Research Topics
Genomes and Genes
Species | Debra T SilvermanSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
The Diesel Exhaust in Miners study: a nested case-control study of lung cancer and diesel exhaustDebra T Silverman
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20816, USA
J Natl Cancer Inst 104:855-68. 2012..Our purpose was to evaluate the relationship between quantitative estimates of exposure to diesel exhaust and lung cancer mortality after adjustment for smoking and other potential confounders...
Why do Black Americans have a higher risk of pancreatic cancer than White Americans?Debra T Silverman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Epidemiology 14:45-54. 2003..For several decades, the incidence of pancreatic cancer has been 50% to 90% higher among blacks than among whites in the United States. The purpose of this study was to identify risk factors that may contribute to this racial disparity...
Does increased urination frequency protect against bladder cancer?Debra T Silverman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
Int J Cancer 123:1644-8. 2008..Increased urination frequency, coupled with possible dilution of the urine from increased water intake, may diminish the effect of urinary carcinogens on bladder cancer risk...- The Diesel Exhaust in Miners Study: III. Interrelations between respirable elemental carbon and gaseous and particulate components of diesel exhaust derived from area sampling in underground non-metal mining facilitiesRoel Vermeulen
Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
Ann Occup Hyg 54:762-73. 2010..The fact that CO correlated with REC, loaded on the same factor, and increased linearly in log-log space supported the use of CO in estimating historical exposure levels to DE... - The Diesel Exhaust in Miners Study: IV. Estimating historical exposures to diesel exhaust in underground non-metal mining facilitiesRoel Vermeulen
Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
Ann Occup Hyg 54:774-88. 2010..These REC exposure estimates were in a plausible range and were used in the investigation of exposure-response relationships in epidemiologic analyses... - Occupation, pesticide exposure and risk of multiple myelomaDalsu Baris
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland 20892, United States
Scand J Work Environ Health 30:215-22. 2004..This population-based case-control study examined the relationship between occupation, living or working on a farm, pesticide exposure, and the risk of multiple myeloma... - Occupation and bladder cancer in a population-based case-control study in Northern New EnglandJoanne S Colt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7240, USA
Occup Environ Med 68:239-49. 2011..We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk... - The diesel exhaust in miners study: I. Overview of the exposure assessment processPatricia A Stewart
Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
Ann Occup Hyg 54:728-46. 2010..Method evaluations indicated that the final estimates were consistent with those from alternative time trend models and demonstrated moderate to high agreement with external data... - Alcohol use and risk of pancreatic cancer: the NIH-AARP Diet and Health StudyLi Jiao
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Am J Epidemiol 169:1043-51. 2009..41, 95% CI: 1.01, 2.00). These findings suggest a moderately increased pancreatic cancer risk with heavy alcohol use, particularly liquor; however, residual confounding by cigarette smoking cannot be completely excluded... - Inside the black box: starting to uncover the underlying decision rules used in a one-by-one expert assessment of occupational exposure in case-control studiesDavid C Wheeler
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Occup Environ Med 70:203-10. 2013..We aimed to identify the underlying rules to enable documentation, review and future use of these expert-based exposure decisions... - Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health studyAnne C M Thiebaut
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
J Natl Cancer Inst 101:1001-11. 2009..Previous research relating dietary fat, a modifiable risk factor, to pancreatic cancer has been inconclusive... - Bladder cancer and reproductive factors among women in SpainAn Tsun Huang
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Cancer Causes Control 20:1907-13. 2009..Women have a lower risk of bladder cancer than men, and hormonal factors related to childbearing may play a role... - Nonsteroidal antiinflammatory drugs and bladder cancer: a pooled analysisSarah E Daugherty
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA
Am J Epidemiol 173:721-30. 2011..04, 95% CI: 0.94, 1.15). Results suggest that nonaspirin NSAIDs, but not aspirin, are associated with a reduction in risk of bladder cancer, particularly for nonsmokers... - Comparison of two expert-based assessments of diesel exhaust exposure in a case-control study: programmable decision rules versus expert review of individual jobsAnjoeka Pronk
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 8106, MSC 7240, Bethesda, MD 20892 7240, USA
Occup Environ Med 69:752-8. 2012..To improve transparency and efficiency, we systematically applied decision rules to questionnaire responses to assess diesel exhaust exposure in the population-based case-control New England Bladder Cancer Study... - The Diesel Exhaust in Miners Study: II. Exposure monitoring surveys and development of exposure groupsJoseph B Coble
Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
Ann Occup Hyg 54:747-61. 2010.... - Common genetic variants in the PSCA gene influence gene expression and bladder cancer riskYi Ping Fu
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:4974-9. 2012.... - Estimating water supply arsenic levels in the New England Bladder Cancer StudyJohn R Nuckols
