Eleanor M Simonsick

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study
    Lisa H Colbert
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    J Am Geriatr Soc 52:1098-104. 2004
  2. ncbi request reprint Estimating cardiorespiratory fitness in well-functioning older adults: treadmill validation of the long distance corridor walk
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 54:127-32. 2006
  3. ncbi request reprint Mobility limitation in self-described well-functioning older adults: importance of endurance walk testing
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Harbor Hospital NIA ASTRA Unit, 3001 S Hanover St Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 63:841-7. 2008
  4. pmc Subclinical hypothyroidism and functional mobility in older adults
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 S Hanover St, Fifth Floor, Baltimore, MD 21225, USA
    Arch Intern Med 169:2011-7. 2009
  5. pmc Drug burden index score and functional decline in older people
    Sarah N Hilmer
    Intramural Research Program, National Institute on Aging, Baltimore and Bethesda, MD, USA
    Am J Med 122:1142-1149.e1-2. 2009
  6. pmc Association between fitness and changes in body composition and muscle strength
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C309, Bethesda, MD 20892, USA
    J Am Geriatr Soc 58:219-26. 2010
  7. pmc Race, socioeconomic resources, and late-life mobility and decline: findings from the Health, Aging, and Body Composition study
    Roland J Thorpe
    Hopkins Center for Health Disparities Solutions, Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, 624 N Broadway Ste 441, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 66:1114-23. 2011
  8. pmc Assessing fatigability in mobility-intact older adults
    Eleanor M Simonsick
    Intramural Research Program, National Institute on Aging, Baltimore, Maryland
    J Am Geriatr Soc 62:347-51. 2014
  9. pmc Racial differences in mortality in older adults: factors beyond socioeconomic status
    Roland J Thorpe
    Hopkins Center for Health Disparities Solutions, Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Baltimore, MD, USA
    Ann Behav Med 43:29-38. 2012
  10. pmc Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study
    Kristen M Beavers
    Department of Internal Medicine, National Institute on Aging, Baltimore, MD, USA
    Am J Clin Nutr 97:552-60. 2013

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study
    Lisa H Colbert
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    J Am Geriatr Soc 52:1098-104. 2004
    ..To examine the association between physical activity and inflammatory markers, with consideration for body fatness and antioxidant use...
  2. ncbi request reprint Estimating cardiorespiratory fitness in well-functioning older adults: treadmill validation of the long distance corridor walk
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 54:127-32. 2006
    ..g., heart rate (HR) and systolic blood pressure (SBP) response) in older adults...
  3. ncbi request reprint Mobility limitation in self-described well-functioning older adults: importance of endurance walk testing
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Harbor Hospital NIA ASTRA Unit, 3001 S Hanover St Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 63:841-7. 2008
    ..This study evaluates standardized administration of an endurance walk test for identifying unrecognized and impending mobility limitation in community elders...
  4. pmc Subclinical hypothyroidism and functional mobility in older adults
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 S Hanover St, Fifth Floor, Baltimore, MD 21225, USA
    Arch Intern Med 169:2011-7. 2009
    ..4 to <4.5 mIU/L), mild subclinical hypothyroid (>or=4.5 to <7.0 mIU/L), or moderate subclinical hypothyroid (>or=7.0 to <or=20.0 mIU/L with a normal free thyroxine level) cross-sectionally and over 2 years...
  5. pmc Drug burden index score and functional decline in older people
    Sarah N Hilmer
    Intramural Research Program, National Institute on Aging, Baltimore and Bethesda, MD, USA
    Am J Med 122:1142-1149.e1-2. 2009
    ..Here we evaluate the association between DBI and functional outcomes in Health, Aging and Body Composition study participants over 5 years...
  6. pmc Association between fitness and changes in body composition and muscle strength
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C309, Bethesda, MD 20892, USA
    J Am Geriatr Soc 58:219-26. 2010
    ..To examine the association between physical fitness, assessed according to ability and time to complete a 400-m walk, on changes in body composition and muscle strength over a 7-year period...
