Reuben P Siraganian

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcepsilonRI signaling
    K Sada
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 97:1352-9. 2001
  2. pmc Mast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants
    Reuben P Siraganian
    Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    FEBS Lett 584:4933-40. 2010
  3. ncbi request reprint Protein tyrosine kinase Syk in mast cell signaling
    Reuben P Siraganian
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 10, Room 1N106, Bethesda, MD 20892, USA
    Mol Immunol 38:1229-33. 2002
  4. ncbi request reprint Mast cell signal transduction from the high-affinity IgE receptor
    Reuben P Siraganian
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Building 10 Room 1N 106, Bethesda, MD 20892, USA
    Curr Opin Immunol 15:639-46. 2003
  5. ncbi request reprint TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells
    Juan Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:37669-77. 2007
  6. pmc FcepsilonRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation
    Ana Cristina G Grodzki
    Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, United States
    Mol Immunol 46:2539-47. 2009
  7. pmc Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells
    Juan Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:8144-54. 2002
  8. ncbi request reprint Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor
    Juan Zhang
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:1811-8. 2004
  9. pmc The transcription factor Zeb2 regulates signaling in mast cells
    Emilia Alina Barbu
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:6278-86. 2012
  10. pmc Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation
    Juan Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Immunol 184:7178-85. 2010

