Neeti Sinha

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Protein structure to function via dynamics
    Neeti Sinha
    Basic Research Laboratory, Center for Cancer Research, Bldg 469, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Protein Pept Lett 9:367-77. 2002
  2. ncbi request reprint Electrostatics in protein binding and function
    Neeti Sinha
    Basic Research Laboratory, Center for Cancer Research, Bldg 469 National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Curr Protein Pept Sci 3:601-14. 2002
  3. pmc Modeling the binding sites of anti-hen egg white lysozyme antibodies HyHEL-8 and HyHEL-26: an insight into the molecular basis of antibody cross-reactivity and specificity
    S Mohan
    Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Biophys J 85:3221-36. 2003
  4. ncbi request reprint Understanding antibody-antigen associations by molecular dynamics simulations: detection of important intra- and inter-molecular salt bridges
    Neeti Sinha
    Structural Biophysics Laboratory, Division of Basic Sciences, Bldg 469 Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Cell Biochem Biophys 47:361-75. 2007
  5. pmc Differences in electrostatic properties at antibody-antigen binding sites: implications for specificity and cross-reactivity
    Neeti Sinha
    Basic Research Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Bldg 469, Frederick, MD 21702, USA
    Biophys J 83:2946-68. 2002
  6. ncbi request reprint Molecular dynamics simulation of a high-affinity antibody-protein complex: the binding site is a mosaic of locally flexible and preorganized rigid regions
    Neeti Sinha
    Johns Hopkins University, Baltimore, MD 21218, USA
    Cell Biochem Biophys 43:253-73. 2005

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Protein structure to function via dynamics
    Neeti Sinha
    Basic Research Laboratory, Center for Cancer Research, Bldg 469, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Protein Pept Lett 9:367-77. 2002
    ..Our electrostatic calculations and molecular dynamic simulations on an antibody-antigen complex further illustrate the importance of protein flexibilities in binding and function...
  2. ncbi request reprint Electrostatics in protein binding and function
    Neeti Sinha
    Basic Research Laboratory, Center for Cancer Research, Bldg 469 National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Curr Protein Pept Sci 3:601-14. 2002
    ..These observations, and several other studies, suggest that a fine tuning of local and global electrostatic properties are essential for protein binding and function...
  3. pmc Modeling the binding sites of anti-hen egg white lysozyme antibodies HyHEL-8 and HyHEL-26: an insight into the molecular basis of antibody cross-reactivity and specificity
    S Mohan
    Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Biophys J 85:3221-36. 2003
    ..Results suggest that affinity maturation may select for high affinity antibodies with either "lock-and-key" preconfigured binding sites, or "preconfigured flexibility" by modulating combining site flexibility...
  4. ncbi request reprint Understanding antibody-antigen associations by molecular dynamics simulations: detection of important intra- and inter-molecular salt bridges
    Neeti Sinha
    Structural Biophysics Laboratory, Division of Basic Sciences, Bldg 469 Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Cell Biochem Biophys 47:361-75. 2007
    ..This study also highlights "hot-spot" molecular interactions in HyHEL63-HEL complex...
  5. pmc Differences in electrostatic properties at antibody-antigen binding sites: implications for specificity and cross-reactivity
    Neeti Sinha
    Basic Research Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Bldg 469, Frederick, MD 21702, USA
    Biophys J 83:2946-68. 2002
    ..In contrast, hydrophobic driven binding and low levels of electrostatic interactions are associated with conformational flexibility and cross-reactivity...
  6. ncbi request reprint Molecular dynamics simulation of a high-affinity antibody-protein complex: the binding site is a mosaic of locally flexible and preorganized rigid regions
    Neeti Sinha
    Johns Hopkins University, Baltimore, MD 21218, USA
    Cell Biochem Biophys 43:253-73. 2005
    ..The functional importance of local inherently flexible regions is to establish intermolecular contacts or they play a key role in molecular recognition, whereas local rigid regions provide the structural framework...