Jill L Silverman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
    Ozlem Bozdagi
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Autism 1:15. 2010
  2. pmc Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP
    Jill L Silverman
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Porter Neuroscience Research Center, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:976-89. 2010
  3. pmc Sociability and motor functions in Shank1 mutant mice
    Jill L Silverman
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Brain Res 1380:120-37. 2011
  4. pmc Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism
    J L Silverman
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
    Neuroscience 171:1197-208. 2010
  5. doi request reprint Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2
    Markus Wohr
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Behav Brain Res 251:50-64. 2013
  6. pmc Low sociability in BTBR T+tf/J mice is independent of partner strain
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
    Physiol Behav 107:649-62. 2012
  7. pmc Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism
    Jill L Silverman
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
    Neuropharmacology 68:210-22. 2013
  8. pmc Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice
    Jennifer Brielmaier
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland, USA
    PLoS ONE 7:e40914. 2012
  9. doi request reprint Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism
    Jill L Silverman
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
    Sci Transl Med 4:131ra51. 2012
  10. doi request reprint Automated three-chambered social approach task for mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, NIH, Bethesda, Maryland, USA
    Curr Protoc Neurosci . 2011

Collaborators

Detail Information

Publications12

  1. pmc Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
    Ozlem Bozdagi
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Autism 1:15. 2010
    ..abstract:..
  2. pmc Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP
    Jill L Silverman
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Porter Neuroscience Research Center, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:976-89. 2010
    ..Our findings suggest that antagonists of mGluR5 receptors may have selective therapeutic efficacy in treating repetitive behaviors in autism...
  3. pmc Sociability and motor functions in Shank1 mutant mice
    Jill L Silverman
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Brain Res 1380:120-37. 2011
    ..Our findings support the interpretation that Shank1 null mice do not demonstrate autism-relevant social interaction deficits, but confirm and extend a role for Shank1 in motor functions...
  4. pmc Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism
    J L Silverman
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
    Neuroscience 171:1197-208. 2010
    ..Our findings support the interpretation that autism-relevant social deficits, vocalizations, and repetitive behaviors are not the result of abnormal stress reactivity in the BTBR mouse model of autism...
  5. doi request reprint Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2
    Markus Wohr
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Behav Brain Res 251:50-64. 2013
    ..The present findings add to the growing literature on the role of neurexins and neuroligins in physiology and behavior relevant to neurodevelopmental disorders. ..
  6. pmc Low sociability in BTBR T+tf/J mice is independent of partner strain
    Mu Yang
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
    Physiol Behav 107:649-62. 2012
    ..Our findings suggest that BTBR has poor abilities to modulate its responses to different social partners, which may be analogous to social cognition deficits in autism, adding to the value of this strain as a mouse model of autism...
  7. pmc Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism
    Jill L Silverman
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
    Neuropharmacology 68:210-22. 2013
    ..This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'...
  8. pmc Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice
    Jennifer Brielmaier
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland, USA
    PLoS ONE 7:e40914. 2012
    ....
  9. doi request reprint Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism
    Jill L Silverman
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
    Sci Transl Med 4:131ra51. 2012
    ..These findings raise the possibility that a single targeted pharmacological intervention may alleviate multiple diagnostic behavioral symptoms of autism...
  10. doi request reprint Automated three-chambered social approach task for mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, NIH, Bethesda, Maryland, USA
    Curr Protoc Neurosci . 2011
    ..The Basic Protocol describes procedures for testing one subject at a time in a single apparatus. A Support Protocol addresses data collection...
  11. pmc Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice
    Mu Yang
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Neurosci 32:6525-41. 2012
    ..These results demonstrate the exquisite specificity of deletions in discrete domains within the Shank3 gene in determining severity of symptoms...
  12. pmc Behavioural phenotyping assays for mouse models of autism
    Jill L Silverman
    National Institute of Mental Health, Porter Neuroscience Research Center, Bethesda, MD 20892 3730, USA
    Nat Rev Neurosci 11:490-502. 2010
    ..Robust phenotypes in mouse models hold great promise as translational tools for discovering effective treatments for components of autism spectrum disorders...