Gibert H Smith


Affiliation: National Institutes of Health
Country: USA


  1. Smith G, Medina D. Does the Mouse Mammary Gland Arise from Unipotent or Multipotent Mammary Stem/Progenitor Cells?. J Mammary Gland Biol Neoplasia. 2018;23:1-3 pubmed publisher
    ..The existence of premalignant mammary populationst that manifest characteristics of lineage limitation argues strongly for this proposition. ..
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    Smith G, Boulanger C. Mammary stem cell repertoire: new insights in aging epithelial populations. Mech Ageing Dev. 2002;123:1505-19 pubmed
    ..Our evidence indicates that a single mammary cell may have the capacity to self-renew through five transplant generations. Even some sixth generation implants show vigorous growth. ..
  3. Boulanger C, Rosenfield S, George A, Smith G. Hormone signaling requirements for the conversion of non-mammary mouse cells to mammary cell fate(s) in vivo. J Mammary Gland Biol Neoplasia. 2015;20:93-101 pubmed publisher
  4. Smith G. Binuclear Cells in the Lactating Mammary Gland: New Insights on an Old Concept?. J Mammary Gland Biol Neoplasia. 2016;21:21-3 pubmed publisher
    ..From a historical perspective, it is more likely that binuclear secretory cells in the lactating mammary gland are a consequence of the DNA synthesis requirement for lactation, rather than an essential element. ..
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    Smith G. Stem cells and mammary cancer in mice. Stem Cell Rev. 2005;1:215-23 pubmed
    ..Retroviral marking via MMTV proviral insertion demonstrates that this process progresses from a single mammary epithelial cell that possesses all the features ascribed to tissue-specific stem cells...
  6. Smith G, Medina D. Re-evaluation of mammary stem cell biology based on in vivo transplantation. Breast Cancer Res. 2008;10:203 pubmed publisher
    ..In the present article, these issues are reviewed and discussed to provide a greater understanding of the complexity of these multiplex interactions...