Joshua H Singer
Affiliation: National Institutes of Health
- Sustained Ca2+ entry elicits transient postsynaptic currents at a retinal ribbon synapseJoshua H Singer
Synaptic Physiology Unit, National Institutes of Health National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 4066, USA
J Neurosci 23:10923-33. 2003..We conclude that the time course of vesicle release from RBCs is inherently transient and, together with the fast kinetics of postsynaptic AMPARs, speeds transmission at this synapse...
- Coordinated multivesicular release at a mammalian ribbon synapseJoshua H Singer
Synaptic Physiology Unit, NIH NINDS, 36 Convent Drive, MSC 4066, Building 36 Room 2C 09, Bethesda, Maryland 20892, USA
Nat Neurosci 7:826-33. 2004..The release synchrony reflected in these multivesicular events suggests that release within an active zone is coordinated during MVR...
- Vesicle depletion and synaptic depression at a mammalian ribbon synapseJoshua H Singer
Synaptic Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
J Neurophysiol 95:3191-8. 2006..The small RRP and very high release probability likely contribute to the transient characteristics of neurotransmission at RBC synapses...
- Fast neurotransmitter release triggered by Ca influx through AMPA-type glutamate receptorsAndres E Chavez
Synaptic Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3701, USA
Nature 443:705-8. 2006..These results describe a fast synapse that operates independently of VGCCs and membrane depolarization and reveal a previously unknown form of feedback inhibition within a neural circuit...
- Multivesicular release and saturation of glutamatergic signalling at retinal ribbon synapsesJoshua H Singer
Departments of Ophthalmology and Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Tarry 5 715, Chicago, IL 60611, USA
J Physiol 580:23-9. 2007..Here, I discuss three postsynaptic mechanisms that permit three different retinal synapses to utilize MVR...
- GABA is an endogenous ligand for synaptic glycine receptorsJoshua H Singer
Departments of Ophthalmology and Physiology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 5 715, Chicago, IL 60611, USA
Neuron 57:475-7. 2008..Lu, Rubio, and Trussell, however, demonstrate in this issue of Neuron the first instance of cotransmission in which two neurotransmitters act on the same postsynaptic receptor...