  7. pmc Race, socioeconomic resources, and late-life mobility and decline: findings from the Health, Aging, and Body Composition study
    Roland J Thorpe
    Hopkins Center for Health Disparities Solutions, Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, 624 N Broadway Ste 441, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 66:1114-23. 2011
    ..This study examines the relationship between race and mobility over 5 years in initially well-functioning older adults and evaluates how a broad set of socioeconomic status indicators affect this relationship...
  8. pmc Assessing fatigability in mobility-intact older adults
    Eleanor M Simonsick
    Intramural Research Program, National Institute on Aging, Baltimore, Maryland
    J Am Geriatr Soc 62:347-51. 2014
    ..To evaluate the criterion validity of two measures of fatigability, defined as performance deterioration or perceived effort to perform a standardized task...
  9. pmc Racial differences in mortality in older adults: factors beyond socioeconomic status
    Roland J Thorpe
    Hopkins Center for Health Disparities Solutions, Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Baltimore, MD, USA
    Ann Behav Med 43:29-38. 2012
    ..Little is known about the simultaneous effect of socioeconomic status (SES), psychosocial, and health-related factors on race differences in mortality in older adults...
  10. pmc Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study
    Kristen M Beavers
    Department of Internal Medicine, National Institute on Aging, Baltimore, MD, USA
    Am J Clin Nutr 97:552-60. 2013
    ..In older adults, every 0.1-m/s slower gait speed is associated with a 12% higher mortality. However, little research has identified risk factors for gait-speed decline...
  11. pmc Hearing loss and cognitive decline in older adults
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    JAMA Intern Med 173:293-9. 2013
    ..Further studies are needed to investigate what the mechanistic basis of this association is and whether hearing rehabilitative interventions could affect cognitive decline...
  12. ncbi request reprint Trunk muscle composition as a predictor of reduced functional capacity in the health, aging and body composition study: the moderating role of back pain
    Gregory E Hicks
    PT, Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, 100 Penn St, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 60:1420-4. 2005
    ..We hypothesize that lower trunk muscle attenuation will be associated with lower functional capacity 3 years later and that back pain status will moderate this relationship...
  13. pmc Body fat distribution and inflammation among obese older adults with and without metabolic syndrome
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Obesity (Silver Spring) 18:2354-61. 2010
    ....
  14. pmc Relationship of race and poverty to lower extremity function and decline: findings from the Women's Health and Aging Study
    Roland James Thorpe
    Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Soc Sci Med 66:811-21. 2008
    ..Thus, while race and poverty status were associated with functional deficits in old age, they do not appear to impact the rate of functional decline or progression of disability over 3 years...
  15. pmc Associations of BMI and adipose tissue area and density with incident mobility limitation and poor performance in older adults
    Rachel A Murphy
    Laboratory of Epidemiology, and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD RAM, IR, and TBH the Sections on Comparative Medicine Pathology, Radiology TCR, and Gerontology and Geriatrics SBK, Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC the Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA HNA the Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA ABN the Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN SS the Center for Aging and Population Health, Department of Medicine, University of Pittsburgh, Pittsburgh, PA BHG and the Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, Baltimore, MD EMS
    Am J Clin Nutr 99:1059-65. 2014
    ..Obesity is a risk factor for disability, but risk of specific adipose depots is not completely understood...
  16. ncbi request reprint Diabetes is associated with subclinical functional limitation in nondisabled older individuals: the Health, Aging, and Body Composition study
    Nathalie de Rekeneire
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Diabetes Care 26:3257-63. 2003
    ....
  17. pmc Joint association of obesity and metabolic syndrome with incident mobility limitation in older men and women--results from the Health, Aging, and Body Composition Study
    Sari Stenholm
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 65:84-92. 2010
    ..Although both obesity and the metabolic syndrome (MetS) are known risk factors for decline in physical function, the joint association of obesity and metabolic alterations with risk of incident mobility limitation is unknown...
  18. pmc Secular trends in body weight in older men born between 1877 and 1941: the Baltimore Longitudinal Study of Aging
    Sari Stenholm
    National Institute on Aging, Clinical Research Branch, Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 65:105-10. 2010
    ..However, it is not known whether higher body weight is maintained in the very old and in the years prior to death. The present study examines whether there are secular trends in body weight in old age among three birth cohorts...
