Gunamani Sithanandam

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence
    Wafa Kammouni
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cell Growth Differ 13:441-8. 2002
  2. ncbi request reprint Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells
    Anna Maciag
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Inc, Frederick, MD 21702, USA
    Carcinogenesis 25:2231-7. 2004
  3. ncbi request reprint Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway
    Gunamani Sithanandam
    Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Building 538, Ft Detrick, Frederick, MD 21702 1201, USA
    Carcinogenesis 24:1581-92. 2003
  4. ncbi request reprint Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549
    Gunamani Sithanandam
    Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Oncogene 24:1847-59. 2005
  5. pmc Alternate paths from epidermal growth factor receptor to Akt in malignant versus nontransformed lung epithelial cells: ErbB3 versus Gab1
    Gunamani Sithanandam
    Basic Research Program, SAIC Frederick, Frederick, Maryland 21702, USA
    Am J Respir Cell Mol Biol 33:490-9. 2005
  6. pmc Anti-tumor efficacy of naked siRNAs for ERBB3 or AKT2 against lung adenocarcinoma cell xenografts
    Gunamani Sithanandam
    Basic Science Program, SAIC Frederick, Inc, Frederick, MD, USA
    Int J Cancer 130:251-8. 2012

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence
    Wafa Kammouni
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cell Growth Differ 13:441-8. 2002
    ..In sum, increased protein expression and activity of K-ras p21 are associated with growth arrest, not with proliferation, in mouse and human lung cell lines...
  2. ncbi request reprint Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells
    Anna Maciag
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Inc, Frederick, MD 21702, USA
    Carcinogenesis 25:2231-7. 2004
    ..Our data suggest that up-regulation of COX-2, with a consequent increase in peroxides and DNA damage, contributes to the dominant oncogenicity of mutant K-ras...
  3. ncbi request reprint Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway
    Gunamani Sithanandam
    Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Building 538, Ft Detrick, Frederick, MD 21702 1201, USA
    Carcinogenesis 24:1581-92. 2003
    ..It could be a useful therapeutic target...
  4. ncbi request reprint Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549
    Gunamani Sithanandam
    Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Oncogene 24:1847-59. 2005
    ..All three Akt isoforms are to varying degrees involved in these cell behaviors, with Akt2 especially implicated in migration and invasion. ErbB3 and the Akts are promising targets for therapy, and siRNAs may be useful for this purpose...
  5. pmc Alternate paths from epidermal growth factor receptor to Akt in malignant versus nontransformed lung epithelial cells: ErbB3 versus Gab1
    Gunamani Sithanandam
    Basic Research Program, SAIC Frederick, Frederick, Maryland 21702, USA
    Am J Respir Cell Mol Biol 33:490-9. 2005
    ..Complexes of EGFR/Grb2/Gab1/Shp2 after TGF-alpha stimulation were prominent only in E10 and C10 cells. Thus, alternate pathways downstream of EGFR regulate mitosis in these paired malignant versus nontransformed lung cell lines...
  6. pmc Anti-tumor efficacy of naked siRNAs for ERBB3 or AKT2 against lung adenocarcinoma cell xenografts
    Gunamani Sithanandam
    Basic Science Program, SAIC Frederick, Inc, Frederick, MD, USA
    Int J Cancer 130:251-8. 2012
    ..There were no significant changes in serum cytokines. These results show that naked siRNAs to ERBB3 or AKT2 may have potential for lung cancer therapy...