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Environ Health Perspect 119:1279-85. 2011..Accurate retrospective exposure assessment over a long time period is a major challenge in conducting epidemiologic studies of environmental factors and diseases with long latency, such as cancer... - Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health CohortRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Am J Epidemiol 167:586-97. 2008..53, 95% CI: 1.13, 5.65; p(trend) = 0.04) in women but not men. The authors observed no association with physical activity. Their results suggest a positive association between adiposity and pancreatic cancer... - Urinary pH, cigarette smoking and bladder cancer riskJuan Alguacil
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
Carcinogenesis 32:843-7. 2011..024). These results suggest that urine pH, which is determined primarily by diet and body surface area, may be an important modifier of smoking and risk of bladder cancer... - Genetic variant as a selection marker for anti-prostate stem cell antigen immunotherapy of bladder cancerIndu Kohaar
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Cir, Bethesda, MD 20892 4605, USA
J Natl Cancer Inst 105:69-73. 2013..Future clinical studies will be needed to validate PSCA as a therapeutic target for bladder cancer... - Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancerWei Tang
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Hum Mol Genet 21:1918-30. 2012..1 protein. Our study shows an example of genetic and functional role of an uncommon protective genetic variant in a complex human disease, such as bladder cancer... - Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European backgroundIdan Menashe
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 7:e29396. 2012..Identification of the aromatic amine metabolism pathway provides support for the ability of this approach to identify pathways with established relevance to bladder carcinogenesis... - Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in SpainKenneth P Cantor
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
Environ Health Perspect 118:1545-50. 2010..Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water... - Serum C-reactive protein and risk of pancreatic cancer in two nested, case-control studiesJason B Douglas
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
Cancer Epidemiol Biomarkers Prev 20:359-69. 2011..Many epidemiologic studies have examined the association between C-reactive protein (CRP) and risk of cancer with inconsistent results... - Smoking and bladder cancer in Spain: effects of tobacco type, timing, environmental tobacco smoke, and genderClaudine Samanic
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 15:1348-54. 2006..2 to 1.7, suggesting that nearly the entire male excess of bladder cancer observed in Spain is explained by cigarette smoking rather than occupational/environmental exposures to other bladder carcinogens... - A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility lociNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Nat Genet 42:978-84. 2010..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis... - A case-control study of smoking and bladder cancer risk: emergent patterns over timeDalsu Baris
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
J Natl Cancer Inst 101:1553-61. 2009.... - Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study CohortGabriella Andreotti
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Int J Cancer 124:2495-500. 2009..Organochlorines were not associated with an excess risk of pancreatic cancer in this study. These findings suggest that herbicides, particularly pendimethalin and EPTC, may be associated with pancreatic cancer... - Serum vitamin D and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian screening trialRachael Z Stolzenberg-Solomon
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, NIH, Rockville, Maryland 20852, USA
Cancer Res 69:1439-47. 2009..015). We did not confirm the previous strong positive association between 25(OH)D and pancreatic cancer; however, the increased risk among participants with low residential UVB exposure is similar... - Cell-cycle control in urothelial carcinoma: large-scale tissue array analysis of tumor tissue from Maine and VermontPetra Lenz
Division of Cancer Epidemiology and Genetics, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD, USA
Cancer Epidemiol Biomarkers Prev 21:1555-64. 2012..Cell-cycle proteins are important predictive markers in urothelial carcinoma but may also exhibit exposure-specific heterogeneity... - Nonsteroidal anti-inflammatory drugs and other analgesic use and bladder cancer in northern New EnglandDalsu Baris
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, North Bethesda, MD 20852, USA
Int J Cancer 132:162-73. 2013..We observed a previously unrecognized risk associated with use of COX-2 inhibitors, which merits further evaluation... - Cigarette smoking and cancer risk: modeling total exposure and intensityJay H Lubin
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Am J Epidemiol 166:479-89. 2007..The intensity effects were statistically homogeneous, indicating that after accounting for risk from total pack-years, intensity patterns were comparable across the diverse cancer sites... - Association between smoking and risk of bladder cancer among men and womenNeal D Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20852, USA
JAMA 306:737-45. 2011..2 per 100,000 person-years) and women (32.5 per 100,000 person-years to 33.2 per 100,000 person-years); however, changing smoking prevalence and cigarette composition warrant revisiting risk estimates for smoking and bladder cancer... - Hair dye use and risk of bladder cancer in the New England bladder cancer studyStella Koutros
Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 129:2894-904. 2011..These results need confirmation with larger numbers, requiring pooling data from multiple studies... - Risk of lung cancer associated with domestic use of coal in Xuanwei, China: retrospective cohort studyFrancesco Barone-Adesi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blv, EPS 8015, Bethesda, MD 20892 7240, USA