  19. ncbi request reprint Cross-sectional associations between trunk muscle composition, back pain, and physical function in the health, aging and body composition study
    Gregory E Hicks
    Clinical Research Branch, National Institute on Aging, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 60:882-7. 2005
    ..We hypothesized that lower trunk muscle area and attenuation (higher fat infiltration) are associated with decreased functional capacity...
  20. pmc Changes in weight at the end of life: characterizing weight loss by time to death in a cohort study of older men
    Dawn E Alley
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Epidemiol 172:558-65. 2010
    ..Results suggest that weight loss in older persons may begin earlier than previously believed. The duration of weight loss for noncancer deaths suggests that even distal changes in energy balance may be linked to risk of death...
  21. pmc The energetic pathway to mobility loss: an emerging new framework for longitudinal studies on aging
    Jennifer A Schrack
    Center on Aging and Health, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Geriatr Soc 58:S329-36. 2010
    ..The main premise is simple: the biochemical processes that maintain life, secure homeostatic equilibrium, and prevent the collapse of health require energy. If energy becomes deficient, adaptive behaviors develop to conserve energy...
  22. ncbi request reprint Lower extremity physical performance and hip bone mineral density in elderly black and white men and women: cross-sectional associations in the Health ABC Study
    Dennis R Taaffe
    The Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    J Gerontol A Biol Sci Med Sci 58:M934-42. 2003
    ..However, it is unclear if these factors coexist or are independent in elderly people, and if a relationship does exist, whether it varies by sex and/or race...
  23. pmc The relationship of the energetic cost of slow walking and peak energy expenditure to gait speed in mid-to-late life
    Jennifer A Schrack
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Phys Med Rehabil 92:28-35. 2013
    ..Peak energy expenditure is highly correlated with usual gait speed; however, it is unknown whether the energetic cost of walking is also an important contributor to usual gait speed when considered as a component of peak walking capacity...
  24. ncbi request reprint Racial differences in glycemic control in a well-functioning older diabetic population: findings from the Health, Aging and Body Composition Study
    Nathalie de Rekeneire
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 9205, USA
    Diabetes Care 26:1986-92. 2003
    ..We further hypothesized that the association of race with poorer glycemic control would be limited to those with lower education or lower income...
  25. pmc At the tipping point: predicting severe mobility difficulty in vulnerable older women
    Josette A Rivera
    Division of Geriatric Medicine and Gerontology, Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Am Geriatr Soc 56:1417-23. 2008
    ..To identify clinical measures that aid detection of impending severe mobility difficulty in older women...
  26. pmc "IDEAL" Aging Is Associated with Lower Resting Metabolic Rate: The Baltimore Longitudinal Study of Aging
    Jennifer A Schrack
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
    J Am Geriatr Soc 62:667-72. 2014
    ..To assess the associations among age, health status, and resting metabolic rate (RMR) in a large population of older adults...
  27. pmc Personality, metabolic rate and aerobic capacity
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 8:e54746. 2013
    ..These findings suggest potential pathways that link personality to health outcomes, such as obesity and longevity...
  28. pmc Hospitalization and change in body composition and strength in a population-based cohort of older persons
    Dawn E Alley
    Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Am Geriatr Soc 58:2085-91. 2010
    ..To examine the association between hospitalization and annual changes in body composition and strength in older adults...
  29. pmc Association of periodontitis and metabolic syndrome in the Baltimore Longitudinal Study of Aging
    Mark J Nesbitt
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA
    Aging Clin Exp Res 22:238-42. 2010
    ..This study examines the association of periodontitis with MetS with and without consideration of systemic inflammatory status...
  30. doi request reprint Is cancer incidence decreased in the frail elderly? Evidence from a prospective cohort study
    Bindu Kanapuru
    Hematology Immunology Unit, Translational Research Section, Clinical Research Branch, Intramural Research Program, National Institute on Aging, 3001 South Hanover Street, 5th Floor, Baltimore, MD 21225 1290, USA Electronic address
    J Geriatr Oncol 4:19-25. 2013
    ..This study aimed to determine cancer incidence in the frail relative to non-frail community resident older adults...
