Alice J Sigurdson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Genetic predisposition to radiation-related cancer and potential implications for risk assessment
    A J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7060, MSC 7238, Bethesda, MD 20892, USA
    Ann ICRP 41:108-16. 2012
  2. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  3. ncbi request reprint Feasibility of assessing the carcinogenicity of neutrons among neutron therapy patients
    Alice J Sigurdson
    Radiation Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Bethesda, Maryland 20892 7238, USA
    Radiat Res 157:483-9. 2002
  4. pmc Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7060, MSC 7238, Bethesda, MD, 20892 7238, USA
    Breast Cancer Res Treat 118:177-84. 2009
  5. pmc Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
    Radiat Res 171:77-88. 2009
  6. pmc Routine diagnostic X-ray examinations and increased frequency of chromosome translocations among U.S. radiologic technologists
    Alice J Sigurdson
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:8825-31. 2008
  7. ncbi request reprint Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
    Lancet 365:2014-23. 2005
  8. ncbi request reprint DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892 7238, USA
    Mutat Res 586:173-88. 2005
  9. ncbi request reprint Long-term storage and recovery of buccal cell DNA from treated cards
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, Maryland 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 15:385-8. 2006
  10. ncbi request reprint Polymorphisms in apoptosis- and proliferation-related genes, ionizing radiation exposure, and risk of breast cancer among U.S. Radiologic Technologists
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 16:2000-7. 2007

Detail Information

Publications67

  1. doi request reprint Genetic predisposition to radiation-related cancer and potential implications for risk assessment
    A J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7060, MSC 7238, Bethesda, MD 20892, USA
    Ann ICRP 41:108-16. 2012
    ..The conclusions in ICRP Publications 79 and 103 appear relevant today...
  2. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  3. ncbi request reprint Feasibility of assessing the carcinogenicity of neutrons among neutron therapy patients
    Alice J Sigurdson
    Radiation Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Bethesda, Maryland 20892 7238, USA
    Radiat Res 157:483-9. 2002
    ....
  4. pmc Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7060, MSC 7238, Bethesda, MD, 20892 7238, USA
    Breast Cancer Res Treat 118:177-84. 2009
    ..06). We found suggestive evidence that common variants in selected estrogen metabolizing genes may modify the association between ionizing radiation exposure and breast cancer risk...
  5. pmc Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
    Radiat Res 171:77-88. 2009
    ..Other pathways such as genes in double-strand break repair, apoptosis and genes related to proliferation should also be pursued...
  6. pmc Routine diagnostic X-ray examinations and increased frequency of chromosome translocations among U.S. radiologic technologists
    Alice J Sigurdson
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:8825-31. 2008
    ..The slope estimate was consistent with expectation based on cytogenetic experience and atomic bomb survivor data...
  7. ncbi request reprint Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
    Lancet 365:2014-23. 2005
    ..We aimed to quantify the long-term risk of thyroid cancer after radiotherapy and chemotherapy...
  8. ncbi request reprint DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892 7238, USA
    Mutat Res 586:173-88. 2005
    ..Measuring this DNA damage phenotype may contribute to the identification of susceptible sub-groups. Our observations require replication in a prospective study with a large number of pre-diagnostic samples...
  9. ncbi request reprint Long-term storage and recovery of buccal cell DNA from treated cards
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, Maryland 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 15:385-8. 2006
    ..Using these methods, treated cards did not consistently provide sufficient quantities of buccal cell gDNA after 7 years of storage for genotyping or WGA...
  10. ncbi request reprint Polymorphisms in apoptosis- and proliferation-related genes, ionizing radiation exposure, and risk of breast cancer among U.S. Radiologic Technologists
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 16:2000-7. 2007
    ..For this reason, potential modification of the relationship between ionizing radiation exposure and breast cancer risk by polymorphic apoptosis gene variants have not been investigated among radiation-exposed women...
  11. ncbi request reprint Cosmic radiation exposure and cancer risk among flight crew
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7238, USA
    Cancer Invest 22:743-61. 2004
    ..To respond responsibly to the real and perceived risks associated with flying, more extensive data are needed, but special efforts should be considered to ensure new projects can genuinely add to our current knowledge...
