R C Sills

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis
    R C Sills
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences PO Box 12233, Research Triangle Park, NC 27709, USA
    Carcinogenesis 25:605-12. 2004
  2. ncbi request reprint Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats
    Robert C Sills
    Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:501-10. 2004
  3. ncbi request reprint Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years
    R C Sills
    Laboratory of Experimental Pathology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 135:373-86. 2001
  4. ncbi request reprint Characterization of carbon disulfide neurotoxicity in C57BL6 mice: behavioral, morphologic, and molecular effects
    R C Sills
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:142-8. 2000
  5. ncbi request reprint Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies
    R C Sills
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:589-99. 1999
  6. ncbi request reprint New models for assessing carcinogenesis: an ongoing process
    R C Sills
    Laboratory of Experimental Pathology, MD B3 08, National Institute Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Toxicol Lett 120:187-98. 2001
  7. doi request reprint Gene expression, biomarkers, and glial cells in nervous system diseases
    Robert C Sills
    National Toxicology Program, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 39:97-8. 2011
  8. ncbi request reprint High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene
    R C Sills
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:657-62. 1999
  9. ncbi request reprint Interdisciplinary neurotoxicity inhalation studies: carbon disulfide and carbonyl sulfide research in F344 rats
    Robert C Sills
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, 111 Alexander Drive, South Campus, MD B3 08, PO Box 12233, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 207:245-50. 2005
  10. ncbi request reprint Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose-response with 1,3-butadiene in mice
    R L Melnick
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:867-78. 1999

Collaborators

Detail Information

Publications51

  1. ncbi request reprint o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis
    R C Sills
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences PO Box 12233, Research Triangle Park, NC 27709, USA
    Carcinogenesis 25:605-12. 2004
    ..These alterations, which are hallmarks of human colon cancer, probably contributed to the pathogenesis of the large intestinal carcinomas in mice following o-nitrotoluene exposure...
  2. ncbi request reprint Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats
    Robert C Sills
    Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:501-10. 2004
    ....
  3. ncbi request reprint Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years
    R C Sills
    Laboratory of Experimental Pathology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 135:373-86. 2001
    ....
  4. ncbi request reprint Characterization of carbon disulfide neurotoxicity in C57BL6 mice: behavioral, morphologic, and molecular effects
    R C Sills
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:142-8. 2000
    ..These data provide supportive evidence that covalent cross-linking of neurofilament proteins is a significant feature of the axonal swellings in mice produced by inhalation exposure to CS2...
  5. ncbi request reprint Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies
    R C Sills
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:589-99. 1999
    ....
  6. ncbi request reprint New models for assessing carcinogenesis: an ongoing process
    R C Sills
    Laboratory of Experimental Pathology, MD B3 08, National Institute Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Toxicol Lett 120:187-98. 2001
    ..The examples will highlight possible ways genetically altered mice may be integrated into a comprehensive research and testing strategy and thereby provide an improved estimation of human health risks...
  7. doi request reprint Gene expression, biomarkers, and glial cells in nervous system diseases
    Robert C Sills
    National Toxicology Program, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 39:97-8. 2011
    ..This overview highlights the major themes of the presentations in General Session 3; these themes are covered in greater detail in four papers in this issue of Toxicologic Pathology...
  8. ncbi request reprint High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene
    R C Sills
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:657-62. 1999
    ..The major finding of K-ras A-->T transversions in lung and Harderian gland neoplasms suggests that this mutation may be important for tumor induction by this class of carcinogens...
  9. ncbi request reprint Interdisciplinary neurotoxicity inhalation studies: carbon disulfide and carbonyl sulfide research in F344 rats
    Robert C Sills
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, 111 Alexander Drive, South Campus, MD B3 08, PO Box 12233, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 207:245-50. 2005
    ..A decrease in cytochrome oxidase activity was considered to be a contributing factor to the pathogenesis of carbonyl sulfide neurotoxicity...
