Research Topics
Species | M C SnellerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral bloodMichael C Sneller
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 118:6845-8. 2011....
Common variable immunodeficiencyM C Sneller
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Med Sci 321:42-8. 2001..Because the spectrum of associated diseases is broad, patients with CVI are seen by a variety of medical specialists. In this review, the pathogenesis, clinical manifestations, diagnosis, and treatment of CVI are discussed...
A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld diseaseM C Sneller
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
J Clin Invest 90:334-41. 1992..The clinical and immunological features of this syndrome resemble the lymphoproliferative/autoimmune disease seen in lpr and gld mice...
Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetranceC E Jackson
Branches of Genetics and Molecular Biology, National Institutes of Health, Bethesda, MD 20892, USA
Am J Hum Genet 64:1002-14. 1999..Thus, the location of mutations within APT1 strongly influences the development and the severity of ALPS...
Clincal, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosisM C Sneller
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 89:1341-8. 1997..Fas gene mutations account for impaired lymphocyte apoptosis in only a subset of patients with ALPS...
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosisS E Straus
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Blood 98:194-200. 2001..These data implicate a role for Fas-mediated apoptosis in preventing B-cell and T-cell lymphomas. Inherited defects in receptor-mediated lymphocyte apoptosis represent a newly appreciated risk factor for lymphomas...
Expression of chemokine and inhibitory receptors on natural killer cells: effect of immune activation and HIV viremiaS Kottilil
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 189:1193-8. 2004....
Orbital socket contracture: a complication of inflammatory orbital disease in patients with Wegener's granulomatosisC Talar-Williams
National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
Br J Ophthalmol 89:493-7. 2005..To describe the clinical characteristics of orbital socket contracture in patients with Wegener's granulomatosis (WG)...
Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expressionU Lopatin
Laboratory of Clinical Investigation, Clinical Research Training Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Blood 97:3161-70. 2001..Nonetheless, in vitro studies showed no influence of IL-10 on the survival of CD4(-)CD8(-) T cells. Overexpression of IL-10 in patients with inherited apoptotic defects is strongly associated with the overt manifestations of ALPS...
Autoimmune lymphoproliferative syndrome: a syndrome associated with inherited genetic defects that impair lymphocytic apoptosis--CT and US featuresN A Avila
Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1182, USA
Radiology 212:257-63. 1999..To describe the imaging findings in patients with autoimmune lymphoproliferative syndrome (ALPS) and to relate the findings to the clinical and genetic features of this recently recognized syndrome...
Active Wegener's granulomatosis is associated with HLA-DR+ CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: reversal with IL-10B R Ludviksson
Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
J Immunol 160:3602-9. 1998..These data suggest that T cells from WG patients overproduce IFN-gamma and TNF-alpha, probably due to dysregulated IL-12 secretion, and that IL-10 may therefore have therapeutic implications for this disease...
Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literatureP E Tarr
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Medicine (Baltimore) 80:123-33. 2001..GS should be ruled out in patients with thymoma or CVID who develop severe, especially opportunistic, infections. Treatment with intravenous immune globulin is recommended for all patients with GS...
