George K Siberry

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Phase I/II, open-label trial of safety and immunogenicity of meningococcal (groups A, C, Y, and W-135) polysaccharide diphtheria toxoid conjugate vaccine in human immunodeficiency virus-infected adolescents
    George K Siberry
    Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
    Pediatr Infect Dis J 29:391-6. 2010
  2. pmc Methicillin-Resistant Staphylococcus aureus Infections in Human Immunodeficiency Virus-Infected Children and Adolescents
    George K Siberry
    Pediatric, Adolescent and Maternal AIDS PAMA Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    AIDS Res Treat 2012:627974. 2012
  3. pmc Bone health in children and adolescents with perinatal HIV infection
    Thanyawee Puthanakit
    Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Int AIDS Soc 16:18575. 2013
  4. pmc Fracture risk by HIV infection status in perinatally HIV-exposed children
    George K Siberry
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 7510, USA
    AIDS Res Hum Retroviruses 28:247-50. 2012
  5. pmc Evaluation of viral load thresholds for predicting new World Health Organization stage 3 and 4 events in HIV-infected children receiving highly active antiretroviral therapy
    George K Siberry
    Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    J Acquir Immune Defic Syndr 60:214-8. 2012
  6. pmc Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants
    George K Siberry
    Pediatric Adolescent Maternal AIDS Branch, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS 26:1151-9. 2012
  7. pmc Safety and immunogenicity of quadrivalent meningococcal conjugate vaccine in 2- to 10-year-old human immunodeficiency virus-infected children
    George K Siberry
    Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
    Pediatr Infect Dis J 31:47-52. 2012
  8. pmc CD4+ lymphocyte-based immunologic outcomes of perinatally HIV-infected children during antiretroviral therapy interruption
    George K Siberry
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 57:223-9. 2011
  9. pmc Aggregate risk of cardiovascular disease among adolescents perinatally infected with the human immunodeficiency virus
    Kunjal Patel
    Department of Epidemiology, Harvard School of Public Health, Boston, MA K P, G R S Center for Biostatistics in AIDS Research, Boston, MA K P, J W, D L J, G R S, P L W Department of Pediatrics, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit S E L Division of Pediatric Clinical Research and Division of Pediatric Infectious Disease and Immunology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL D C L, G B S, J D W, T L M Saban Research Institute of Children s Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA M E G Section of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis L A D M Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA R B V D Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD G K S Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston W T S Department of Pediatrics, Northwestern University Feinberg School of Medicine, Children s Memorial Hospital, Chicago, IL L Y Division of Cardiology, University of Maryland School of Medicine, Brazil
    Circulation 129:1204-12. 2014
  10. pmc Antiretroviral treatment of US children with perinatally acquired HIV infection: temporal changes in therapy between 1991 and 2009 and predictors of immunologic and virologic outcomes
    Russell B Van Dyke
    Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA, USA
    J Acquir Immune Defic Syndr 57:165-73. 2011

Detail Information

Publications35

  1. pmc Phase I/II, open-label trial of safety and immunogenicity of meningococcal (groups A, C, Y, and W-135) polysaccharide diphtheria toxoid conjugate vaccine in human immunodeficiency virus-infected adolescents
    George K Siberry
    Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
    Pediatr Infect Dis J 29:391-6. 2010
    ..Quadrivalent meningococcal polysaccharide conjugate vaccine (MCV4) is routinely recommended for healthy youth in the United States, but there are no data about its use in HIV-infected people...
  2. pmc Methicillin-Resistant Staphylococcus aureus Infections in Human Immunodeficiency Virus-Infected Children and Adolescents
    George K Siberry
    Pediatric, Adolescent and Maternal AIDS PAMA Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    AIDS Res Treat 2012:627974. 2012
    ..MRSA occurred at a rate of 11.1 infections/1,000 PY in HIV-infected youth but invasive disease was uncommon. Geographic location, black race, and increased VL, but not immunosuppression, were independently associated with MRSA risk...
  3. pmc Bone health in children and adolescents with perinatal HIV infection
    Thanyawee Puthanakit
    Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Int AIDS Soc 16:18575. 2013
    ....
  4. pmc Fracture risk by HIV infection status in perinatally HIV-exposed children
    George K Siberry
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 7510, USA
    AIDS Res Hum Retroviruses 28:247-50. 2012
    ..2 per 1000 person-years and 1.1 per 1000 person-years, respectively. The incidence rate ratio was 1.1 (95% CI 0.2, 5.5). There was no evidence of a substantially increased risk of fracture in HIV-infected compared to HEU children...