  31. pmc The role of energetic cost in the age-related slowing of gait speed
    Jennifer A Schrack
    Center on Aging and Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21225, USA
    J Am Geriatr Soc 60:1811-6. 2012
    ..To determine whether slow gait represents a compensatory strategy to reduce the energetic cost of walking with age...
  32. pmc Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction
    E Jeffrey Metter
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
    Diabetes Care 31:1026-30. 2008
    ..To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality...
  33. pmc Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older women
    Carlos O Weiss
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 65:287-94. 2010
    ..We assessed whether the relationship of three main physiological systems-cardiac, pulmonary, and musculoskeletal-to EC is independent or interactive and whether their effect on EC varies with respect to frailty status...
  34. pmc Comparison of the Cosmed K4b(2) portable metabolic system in measuring steady-state walking energy expenditure
    Jennifer A Schrack
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9292. 2010
    ..The purpose of this study was to assess the accuracy of the Cosmed K4b(2) portable metabolic analyzer against a traditional, stationary gas exchange system (the Medgraphics D-Series) during steady-state, submaximal walking exercise...
  35. ncbi request reprint Is a fall just a fall: correlates of falling in healthy older persons. The Health, Aging and Body Composition Study
    Nathalie de Rekeneire
    Laboratory of Epidemiology, Demography and Biometry and Gerontology Research Center, National Institute on Aging, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 51:841-6. 2003
    ..To identify factors associated with falling in well-functioning older people...
  36. pmc Lipid peroxidation and depressed mood in community-dwelling older men and women
    Yuri Milaneschi
    Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center GGZ inGeest, Amsterdam, The Netherlands
    PLoS ONE 8:e65406. 2013
    ..Further studies are needed to explore whether the modulation of oxidative stress may break down the link between late-life depression and its deleterious health consequences...
  37. doi request reprint Lifestyle factors and incident mobility limitation in obese and non-obese older adults
    Annemarie Koster
    Department of Health Care Studies, Medical Sociology Section, Universiteit Maastricht, Maastricht, The Netherlands
    Obesity (Silver Spring) 15:3122-32. 2007
    ..This study examines the association between incident mobility limitation and 4 lifestyle factors: smoking, alcohol intake, physical activity, and diet in well-functioning obese (n = 667) and non-obese (n = 2027) older adults...
  38. pmc Sensitivity analysis for nonignorable missingness and outcome misclassification from proxy reports
    Michelle Shardell
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Epidemiology 24:215-23. 2013
    ..Simulation studies show that the proposed methods perform well. We provide SAS programs in the eAppendix (http://links.lww.com/EDE/A646) to enhance the methods' accessibility...
  39. ncbi request reprint A drug burden index to define the functional burden of medications in older people
    Sarah N Hilmer
    Laboratory of Clinical Investigation and Clinical Research Branch, Intramural Research Program, National Institute on Aging, Baltimore and Bethesda, MD, USA
    Arch Intern Med 167:781-7. 2007
    ..We developed an index to determine drug burden based on pharmacologic principles. We evaluated the relationship of this index to physical and cognitive performance apart from disease indication...
  40. ncbi request reprint Transitions to mobility difficulty associated with lower extremity osteoarthritis in high functioning older women: longitudinal data from the Women's Health and Aging Study II
    Shari M Ling
    Clinical Research Branch, National Institute on Aging Intramural Research Program, and Center on Aging and Health, The Johns Hopkins Medical Institutions, 3001 South Hanover Street, Baltimore, MD 21225, USA
    Arthritis Rheum 55:256-63. 2006
    ..To assess the impact of lower extremity osteoarthritis (OA) on transitions to mobility difficulty, and to assess the influence of pain, excess weight, and quadriceps strength on these transitions...
  41. ncbi request reprint Just get out the door! Importance of walking outside the home for maintaining mobility: findings from the women's health and aging study
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 53:198-203. 2005
    ..To determine the association between volitional walking behavior and change in walking ability and lower extremity function over 1 year in functionally limited older women...
  42. ncbi request reprint Assessing the "physical cliff": detailed quantification of age-related differences in daily patterns of physical activity
    Jennifer A Schrack
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
    J Gerontol A Biol Sci Med Sci 69:973-9. 2014
    ....
