. pmc Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans
    Marco Orru
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, 251 Bayview Blvd, Baltimore, MD, USA
    Neuropharmacology 67:476-84. 2013
    ..The present results demonstrate a unique psychostimulant profile of paraxanthine, which might contribute to the reinforcing effects of caffeine in humans...
  18. ncbi request reprint Human cocaine-seeking behavior and its control by drug-associated stimuli in the laboratory
    Leigh V Panlilio
    Preclinical Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
    Neuropsychopharmacology 30:433-43. 2005
    ..The similarity of the response patterns in humans and animals also supports the use of second-order schedules in animals as a valid model of human drug seeking...
  19. ncbi request reprint Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens
    Marcello Solinas
    Section of Preclinical Pharmacology, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 22:6321-4. 2002
    ..This suggests that caffeine, because of its ability to block adenosine A1 receptors, shares neurochemical properties with other psychostimulants, which could contribute to the widespread consumption of caffeine-containing beverages...
  20. ncbi request reprint The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport
    Marcello Solinas
    Laboratoire de Biologie et Physiologie Cellulaires, CNRS 6187, Universite de Poitiers, Poitiers, France
    J Pharmacol Exp Ther 321:370-80. 2007
    ....
  21. ncbi request reprint Selective psychostimulant sensitization by food restriction: differential changes in accumbens shell and core dopamine
    Cristina Cadoni
    Department of Toxicology, University of Cagliari and Centre of Excellence for Neurobiology of Addiction, Via Ospedale 72, 09124 Cagliari, Italy
    Eur J Neurosci 18:2326-34. 2003
    ..The present results indicate that a sensitized dopamine response in the nucleus accumbens core is a general feature of the expression of behavioural sensitization...
  22. ncbi request reprint Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide
    Marcello Solinas
    Laboratoire de Biologie et Physiologie Cellulaires, Centre National de la Recherche Scientifique VMR6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022, Poitiers, France
    J Pharmacol Exp Ther 321:1127-34. 2007
    ..Nicotinic, but not muscarinic, modulation of THC discrimination involves elevations in endogenous levels of anandamide...
  23. ncbi request reprint Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in rats
    Marcello Solinas
    Centre National de la Recherche Scientifique UMR 6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
    Nat Protoc 1:1194-206. 2006
    ....
  24. pmc Endocannabinoid system involvement in brain reward processes related to drug abuse
    Marcello Solinas
    Institut de Physiologie et Biologie Cellulaires, University of Poitiers, Centre National de la Recherche Scientifique UMR 6187, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
    Pharmacol Res 56:393-405. 2007
    ..Altogether, evidence points to the endocannadinoid system as a promising target for the development of medications for the treatment of drug abuse...
  25. ncbi request reprint Neuropeptide Y protects against methamphetamine-induced neuronal apoptosis in the mouse striatum
    Nathalie Thiriet
    Centre National de la Recherche Scientifique 6187, University of Poitiers, 86000 Poitiers, France
    J Neurosci 25:5273-9. 2005
    ..Given the similarity between the cell death patterns induced by METH and by disorders such as Huntington's disease, our results suggest that NPY analogs might be useful therapeutic agents against some neurodegenerative processes...
  26. pmc Environmental enrichment during adolescence regulates gene expression in the striatum of mice
    Nathalie Thiriet
    Institut de Biologie et Physiologie Cellulaires, University of Poitiers, 40 Avenue du Recteur Pineau, Poitiers, France
    Brain Res 1222:31-41. 2008
    ..The striatal gene expression regulation by environment that we report here may play a role in the resistance to the effects of drugs of abuse and dopaminergic neurotoxins previously reported...
  27. ncbi request reprint Effect of 3,4-methylendioxymethamphetamine (MDMA, "ecstasy") on dopamine transmission in the nucleus accumbens shell and core
    Cristina Cadoni
    CNR Istitute of Neuroscience, Section of Cagliari, Cagliari, Italy
    Brain Res 1055:143-8. 2005
    ..2 mg/kg was not significantly different in the shell compared to the core of nucleus accumbens. This study extends to MDMA the property of other drugs of abuse to increase preferentially nucleus accumbens shell dopamine...
  28. ncbi request reprint Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse
    Marcello Solinas
    Institut de Biologie et Physiologie Cellulaires, Centre National de la Recherche Scientifique 6187, University of Poitiers, 86022 Poitiers, France
    J Neurosci 27:5615-20. 2007
    ..Importantly, MLA reversed the effects of cannabinoids at doses that did not produce depressant or toxic effects, further pointing to alpha7 nicotinic antagonists as potentially useful agents in the treatment of cannabis abuse in humans...