Research Topics
Species | Marcello SolinasSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systemsMarcello Solinas
Preclinical Pharmacology Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA
Neuropsychopharmacology 30:2035-45. 2005..These findings support the proposed therapeutic utility of cannabinoid agonists and antagonists in eating disorders...- Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in ratsMarcello Solinas
Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Division of Intramural Research, National Institute of Health, Room 318, 5500 Nathan Shock Drive, Baltimore, MD, 21224, USA
Psychopharmacology (Berl) 179:804-12. 2005..Many behavioral effects of delta-9-tetrahydrocannabinol (THC), including its discriminative-stimulus effects, are modulated by endogenous opioid systems... - Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brainSergi Ferre
National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Front Biosci 13:2391-9. 2008..The analysis of the function of A1-A2A receptor heteromers during chronic treatment with caffeine gives new clues about the well-known phenomenon of tolerance to the psychostimulant effects of caffeine... - Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulationDavide Quarta
Preclinical Pharmacology Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurochem 91:873-80. 2004..Furthermore, these results underscore the role of A(1) vs. A(2A) receptor antagonism in the central effects of caffeine... - Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposureDavide Quarta
Preclinical Pharmacology, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurochem 88:1151-8. 2004..Development of tolerance to the dopamine-releasing effects of caffeine in the shell of the NAc may explain its weak addictive properties and atypical psychostimulant profile... - Previous exposure to THC alters the reinforcing efficacy and anxiety-related effects of cocaine in ratsLeigh V Panlilio
Department of Health and Human Services, Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Neuropsychopharmacology 32:646-57. 2007..This enhanced anxiogenic effect-which was verified in Experiment 3 using another model of anxiety, the light-dark test-may explain the reduced reinforcing value of cocaine observed in THC-exposed rats in Experiment 1... - Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in ratsMarcello Solinas
Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Neuropsychopharmacology 30:2046-57. 2005.... - Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in ratsZuzana Justinova
Preclinical Pharmacology Section, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
J Pharmacol Exp Ther 307:977-86. 2003..Therefore, adenosine A1 and A2A receptors appear to play important but differential roles in the modulation of the discriminative-stimulus effects of methamphetamine and cocaine... - Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in ratsMarcello Solinas
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurochem 98:408-19. 2006..Thus, these results indicate that anandamide, through the activation of the mesolimbic dopaminergic system, participates in the signaling of brain reward processes... - Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine releaseDavide Quarta
Behavioral Neuroscience Branch, National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 32:35-42. 2007..These results reveal that striatal non-alpha(7) nicotinic acetylcholine receptors form part of heteromeric dopamine autoreceptor complexes that modulate dopamine release... - Involvement of adenosine A1 receptors in the discriminative-stimulus effects of caffeine in ratsMarcello Solinas
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, NIDA-IRP, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 179:576-86. 2005.... - Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administrationMarzena Karcz-Kubicha
Preclinical Pharmacology Section, Behavioral Neuroscience Branch, NIDA, NIH, IRP, Department of Health and Human Services, Baltimore, MD, USA
Neuropsychopharmacology 28:1281-91. 2003.... 