  43. pmc Hearing loss and gait speed among older adults in the United States
    Lingsheng Li
    Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD 21205, United States
    Gait Posture 38:25-9. 2013
    ..Determining if hearing loss is independently associated with gait speed is critical toward understanding whether hearing rehabilitative interventions could help mitigate declines in physical functioning in older adults...
  44. pmc Sex-specific correlates of walking speed in a wide age-ranged population
    Magdalena I Tolea
    Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Gerontol B Psychol Sci Soc Sci 65:174-84. 2010
    ..If these patterns are confirmed in longitudinal studies, personality may be an important target for prevention...
  45. pmc Sex-specific gait patterns of older adults with knee osteoarthritis: results from the Baltimore longitudinal study of aging
    Seung uk Ko
    Clinical Research Branch, NIA NIH, Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Curr Gerontol Geriatr Res 2011:175763. 2011
    ..These differences were not observed in men. Understanding sex-specific differences in gait adaptation to knee-OA may inform the development of appropriate strategies for early detection and intervention for knee-OA in men and women...
  46. ncbi request reprint The association of race and socioeconomic status with cardiovascular disease indicators among older adults in the health, aging, and body composition study
    Ronica N Rooks
    Laboratory of Epidemiology, National Institute on Aging, Bethesda, Maryland, USA
    J Gerontol B Psychol Sci Soc Sci 57:S247-56. 2002
    ..But, accounting for a broad interpretation of socioeconomic status (SES) (i.e., education, family income, home ownership, and other assets) would reduce these differences...
  47. ncbi request reprint Association between physical and cognitive function in healthy elderly: the health, aging and body composition study
    Caterina Rosano
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroepidemiology 24:8-14. 2005
    ..Longitudinal studies are needed to determine the direction of causality in this relationship...
  48. pmc Black and white differences in cognitive function test scores: what explains the difference?
    Kala M Mehta
    Division of Geriatrics, University of California at San Francisco, 94121, USA
    J Am Geriatr Soc 52:2120-7. 2004
    ..This study evaluates whether differences in health and socioeconomic indicators, including literacy level, can explain differences in cognitive function test scores between older black and white adults...
  49. ncbi request reprint Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 57:M326-32. 2002
    ....
  50. ncbi request reprint Obesity, regional body fat distribution, and the metabolic syndrome in older men and women
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:777-83. 2005
    ..We determined whether patterns of regional fat deposition are associated with metabolic syndrome in older adults...
  51. ncbi request reprint Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 60:324-33. 2005
    ..This study aims to investigate whether low muscle mass, low muscle strength, and greater fat infiltration into the muscle predict incident mobility limitation...
  52. ncbi request reprint Type and intensity of activity and risk of mobility limitation: the mediating role of muscle parameters
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Am Geriatr Soc 53:762-70. 2005
    ..To investigate the association between different types of physical activity behavior and incident mobility limitation in older men and women and to examine whether muscle parameters mediate these associations...
  53. ncbi request reprint Weight change, weight change intention, and the incidence of mobility limitation in well-functioning community-dwelling older adults
    Jung Sun Lee
    Healthy Aging Research Program, Department of Epidemiology, University of Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 60:1007-12. 2005
    ..The aim of this study was to determine whether weight, weight change, and weight change intention are associated with risk for mobility limitation in elderly persons...
  54. ncbi request reprint How does low back pain impact physical function in independent, well-functioning older adults? Evidence from the Health ABC Cohort and implications for the future
    Debra K Weiner
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15206, USA
    Pain Med 4:311-20. 2003
    ..To determine the relationships between low back pain (LBP) frequency and intensity and self-reported and performance-based physical function in a large cohort of well-functioning older adults...
  55. ncbi request reprint Serum leptin concentrations and body adipose measures in older black and white adults
    Constance E Ruhl
    Social and Scientific Systems, Inc, 8758 Georgia Avenue, Silver Spring, MD 20910, USA
    Am J Clin Nutr 80:576-83. 2004
    ..Among US adults, serum leptin concentrations are higher in women than in men and are higher in blacks than in whites independent of anthropometric measures of body fatness...
