Arno G Siraki

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl metabolizing enzymes. II. Aromatic aldehydes
    Hossein Niknahad
    Faculty of Pharmacy, Department of Pharmacology and Toxicology, Shiraz University of Medical Sciences, Shiraz, 71345, Fars, Iran
    Chem Biol Interact 143:119-28. 2003
  2. pmc Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 21:1143-53. 2008
  3. pmc Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 20:1038-45. 2007
  4. pmc Glutathione-induced radical formation on lactoperoxidase does not correlate with the enzyme's peroxidase activity
    Marcelo G Bonini
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, MD, USA
    Free Radic Biol Med 42:985-92. 2007
  5. pmc Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes
    Marcelo G Bonini
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 42:530-40. 2007
  6. ncbi request reprint Application of quantitative structure-toxicity relationships for the comparison of the cytotoxicity of 14 p-benzoquinone congeners in primary cultured rat hepatocytes versus PC12 cells
    Arno G Siraki
    Leslie Dan Faculty of Pharmacy, University of Toronto, ON, Canada M5S 2S2
    Toxicol Sci 81:148-59. 2004
  7. ncbi request reprint Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes
    Arno G Siraki
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, 19 Russell Street, Toronto, Ontario, Canada M5S 2S2
    Free Radic Biol Med 32:2-10. 2002
  8. ncbi request reprint Application of quantitative structure-toxicity relationships for acute NSAID cytotoxicity in rat hepatocytes
    Arno G Siraki
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, 19 Russell Street, Toronto, Ont, Canada M5S 2S2
    Chem Biol Interact 151:177-91. 2005
  9. ncbi request reprint Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. I. Aliphatic alkenals
    Hossein Niknahad
    Faculty of Pharmacy, Department of Pharmacology and Toxicology, Shiraz University of Medical Sciences, 71345, Fars, Shiraz, Iran
    Chem Biol Interact 143:107-17. 2003
  10. ncbi request reprint N-oxidation of aromatic amines by intracellular oxidases
    Arno G Siraki
    Faculty of Pharmacy, University of Toronto, Ont, Canada
    Drug Metab Rev 34:549-64. 2002

Detail Information

Publications11

  1. ncbi request reprint Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl metabolizing enzymes. II. Aromatic aldehydes
    Hossein Niknahad
    Faculty of Pharmacy, Department of Pharmacology and Toxicology, Shiraz University of Medical Sciences, Shiraz, 71345, Fars, Iran
    Chem Biol Interact 143:119-28. 2003
    ..g. xylitol) prevented salicylaldehyde and cinnamaldehyde cytotoxicity similarly. This could be explained as salicylaldehyde was not a substrate for the ALDHs and would then be more dependent on ADH for detoxification...
  2. pmc Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 21:1143-53. 2008
    ..We propose that drug-induced free radical formation on MPO may play a role in the origin of agranulocytosis...
  3. pmc Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 20:1038-45. 2007
    ..We propose that drug-dependent free radical formation on MPO may play a role in the origin of agranulocytosis...
  4. pmc Glutathione-induced radical formation on lactoperoxidase does not correlate with the enzyme's peroxidase activity
    Marcelo G Bonini
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, MD, USA
    Free Radic Biol Med 42:985-92. 2007
    ....
  5. pmc Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes
    Marcelo G Bonini
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 42:530-40. 2007
    ....
  6. ncbi request reprint Application of quantitative structure-toxicity relationships for the comparison of the cytotoxicity of 14 p-benzoquinone congeners in primary cultured rat hepatocytes versus PC12 cells
    Arno G Siraki
    Leslie Dan Faculty of Pharmacy, University of Toronto, ON, Canada M5S 2S2
    Toxicol Sci 81:148-59. 2004
    ..To our knowledge, this is the first QSTR derived for p-benzoquinone cytotoxicity in these cell types and could form the basis for distinguishing certain cell-specific cytotoxic mechanisms...
  7. ncbi request reprint Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes
    Arno G Siraki
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, 19 Russell Street, Toronto, Ontario, Canada M5S 2S2
    Free Radic Biol Med 32:2-10. 2002
    ..Hepatocyte catalyzed dichlorofluorescin oxidation induced by oxidase substrates, e.g., benzylamine, was correlated with the cytotoxicity induced in catalase-inhibited hepatocytes...
  8. ncbi request reprint Application of quantitative structure-toxicity relationships for acute NSAID cytotoxicity in rat hepatocytes
    Arno G Siraki
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, 19 Russell Street, Toronto, Ont, Canada M5S 2S2
    Chem Biol Interact 151:177-91. 2005
    ..In summary, we have used QSTRs as a tool to distinguish the cytotoxic mechanism of two groups of NSAIDs, which, if analyzed together as one group, did not reveal such mechanism-based differences...
  9. ncbi request reprint Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. I. Aliphatic alkenals
    Hossein Niknahad
    Faculty of Pharmacy, Department of Pharmacology and Toxicology, Shiraz University of Medical Sciences, 71345, Fars, Shiraz, Iran
    Chem Biol Interact 143:107-17. 2003
    ..There was also marked cytotoxic synergism between acrolein and decadienal presumably because of ALDH inactivation by acrolein...
  10. ncbi request reprint N-oxidation of aromatic amines by intracellular oxidases
    Arno G Siraki
    Faculty of Pharmacy, University of Toronto, Ont, Canada
    Drug Metab Rev 34:549-64. 2002
    ..This suggests that in intact hepatocytes CYP1A2 may also catalyze a one-electron oxidation of some arylamines to form prooxidant cation radicals, which cooxidize GSH to form the reactive oxygen species...
  11. ncbi request reprint Prooxidant activity of free radicals derived from phenol-containing neurotransmitters
    Arno G Siraki
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, 19 Russell St, Toronto, Ontario, Canada M5S 2S2
    Toxicology 177:81-90. 2002
    ..These results show that biogenic amines form prooxidant radicals, when metabolized by peroxidase, cooxidize cellular antioxidants (ascorbate, NADH, or cysteine)...