Debra T Silverman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The Diesel Exhaust in Miners Study: IV. Estimating historical exposures to diesel exhaust in underground non-metal mining facilities
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:774-88. 2010
  2. pmc The Diesel Exhaust in Miners study: a nested case-control study of lung cancer and diesel exhaust
    Debra T Silverman
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20816, USA
    J Natl Cancer Inst 104:855-68. 2012
  3. doi request reprint Does increased urination frequency protect against bladder cancer?
    Debra T Silverman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Cancer 123:1644-8. 2008
  4. ncbi request reprint Why do Black Americans have a higher risk of pancreatic cancer than White Americans?
    Debra T Silverman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Epidemiology 14:45-54. 2003
  5. pmc The Diesel Exhaust in Miners Study: III. Interrelations between respirable elemental carbon and gaseous and particulate components of diesel exhaust derived from area sampling in underground non-metal mining facilities
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:762-73. 2010
  6. ncbi request reprint Occupation, pesticide exposure and risk of multiple myeloma
    Dalsu Baris
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland 20892, United States
    Scand J Work Environ Health 30:215-22. 2004
  7. pmc The diesel exhaust in miners study: I. Overview of the exposure assessment process
    Patricia A Stewart
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:728-46. 2010
  8. pmc The Diesel Exhaust in Miners Study: II. Exposure monitoring surveys and development of exposure groups
    Joseph B Coble
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:747-61. 2010
  9. pmc Occupation and bladder cancer in a population-based case-control study in Northern New England
    Joanne S Colt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7240, USA
    Occup Environ Med 68:239-49. 2011
  10. pmc Differential urinary specific gravity as a molecular phenotype of the bladder cancer genetic association in the urea transporter gene, SLC14A1
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Int J Cancer 133:3008-13. 2013

Detail Information

Publications58

  1. pmc The Diesel Exhaust in Miners Study: IV. Estimating historical exposures to diesel exhaust in underground non-metal mining facilities
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:774-88. 2010
    ..These REC exposure estimates were in a plausible range and were used in the investigation of exposure-response relationships in epidemiologic analyses...
  2. pmc The Diesel Exhaust in Miners study: a nested case-control study of lung cancer and diesel exhaust
    Debra T Silverman
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20816, USA
    J Natl Cancer Inst 104:855-68. 2012
    ..Our purpose was to evaluate the relationship between quantitative estimates of exposure to diesel exhaust and lung cancer mortality after adjustment for smoking and other potential confounders...
  3. doi request reprint Does increased urination frequency protect against bladder cancer?
    Debra T Silverman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Cancer 123:1644-8. 2008
    ..Increased urination frequency, coupled with possible dilution of the urine from increased water intake, may diminish the effect of urinary carcinogens on bladder cancer risk...
  4. ncbi request reprint Why do Black Americans have a higher risk of pancreatic cancer than White Americans?
    Debra T Silverman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Epidemiology 14:45-54. 2003
    ..For several decades, the incidence of pancreatic cancer has been 50% to 90% higher among blacks than among whites in the United States. The purpose of this study was to identify risk factors that may contribute to this racial disparity...
  5. pmc The Diesel Exhaust in Miners Study: III. Interrelations between respirable elemental carbon and gaseous and particulate components of diesel exhaust derived from area sampling in underground non-metal mining facilities
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:762-73. 2010
    ..The fact that CO correlated with REC, loaded on the same factor, and increased linearly in log-log space supported the use of CO in estimating historical exposure levels to DE...
  6. ncbi request reprint Occupation, pesticide exposure and risk of multiple myeloma
    Dalsu Baris
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland 20892, United States
    Scand J Work Environ Health 30:215-22. 2004
    ..This population-based case-control study examined the relationship between occupation, living or working on a farm, pesticide exposure, and the risk of multiple myeloma...
  7. pmc The diesel exhaust in miners study: I. Overview of the exposure assessment process
    Patricia A Stewart
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:728-46. 2010
    ..Method evaluations indicated that the final estimates were consistent with those from alternative time trend models and demonstrated moderate to high agreement with external data...
  8. pmc The Diesel Exhaust in Miners Study: II. Exposure monitoring surveys and development of exposure groups
    Joseph B Coble
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:747-61. 2010
    ....
  9. pmc Occupation and bladder cancer in a population-based case-control study in Northern New England
    Joanne S Colt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7240, USA
    Occup Environ Med 68:239-49. 2011
    ..We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk...
  10. pmc Differential urinary specific gravity as a molecular phenotype of the bladder cancer genetic association in the urea transporter gene, SLC14A1
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Int J Cancer 133:3008-13. 2013
    ....