  5. pmc Evaluation of viral load thresholds for predicting new World Health Organization stage 3 and 4 events in HIV-infected children receiving highly active antiretroviral therapy
    George K Siberry
    Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    J Acquir Immune Defic Syndr 60:214-8. 2012
    ..This study evaluated a wide range of viral load (VL) thresholds to identify a cut-point that best predicts new clinical events in children on stable highly active antiretroviral therapy (HAART)...
  6. pmc Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants
    George K Siberry
    Pediatric Adolescent Maternal AIDS Branch, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS 26:1151-9. 2012
    ..To evaluate the association of tenofovir disoproxil fumarate (TDF) use during pregnancy with early growth parameters in HIV-exposed, uninfected (HEU) infants...
  7. pmc Safety and immunogenicity of quadrivalent meningococcal conjugate vaccine in 2- to 10-year-old human immunodeficiency virus-infected children
    George K Siberry
    Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
    Pediatr Infect Dis J 31:47-52. 2012
    ....
  8. pmc CD4+ lymphocyte-based immunologic outcomes of perinatally HIV-infected children during antiretroviral therapy interruption
    George K Siberry
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 57:223-9. 2011
    ..To assess the characteristics and outcomes of antiretroviral treatment (ART) interruption (TI) in perinatally HIV-infected children...
  9. pmc Aggregate risk of cardiovascular disease among adolescents perinatally infected with the human immunodeficiency virus
    Kunjal Patel
    Department of Epidemiology, Harvard School of Public Health, Boston, MA K P, G R S Center for Biostatistics in AIDS Research, Boston, MA K P, J W, D L J, G R S, P L W Department of Pediatrics, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit S E L Division of Pediatric Clinical Research and Division of Pediatric Infectious Disease and Immunology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL D C L, G B S, J D W, T L M Saban Research Institute of Children s Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA M E G Section of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis L A D M Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA R B V D Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD G K S Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston W T S Department of Pediatrics, Northwestern University Feinberg School of Medicine, Children s Memorial Hospital, Chicago, IL L Y Division of Cardiology, University of Maryland School of Medicine, Brazil
    Circulation 129:1204-12. 2014
    ....
  10. pmc Antiretroviral treatment of US children with perinatally acquired HIV infection: temporal changes in therapy between 1991 and 2009 and predictors of immunologic and virologic outcomes
    Russell B Van Dyke
    Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA, USA
    J Acquir Immune Defic Syndr 57:165-73. 2011
    ..We sought to describe the disease status of a large cohort of such children and identify predictors of their current CD4 count and HIV viral load (VL)...
  11. pmc Predictors of highly active antiretroviral therapy utilization for behaviorally HIV-1-infected youth: impact of adult versus pediatric clinical care site
    Allison L Agwu
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Adolesc Health 50:471-7. 2012
    ..We assessed the impact of receiving care at an adult or pediatric HIV clinical site on initiation and discontinuation of the first HAART regimen in behaviorally infected youth (BIY)...
  12. pmc Disparities in antiretroviral treatment: a comparison of behaviorally HIV-infected youth and adults in the HIV Research Network
    Allison L Agwu
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 58:100-7. 2011
    ..We hypothesized that behaviorally HIV-infected youth (BIY) ages 18 to 24 years are less likely than adults (25 years or older) to receive HAART and, once initiated, more likely to discontinue their first HAART regimen...
  13. pmc Randomized controlled trial of cephalexin versus clindamycin for uncomplicated pediatric skin infections
    Aaron E Chen
    Johns Hopkins University, Department of Pediatrics, Division of Pediatric Emergency Medicine, CMSC 144, 600 N Wolfe St, Baltimore, MD 21287, USA
    Pediatrics 127:e573-80. 2011
    ..We hypothesized that clindamycin would be superior to cephalexin (an antibiotic without MRSA activity) for treatment of these infections...
  14. doi request reprint Bone mineral density in children and adolescents with perinatal HIV infection
    Linda A DiMeglio
    Section of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    AIDS 27:211-20. 2013
    ..To estimate prevalence of low bone mineral density (BMD) in perinatally HIV-infected (HIV+) and HIV-exposed but uninfected (HEU) children, and to determine predictors of BMD in HIV+...