  12. pmc Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 32:69-73. 2011
    ..02), supporting the notion the assay may be a measure of cancer susceptibility. The Comet and HCR assays were unrelated to lung cancer risk...
  13. pmc Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Bethesda, Maryland, 20892 7238, USA
    BMC Cancer 4:9. 2004
    ..Thus, 19 single nucleotide polymorphisms (SNPs) in eight genes involved in base excision repair (XRCC1, APEX, POLD1), BRCA1 protein interaction (BRIP1, ZNF350, BRCA2), and growth regulation (TGFss1, IGFBP3) were evaluated...
  14. ncbi request reprint Second cancers after radiotherapy: any evidence for radiation-induced genomic instability?
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892 7238, USA
    Oncogene 22:7018-27. 2003
    ....
  15. ncbi request reprint Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
    Int J Cancer 122:177-82. 2008
    ..The suggestive evidence found for modification of radiation-related breast cancer risk for 5 of the 55 SNPs evaluated requires confirmation in larger studies of women with quantified radiation breast doses in the low-to-moderate range...
  16. pmc A prospective study of medical diagnostic radiography and risk of thyroid cancer
    Gila Neta
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Am J Epidemiol 177:800-9. 2013
    ....
  17. doi request reprint Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists
    Preetha Rajaraman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Int J Cancer 123:2713-6. 2008
    ..1-21.3; EOR/Gy(AC/CC) = 0.6, 95% CI = <0, 4.6; p(het) = 0.01). These results suggest that common variants in nucleotide excision repair genes may modify the association between occupational radiation exposure and breast cancer risk...
  18. pmc Common genetic variants in metabolism and detoxification pathways and the risk of papillary thyroid cancer
    Briseis Aschebrook-Kilfoy
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Relat Cancer 19:333-44. 2012
    ..Larger studies with improved exposure assessment should address potential modification of PTC risk by alcohol and tobacco intake to confirm or refute our findings...
  19. ncbi request reprint Thyroid cancer in childhood cancer survivors: a detailed evaluation of radiation dose response and its modifiers
    Cécile M Ronckers
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland
    Radiat Res 166:618-28. 2006
    ..In summary, we applied models derived from radiobiology to describe the radiation dose-response curve for thyroid cancer in an epidemiological study and found convincing evidence for a downturn in risk at high doses...
  20. ncbi request reprint Retrospective biodosimetry among United States radiologic technologists
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Radiat Res 167:727-34. 2007
    ..S. radiologic technologists...
  21. pmc Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 17:2007-11. 2008
    ..001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway...
  22. ncbi request reprint Breast cancer incidence in U.S. radiologic technologists
    Michele Morin Doody
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7238, USA
    Cancer 106:2707-15. 2006
    ....
  23. ncbi request reprint Lung cancer risk among US radiologic technologists, 1983-1998
    Preetha Rajaraman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892 7238, USA
    Int J Cancer 119:2481-6. 2006
    ..Overall, we find very limited evidence that chronic low-to-moderate dose occupational exposure increased lung cancer risk in the US Radiologic Technologist cohort...
  24. pmc Risk of cataract after exposure to low doses of ionizing radiation: a 20-year prospective cohort study among US radiologic technologists
    Gabriel Chodick
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7238, USA
    Am J Epidemiol 168:620-31. 2008
    ....
  25. pmc Increased frequency of chromosome translocations associated with diagnostic x-ray examinations
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Radiat Res 170:149-55. 2008
    ..002 to 0.013; P = 0.01). Chromosome damage has been linked with elevated cancer risk, and we found that cumulative radiation exposure from medical X-ray examinations was associated with increased numbers of chromosome translocations...
  26. pmc Common single nucleotide polymorphisms in genes related to immune function and risk of papillary thyroid cancer
    Alina V Brenner
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
    PLoS ONE 8:e57243. 2013
    ..Our results require replication but suggest that the SERPINA5 gene, which codes for the protein C inhibitor involved in many biological processes including inflammation, may be a new susceptibility locus for PTC...