  10. ncbi request reprint Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose-response with 1,3-butadiene in mice
    R L Melnick
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:867-78. 1999
    ..Cancer potency of chloroprene is greater in the mouse lung than in the rat lung, but greater in the rat kidney than in the mouse kidney and nearly equivalent in the mammary gland of each species...
  11. ncbi request reprint High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years
    S Hayashi
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 29:422-9. 2001
    ..major finding of A to T transversions or A to G transitions in forestomach and lung tumors suggests that ADBAQ or its metabolites target adenine bases in the ras proto-oncogenes and that these mutations play a dominant role in multi-organ..
  12. ncbi request reprint Chemical-specific alterations in ras, p53, and beta-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years
    H L Hong
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 191:227-34. 2003
    ..It also suggests that these mutations play a role in the pathogenesis of the respective hemangiosarcomas in B6C3F1(1) mice...
  13. ncbi request reprint Inhalation toxicity and carcinogenicity studies of cobalt sulfate
    J R Bucher
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 49:56-67. 1999
    ..Adrenal pheochromocytomas were increased in female rats, and possibly in male rats...
  14. ncbi request reprint Loss of E-cadherin expression in gastric intestinal metaplasia and later stage p53 altered expression in gastric carcinogenesis
    T R Devereux
    Laboratory of Experimental Pathology and NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Exp Toxicol Pathol 53:237-46. 2001
    ..These results suggest that the Wnt signaling pathway is not upregulated in this type of cancer...
  15. ncbi request reprint Effect of 26 week magnetic field exposures in a DMBA initiation-promotion mammary gland model in Sprague-Dawley rats
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:899-904. 1999
    ..This study does not support the hypothesis that magnetic field exposure can promote breast cancer in this rat model...
  16. ncbi request reprint Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    N J Walker
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 54:330-7. 2000
    ....
  17. ncbi request reprint Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency) magnetic fields in F344/N rats
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:267-78. 1999
    ..These data, when considered as a whole, are interpreted as indicating that chronic exposure to pure linearly polarized 60 Hz magnetic fields has little or no effect on cancer development in the F344/N rat...
  18. ncbi request reprint Frequency of ras mutations in liver neoplasms from B6C3F1 mice exposed to tetrafluoroethylene for two years
    H H Hong
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:646-50. 1998
    ..The ras mutation frequency and spectrum were similar to those of the structurally related chemical tetrachloroethylene...
  19. ncbi request reprint Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice
    Yongbaek Kim
    Laboratory of Experimental Pathology National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:307-12. 2005
    ..The observed findings are similar in part to the genetic alterations reported in human brain tumors...
  20. ncbi request reprint Comparative carcinogenicity of 1,3-butadiene, isoprene, and chloroprene in rats and mice
    R L Melnick
    National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 135:27-42. 2001
    ..Epidemiology data for isoprene and chloroprene are not considered adequate to evaluate the potential carcinogenicity of these agents in humans...
  21. ncbi request reprint Two-year and lifetime toxicity and carcinogenicity studies of ozone in B6C3F1 mice
    R A Herbert
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:539-48. 1996
    ..5 or 1.0 ppm of ozone for 2 yrs, which persist with continued exposure to 30 mo. It is uncertain whether or not the marginal increase (p > 0.05) of alveolar/bronchiolar neoplasms in male B6C3F1 mice resulted from exposure to ozone...
  22. ncbi request reprint Predominant K-ras codon 12 G --> A transition in chemically induced lung neoplasms in B6C3F1 mice
    Thai Vu T Ton
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:16-21. 2004
    ....
  23. ncbi request reprint Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344/N rats and B6C3F1 mice
    P C Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 82:399-412. 2008
    ..Under these experimental conditions, carcinogenic activity of 2MI was demonstrated in male and female rats and mice...
  24. ncbi request reprint Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice
    M J Hooth
    National Institute of Environmental Health Sciences, Mail Drop EC 35, 79 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 42:1757-68. 2004
    ..Squamous cell papillomas and carcinomas of the forestomach were observed in male and female mice but the incidences were within the NTP historical control range and were not considered to be related to trans-cinnamaldehyde exposure...