BMJ 345:e5414. 2012..To estimate the risk of lung cancer associated with the use of different types of coal for household cooking and heating... - Multiple myeloma and diesel and other occupational exposures in swedish construction workersWon Jin Lee
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Int J Cancer 107:134-8. 2003..Occupational exposure to diesel exhaust in the Swedish construction industry may present a small risk of multiple myeloma, but lack of an exposure-response trend tempers our ability to draw clear conclusions... - A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3Montserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Hum Mol Genet 20:4282-9. 2011..Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis... - Comparison of Algorithm-based Estimates of Occupational Diesel Exhaust Exposure to Those of Multiple Independent Raters in a Population-based Case-Control StudyMelissa C Friesen
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MA, USA
Ann Occup Hyg 57:470-81. 2013.... - Measurement of urine pH for epidemiological studies on bladder cancerJuan Alguacil
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Eur J Epidemiol 22:91-8. 2007.... - Occupational risk factors and pancreatic cancer: a review of recent findingsGabriella Andreotti
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Mol Carcinog 51:98-108. 2012..We conclude that the strongest and most consistent findings linking occupational exposures with pancreatic cancer risk to date are for chlorinated hydrocarbons and PAHs... - Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trialJason B Douglas
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
Cancer Epidemiol Biomarkers Prev 19:2298-306. 2010..Increased IGF-II and decreased IGF binding protein (IGFBP)-3 serum concentrations have been linked to a number of other cancers... - Correlation of LINE-1 methylation levels in patient-matched buffy coat, serum, buccal cell, and bladder tumor tissue DNA samplesDana Van Bemmel
Occupational and Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 21:1143-8. 2012..To date, most studies have used genomic DNA isolated from blood or urine as a surrogate marker of global DNA methylation levels in bladder tumor tissue... - Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases... - Smokeless and other noncigarette tobacco use and pancreatic cancer: a case-control study based on direct interviewsJuan Alguacil
Division of Cancer Epidemiology and Genetics. National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20852, USA
Cancer Epidemiol Biomarkers Prev 13:55-8. 2004..6; 95% CI: 0.1-2.8). Our results suggest that heavy use of smokeless tobacco, and to a lesser extent, cigar smoking may increase the risk of pancreatic cancer among nonsmokers of cigarettes... - Sampling private wells at past homes to estimate arsenic exposure: a methodologic study in New EnglandJoanne S Colt
Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
J Expo Anal Environ Epidemiol 12:329-34. 2002..Various approaches for improving the success rates for sampling water from private wells are discussed, as is the use of predictive modeling to impute exposures when sampling is not feasible... - Meat and meat-mutagen intake and pancreatic cancer risk in the NIH-AARP cohortRachael Z Stolzenberg-Solomon
National Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health Human Services, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 16:2664-75. 2007..006) increased risk in men and women combined. These findings support the hypothesis that meat intake, particularly meat cooked at high temperatures and associated mutagens, may play a role in pancreatic cancer development... - Bladder cancer mortality and private well use in New England: an ecological studyJoseph D Ayotte
US Geological Survey, New Hampshire-Vermont Water Science Center, Pembroke, USA
J Epidemiol Community Health 60:168-72. 2006..Analytical studies are underway to clarify the relation between suspected water contaminants, particularly arsenic, and raised bladder cancer rates in northern New England... - Modeling the probability of arsenic in groundwater in New England as a tool for exposure assessmentJoseph D Ayotte
U S Geological Survey NH VT Water Science Center, 361 Commerce Way, Pembroke, New Hampshire 03275, USA
Environ Sci Technol 40:3578-85. 2006..Due to the complexity of the fractured bedrock aquifers in the region, well depth and related variables also are not significant predictors... - Total fluid and water consumption and the joint effect of exposure to disinfection by-products on risk of bladder cancerDominique S Michaud
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Environ Health Perspect 115:1569-72. 2007..A pooled analysis based on six case-control studies observed a positive association between tap water and bladder cancer but none for nontap fluid intake, suggesting that contaminants in tap water may be responsible for the excess risk... - Risk of bladder cancer associated with family history of cancer: do low-penetrance polymorphisms account for the increase in risk?Cristiane Murta-Nascimento
Institut Municipal d Investigacio Medica, Carrer del Dr Aiguader 88, E 08003, Barcelona, Spain
Cancer Epidemiol Biomarkers Prev 16:1595-600. 2007..Whether these correspond to low-penetrance cancer-predisposing polymorphisms acting together and/or interacting with environmental factors warrants further research... - Added sugar and sugar-sweetened foods and beverages and the risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health StudyYing Bao
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 88:431-40. 2008..Although it has been hypothesized that hyperglycemia, hyperinsulinemia, and insulin resistance are involved in the development of pancreatic cancer, results from epidemiologic studies of added sugar intake are inconclusive...