  11. pmc Lifetime adiposity and risk of pancreatic cancer in the NIH-AARP Diet and Health Study cohort
    Rachael Z Stolzenberg-Solomon
    Branches of Nutritional Epidemiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD
    Am J Clin Nutr 98:1057-65. 2013
    ..The association of excess body weight across a lifetime with pancreatic cancer has not been examined extensively...
  12. pmc Alcohol use and risk of pancreatic cancer: the NIH-AARP Diet and Health Study
    Li Jiao
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Am J Epidemiol 169:1043-51. 2009
    ..41, 95% CI: 1.01, 2.00). These findings suggest a moderately increased pancreatic cancer risk with heavy alcohol use, particularly liquor; however, residual confounding by cigarette smoking cannot be completely excluded...
  13. pmc Reproductive factors and menopausal hormone therapy and bladder cancer risk in the NIH-AARP Diet and Health Study
    Sarah E Daugherty
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 133:462-72. 2013
    ..34-0.83) compared with women who did not report MHT use. No association was observed for estrogen only users (HR=0.82; 95% CI: 0.58-1.15). Our results suggest a putative role for sex hormones in the etiology of bladder cancer among women...
  14. doi request reprint Inside the black box: starting to uncover the underlying decision rules used in a one-by-one expert assessment of occupational exposure in case-control studies
    David C Wheeler
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Occup Environ Med 70:203-10. 2013
    ..We aimed to identify the underlying rules to enable documentation, review and future use of these expert-based exposure decisions...
  15. pmc Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study
    Anne C M Thiebaut
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Natl Cancer Inst 101:1001-11. 2009
    ..Previous research relating dietary fat, a modifiable risk factor, to pancreatic cancer has been inconclusive...
  16. pmc Bladder cancer and reproductive factors among women in Spain
    An Tsun Huang
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 20:1907-13. 2009
    ..Women have a lower risk of bladder cancer than men, and hormonal factors related to childbearing may play a role...
  17. pmc Nonsteroidal antiinflammatory drugs and bladder cancer: a pooled analysis
    Sarah E Daugherty
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Am J Epidemiol 173:721-30. 2011
    ..04, 95% CI: 0.94, 1.15). Results suggest that nonaspirin NSAIDs, but not aspirin, are associated with a reduction in risk of bladder cancer, particularly for nonsmokers...
  18. pmc Comparison of two expert-based assessments of diesel exhaust exposure in a case-control study: programmable decision rules versus expert review of individual jobs
    Anjoeka Pronk
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 8106, MSC 7240, Bethesda, MD 20892 7240, USA
    Occup Environ Med 69:752-8. 2012
    ..To improve transparency and efficiency, we systematically applied decision rules to questionnaire responses to assess diesel exhaust exposure in the population-based case-control New England Bladder Cancer Study...
  19. pmc Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:4974-9. 2012
    ....
  20. doi request reprint Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort
    Rachael Z Stolzenberg-Solomon
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Am J Epidemiol 167:586-97. 2008
    ..53, 95% CI: 1.13, 5.65; p(trend) = 0.04) in women but not men. The authors observed no association with physical activity. Their results suggest a positive association between adiposity and pancreatic cancer...
  21. pmc Estimating water supply arsenic levels in the New England Bladder Cancer Study
    John R Nuckols
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Environ Health Perspect 119:1279-85. 2011
    ..Accurate retrospective exposure assessment over a long time period is a major challenge in conducting epidemiologic studies of environmental factors and diseases with long latency, such as cancer...
  22. pmc Urinary pH, cigarette smoking and bladder cancer risk
    Juan Alguacil
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 32:843-7. 2011
    ..024). These results suggest that urine pH, which is determined primarily by diet and body surface area, may be an important modifier of smoking and risk of bladder cancer...
  23. pmc Comparison of algorithm-based estimates of occupational diesel exhaust exposure to those of multiple independent raters in a population-based case-control study
    Melissa C Friesen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MA, USA
    Ann Occup Hyg 57:470-81. 2013
    ....
  24. pmc Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Res 73:2211-20. 2013
    ..Our findings could have implications for targeted prevention strategies. However, other smoking-related diseases, as well as practical and ethical considerations, need to be considered before any recommendations could be made...
  25. pmc Genetic variant as a selection marker for anti-prostate stem cell antigen immunotherapy of bladder cancer
    Indu Kohaar
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Cir, Bethesda, MD 20892 4605, USA
    J Natl Cancer Inst 105:69-73. 2013
    ..Future clinical studies will be needed to validate PSCA as a therapeutic target for bladder cancer...
  26. pmc Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer
    Wei Tang
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Hum Mol Genet 21:1918-30. 2012
    ..1 protein. Our study shows an example of genetic and functional role of an uncommon protective genetic variant in a complex human disease, such as bladder cancer...