  25. ncbi request reprint Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years
    H H Hong
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:529-34. 2000
    ....
  26. doi request reprint Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors
    Nobuko Wakamatsu
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:743-52. 2008
    ..The gene expression analysis suggested the formation of alveolar/bronchiolar carcinomas in cumene-exposed mice typically involves mutation of K-ras, which results in increased Erk MAP kinase signaling and modification of histones...
  27. ncbi request reprint Neurotoxicity produced by dibromoacetic acid in drinking water of rats
    V C Moser
    Neurotoxicology Division, NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
    Toxicol Sci 79:112-22. 2004
    ..2 g/l, lowest concentration tested), whereas this dosage was a no-effect level for neuropathological changes. These studies suggest that neurotoxicity should be considered in the overall hazard evaluation of haloacetic acids...
  28. ncbi request reprint Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene
    Thai Vu Ton
    Environmental Toxicology Program and Environmental Carcinogenesis Program, National Institute of Environmental Health Sciences, MD B3 08, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 166:112-20. 2007
    ....
  29. ncbi request reprint Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice
    Christopher D Houle
    Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 34:752-62. 2006
    ..Our results demonstrate that p53 and H-ras mutations are relatively common in control and chemically induced mouse mammary carcinomas although both chemicals can alter the mutational spectra and more commonly induce concurrent mutations...
  30. pmc Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer
    Nobuko Wakamatsu
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 35:75-80. 2007
    ..In this report, the major known molecular alterations in lung tumorigenesis of mice are reviewed and compared to those in humans...
  31. pmc K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse
    Hue Hua L Hong
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 35:81-5. 2007
    ..This suggests that EO specifically targets the K-ras gene in multiple tissue types and that this event is a critical component of EO-induced tumorigenesis...
  32. pmc Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene
    Hue Hua L Hong
    1 Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:720-6. 2008
    ..The pattern of mutations identified in the lung tumors suggests that DNA damage and genomic instability may be contributing factors to the mutation profile and development of lung cancer in mice exposed to cumene...
  33. pmc A review of the molecular mechanisms of chemically induced neoplasia in rat and mouse models in National Toxicology Program bioassays and their relevance to human cancer
    Mark J Hoenerhoff
    Cellular and Molecular Pathology Branch, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27519, USA
    Toxicol Pathol 37:835-48. 2009
    ..These studies also emphasize the importance of molecular evaluation of chemically induced rodent tumors for providing greater public health significance for NTP evaluated compounds...
  34. ncbi request reprint Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT
    Hue Hua L Hong
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 48:299-306. 2007
    ....
  35. ncbi request reprint Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years
    Theodora R Devereux
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, PO Box 12233, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Carcinogenesis 23:1737-43. 2002
    ..These results suggest that MAPK is activated during vanadium pentoxide-induced B6C3F1 mouse lung tumorigenesis following K-ras mutation and loss of the wild-type K-ras allele...
  36. ncbi request reprint Applications of magnetic resonance microscopy
    Robert R Maronpot
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:42-8. 2004
    ..More specifically, this application is the use of magnetic resonance microscopy (MRM) in conjunction with new staining methodologies that now make MRM routinely available to the widest range of investigators...
  37. ncbi request reprint Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy)
    Luca Lambertini
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:292-9. 2005
    ..The p53 mutational frequency and patterns from our study were different from those reported in human PUVA-type tumors...
  38. ncbi request reprint Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks
    Daniel L Morgan
    Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 200:131-45. 2004
    ..Our studies demonstrate that this environmental air contaminant has the potential to cause a wide spectrum of brain lesions that are dependent on the degree and duration of exposure...
  39. doi request reprint Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice
    S A Lahousse
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Vet Pathol 48:875-84. 2011
    ..These data suggest that formation of hepatocellular adenomas and carcinomas in oxazepam-exposed mice involves alteration of the Wnt signaling pathway, oxidative stress, and potential epigenetic alterations...