  56. ncbi request reprint The association between physical function and lifestyle activity and exercise in the health, aging and body composition study
    Jennifer S Brach
    Department of Physical Therapy, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvannia 15260, USA
    J Am Geriatr Soc 52:502-9. 2004
    ..To determine whether older adults who exercise demonstrate higher levels of physical function than those who do not exercise but are physically active throughout the day...
  57. ncbi request reprint Neck and shoulder pain in 70- to 79-year-old men and women: findings from the Health, Aging and Body Composition Study
    Molly T Vogt
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Spine J 3:435-41. 2003
    ..Musculoskeletal pain in the cervicobrachial region is considered a major health problem among adults of working age, but little is known about the impact of this pain in the elderly...
  58. ncbi request reprint Energy requirements in the eighth decade of life
    Stephane Blanc
    University of Wisconsin Madison, WI 53706, USA
    Am J Clin Nutr 79:303-10. 2004
    ..Knowledge of energy requirements among relatively healthy elderly is limited...
  59. ncbi request reprint Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study
    Brenda W J H Penninx
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Biol Psychiatry 54:566-72. 2003
    ..In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation...
  60. ncbi request reprint Walking performance and cardiovascular response: associations with age and morbidity--the Health, Aging and Body Composition Study
    Anne B Newman
    Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Gerontol A Biol Sci Med Sci 58:715-20. 2003
    ..The long-distance corridor walk is a timed 400-meter walk test used to assess walking endurance in well-functioning men and women aged 70-79 in the Health, Aging and Body Composition Study...
  61. ncbi request reprint Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: findings from the Health, Aging, and Body Composition study
    Paul Holvoet
    Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 23:1444-8. 2003
    ..Therefore, we studied the association between high, predicted CHD risk and oxLDL in the Health ABC cohort...
  62. ncbi request reprint Prevalence and correlates of anxiety symptoms in well-functioning older adults: findings from the health aging and body composition study
    Kala M Mehta
    Division of Geriatrics, University of California at San Francisco, San Francisco, California 94121
    J Am Geriatr Soc 51:499-504. 2003
    ..To determine the prevalence and correlates of anxiety symptoms in the absence of depression, in older black and white people...
  63. ncbi request reprint The ankle brachial index and change in lower extremity functioning over time: the Women's Health and Aging Study
    Mary Mcgrae McDermott
    Department of Medicine and Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois, USA
    J Am Geriatr Soc 50:238-46. 2002
    ..To define the association between baseline ankle brachial index (ABI) level and subsequent onset of severe disability...
  64. ncbi request reprint Is there a biomedical explanation for socioeconomic differences in incident mobility limitation?
    Annemarie Koster
    Department of Health Care Studies, Section Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
    J Gerontol A Biol Sci Med Sci 60:1022-7. 2005
    ..This study examines the association between socioeconomic status and incident mobility limitation in well-functioning older adults, and seeks to determine whether this link could be explained by biomedical factors...
  65. ncbi request reprint Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida 32608, USA
    J Am Geriatr Soc 53:1675-80. 2005
    ..To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons...
  66. pmc Limited literacy and mortality in the elderly: the health, aging, and body composition study
    Rebecca L Sudore
    University of California, San Francisco, CA 94121, USA
    J Gen Intern Med 21:806-12. 2006
    ..While limited literacy is common and its prevalence increases with age, no prospective study has assessed whether limited literacy is associated with mortality in older adults...
  67. ncbi request reprint Body mass index and serum leptin concentration independently estimate percentage body fat in older adults
    Constance E Ruhl
    Social and Scientific Systems Inc, Silver Spring, MD, USA
    Am J Clin Nutr 85:1121-6. 2007
    ....
  68. ncbi request reprint Multitasking: association between poorer performance and a history of recurrent falls
    Kimberly A Faulkner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:570-6. 2007
    ..To examine the association between poorer performance on concurrent walking and reaction time and recurrent falls...