Collaborators

Detail Information

Publications25

  1. ncbi request reprint SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcepsilonRI signaling
    K Sada
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 97:1352-9. 2001
    ..Furthermore, the localization of Syk in glycolipid-enriched microdomains by itself is not enough to generate or enhance signaling events...
  2. pmc Mast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants
    Reuben P Siraganian
    Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    FEBS Lett 584:4933-40. 2010
    ..The use of siRNA has defined the relative contribution of Syk, Fyn and Gab2 to signaling and has made possible a screening study to identify previously unrecognized molecules that are involved in these pathways...
  3. ncbi request reprint Protein tyrosine kinase Syk in mast cell signaling
    Reuben P Siraganian
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 10, Room 1N106, Bethesda, MD 20892, USA
    Mol Immunol 38:1229-33. 2002
    ..Studies in Syk deficient mast cells have defined the pathways that are activated upstream and downstream of Syk and have demonstrated the functional importance of the linker region of Syk in signaling in mast cells...
  4. ncbi request reprint Mast cell signal transduction from the high-affinity IgE receptor
    Reuben P Siraganian
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Building 10 Room 1N 106, Bethesda, MD 20892, USA
    Curr Opin Immunol 15:639-46. 2003
    ..The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules...
  5. ncbi request reprint TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells
    Juan Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:37669-77. 2007
    ..These results suggest that TOM1L1 is a novel protein involved in the FcepsilonRI signal transduction for the generation of cytokines...
  6. pmc FcepsilonRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation
    Ana Cristina G Grodzki
    Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, United States
    Mol Immunol 46:2539-47. 2009
    ..The results also indicate that NFAT was activated at lower intracellular signals compared to degranulation. Therefore, FcvarepsilonRI activation can result in nuclear signals in the absence of the release of mediators...
  7. pmc Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells
    Juan Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:8144-54. 2002
    ....
  8. ncbi request reprint Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor
    Juan Zhang
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:1811-8. 2004
    ..These results suggest that Cbl-b and c-Cbl have divergent effects on Fc epsilon RI signal transduction and that Cbl-b, but not c-Cbl, functions as a negative regulator of Fc epsilon RI-induced degranulation...
  9. pmc The transcription factor Zeb2 regulates signaling in mast cells
    Emilia Alina Barbu
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:6278-86. 2012
    ..The results indicate that the transcription factor Zeb2 controls the expression of molecules thereby regulating signaling in mast cells...
  10. pmc Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation
    Juan Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Immunol 184:7178-85. 2010
    ..The result also indicates that the system used is efficient for searching molecules implicated in complex receptor-induced signaling...
  11. pmc The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells
    Emilia Alina Barbu
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:15761-8. 2010
    ....
  12. ncbi request reprint Phospholipase D1 regulates high-affinity IgE receptor-induced mast cell degranulation
    Tomohiro Hitomi
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 104:4122-8. 2004
    ..These results indicate that constitutive basal PLD1 activity by regulating phosphatidic acid formation controls the early signals initiated by FcepsilonRI aggregation that lead to mast cell degranulation...
  13. ncbi request reprint Alterations in granule matrix and cell surface of focal adhesion kinase-deficient mast cells
    Daniel Vial
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:6178-86. 2003
    ..These results indicate that FAK plays a role in regulating the glycosaminoglycan content of the secretory granules and influences the cell surface morphology of mast cells...
  14. pmc Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation
    Rodrigo Orlandini de Castro
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:8194-204. 2012
    ..Therefore, once phosphorylated, the terminal tyrosines of Syk bind complexes of proteins that are positive and negative regulators of signaling in mast cells...
  15. pmc Tyrosines in the carboxyl terminus regulate Syk kinase activity and function
    Rodrigo O de Castro
    Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:26674-84. 2010
    ..Therefore, these results indicate that these tyrosines in the tail region play a critical role in regulating the kinase activity and function of Syk...
  16. ncbi request reprint Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway
    Haifeng Song
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Immunol 178:926-35. 2007
    ....
  17. doi request reprint The low affinity IgG receptor Fc gamma RIIB contributes to the binding of the mast cell specific antibody, mAb BGD6
    Michel F Guiraldelli
    Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Immunol 45:2411-8. 2008
    ..These results are consistent with a model where mAb BGD6 binds through its Fab portion to a approximately 110 kDa protein and the Fc tail interacts with Fc gamma RIIB (CD32)...
  18. ncbi request reprint The adapter molecule Gab2 regulates Fc epsilon RI-mediated signal transduction in mast cells
    Zhi Hui Xie
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:4682-91. 2002
    ....
  19. pmc Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis
    Enrique Zudaire
    CCBB, CCR, National Cancer Institute, Bldg 10, RM, 12N226, Bethesda, MD 20892, USA
    Am J Pathol 168:280-91. 2006
    ..Our collective data suggest a new role for AM as a cross-talk molecule that integrates tumor and MC communication, underlying a unique promotion mechanism of human cancers...
  20. ncbi request reprint Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?
    Surajit Ganguly
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 282:32758-64. 2007
    ..Pineal FcepsilonRIalpha and FcepsilonRIgamma may represent a previously unrealized molecular link between the neuroendocrine and immune systems...
  21. ncbi request reprint Dendritic cell modulation by mast cells controls the Th1/Th2 balance in responding T cells
    Alessandra Mazzoni
    Experimental Immunology Branch, National Cancer Institute, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 177:3577-81. 2006
    ..Therefore, by acting upon DC at sites of inflammation, mast cells play a critical role in determining the polarity of Ag-specific T cell responses in vivo...
  22. ncbi request reprint Mast cell-specific gangliosides and FcepsilonRI follow the same endocytic pathway from lipid rafts in RBL-2H3 cells
    Constance Oliver
    Department of Cell and Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeirao Preto Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    J Histochem Cytochem 55:315-25. 2007
    ..This study contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  23. pmc IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species
    Laura M Sly
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Immunol 181:3850-60. 2008
    ..In support of the essential role that IgE-induced ROS plays in IgE-enhanced BMMC survival, we found the addition of H(2)O(2) to IgE+Ag-stimulated BMMCs leads to IL-3 secretion...
  24. pmc Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 378:1023-9. 2004
    ..Our results demonstrate fundamental differences between GPVI and GPIb-IX-V in the regulation of tyrosine phosphorylation of Syk and PLCg2 consistent with the functional impairment of phospholipase in signalling by GPIb-IX-V...
  25. ncbi request reprint Identification and characterization of undifferentiated mast cells in mouse bone marrow
    Maria Celia Jamur
    Faculdade de Medicina de Ribeirao Preto, Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Blood 105:4282-9. 2005
    ..When injected into lethally irradiated mice, these cells are able to reconstitute the mast cell population in the spleen...