  27. pmc Common genetic variants in sex hormone pathway genes and papillary thyroid cancer risk
    Sara J Schonfeld
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7238, USA
    Thyroid 22:151-6. 2012
    ..We hypothesized that polymorphic variation in hormone pathway genes is associated with the risk of developing papillary thyroid cancer...
  28. doi request reprint No evidence for differences in DNA damage assessed before and after a cancer diagnosis
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 17:990-4. 2008
    ..More work is needed to characterize the effect of cancer diagnosis on other phenotypic assays...
  29. pmc Interventional radiography and mortality risks in U.S. radiologic technologists
    Martha S Linet
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7238, USA
    Pediatr Radiol 36:113-20. 2006
    ..The present study cannot rule out increased risks of cerebrovascular disease, specific cancers, and diseases with low case-fatality rates or a long latency period preceding death...
  30. pmc Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists
    Sara J Schonfeld
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, 6120 Executive Blvd MSC 7238, Bethesda, MD 20892, USA
    Cancer Causes Control 21:1857-66. 2010
    ..Polymorphic variation in oxidative stress and inflammatory-mediated pathway genes may modify radiation-related breast cancer risk...
  31. ncbi request reprint Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologists
    Shinji Yoshinaga
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 115:828-34. 2005
    ..013 and 0.027, respectively). This study provides some evidence that chronic occupational exposure to IR at low to moderate levels can increase the risk of BCC, and that this risk may be modified by pigmentation characteristics...
  32. ncbi request reprint Smoking cigarettes before first childbirth and risk of breast cancer
    Mina Ha
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Epidemiol 166:55-61. 2007
    ....
  33. pmc Common obesity-related genetic variants and papillary thyroid cancer risk
    Cari M Kitahara
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, EPS 7056, 6120 Executive Blvd, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 21:2268-71. 2012
    ....
  34. pmc Absolute risk prediction of second primary thyroid cancer among 5-year survivors of childhood cancer
    Stephanie A Kovalchik
    National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    J Clin Oncol 31:119-27. 2013
    ..We developed three absolute risk models for second primary thyroid cancer to assist with long-term clinical monitoring of childhood cancer survivors...
  35. pmc Common genetic variants in the 8q24 region and risk of papillary thyroid cancer
    Gila Neta
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Laryngoscope 122:1040-2. 2012
    ..A genome-wide scan in 26 families with papillary thyroid cancer (PTC) also found susceptibility loci in 8q24, supporting a closer evaluation of this chromosomal region in relation to the risk of sporadic PTC...
  36. pmc Chemotherapy and thyroid cancer risk: a report from the childhood cancer survivor study
    Lene H S Veiga
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard EPS 7051, MSC 7238, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 21:92-101. 2012
    ..We evaluated the chemotherapy-related risk of thyroid cancer in childhood cancer survivors and the possible joint effects of chemotherapy and radiotherapy...
  37. ncbi request reprint The mortality risk of smoking and obesity combined
    D Michal Freedman
    National Cancer Institute, Division of Epidemiology and Genetics, Bethesda, Maryland 20892, USA
    Am J Prev Med 31:355-62. 2006
    ..This nationwide, prospective mortality study of U.S. radiologic technologists was designed to evaluate the combined mortality risks of obesity and smoking...
  38. pmc Sunlight, polymorphisms of vitamin D-related genes and risk of breast cancer
    Barbara J Fuhrman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd MSC 7238, Bethesda, MD 20892 7238, USA
    Anticancer Res 33:543-51. 2013
    ..We investigated six polymorphisms in CYP24A1 and two in the VDR gene in association with breast cancer risk...
  39. pmc The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer
    Denise L Stredrick
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5060, USA
    Hum Mutat 27:538-44. 2006
    ..S49C, may be breast cancer susceptibility alleles. Because of their low frequency, even larger sample sizes are required to more firmly establish these associations...
  40. ncbi request reprint Cancer risks among radiologists and radiologic technologists: review of epidemiologic studies
    Shinji Yoshinaga
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Radiology 233:313-21. 2004
    ....