  27. pmc Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background
    Idan Menashe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e29396. 2012
    ..Identification of the aromatic amine metabolism pathway provides support for the ability of this approach to identify pathways with established relevance to bladder carcinogenesis...
  28. pmc Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain
    Kenneth P Cantor
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 118:1545-50. 2010
    ..Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water...
  29. ncbi request reprint Smoking and bladder cancer in Spain: effects of tobacco type, timing, environmental tobacco smoke, and gender
    Claudine Samanic
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:1348-54. 2006
    ..2 to 1.7, suggesting that nearly the entire male excess of bladder cancer observed in Spain is explained by cigarette smoking rather than occupational/environmental exposures to other bladder carcinogens...
  30. pmc Serum C-reactive protein and risk of pancreatic cancer in two nested, case-control studies
    Jason B Douglas
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 20:359-69. 2011
    ..Many epidemiologic studies have examined the association between C-reactive protein (CRP) and risk of cancer with inconsistent results...
  31. ncbi request reprint Cigarette smoking and cancer risk: modeling total exposure and intensity
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Am J Epidemiol 166:479-89. 2007
    ..The intensity effects were statistically homogeneous, indicating that after accounting for risk from total pack-years, intensity patterns were comparable across the diverse cancer sites...
  32. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  33. pmc A case-control study of smoking and bladder cancer risk: emergent patterns over time
    Dalsu Baris
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    J Natl Cancer Inst 101:1553-61. 2009
    ....
  34. pmc Serum vitamin D and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian screening trial
    Rachael Z Stolzenberg-Solomon
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, NIH, Rockville, Maryland 20852, USA
    Cancer Res 69:1439-47. 2009
    ..015). We did not confirm the previous strong positive association between 25(OH)D and pancreatic cancer; however, the increased risk among participants with low residential UVB exposure is similar...
  35. pmc Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 124:2495-500. 2009
    ..Organochlorines were not associated with an excess risk of pancreatic cancer in this study. These findings suggest that herbicides, particularly pendimethalin and EPTC, may be associated with pancreatic cancer...
  36. ncbi request reprint Multiple myeloma and diesel and other occupational exposures in swedish construction workers
    Won Jin Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Int J Cancer 107:134-8. 2003
    ..Occupational exposure to diesel exhaust in the Swedish construction industry may present a small risk of multiple myeloma, but lack of an exposure-response trend tempers our ability to draw clear conclusions...
  37. pmc Cell-cycle control in urothelial carcinoma: large-scale tissue array analysis of tumor tissue from Maine and Vermont
    Petra Lenz
    Division of Cancer Epidemiology and Genetics, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD, USA
    Cancer Epidemiol Biomarkers Prev 21:1555-64. 2012
    ..Cell-cycle proteins are important predictive markers in urothelial carcinoma but may also exhibit exposure-specific heterogeneity...
  38. doi request reprint Nonsteroidal anti-inflammatory drugs and other analgesic use and bladder cancer in northern New England
    Dalsu Baris
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, North Bethesda, MD 20852, USA
    Int J Cancer 132:162-73. 2013
    ..We observed a previously unrecognized risk associated with use of COX-2 inhibitors, which merits further evaluation...
  39. pmc Hair dye use and risk of bladder cancer in the New England bladder cancer study
    Stella Koutros
    Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 129:2894-904. 2011
    ..These results need confirmation with larger numbers, requiring pooling data from multiple studies...
  40. pmc Association between smoking and risk of bladder cancer among men and women
    Neal D Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20852, USA
    JAMA 306:737-45. 2011
    ..2 per 100,000 person-years) and women (32.5 per 100,000 person-years to 33.2 per 100,000 person-years); however, changing smoking prevalence and cigarette composition warrant revisiting risk estimates for smoking and bladder cancer...
  41. ncbi request reprint Measurement of urine pH for epidemiological studies on bladder cancer
    Juan Alguacil
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Eur J Epidemiol 22:91-8. 2007
    ....
  42. pmc Risk of lung cancer associated with domestic use of coal in Xuanwei, China: retrospective cohort study
    Francesco Barone-Adesi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blv, EPS 8015, Bethesda, MD 20892 7240, USA
    BMJ 345:e5414. 2012
    ..To estimate the risk of lung cancer associated with the use of different types of coal for household cooking and heating...
  43. pmc A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 20:4282-9. 2011
    ..Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis...
  44. doi request reprint Genome-wide association study identifies multiple loci associated with bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 23:1387-98. 2014
    ....
