Mykyta V Sokolov

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Lessons Learned about Human Stem Cell Responses to Ionizing Radiation Exposures: A Long Road Still Ahead of Us
    Mykyta Sokolov
    Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Mol Sci 14:15695-723. 2013
  2. pmc Whole-genome gene expression profiling reveals the major role of nitric oxide in mediating the cellular transcriptional response to ionizing radiation in normal human fibroblasts
    Mykyta V Sokolov
    Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Genomics 100:277-81. 2012
  3. pmc Unraveling the global microRNAome responses to ionizing radiation in human embryonic stem cells
    Mykyta V Sokolov
    Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e31028. 2012
  4. pmc Radiation-induced bystander effects in cultured human stem cells
    Mykyta V Sokolov
    Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e14195. 2010
  5. pmc Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation
    Mykyta V Sokolov
    Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gene 455:8-15. 2010
  6. pmc Intercellular communication of cellular stress monitored by gamma-H2AX induction
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA
    Carcinogenesis 30:1686-95. 2009
  7. pmc Effects of DNA-targeted ionizing radiation produced by 5-[125I]iodo-2'-deoxyuridine on global gene expression in primary human cells
    Mykyta V Sokolov
    Nuclear Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    BMC Genomics 8:192. 2007
  8. ncbi request reprint Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts
    Mykyta V Sokolov
    Department of Nuclear Medicine, Clinical Center, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Oncogene 24:7257-65. 2005
  9. pmc Dynamics of the transcriptome response of cultured human embryonic stem cells to ionizing radiation exposure
    Mykyta V Sokolov
    Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, United States
    Mutat Res 709:40-8. 2011
  10. ncbi request reprint gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication
    Mykyta V Sokolov
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20895, USA
    Cell Cycle 6:2210-2. 2007

Detail Information

Publications11

  1. pmc Lessons Learned about Human Stem Cell Responses to Ionizing Radiation Exposures: A Long Road Still Ahead of Us
    Mykyta Sokolov
    Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Mol Sci 14:15695-723. 2013
    ..We discuss here that hSC responses to IR differ notably across many types of hSC which may represent the distinct roles these cells play in development, regeneration and/or maintenance of homeostasis. ..
  2. pmc Whole-genome gene expression profiling reveals the major role of nitric oxide in mediating the cellular transcriptional response to ionizing radiation in normal human fibroblasts
    Mykyta V Sokolov
    Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Genomics 100:277-81. 2012
    ..NO scavenging in irradiated IMR-90 cells results in induction of p53 signaling, DNA damage and DNA repair pathways...
  3. pmc Unraveling the global microRNAome responses to ionizing radiation in human embryonic stem cells
    Mykyta V Sokolov
    Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e31028. 2012
    ..Our findings reveal a fundamental role of miRNAome in modulating the radiation response, and identify novel molecular targets of radiation in hESC...
  4. pmc Radiation-induced bystander effects in cultured human stem cells
    Mykyta V Sokolov
    Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e14195. 2010
    ..To mechanistically interrogate RIBE responses and to gain novel insights into RIBE specifically in hSC compartment, both medium transfer and cell co-culture bystander protocols were employed...
  5. pmc Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation
    Mykyta V Sokolov
    Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gene 455:8-15. 2010
    ..Our data suggest that exposure of hESC to relatively low doses of IR as a model genotoxic agent does not significantly affect pluripotency of the surviving fraction of hESC...
  6. pmc Intercellular communication of cellular stress monitored by gamma-H2AX induction
    Jennifer S Dickey
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA
    Carcinogenesis 30:1686-95. 2009
    ....
  7. pmc Effects of DNA-targeted ionizing radiation produced by 5-[125I]iodo-2'-deoxyuridine on global gene expression in primary human cells
    Mykyta V Sokolov
    Nuclear Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    BMC Genomics 8:192. 2007
    ..DNA microarray dataset was independently partially validated with quantitative real-time PCR (RT-PCR)...
  8. ncbi request reprint Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts
    Mykyta V Sokolov
    Department of Nuclear Medicine, Clinical Center, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Oncogene 24:7257-65. 2005
    ..These studies show that H2AX phosphorylation is an early step in the bystander effect and that the DNA DSBs underlying gamma-H2AX focus formation may be responsible for its downstream manifestations...
  9. pmc Dynamics of the transcriptome response of cultured human embryonic stem cells to ionizing radiation exposure
    Mykyta V Sokolov
    Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, United States
    Mutat Res 709:40-8. 2011
    ....
  10. ncbi request reprint gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication
    Mykyta V Sokolov
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20895, USA
    Cell Cycle 6:2210-2. 2007
    ..This extra view points to some possibilities that might explain why DDR in human cells can be observed under bystander conditions...
  11. pmc Human embryonic stem cell responses to ionizing radiation exposures: current state of knowledge and future challenges
    Mykyta V Sokolov
    Nuclear Medicine Division, Radiology and Imaging Sciences Department, Clinical Center, National Institutes of Health NIH, 9000 Rockville Pike, Bldg 10, room 4D49, Bethesda, MD 20892, USA
    Stem Cells Int 2012:579104. 2012
    ....