E G Snyderwine

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Mammary gland carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats: possible mechanisms
    E G Snyderwine
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892 4255, USA
    Cancer Lett 143:211-5. 1999
  2. ncbi request reprint Mammary gland carcinogenesis by food-derived heterocyclic amines: metabolism and additional factors influencing carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    Elizabeth G Snyderwine
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute Center for Cancer Research, Bethesda, Maryland 20892, USA
    Environ Mol Mutagen 39:165-70. 2002
  3. ncbi request reprint H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer
    Minshu Yu
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA
    Carcinogenesis 23:2123-8. 2002
  4. ncbi request reprint Effect of CYP1A2 deficiency on heterocyclic amine DNA adduct levels in mice
    E G Snyderwine
    Department of Veterinary Medicine, King Saud University, Buraydah, Saudi Arabia
    Food Chem Toxicol 40:1529-33. 2002
  5. ncbi request reprint Mutagenesis and DNA adduct formation in the mouse mammary gland exposed to 2-hydroxyamino-1-methyl-6-phenylimidazo-[4,5-b]pyridine in whole organ culture
    Elizabeth G Snyderwine
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA
    Mutagenesis 18:7-12. 2003
  6. ncbi request reprint Mammary gland carcinogenesis by food-derived heterocyclic amines and studies on the mechanisms of carcinogenesis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    Elizabeth G Snyderwine
    Chemical Carcinogenesis Section, NCI Center for Cancer Research, Building 37, Room 3C28, 37 Convent Drive MSC 4258, Bethesda, MD 20892, USA
    Mutat Res 506:145-52. 2002
  7. ncbi request reprint Highlights of the eighth international conference on carcinogenic/mutagenic N-substituted aryl compounds
    Elizabeth G Snyderwine
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892 4258, USA
    Mutat Res 506:1-8. 2002
  8. ncbi request reprint DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder, and kidney of congenic mice differing in Ah responsiveness and N-acetyltransferase genotype
    P V Nerurkar
    Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702 1201, USA
    Cancer Res 55:3043-9. 1995
  9. ncbi request reprint 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) modulates lactogenic hormone-mediated differentiation and gene expression in HC11 mouse mammary epithelial cells
    L Shan
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cell Growth Differ 12:649-56. 2001
  10. ncbi request reprint Carcinogenicity and mutagenicity of heterocyclic amines in transgenic mouse models
    S S Thorgeirsson
    Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Cancer Lett 143:245-7. 1999

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Mammary gland carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats: possible mechanisms
    E G Snyderwine
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892 4255, USA
    Cancer Lett 143:211-5. 1999
    ..The results to date indicate that PhIP has multiple effects on the mammary gland and hormone status in rats that could potentially play a role in its ability to induce mammary gland cancer...
  2. ncbi request reprint Mammary gland carcinogenesis by food-derived heterocyclic amines: metabolism and additional factors influencing carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    Elizabeth G Snyderwine
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute Center for Cancer Research, Bethesda, Maryland 20892, USA
    Environ Mol Mutagen 39:165-70. 2002
    ....
  3. ncbi request reprint H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer
    Minshu Yu
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA
    Carcinogenesis 23:2123-8. 2002
    ..The results support the notion that mutations in H-ras codons 12 and 13 are largely PhIP-DNA adduct-induced and involved in the initiation and development of mammary gland cancer in rats exposed to PhIP...
  4. ncbi request reprint Effect of CYP1A2 deficiency on heterocyclic amine DNA adduct levels in mice
    E G Snyderwine
    Department of Veterinary Medicine, King Saud University, Buraydah, Saudi Arabia
    Food Chem Toxicol 40:1529-33. 2002
    ..However, the data raise the possibility that other cytochromes P450 as well as other pathways of activation potentially contribute to DNA adduct formation in specific organs, depending on the HCA substrate...
  5. ncbi request reprint Mutagenesis and DNA adduct formation in the mouse mammary gland exposed to 2-hydroxyamino-1-methyl-6-phenylimidazo-[4,5-b]pyridine in whole organ culture
    Elizabeth G Snyderwine
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA
    Mutagenesis 18:7-12. 2003
    ..The findings indicate that mammotrophic hormones influence the mutagenicity of PhIP in the mammary gland in vitro and emphasize the importance of hormonal milieu on carcinogen-DNA adduct-induced mutations in this organ...
  6. ncbi request reprint Mammary gland carcinogenesis by food-derived heterocyclic amines and studies on the mechanisms of carcinogenesis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    Elizabeth G Snyderwine
    Chemical Carcinogenesis Section, NCI Center for Cancer Research, Building 37, Room 3C28, 37 Convent Drive MSC 4258, Bethesda, MD 20892, USA
    Mutat Res 506:145-52. 2002
    ....
  7. ncbi request reprint Highlights of the eighth international conference on carcinogenic/mutagenic N-substituted aryl compounds
    Elizabeth G Snyderwine
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892 4258, USA
    Mutat Res 506:1-8. 2002
    ....
  8. ncbi request reprint DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder, and kidney of congenic mice differing in Ah responsiveness and N-acetyltransferase genotype
    P V Nerurkar
    Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702 1201, USA
    Cancer Res 55:3043-9. 1995
    ..5-fold increase in adducts but only in the Ah-responsive, rapid acetylator mice. In sum, these polymorphisms influenced the level of IQ-DNA adducts in the kidney, urinary bladder, and colon in complex ways...
