Boris P Sokolov
Affiliation: National Institutes of Health
- Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependenceBoris P Sokolov
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
J Neurosci Res 72:756-67. 2003..We hypothesize that these mechanisms may be related to alcohol abuse traits or long-term effects of alcohol...
- Methamphetamine causes alterations in the MAP kinase-related pathways in the brains of mice that display increased aggressivenessBoris P Sokolov
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 31:956-66. 2006..These findings suggest that alterations in MAP kinase-related pathways in the prefronto-striatal circuitries might be involved in the manifestation of aggressive behaviors in mice...
- Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?Boris P Sokolov
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA
Int J Neuropsychopharmacol 10:547-55. 2007..The possible mechanisms of oligodendroglial abnormalities may involve functional variations in oligodendroglia-related genes, epigenetic regulation of chromatin, DA system hyperactivity and other mechanisms...
- Mouse brain gene expression changes after acute and chronic amphetamineBoris P Sokolov
Molecular Neurobiology Branch, NIDA IRP, NIH, Baltimore, Maryland, USA
J Neurochem 84:244-52. 2003..Each of these genes, including transcription factor, cellular regulatory, structural and other gene family members, are candidates to contribute to brain adaptations to psychostimulants...
- Allele C-specific methylation of the 5-HT2A receptor gene: evidence for correlation with its expression and expression of DNA methylase DNMT1Oxana O Polesskaya
Molecular Neurobiology Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, Maryland 21224, USA
J Neurosci Res 83:362-73. 2006..These findings support the hypothesis that allele-specific DNA methylation is involved in regulation of 5HT2AR expression, influencing expression differences between alleles C and T...
- Novel putative nonprotein-coding RNA gene from 11q14 displays decreased expression in brains of patients with schizophreniaOxana O Polesskaya
Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci Res 74:111-22. 2003..These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors...
- Chronic methamphetamine increases fighting in miceBoris P Sokolov
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Pharmacol Biochem Behav 77:319-26. 2004..Thus, intermittent administration of METH might be useful as a pharmacological model to study the biochemical and molecular bases of aggressiveness...
- Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenicsOxana O Polesskaya
Molecular Neurobiology Branch, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
J Neurosci Res 67:812-22. 2002..03). The data suggest that increased prevalence of allele "C" among schizophrenics may be due to intrinsically low expression of this allele, which may contribute to a deficit in 5-HT2AR expression in some schizophrenics...
- Microarray analysis of postmortem temporal cortex from patients with schizophreniaChristopher Aston
Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, USA
J Neurosci Res 77:858-66. 2004..These findings support the hypothesis that schizophrenia is associated with abnormalities in oligodendroglia and provide initial evidence suggesting a role for epigenetic mechanisms and altered circadian rhythms in this disorder...