  15. pmc Incidence of opportunistic illness before and after initiation of highly active antiretroviral therapy in children
    Steven R Nesheim
    From the Emory University School of Medicine Epidemiology Branch, Quantitative Sciences and Informatics Branch, Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention Northrop Grumman Inc, Atlanta, GA Pediatric Adolescent Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD Baylor College of Medicine, Houston, TX and University of South Florida School of Medicine, Tampa, FL
    Pediatr Infect Dis J 32:1089-95. 2013
    ..Little is known about immune reconstitution inflammatory syndrome in children in the United States...
  16. ncbi request reprint Discordance between Staphylococcus aureus nasal colonization and skin infections in children
    Aaron E Chen
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Pediatr Infect Dis J 28:244-6. 2009
    ..aureus, but significant discordance between nasal and wound isolates. Recurrent skin and soft tissue infections were common but unrelated to baseline methicillin-resistant S. aureus nasal colonization status...
  17. doi request reprint Cardiac biomarkers in HIV-exposed uninfected children
    James D Wilkinson
    Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    AIDS 27:1099-108. 2013
    ..To evaluate associations of cardiac biomarkers with in-utero antiretroviral drug exposures and cardiac function/structure measured by echocardiograms in HIV-exposed but uninfected (HEU) children...
  18. pmc Evaluation of risk for late language emergence after in utero antiretroviral drug exposure in HIV-exposed uninfected infants
    Mabel L Rice
    From the Speech, Language, Hearing Department, University of Kansas, Lawrence, KS Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD Bronx Lebanon Hospital Center, Albert Einstein College of Medicine, Bronx, NY Northwestern University Feinberg School of Medicine, Psychiatry and Behavioral Sciences, Chicago, IL Epidemiology and Statistics Program, Division of Scientific Programs, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD Department of Research Pediatrics, Maternal, Child and Adolescent Program for Infectious Diseases and Virology, Keck School of Medicine of USC, Los Angeles, CA Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA and National Institute of Mental Health, National Institutes of Health, Bethesda, MD
    Pediatr Infect Dis J 32:e406-13. 2013
    ..Safety is a concern for infants who were HIV-exposed but uninfected, particularly for neurodevelopmental problems, such as language delays...
  19. pmc Associations of medically documented psychiatric diagnoses and risky health behaviors in highly active antiretroviral therapy-experienced perinatally HIV-infected youth
    Suad Kapetanovic
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1276, USA
    AIDS Patient Care STDS 25:493-501. 2011
    ..33, p=0.015). There is a need for a continued close partnership between HIV specialty care providers and mental health services treating perinatally HIV-infected youth with an added focus on improving treatment adherence...
  20. pmc Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005
    Andrew P Steenhoff
    Department of Pediatrics, Children s Hospital Philadelphia, Pennsylvania, USA
    AIDS 25:717-20. 2011
    ..98; confidence interval 1.05-15.13) was associated with CAP. Herd immunity through pneumococcal immunization may have diluted the effect of individual immunization in this cohort...
  21. ncbi request reprint No decrease in clindamycin susceptibility despite increased use of clindamycin for pediatric community-associated methicillin-resistant Staphylococcus aureus skin infections
    Jillian M Szczesiul
    Department of Pharmacy, The Johns Hopkins Hospital, The Johns Hopkins University, Baltimore, MD, USA
    Pediatr Infect Dis J 26:852-4. 2007
    ..Despite a significant increase in empiric clindamycin use, 97% of community-associated-MRSA isolates retained susceptibility to clindamycin...
  22. pmc Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents
    George K Siberry
    Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Clin Immunol 142:201-8. 2012
    ..29%, p = 0.010). HIV-infected children and adolescents in this study had an increased incidence of asthma and AD, a finding critical for millions of HIV-infected children worldwide...
  23. pmc Infant growth outcomes after maternal tenofovir disoproxil fumarate use during pregnancy
    Carla E Ransom
    Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN Center for Biostatistics in AIDS Research and Department of Epidemiology, Harvard School of Public Health, Boston, MA Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD and Department of Obstetrics and Gynecology, Duke University Medical School, Durham, NC
    J Acquir Immune Defic Syndr 64:374-81. 2013
    ..To determine whether maternal use of tenofovir disoproxil fumarate for treatment of HIV in pregnancy predicts fetal and infant growth...
