R C Sills

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. request reprint
    Sills R, Hailey J, Neal J, Boorman G, Haseman J, Melnick R. Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies. Toxicol Pathol. 1999;27:589-99 pubmed
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    Sills R, Hong H, Boorman G, Devereux T, Melnick R. Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years. Chem Biol Interact. 2001;135-136:373-86 pubmed
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    Sills R, Hong H, Melnick R, Boorman G, Devereux T. High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadie. Carcinogenesis. 1999;20:657-62 pubmed
    ..The major finding of K-ras A-->T transversions in lung and Harderian gland neoplasms suggests that this mutation may be important for tumor induction by this class of carcinogens...
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    Sills R, Valentine W, Moser V, Graham D, Morgan D. Characterization of carbon disulfide neurotoxicity in C57BL6 mice: behavioral, morphologic, and molecular effects. Toxicol Pathol. 2000;28:142-8 pubmed
    ..These data provide supportive evidence that covalent cross-linking of neurofilament proteins is a significant feature of the axonal swellings in mice produced by inhalation exposure to CS2...
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    Sills R, Morgan D, Herr D, Little P, George N, Ton T, et al. Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats. Toxicol Pathol. 2004;32:501-10 pubmed
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    Sills R, Harry G, Valentine W, Morgan D. Interdisciplinary neurotoxicity inhalation studies: carbon disulfide and carbonyl sulfide research in F344 rats. Toxicol Appl Pharmacol. 2005;207:245-50 pubmed
    ..A decrease in cytochrome oxidase activity was considered to be a contributing factor to the pathogenesis of carbonyl sulfide neurotoxicity...