  45. doi request reprint Occupational risk factors and pancreatic cancer: a review of recent findings
    Gabriella Andreotti
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Carcinog 51:98-108. 2012
    ..We conclude that the strongest and most consistent findings linking occupational exposures with pancreatic cancer risk to date are for chlorinated hydrocarbons and PAHs...
  46. pmc Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    Jason B Douglas
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 19:2298-306. 2010
    ..Increased IGF-II and decreased IGF binding protein (IGFBP)-3 serum concentrations have been linked to a number of other cancers...
  47. ncbi request reprint Sampling private wells at past homes to estimate arsenic exposure: a methodologic study in New England
    Joanne S Colt
    Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    J Expo Anal Environ Epidemiol 12:329-34. 2002
    ..Various approaches for improving the success rates for sampling water from private wells are discussed, as is the use of predictive modeling to impute exposures when sampling is not feasible...
  48. doi request reprint Smoky coal, tobacco smoking, and lung cancer risk in Xuanwei, China
    Christopher Kim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, United States School of Public Health, Yale University, New Haven, CT 06520, United States Electronic address
    Lung Cancer 84:31-5. 2014
    ..Here, we explored the differential association of tobacco use and lung cancer risk by the intensity, duration, and type of coal used...
  49. doi request reprint Genome-wide association study identifies two susceptibility loci for osteosarcoma
    Sharon A Savage
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD, USA
    Nat Genet 45:799-803. 2013
    ..2 (rs7591996 and rs10208273; P = 1.0 × 10⁻⁸ and 2.9 × 10⁻⁷, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma...
  50. pmc Correlation of LINE-1 methylation levels in patient-matched buffy coat, serum, buccal cell, and bladder tumor tissue DNA samples
    Dana Van Bemmel
    Occupational and Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 21:1143-8. 2012
    ..To date, most studies have used genomic DNA isolated from blood or urine as a surrogate marker of global DNA methylation levels in bladder tumor tissue...
  51. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  52. ncbi request reprint Smokeless and other noncigarette tobacco use and pancreatic cancer: a case-control study based on direct interviews
    Juan Alguacil
    Division of Cancer Epidemiology and Genetics National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:55-8. 2004
    ..6; 95% CI: 0.1-2.8). Our results suggest that heavy use of smokeless tobacco, and to a lesser extent, cigar smoking may increase the risk of pancreatic cancer among nonsmokers of cigarettes...
  53. ncbi request reprint Meat and meat-mutagen intake and pancreatic cancer risk in the NIH-AARP cohort
    Rachael Z Stolzenberg-Solomon
    National Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health Human Services, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 16:2664-75. 2007
    ..006) increased risk in men and women combined. These findings support the hypothesis that meat intake, particularly meat cooked at high temperatures and associated mutagens, may play a role in pancreatic cancer development...
  54. ncbi request reprint Risk of bladder cancer associated with family history of cancer: do low-penetrance polymorphisms account for the increase in risk?
    Cristiane Murta-Nascimento
    Institut Municipal d Investigacio Medica, Carrer del Dr Aiguader 88, E 08003, Barcelona, Spain
    Cancer Epidemiol Biomarkers Prev 16:1595-600. 2007
    ..Whether these correspond to low-penetrance cancer-predisposing polymorphisms acting together and/or interacting with environmental factors warrants further research...
  55. pmc Total fluid and water consumption and the joint effect of exposure to disinfection by-products on risk of bladder cancer
    Dominique S Michaud
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 115:1569-72. 2007
    ..A pooled analysis based on six case-control studies observed a positive association between tap water and bladder cancer but none for nontap fluid intake, suggesting that contaminants in tap water may be responsible for the excess risk...
  56. ncbi request reprint Modeling the probability of arsenic in groundwater in New England as a tool for exposure assessment
    Joseph D Ayotte
    U S Geological Survey NH VT Water Science Center, 361 Commerce Way, Pembroke, New Hampshire 03275, USA
    Environ Sci Technol 40:3578-85. 2006
    ..Due to the complexity of the fractured bedrock aquifers in the region, well depth and related variables also are not significant predictors...
  57. pmc Bladder cancer mortality and private well use in New England: an ecological study
    Joseph D Ayotte
    US Geological Survey, New Hampshire Vermont Water Science Center, Pembroke, USA
    J Epidemiol Community Health 60:168-72. 2006
    ..To investigate the possible relation between bladder cancer mortality among white men and women and private water use in New England, USA, where rates have been persistently raised and use of private water supplies (wells) common...
  58. pmc Added sugar and sugar-sweetened foods and beverages and the risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study
    Ying Bao
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 88:431-40. 2008
    ..Although it has been hypothesized that hyperglycemia, hyperinsulinemia, and insulin resistance are involved in the development of pancreatic cancer, results from epidemiologic studies of added sugar intake are inconclusive...