R C Sills
Affiliation: National Institutes of Health
Sills R, Hailey J, Neal J, Boorman G, Haseman J, Melnick R. Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies. Toxicol Pathol. 1999;27:589-99 pubmed
Sills R, Hong H, Boorman G, Devereux T, Melnick R. Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years. Chem Biol Interact. 2001;135-136:373-86 pubmed
Sills R, Hong H, Melnick R, Boorman G, Devereux T. High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadie. Carcinogenesis. 1999;20:657-62 pubmed
..The major finding of K-ras A-->T transversions in lung and Harderian gland neoplasms suggests that this mutation may be important for tumor induction by this class of carcinogens...
Sills R, Valentine W, Moser V, Graham D, Morgan D. Characterization of carbon disulfide neurotoxicity in C57BL6 mice: behavioral, morphologic, and molecular effects. Toxicol Pathol. 2000;28:142-8 pubmed
..These data provide supportive evidence that covalent cross-linking of neurofilament proteins is a significant feature of the axonal swellings in mice produced by inhalation exposure to CS2...
Sills R, Morgan D, Herr D, Little P, George N, Ton T, et al
. Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats. Toxicol Pathol. 2004;32:501-10 pubmed
Sills R, Harry G, Valentine W, Morgan D. Interdisciplinary neurotoxicity inhalation studies: carbon disulfide and carbonyl sulfide research in F344 rats. Toxicol Appl Pharmacol. 2005;207:245-50 pubmed
..A decrease in cytochrome oxidase activity was considered to be a contributing factor to the pathogenesis of carbonyl sulfide neurotoxicity...