  9. ncbi request reprint 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) modulates lactogenic hormone-mediated differentiation and gene expression in HC11 mouse mammary epithelial cells
    L Shan
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cell Growth Differ 12:649-56. 2001
    ..The findings have implications for a novel mechanism of action of the mammary gland carcinogen PhIP...
  10. ncbi request reprint Carcinogenicity and mutagenicity of heterocyclic amines in transgenic mouse models
    S S Thorgeirsson
    Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Cancer Lett 143:245-7. 1999
    ....
  11. ncbi request reprint Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
    N Sadrieh
    Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Carcinogenesis 16:1549-55. 1995
    ..Furthermore, the poor metabolic activation of MeIQx by CYP3A and CYP2C, coupled with low constitutive levels of CYP1A isozymes, provide a metabolic explanation for the low hepatocarcinogenic potency of MeIQx in cynomolgus monkeys...
  12. ncbi request reprint Transgenic mouse models in carcinogenesis research and testing
    S S Thorgeirsson
    Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Room 3C28, Building 37, 37 Convent Drive MSC4255, Bethesda, MD, USA
    Toxicol Lett 112:553-5. 2000
    ....
  13. ncbi request reprint Mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mammary gland of Big Blue rats on high-and low-fat diets
    Minshu Yu
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, MSC 425, Bethesda, MD 20892 425, USA
    Carcinogenesis 23:877-84. 2002
    ..The findings from these studies suggest that 5'-CAG(Pu)-3' is an additional characteristic target site for PhIP-guanine adduct-induced mutations in vivo in the mammary gland...
  14. ncbi request reprint Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenz[a]anthracene
    Andriana D Papaconstantinou
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 118:17-24. 2006
    ..Several of the altered proteins, including hsp27, hsp86 and stathmin, may ultimately serve as markers of early breast cancer development...
  15. ncbi request reprint Steroid hormone receptor expression and proliferation in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
    Cunping Qiu
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 26:763-9. 2005
    ....
  16. pmc Susceptibility of rats to mammary gland carcinogenesis by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) varies with age and is associated with the induction of differential gene expression
    Liang Shan
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Center for Cancer Research, Building 37, National Cancer Institute NIH, Bethesda, MD 20892 4262, USA
    Am J Pathol 165:191-202. 2004
    ....
  17. pmc Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas
    Liang Shan
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892 4262, USA
    Am J Pathol 163:2495-502. 2003
    ..The results implicate Id4 in rat mammary gland carcinogenesis and suggest that Id4 may contribute to carcinogenesis by inhibiting mammary epithelial cell differentiation and stimulating mammary epithelial cell growth...
  18. ncbi request reprint Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
    Cunping Qiu
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Health of Institutes, Bethesda, Maryland 20892 4262, USA
    Cancer Res 63:5674-8. 2003
    ..The H-ras pathway is linked to the cell cycle via cyclin D1. The results from the current study implicate cyclin D1/Cdk4, phospho-Rb as a central pathway in PhIP-induced rat mammary gland carcinogenesis...
  19. ncbi request reprint Allelic imbalance and altered expression of genes in chromosome 2q11-2q16 from rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
    Cunping Qiu
    Chimical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4262, USA
    Oncogene 22:1253-60. 2003
    ..05, Spearman Rank Order Correlation). The findings from the current study implicate molecular alterations in the proximal region of 2q in PhIP-induced rat mammary gland carcinomas...
  20. ncbi request reprint cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene
    Liang Shan
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Carcinogenesis 23:1561-8. 2002
    ..The similarities in gene expression between PhIP- and DMBA-induced carcinomas raise the possibility that several molecular pathways for rat mammary gland transformation are maintained irrespective of the carcinogenic initiating agent...
  21. ncbi request reprint Comparative genomic hybridization analysis of PhIP-induced mammary carcinomas in rats reveals a cytogenetic signature
    Allen T Christian
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, L 452 Livermore, CA 94551, USA
    Mutat Res 506:113-9. 2002
    ..This indicates that PhIP has a recognizable cytogenetic signature in rat mammary gland carcinomas...
  22. ncbi request reprint Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a
    Andriana D Papaconstantinou
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    FEBS Lett 581:29-33. 2007
    ..The results of this study are consistent with the notion that activated STAT5a may provide a growth advantage in some types of mammary gland cancers...
  23. ncbi request reprint Gene expression profiling of chemically induced rat mammary gland cancer
    Liang Shan
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4262, USA
    Carcinogenesis 26:503-9. 2005
    ....
  24. ncbi request reprint Possible role of Stat5a in rat mammary gland carcinogenesis
    Liang Shan
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, CCR, NCI, Building 37, Room 4146, 37 Convent Dr, Bethesda, MD, 20892 4262, USA
    Breast Cancer Res Treat 88:263-72. 2004
    ..Nuclear expression of Stat5a in human breast cancers also correlated with the PCNA nuclear labeling index. The findings implicate activated Stat5a in mammary gland cancer development in the rat and human...
  25. ncbi request reprint Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas
    Liang Shan
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892 4262, USA
    Toxicol Pathol 33:768-75. 2005
    ..The elevated expression of the prolactin receptor in carcinomas concomitant with several components of the mitogenic prolactin signaling pathway implicated prolactin/prolactin receptor/Stat5a/cyclin D1 in rat mammary gland malignancy...