  41. ncbi request reprint Papillary thyroid cancer and polymorphic variants in TSHR- and RET-related genes: a nested case-control study within a cohort of U.S. radiologic technologists
    Stefan Lonn
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7053, 6120 Executive Boulevard, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 16:174-7. 2007
    ..7 (95% confidence interval, 1.1-11.8) for those who were homozygous (P(trend) = 0.001). Our data provide limited evidence that TSHR- and RET-related genes are related to papillary thyroid cancer risk...
  42. ncbi request reprint An application of a weighting method to adjust for nonresponse in standardized incidence ratio analysis of cohort studies
    R Sowmya Rao
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, Bethesda, MD 20892 7244, USA
    Ann Epidemiol 15:129-36. 2005
    ..We propose an analytic approach to reduce the impact of nonresponse in the analyses of SIRs...
  43. pmc Nonsteroidal antiinflammatory drugs and bladder cancer: a pooled analysis
    Sarah E Daugherty
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Am J Epidemiol 173:721-30. 2011
    ..04, 95% CI: 0.94, 1.15). Results suggest that nonaspirin NSAIDs, but not aspirin, are associated with a reduction in risk of bladder cancer, particularly for nonsmokers...
  44. pmc Common genetic variants related to genomic integrity and risk of papillary thyroid cancer
    Gila Neta
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Rockville, MD 20852 7244, USA
    Carcinogenesis 32:1231-7. 2011
    ..01, including HUS1, ALKBH3, HDAC4, BAK1, FAF1_CDKN2C, DACT3 and FZD6. Our results suggest a possible role of genes involved in maintenance of genomic integrity in relation to risk of PTC...
  45. ncbi request reprint Second cancers after radiotherapy: any evidence for radiation-induced genomic instability?
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland, USA
    Radiat Res 163:702-3. 2005
  46. ncbi request reprint Cancer incidence in the US radiologic technologists health study, 1983-1998
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer 97:3080-9. 2003
    ..However, characterizing risk at low doses requires large populations and ideally should include a large proportion of women, both of which rarely are available...
  47. pmc Hormone-related risk factors and postmenopausal breast cancer among nulliparous versus parous women: An aggregated study
    Sara J Schonfeld
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
    Am J Epidemiol 173:509-17. 2011
    ..Although the baseline risk is higher for nulliparous women compared with parous women, these results suggest that the associations between hormone-related factors and breast cancer do not differ by parity...
  48. ncbi request reprint Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals
    Joni L Rutter
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    Hum Mutat 22:121-8. 2003
    ..Further analysis in unselected cases will be required to know whether the identified variants play a role in genetic predisposition to breast cancer in the general population. Hum Mutat 22:121-128, 2003. Published 2003 Wiley-Liss, Inc...
  49. ncbi request reprint Can low-dose radiation increase risk of cardiovascular disease?
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet 372:697-9. 2008
  50. pmc International study of factors affecting human chromosome translocations
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Mutat Res 652:112-21. 2008
    ..Our data provide stable estimates of background TF by age, gender, race, and smoking status and suggest an acceleration of chromosome damage above age 60 and among those with a history of smoking cigarettes...
  51. ncbi request reprint Candidate single nucleotide polymorphism selection using publicly available tools: a guide for epidemiologists
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
    Am J Epidemiol 164:794-804. 2006
    ..The authors show a "real world" application of some existing bioinformatics tools for use in large epidemiologic studies and genetic analyses. They also reviewed alternative approaches that provide related information...
  52. pmc Marijuana use and testicular germ cell tumors
    Britton Trabert
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer 117:848-53. 2011
    ..The purpose of this study was to evaluate the relation between marijuana use and TGCTs in a hospital-based case-control study...
  53. ncbi request reprint Prenatal and perinatal risk factors and testicular cancer: a hospital-based case-control study
    Gabe S Sonke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Oncol Res 16:383-7. 2007
    ..For other factors, which are less direct measures of maternal estrogens, the modest associations found indicate a suggestive pattern in support of the excess estrogen hypothesis...
