Jeffrey C Smith

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms
    J C Smith
    Cellular and Systems Neurobiology Section, Porter Neuroscience Research Center, NINDS, NIH, Bethesda, MD 20892, USA
    J Neurophysiol 98:3370-87. 2007
  2. pmc Structural and functional architecture of respiratory networks in the mammalian brainstem
    Jeffrey C Smith
    Porter Neuroscience Research Center, Building 35, Room 3C 917, 35 Convent Drive, NINDS, NIH, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 364:2577-87. 2009
  3. ncbi request reprint Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model
    J C Smith
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 4455, USA
    Respir Physiol 122:131-47. 2000
  4. pmc Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P
    Krzysztof Ptak
    Cellular and Systems Neurobiology Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:3720-37. 2009
  5. pmc TASK channels contribute to the K+-dominated leak current regulating respiratory rhythm generation in vitro
    Hidehiko Koizumi
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:4273-84. 2010
  6. doi request reprint Brainstem respiratory networks: building blocks and microcircuits
    Jeffrey C Smith
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, MD, USA
    Trends Neurosci 36:152-62. 2013
  7. doi request reprint Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre-Bötzinger complex in vitro
    Hidehiko Koizumi
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:1773-85. 2008
  8. pmc Structural-functional properties of identified excitatory and inhibitory interneurons within pre-Botzinger complex respiratory microcircuits
    Hidehiko Koizumi
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 33:2994-3009. 2013
  9. pmc Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network
    Christopher A Del Negro
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Biophys J 82:206-14. 2002
  10. ncbi request reprint Persistent sodium current, membrane properties and bursting behavior of pre-bötzinger complex inspiratory neurons in vitro
    Christopher A Del Negro
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4455, USA
    J Neurophysiol 88:2242-50. 2002

Detail Information

Publications19

  1. pmc Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms
    J C Smith
    Cellular and Systems Neurobiology Section, Porter Neuroscience Research Center, NINDS, NIH, Bethesda, MD 20892, USA
    J Neurophysiol 98:3370-87. 2007
    ..We conclude that the respiratory network has rhythmogenic capabilities at multiple levels of network organization, allowing expression of motor patterns specific for various physiological and pathophysiological respiratory behaviors...
  2. pmc Structural and functional architecture of respiratory networks in the mammalian brainstem
    Jeffrey C Smith
    Porter Neuroscience Research Center, Building 35, Room 3C 917, 35 Convent Drive, NINDS, NIH, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 364:2577-87. 2009
    ....
  3. ncbi request reprint Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model
    J C Smith
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 4455, USA
    Respir Physiol 122:131-47. 2000
    ....
  4. pmc Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P
    Krzysztof Ptak
    Cellular and Systems Neurobiology Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:3720-37. 2009
    ..We conclude that raphé 5-HT neurons excite key circuit components required for generation of respiratory motor output...
  5. pmc TASK channels contribute to the K+-dominated leak current regulating respiratory rhythm generation in vitro
    Hidehiko Koizumi
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:4273-84. 2010
    ..We conclude that TASK-like channels play a major functional role in chemosensory modulation of respiratory rhythm generation in the pre-Bötzinger complex in vitro...
  6. doi request reprint Brainstem respiratory networks: building blocks and microcircuits
    Jeffrey C Smith
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, MD, USA
    Trends Neurosci 36:152-62. 2013
    ..These insights open the possibility for site- and mechanism-specific interventions to treat various disorders of the neural control of breathing...
  7. doi request reprint Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre-Bötzinger complex in vitro
    Hidehiko Koizumi
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:1773-85. 2008
    ..We propose a paradigm whereby NaP and Leak represent a functional set of subthreshold conductances that endow the pre-BötC with rhythmogenic properties and represent targets for modulatory control of inspiratory rhythm generation...
  8. pmc Structural-functional properties of identified excitatory and inhibitory interneurons within pre-Botzinger complex respiratory microcircuits
    Hidehiko Koizumi
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 33:2994-3009. 2013
    ....
  9. pmc Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network
    Christopher A Del Negro
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Biophys J 82:206-14. 2002
    ....
  10. ncbi request reprint Persistent sodium current, membrane properties and bursting behavior of pre-bötzinger complex inspiratory neurons in vitro
    Christopher A Del Negro
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4455, USA
    J Neurophysiol 88:2242-50. 2002
    ....
  11. doi request reprint Functional imaging, spatial reconstruction, and biophysical analysis of a respiratory motor circuit isolated in vitro
    Hidehiko Koizumi
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:2353-65. 2008
    ....
  12. ncbi request reprint Isolation of the kernel for respiratory rhythm generation in a novel preparation: the pre-Bötzinger complex "island"
    S M Johnson
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4455, USA
    J Neurophysiol 85:1772-6. 2001
    ..Our results provide further evidence for a rhythmogenic kernel in the pre-BötC in vitro and demonstrate that the islands are ideal preparations for studying the kernel's intrinsic properties...
  13. ncbi request reprint Neuronal pacemaker for breathing visualized in vitro
    N Koshiya
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 400:360-3. 1999
    ..These results provide evidence that the neuronal kernel for rhythm generation consists of a network of synaptically-coupled pacemaker neurons...
  14. pmc Dual Effects of 5-HT1a Receptor Activation on Breathing in Neonatal Mice
    Andrea E Corcoran
    Department of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, Alaska 99775, Departments of Neurology and Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06520, Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756, Department of Anesthesia, Perioperative and Pain Medicine, Boston Children s Hospital, Boston, Massachusetts 02115, Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, Veteran s Affairs Medical Center, Iowa City, Iowa 52242, and Departments of Neurology, and Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242
    J Neurosci 34:51-9. 2014
    ..The former effect is presumably due to inhibition of inhibitory interneurons embedded in the respiratory network. ..
  15. pmc Real-time kinetic modeling of voltage-gated ion channels using dynamic clamp
    Lorin S Milescu
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Biophys J 95:66-87. 2008
    ..The computational procedure was implemented in the free QuB software, running under Microsoft Windows and featuring a friendly graphical user interface...
  16. ncbi request reprint Models of respiratory rhythm generation in the pre-Bötzinger complex. III. Experimental tests of model predictions
    C A Del Negro
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4455, USA
    J Neurophysiol 86:59-74. 2001
    ..We conclude that the pacemaker cell and network models explain features of inspiratory rhythm generation in vitro...
  17. ncbi request reprint Intrinsic bursters increase the robustness of rhythm generation in an excitatory network
    L K Purvis
    Laboratory for Neuroengineering and School of Electrical and Computer Engineering, Georgia Institute of Technology, 313 Ferst Drive, Atlanta, GA 30332 0535, USA
    J Neurophysiol 97:1515-26. 2007
    ..The largest increase in dynamic range occurs when the number of pacemakers in the network is greater than 20% of the population. Experimental tests of our model predictions are proposed...
  18. ncbi request reprint Functional respiratory rhythm generating networks in neonatal mice lacking NMDAR1 gene
    G D Funk
    Department of Physiological Science, University of California, Los Angeles 90095 1527, USA
    J Neurophysiol 78:1414-20. 1997
    ..More importantly, they suggest that NMDA receptors are not obligatory for the prenatal development of circuits producing respiratory rhythm...
  19. ncbi request reprint The Wnt/beta-catenin pathway posteriorizes neural tissue in Xenopus by an indirect mechanism requiring FGF signalling
    P M Domingos
    Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Dev Biol 239:148-60. 2001
    ..We show that this posteriorizing activity occurs by an indirect and noncell-autonomous mechanism requiring FGF signalling...