The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeysZuzana Justinova
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 25:5645-50. 2005..These findings strongly suggest that release of endogenous cannabinoids is involved in brain reward processes and that activation of cannabinoid CB(1) receptors by anandamide could be part of the signaling of natural rewarding events...- Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptorsCarmen Mazzola
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore, Maryland 21224, USA
Learn Mem 16:332-7. 2009..These findings demonstrate novel mechanisms for memory enhancement by activation of PPAR-alpha, either directly by administering a PPAR-alpha agonist or indirectly by administering a FAAH inhibitor... - Two brain sites for cannabinoid rewardAbraham Zangen
National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 26:4901-7. 2006..These findings link the sites of rewarding action of Delta9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of rewarding action... - Human cocaine-seeking behavior and its control by drug-associated stimuli in the laboratoryLeigh V Panlilio
Preclinical Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
Neuropsychopharmacology 30:433-43. 2005..The similarity of the response patterns in humans and animals also supports the use of second-order schedules in animals as a valid model of human drug seeking... - Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbensMarcello Solinas
Section of Preclinical Pharmacology, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health Intramural Research Program, Baltimore, Maryland 21224, USA
J Neurosci 22:6321-4. 2002..This suggests that caffeine, because of its ability to block adenosine A1 receptors, shares neurochemical properties with other psychostimulants, which could contribute to the widespread consumption of caffeine-containing beverages... - The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transportMarcello Solinas
Laboratoire de Biologie et Physiologie Cellulaires, CNRS 6187, Universite de Poitiers, Poitiers, France
J Pharmacol Exp Ther 321:370-80. 2007.... - Selective psychostimulant sensitization by food restriction: differential changes in accumbens shell and core dopamineCristina Cadoni
Department of Toxicology, University of Cagliari and Centre of Excellence for Neurobiology of Addiction, Via Ospedale 72, 09124 Cagliari, Italy
Eur J Neurosci 18:2326-34. 2003..The present results indicate that a sensitized dopamine response in the nucleus accumbens core is a general feature of the expression of behavioural sensitization... - Environmental enrichment during adolescence regulates gene expression in the striatum of miceNathalie Thiriet
Institut de Biologie et Physiologie Cellulaires, University of Poitiers, 40 Avenue du Recteur Pineau, Poitiers, France
Brain Res 1222:31-41. 2008..The striatal gene expression regulation by environment that we report here may play a role in the resistance to the effects of drugs of abuse and dopaminergic neurotoxins previously reported... - Endocannabinoid system involvement in brain reward processes related to drug abuseMarcello Solinas
Institut de Physiologie et Biologie Cellulaires, University of Poitiers, Centre National de la Recherche Scientifique UMR 6187, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
Pharmacol Res 56:393-405. 2007..Altogether, evidence points to the endocannadinoid system as a promising target for the development of medications for the treatment of drug abuse... - Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuseMarcello Solinas
Institut de Biologie et Physiologie Cellulaires, Centre National de la Recherche Scientifique 6187, University of Poitiers, 86022 Poitiers, France
J Neurosci 27:5615-20. 2007..Importantly, MLA reversed the effects of cannabinoids at doses that did not produce depressant or toxic effects, further pointing to alpha7 nicotinic antagonists as potentially useful agents in the treatment of cannabis abuse in humans... - Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in ratsMarcello Solinas
Centre National de la Recherche Scientifique UMR 6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
Nat Protoc 1:1194-206. 2006.... - Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamideMarcello Solinas
Laboratoire de Biologie et Physiologie Cellulaires, Centre National de la Recherche Scientifique VMR6187, University of Poitiers, 40 Avenue du Recteur Pineau, 86022, Poitiers, France
J Pharmacol Exp Ther 321:1127-34. 2007..Nicotinic, but not muscarinic, modulation of THC discrimination involves elevations in endogenous levels of anandamide... - Neuropeptide Y protects against methamphetamine-induced neuronal apoptosis in the mouse striatumNathalie Thiriet
Centre National de la Recherche Scientifique 6187, University of Poitiers, 86000 Poitiers, France
J Neurosci 25:5273-9. 2005..Given the similarity between the cell death patterns induced by METH and by disorders such as Huntington's disease, our results suggest that NPY analogs might be useful therapeutic agents against some neurodegenerative processes... - Effect of 3,4-methylendioxymethamphetamine (MDMA, "ecstasy") on dopamine transmission in the nucleus accumbens shell and coreCristina Cadoni
CNR Istitute of Neuroscience, Section of Cagliari, Cagliari, Italy
Brain Res 1055:143-8. 2005..2 mg/kg was not significantly different in the shell compared to the core of nucleus accumbens. This study extends to MDMA the property of other drugs of abuse to increase preferentially nucleus accumbens shell dopamine...