  69. ncbi request reprint Knee extension strength cutpoints for maintaining mobility
    Todd M Manini
    Institute on Aging, Department of Aging and Geriatric Research, Amsterdam, The Netherlands
    J Am Geriatr Soc 55:451-7. 2007
    ..To identify levels of knee extensor strength that are associated with high and low risk of incident severe mobility limitation (SML) in initially well-functioning older adults...
  70. pmc Scared to death: results from the Health, Aging, and Body Composition study
    Gretchen A Brenes
    Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Geriatr Psychiatry 15:262-5. 2007
    ..The purpose of this study is to determine if anxiety is associated with mortality and if race moderates and depression mediates this relationship...
  71. pmc Anxiety symptoms and decline in physical function over 5 years in the health, aging and body composition study
    Kala M Mehta
    Division of Geriatrics, Department of Psychiatry, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 55:265-70. 2007
    ..To examine the relationship between anxiety and functional decline...
  72. pmc Correlates of use of antifracture therapy in older women with low bone mineral density
    Kathryn M Ryder
    The University of Tennessee Health Science Center, Memphis, TN, USA
    J Gen Intern Med 21:636-41. 2006
    ..Guidelines exist for treatment of low bone mineral density (BMD). Little is known about patient characteristics associated with use of treatment...
  73. pmc A little exercise
    Luigi Ferrucci
    J Gerontol A Biol Sci Med Sci 61:1154-6. 2006
  74. ncbi request reprint Cystatin C and measures of physical function in elderly adults: the Health, Aging, and Body Composition (HABC) Study
    Michelle C Odden
    General Internal Medicine Section, San Francisco VA Medical Center, Department of Nephrology, University of California, San Francisco, CA 94121, USA
    Am J Epidemiol 164:1180-9. 2006
    ..73 m2. In these older adults, mild decrements in kidney function, as measured by cystatin C concentration, were associated with poorer physical function...
  75. ncbi request reprint Dog ownership, walking behavior, and maintained mobility in late life
    Roland J Thorpe
    Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins Medical Institutions, Balitmore Maryland 21224, USA
    J Am Geriatr Soc 54:1419-24. 2006
    ..To examine dog walking among dog owners and the relationship between walking behavior of dog owners and non-dog owners and maintained gait speed over 3 years...
  76. ncbi request reprint Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study
    M Kathleen Figaro
    Department of Medicine, Vanderbilt University Medical Center GRECC, 1310 24th Ave South, Room 4B111, Nashville, TN 37212, USA
    Diabetes Care 29:2039-45. 2006
    ..We examined the effect of C-reactive protein (CRP) and interleukin-6 (IL-6) on the incident mobility limitation in older adults with and without diabetes...
  77. pmc Magnesium and muscle performance in older persons: the InCHIANTI study
    Ligia J Dominguez
    Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy
    Am J Clin Nutr 84:419-26. 2006
    ..The role of magnesium in maintaining muscle integrity and function in older adults is largely unknown...
  78. ncbi request reprint Limited literacy in older people and disparities in health and healthcare access
    Rebecca L Sudore
    Department of Medicine, Division of Geriatrics, University of California San Francisco, San Francisco, CA, USA
    J Am Geriatr Soc 54:770-6. 2006
    ..To determine the relationship between health literacy, demographics, and access to health care...
  79. ncbi request reprint Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the Health, Aging and Body Composition study
    Nicole Vogelzangs
    Department of Psychiatry and Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:563-9. 2007
    ..This study investigated the cross-sectional relationship between psychosocial risk factors and the metabolic syndrome in a community-based sample of older persons...
  80. ncbi request reprint Vascular disease and future risk of depressive symptomatology in older adults: findings from the Health, Aging, and Body Composition study
    Benjamin T Mast
    Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
    Biol Psychiatry 64:320-6. 2008
    ..Although neuroimaging studies provide evidence for an association between depression and severity of vascular lesions in the brain, studies of depression and indicators of vascular risk have been less consistent...
  81. ncbi request reprint Diabetes mellitus, glycemic control, and incident depressive symptoms among 70- to 79-year-old persons: the health, aging, and body composition study
    Cinzia Maraldi
    Institute on Aging, University of Florida, USA
    Arch Intern Med 167:1137-44. 2007
    ..The causal mechanisms and temporal sequence of this association have not been clearly delineated. This study investigated the prospective relationship between DM and depressive symptoms...