  54. pmc Variation in base excision repair capacity
    David M Wilson
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, United States
    Mutat Res 711:100-12. 2011
    ..We also discuss studies that associate BER deficiency with disease risk and the current state of BER capacity measurement assays...
  55. ncbi request reprint Trends in the incidence of testicular germ cell tumors in the United States
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7060, Bethesda, MD 20892 7234, USA
    Cancer 97:63-70. 2003
    ..This study was conducted to examine whether rates among white men in the United States have begun to stabilize and whether rates among black men in the United States have remained low...
  56. pmc The impact of delayed blood centrifuging, choice of collection tube, and type of assay on 25-hydroxyvitamin D concentrations
    Chu Ling Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Mailstop 7238, Rockville, MD 20852, USA
    Cancer Causes Control 21:643-8. 2010
    ..01), but the difference was significant only after substantial centrifuging delays (96 h). Our study suggests no necessity for requiring immediate processing of blood samples after collection or for the choice of a tube type or assay...
  57. ncbi request reprint Genetic variation and willingness to participate in epidemiologic research: data from three studies
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7091, MSC 7238, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 14:2449-53. 2005
    ..To the extent possible, investigators should evaluate their own genetic data for bias in response categories...
  58. doi request reprint The Increase in Thyroid Cancer Incidence During the Last Four Decades Is Accompanied by a High Frequency of BRAF Mutations and a Sharp Increase in RAS Mutations
    Chan Kwon Jung
    Department of Pathology C K J, Y E N, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 Department of Hospital Pathology C K J, The Catholic University of Korea, Seoul 137 701, Republic of Korea and Radiation Epidemiology and Biostatistics Branches J H L, A v B, M P L, A J S, Division of Cancer Epidemiology and Genetics and Cancer Genetics Branch S A W, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Clin Endocrinol Metab 99:E276-85. 2014
    ..The increased incidence is not likely to be due to environmental or therapeutic radiation because the percentage of RET/PTC rearrangements decreased. ..
  59. ncbi request reprint International patterns and trends in testis cancer incidence
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Int J Cancer 115:822-7. 2005
    ..Rates appear to be leveling off in some populations. The increases in testis cancer remain unexplained, although changes in the prevalence of important risk factors for this disease may be responsible...
  60. ncbi request reprint A case-control study of dietary phytoestrogens and testicular cancer risk
    Farzana L Walcott
    Department of Epidemiology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Nutr Cancer 44:44-51. 2002
    ..This hypothesis-generating study does not support the premise that dietary phytoestrogens increase or decrease testicular cancer risk in young men...
  61. ncbi request reprint Re: Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk
    Michael Hauptmann
    J Natl Cancer Inst 95:1251-2. 2003
  62. ncbi request reprint Effects of smoking and radiotherapy on lung carcinoma in breast carcinoma survivors
    Melissa B Ford
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 98:1457-64. 2003
    ..The authors analyzed smoking, radiation, and both exposures on lung carcinoma development in women who were treated previously for breast carcinoma...
  63. ncbi request reprint CHEK2:1100delC and female breast cancer in the United States
    Lutecia H Mateus Pereira
    Int J Cancer 112:541-3. 2004
  64. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...
  65. ncbi request reprint A common coding variant in CASP8 is associated with breast cancer risk
    Angela Cox
    Sheffield University Medical School, Sheffield S10 2RX, UK
    Nat Genet 39:352-8. 2007
    ..02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies...
  66. ncbi request reprint Comparison between cancers identified by state cancer registry, self-report, and death certificate in a prospective cohort study of US radiologic technologists
    D Michal Freedman
    Int J Epidemiol 35:495-7. 2006
  67. ncbi request reprint Thyroid cancer and employment as a radiologic technologist
    Erik W Zabel
    Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 119:1940-5. 2006
    ..04, 95% CI = 1.01-10.78). These data provide modest evidence of an association between employment as a radiologic technologist and thyroid cancer risk; however, the findings require confirmation with more accurate exposure models...