Michail V Sitkovsky

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors
    Michail V Sitkovsky
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Building 10, Room 11N256, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 22:657-82. 2004
  2. pmc Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival
    Manfred Thiel
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 2:e853. 2007
  3. ncbi request reprint Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs
    Dmitriy E Lukashev
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Room 11N 256, Bethesda, MD 20892, USA
    Biochem Pharmacol 65:2081-90. 2003
  4. ncbi request reprint The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases
    Manfred Thiel
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 11N311, 10 Center Drive, Bethesda, MD 20892 1892, USA
    Microbes Infect 5:515-26. 2003
  5. pmc Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury
    Manfred Thiel
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Biol 3:e174. 2005
  6. ncbi request reprint Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo
    Gregorio Gomez
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 11N311, 10 Center Dr MSC 1892, Bethesda, MD 20892 1892, USA
    Blood 102:4472-8. 2003
  7. ncbi request reprint Use of the A(2A) adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo
    Michail V Sitkovsky
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Biochem Pharmacol 65:493-501. 2003
  8. ncbi request reprint Immunomodulatory and neuroprotective effects of inosine
    Gyorgy Hasko
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 11N311, 10 Center Drive, Bethesda, MD 20892 1892, USA
    Trends Pharmacol Sci 25:152-7. 2004
  9. ncbi request reprint A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen
    Dmitriy E Lukashev
    Biochemistry and Immunopharmacology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Recept Signal Transduct Res 23:33-52. 2003
  10. pmc Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice
    Hidefumi Kojima
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Proc Natl Acad Sci U S A 99:2170-4. 2002

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors
    Michail V Sitkovsky
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Building 10, Room 11N256, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 22:657-82. 2004
    ..Targeting A2A adenosine receptors may have important clinical applications...
  2. pmc Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival
    Manfred Thiel
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 2:e853. 2007
    ....
  3. ncbi request reprint Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs
    Dmitriy E Lukashev
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Room 11N 256, Bethesda, MD 20892, USA
    Biochem Pharmacol 65:2081-90. 2003
    ....
  4. ncbi request reprint The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases
    Manfred Thiel
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 11N311, 10 Center Drive, Bethesda, MD 20892 1892, USA
    Microbes Infect 5:515-26. 2003
    ..While adenosinergic downregulation of tissue damage is beneficial in acute inflammation, chronic suppression of the immune system by adenosine may account for immunoparalysis in long-term septic patients...
  5. pmc Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury
    Manfred Thiel
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Biol 3:e174. 2005
    ..The reported observations may also answer the long-standing question as to why the lungs are the most susceptible to inflammatory injury and why lung failure usually precedes multiple organ failure...
  6. ncbi request reprint Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo
    Gregorio Gomez
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 11N311, 10 Center Dr MSC 1892, Bethesda, MD 20892 1892, USA
    Blood 102:4472-8. 2003
    ..Thus, we demonstrate that A2a and A3 adenosine receptors are differentially utilized by inosine for the down-regulation of tissue damage under different inflammatory conditions in vivo...
  7. ncbi request reprint Use of the A(2A) adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo
    Michail V Sitkovsky
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Biochem Pharmacol 65:493-501. 2003
    ....
  8. ncbi request reprint Immunomodulatory and neuroprotective effects of inosine
    Gyorgy Hasko
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 11N311, 10 Center Drive, Bethesda, MD 20892 1892, USA
    Trends Pharmacol Sci 25:152-7. 2004
  9. ncbi request reprint A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen
    Dmitriy E Lukashev
    Biochemistry and Immunopharmacology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Recept Signal Transduct Res 23:33-52. 2003
    ..These results, interpreted in the context of the known three-dimensional structure of the complex of SEB and TCR, are consistent with the view that serine-88 is important for the contact of the TCR beta chain with SEB...
  10. pmc Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice
    Hidefumi Kojima
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Proc Natl Acad Sci U S A 99:2170-4. 2002
    ....
  11. ncbi request reprint Targeting G protein-coupled A2a adenosine receptors to engineer inflammation in vivo
    Gregorio Gomez
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 11N311, 10 Center Drive MSC 1892, Bethesda, MD 20892 1892, USA
    Int J Biochem Cell Biol 35:410-4. 2003
    ..Recognition of A2a receptors as "natural" or endogenous brakes of inflammation provides the intellectual scaffolding needed to pursue these goals...
  12. ncbi request reprint The 'danger' sensors that STOP the immune response: the A2 adenosine receptors?
    Michail V Sitkovsky
    New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, MA 02115, USA
    Trends Immunol 26:299-304. 2005
    ..Regulation by extracellular adenosine would protect normal organs from injury and/or re-direct immune responses...
  13. pmc Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway
    Alexander Chouker
    Department of Anesthesiology Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Mol Med 14:116-23. 2008
    ..The presented data demonstrate that total body hypoxia-triggered pathway provides protection in acute hepatitis and that hypoxia (upstream) and A2AR (downstream) function in the same immunosuppressive and liver tissue-protecting pathway...
  14. ncbi request reprint Hypoxia-inducible factor 1alpha-deficient chimeric mice as a model to study abnormal B lymphocyte development and autoimmunity
    Hidefumi Kojima
    Division on Immunology, Institute for Medical Science, Dokkyo University School of Medicine, Tochigi, Japan
    Methods Enzymol 381:218-29. 2004
  15. ncbi request reprint HIF-1 alpha deficiency perturbs T and B cell functions
    Hidefumi Kojima
    Division of Immunology, Institute for Medical Science, Dokkyo University School of Medicine, Tochigi, Japan
    Curr Pharm Des 9:1827-32. 2003
    ..B1 lymphocytes of fetal origin, on the other hand, accumulate and may produce auto-antibodies and autoimmunity...