  82. ncbi request reprint Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study
    Hal H Atkinson
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Claude D Pepper Older Americans Independence Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 62:844-50. 2007
    ..This study examines the relationship between cognitive function and subsequent gait speed decline among high-functioning older adults...
  83. ncbi request reprint Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability
    Anne B Newman
    Department of Epidemiology, Physical Therapy, University of Pittsburgh, Pittsburgh, PA 15213, USA
    JAMA 295:2018-26. 2006
    ..Extended walking tests have been examined as outcome predictors in medically ill populations but not in community-dwelling older adults...
  84. ncbi request reprint Myeloperoxidase polymorphism and cognitive decline in older adults in the Health, Aging, and Body Composition Study
    Sandra K Pope
    Department of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Epidemiol 163:1084-90. 2006
    ..Interactions between MPO and race, sex, or the apolipoprotein gene were not significant. In this sample, MPO AA, associated with decreased production of myeloperoxidase, was found to be a risk factor for cognitive decline...
  85. ncbi request reprint Associations of back and leg pain with health status and functional capacity of older adults: findings from the retirement community back pain study
    Gregory E Hicks
    University of Delaware, Department of Physical Therapy, 303 McKinly Lab, Newark, DE 19716, USA
    Arthritis Rheum 59:1306-13. 2008
    ..Our objective was to determine whether LBP and concurrent leg pain are associated with health-related quality of life (HRQOL) and function in a cohort of older adults, and to examine care-seeking behaviors related to LBP...
  86. pmc Association between nighttime sleep and napping in older adults
    Suzanne E Goldman
    Department of Neurology, Sleep Disorders Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Sleep 31:733-40. 2008
    ..Napping might indicate deficiencies in nighttime sleep, but the relationship is not well defined. We assessed the association of nighttime sleep duration and fragmentation with subsequent daytime sleep...
  87. ncbi request reprint Association of inflammatory markers with socioeconomic status
    Annemarie Koster
    Department of Health Care Studies, Section of Medical Sociology, Universiteit Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:284-90. 2006
    ....
  88. ncbi request reprint Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Circulation 111:3384-90. 2005
    ..The objective of this investigation was to determine whether aPWV is associated with total and cardiovascular (CV) mortality and CV events in a community-dwelling sample of older adults...
  89. ncbi request reprint Fitness and cognition: encouraging findings and methodological considerations for future work
    Eleanor M Simonsick
    J Am Geriatr Soc 51:570-1. 2003
  90. ncbi request reprint Influenza vaccination by race among disabled community dwelling older women
    Kevin D Frick
    Johns Hopkins Bloomberg School of Public Health, Department of Health Policy and Management, USA
    J Health Care Poor Underserved 15:220-36. 2004
    ..The utilization rate did not approach the Healthy People 2010 target...
  91. pmc Hypercortisolemic depression is associated with the metabolic syndrome in late-life
    Nicole Vogelzangs
    Department of Psychiatry and EMGO Institute, VU University Medical Center, Oldenaller 1, 1081 HJ Amsterdam, The Netherlands
    Psychoneuroendocrinology 32:151-9. 2007
    ..Such a link could be due to increased HPA-axis activity. This study investigates the cross-sectional relationship between depression, urinary cortisol and metabolic syndrome in an older population...
  92. ncbi request reprint Weight-loss intention in the well-functioning, community-dwelling elderly: associations with diet quality, physical activity, and weight change
    Jung Sun Lee
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Avenue, 5th Floor, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 80:466-74. 2004
    ..Many older adults desire to lose weight, yet the proportion with a health-related weight-loss indication, weight-loss strategies, and success is unknown...
  93. ncbi request reprint Race and sex differences in age-related hearing loss: the Health, Aging and Body Composition Study
    Elizabeth P Helzner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 53:2119-27. 2005
    ..To determine the prevalence of and risk factors for hearing loss in a sample of 2,052 older adults (aged 73-84; 46.9% male, 37.3% black) enrolled in the Health, Aging and Body Composition (Health ABC) Study...