  24. doi request reprint Thinking about HIV infection
    Evelyn P Simpkins
    Division of General Pediatrics and Adolescent Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Pediatr Rev 30:337-48; quiz 349. 2009
    ..Recommendations for immunizations and chemoprophylaxis vary with the patient's CD4 count. Condoms made from latex, polyurethane, or other synthetic materials have been shown to decrease the transmission of STIs, including HIV infection...
  25. doi request reprint Antibody response to hepatitis A immunization among human immunodeficiency virus-infected children and adolescents
    George K Siberry
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Pediatr Infect Dis J 27:465-8. 2008
    ..In multivariate analysis, CD4 >or=25% and young age were independent predictors of HAV seropositivity. Of 7 children given a third HAV vaccine dose because of negative HAV antibody after 2 doses, 2 (29%) became seropositive...
  26. doi request reprint Growing up with HIV: children, adolescents, and young adults with perinatally acquired HIV infection
    Rohan Hazra
    Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Center for Research for Mothers and Children, National Institutes of Health, Rockville, Maryland 20852, USA
    Annu Rev Med 61:169-85. 2010
    ....
  27. ncbi request reprint Low prevalence of pertussis among children admitted with respiratory symptoms during respiratory syncytial virus season
    George K Siberry
    Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Infect Control Hosp Epidemiol 27:95-7. 2006
    ..6%) of 166 children admitted to the hospital during RSV season were Bordetella pertussis PCR positive during a nonepidemic period. These data show that screening may not be useful when pertussis prevalence is low...
  28. ncbi request reprint Evolving epidemiology of pediatric Staphylococcus aureus cutaneous infections in a Baltimore hospital
    Aaron E Chen
    Department of Pediatrics, The Johns Hopkins University, Baltimore, MD, USA
    Pediatr Emerg Care 22:717-23. 2006
    ....
  29. ncbi request reprint Increase in tuberculin skin test converters among health care workers after a change from Tubersol to Aplisol
    Kari A Gillenwater
    Department of Pediatrics, Johns Hopkins Medical Institutions, 200 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Infect Control 34:651-4. 2006
    ....
  30. pmc Prevalence and predictors of elevated aspartate aminotransferase-to-platelet ratio index in Latin American perinatally HIV-infected children
    George K Siberry
    From the Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda Westat, Rockville, MD Department of Infectious Diseases, Hospital Federal dos Servidores do Estado Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro Vertical Transmission Unit, Femina Hospital, Porto Alegre Department of Pediatrics, University of São Paulo Faculty of Medicine of Ribeirão Preto, Ribeirão Preto and Department of Pediatrics, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Pediatr Infect Dis J 33:177-82. 2014
    ..We characterized elevated aspartate aminotransferase-to-platelet ratio index (APRI), a marker of possible liver fibrosis, in perinatally HIV-infected children...
  31. pmc Preexposure prophylaxis for adolescents and young adults at risk for HIV infection: is an ounce of prevention worth a pound of cure?
    Jill E Pace
    Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 7510, USA
    Clin Infect Dis 56:1149-55. 2013
    ..YMSM and minority youth are at substantial HIV risk and urgently need effective HIV prevention tools for which the short and long-term benefits and risks have been carefully considered...
  32. ncbi request reprint Nontypeable Haemophilus influenzae meningitis complicated by hearing loss in a 9-year-old HIV-infected boy
    Allison George Agwu
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    AIDS Patient Care STDS 20:531-5. 2006
    ..Placement of cochlear implant improved hearing thresholds. Nontypeable H. influenzae meningitis and use of cochlear implants have not previously been in HIV-infected children...
  33. ncbi request reprint Immune reconstitution syndrome precipitated by bacille Calmette Guerin after initiation of antiretroviral therapy
    George K Siberry
    Division of Pediatric Infectious Diseases and General Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Pediatr Infect Dis J 25:648-9. 2006
    ..We report the earliest onset of BCG-related immune reconstitution syndrome developing 1 week after initiation of ART...
  34. pmc A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinoviruses
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA
    Am J Respir Crit Care Med 185:508-16. 2012
    ..Moreover, although several hypotheses have been advanced to explain virus-induced exacerbations, their mechanism remains unclear...
  35. pmc Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads
    Deborah Persaud
    Department of Pediatrics, Johns Hopkins University School of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 78:968-79. 2004
    ..Thus, in most children on HAART with clinically undetectable viremia, there is continued virus production without evolution of resistance in the protease gene...