  40. doi request reprint Commentary: update on animal models for NTP studies
    Angela P King-Herbert
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences National Toxicology Program NIEHS NTP, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 38:180-1. 2010
    ..The use of multiple strains of mice will be explored through a new branch within the NTP, the Host Susceptibility Branch. Several rat models were evaluated; the Harlan Sprague Dawley rat is currently being used in the NTP studies...
  41. ncbi request reprint Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years
    Shim Mo Hayashi
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 146:251-61. 2003
    ....
  42. doi request reprint K-ras cancer gene mutations in lung tumors from female Swiss (CD-1) mice exposed transplacentally to 3'-azido-3'-deoxythymidine
    Takatoshi Koujitani
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 49:720-6. 2008
    ..K-ras Codon 12 G-->T transversions (TGT mutations) may be induced by oxidative DNA damage and 8-oxoguanine (8-oxoG), while K-ras Codon 12 G-->C transversions (CGT mutations) may be due to further oxidative lesions of guanine and 8-oxoG...
  43. ncbi request reprint Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643
    Mari Iida
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
    Carcinogenesis 24:757-70. 2003
    ....
  44. ncbi request reprint Neurotoxicological evaluation of two disinfection by-products, bromodichloromethane and dibromoacetonitrile, in rats
    Virginia C Moser
    Neurotoxicology Division, NHEERL ORD, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 230:137-44. 2007
    ..Lowered fluid consumption was the most sensitive and consistent endpoint in the present studies. Thus, unlike the haloacetic acids, neurotoxicity may not be a concern for toxicity of halomethanes or haloacetonitriles...
  45. ncbi request reprint Inhalational exposure to carbonyl sulfide produces altered brainstem auditory and somatosensory-evoked potentials in Fischer 344N rats
    David W Herr
    Neurotoxicology Division, MD B105 05, NHEERL, ORD, USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:118-35. 2007
    ..This series of experiments demonstrates that COS produces changes in brainstem auditory and cortical somatosensory neurophysiological responses that correlate with previously described histopathological damage...
  46. ncbi request reprint Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens
    Mari Iida
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
    Carcinogenesis 26:689-99. 2005
    ....
  47. ncbi request reprint Expression of potential beta-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice
    Colleen H Anna
    Laboratory of Molecular Carcinogenesis NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 190:135-45. 2003
    ..Moreover, it is likely increased cyclin D1 expression results at least in part from Catnb mutation, beta-catenin accumulation, and increased Wnt signaling...
  48. ncbi request reprint Major carcinogenic pathways identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats
    Yongbaek Kim
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, MD B3 08, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 214:144-51. 2006
    ..This study demonstrated that mesotheliomas in rats exposed to o-NT- and BCA were similar to mesotheliomas in humans, at least at the cellular and molecular level...
  49. ncbi request reprint Overview of the molecular biology of hepatocellular neoplasms and hepatoblastomas of the mouse liver
    Yongbaek Kim
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:175-80. 2005
    ..Cyclin D1 may provide an advantage during tumor progression of hepatocellular neoplasms and hepatoblastomas. The review will also focus on other genes which are important in mouse and human liver tumors...
  50. ncbi request reprint Epididymal sperm granuloma induced by chronic administration of 2-methylimidazole in B6C3F1 mice
    Yoshiro Tani
    Laboratory of Experimental Pathology, National Institute of Environmental Sciences, NIH, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 33:313-9. 2005
    ..The results imply that 2-year treatment of B6C3F1 mice with 2-MI can induce epididymal SGs, primarily followed by more severe testicular GEA. The potential mechanism of SG induction by 2-MI is discussed...
  51. ncbi request reprint Hepatoblastomas in mice in the US National Toxicology Program (NTP) studies
    Vladimir S Turusov
    NN Blokhin Cancer Research Centre, Moscow, Russian Federation
    Toxicol Pathol 30:580-91. 2002
    ..Therefore, it seems reasonable to combine the incidence of mice with hepatoblastomas and the incidence of mice with hepatocellular carcinomas in hazard identification studies...