Hong Bing Shu

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
    H B Shu
    National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Department of Immunology, Denver 80206, USA
    J Leukoc Biol 65:680-3. 1999
  2. ncbi B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1
    H B Shu
    Department of Immunology, National Jewish Medical and Research Center and University of Colorado School of Medicine, 1400 Jackson Street, K516c, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 97:9156-61. 2000
  3. ncbi Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways
    Ke Jun Han
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Biol Chem 279:15652-61. 2004
  4. ncbi PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis
    Jun Zhang
    National Jewish Medical and Research Center, 1400 Jackson Street, K516c, Denver, CO 80206, USA
    FEBS Lett 570:97-101. 2004
  5. ncbi TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis
    Liang Guo Xu
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Biol Chem 279:17278-82. 2004
  6. ncbi Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB
    Jun Zhang
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Biol Chem 279:17819-25. 2004
  7. ncbi Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1
    Liang Guo Xu
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    J Leukoc Biol 72:410-6. 2002
  8. ncbi Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1
    John K Cusick
    National Jewish Research Center, Department of Immunology, 1400 Jackson Street, Denver, CO 80220, USA
    Biochem Biophys Res Commun 340:535-43. 2006
  9. ncbi TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production
    Liang Guo Xu
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 169:6883-9. 2002
  10. ncbi VISA is an adapter protein required for virus-triggered IFN-beta signaling
    Liang Guo Xu
    Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Mol Cell 19:727-40. 2005

Research Grants

  1. AMID in Apoptosis and p53-Mediated Downstream Effects
    Hong Bing Shu; Fiscal Year: 2004
  2. Intracellular Signaling Triggered by Tall-1/BCMA
    Hong Bing Shu; Fiscal Year: 2005
  3. NKIP signaling and functions
    Hong Bing Shu; Fiscal Year: 2006

Collaborators

Detail Information

Publications42

  1. ncbi TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
    H B Shu
    National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Department of Immunology, Denver 80206, USA
    J Leukoc Biol 65:680-3. 1999
    ..Furthermore, TALL-1 expression is dramatically down-regulated by phorbol myristate acetate/ionomycin...
  2. ncbi B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1
    H B Shu
    Department of Immunology, National Jewish Medical and Research Center and University of Colorado School of Medicine, 1400 Jackson Street, K516c, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 97:9156-61. 2000
    ..The identification of BCMA as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases...
  3. ncbi Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways
    Ke Jun Han
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Biol Chem 279:15652-61. 2004
    ....
  4. ncbi PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis
    Jun Zhang
    National Jewish Medical and Research Center, 1400 Jackson Street, K516c, Denver, CO 80206, USA
    FEBS Lett 570:97-101. 2004
    ..Furthermore, PIASy also inhibits IRF-3, IRF-7 and Sendai virus-induced ISRE activation. Our results suggest that PIASy is an inhibitor of TRIF-induced ISRE and NF-kappaB activation but not apoptosis...
  5. ncbi TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis
    Liang Guo Xu
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Biol Chem 279:17278-82. 2004
    ..Our studies identified a novel TRAF family member that is involved in MEKK3 signaling and apoptosis...
  6. ncbi Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB
    Jun Zhang
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Biol Chem 279:17819-25. 2004
    ..Our findings suggest that ZUD is an inhibitor of NF-kappaB activation and that this protein may provide an alternative regulatory mechanism for NF-kappaB-mediated transcription...
  7. ncbi Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1
    Liang Guo Xu
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    J Leukoc Biol 72:410-6. 2002
    ..The identification of TALL-1-up-regulated genes will help explain the mechanisms of TALL-1-triggered biological and pathological effects and to identify molecular targets for intervention of lupus-like autoimmune diseases...
  8. ncbi Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1
    John K Cusick
    National Jewish Research Center, Department of Immunology, 1400 Jackson Street, Denver, CO 80220, USA
    Biochem Biophys Res Commun 340:535-43. 2006
    ..Additionally, OSR1 phosphorylated the RELT family members in an in vitro kinase assay. These results report two novel homologues of RELT that interact with RELT and are phosphorylated by the OSR1 kinase...
  9. ncbi TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production
    Liang Guo Xu
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 169:6883-9. 2002
    ..Moreover, overexpression of TRAF3 inhibits BAFF-R-mediated NF-kappaB activation and IL-10 production. Taken together, our findings suggest that TRAF3 is a negative regulator of BAFF-R-mediated NF-kappaB activation and IL-10 production...
  10. ncbi VISA is an adapter protein required for virus-triggered IFN-beta signaling
    Liang Guo Xu
    Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Mol Cell 19:727-40. 2005
    ..These findings suggest that VISA is critically involved in both virus-triggered TLR3-independent and TLR3-mediated antiviral IFN signaling...
  11. ncbi TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling
    Liang Hua Bin
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    J Biol Chem 278:24526-32. 2003
    ..Our findings suggest that TIRP is involved in IL-1-triggered NF-kappaB activation and functions upstream of IRAK, IRAK-2, TRAF6, and IKKbeta..
  12. ncbi Ligand-receptor binding revealed by the TNF family member TALL-1
    Yingfang Liu
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Nature 423:49-56. 2003
    ....
  13. ncbi Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair
    Liang Hua Bin
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 171:924-30. 2003
    ..Our findings suggest that UGRP1-MARCO is a ligand-receptor pair that is probably involved in inflammation and pathogen clearance in the lung...
  14. ncbi Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling
    Ke Jun Han
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 285:12543-50. 2010
    ..Finally, we demonstrated that TRIS was associated with TRIF upon TLR3 activation by poly(I-C). These findings reveal an unexpected mechanism of TLR3-mediated signaling...
  15. ncbi VISA is required for B cell expression of TLR7
    Liang Guo Xu
    Integrated Department of Immunology, University of Colorado School of Medicine, Denver, CO 80206, USA
    J Immunol 188:248-58. 2012
    ..Thus, our findings suggest an unexpected link between VISA-mediated cytosolic RLR signaling and autoimmunity...
  16. ncbi Regulation of IRF2 transcriptional activity by its sumoylation
    Ke Jun Han
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Biochem Biophys Res Commun 372:772-8. 2008
    ..Our findings suggest that sumoylation of IRF2 regulates its transcriptional activities...
  17. ncbi GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth
    Bicheng Zhang
    HHMI, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Cell Res 18:900-10. 2008
    ..When somewhat over- or underexpressed, GIDE slows or accelerates cell growth, respectively. These pro-apoptotic or growth inhibition effects of GIDE may account for its absence in tumor cells...
  18. ncbi Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands
    Yingfang Liu
    National Jewish Medical and Research Center, Integrated Department of Immunology, Denver, CO 80206, USA
    Cell 108:383-94. 2002
    ..Finally, we found the virus-like cluster of sTALL-1 exists in physiological condition. We propose that this virus-like assembly of sTALL-1 is the functional unit for TALL-1 in vivo...
  19. ncbi TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling
    Xiaoqin Su
    College of Life Sciences, Peking University, Beijing, China
    Eur J Immunol 36:199-206. 2006
    ..Our findings provide a novel mechanism for negative regulation of TRIF-mediated signaling...
  20. ncbi SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
    Jun Huang
    College of Life Sciences, Peking University, Beijing, China
    EMBO J 24:4018-28. 2005
    ..These findings suggest that SIKE is a physiological suppressor of IKKepsilon and TBK1 and plays an inhibitory role in virus- and TLR3-triggered IRF-3 but not NF-kappaB activation pathways...
  21. ncbi The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis
    Jun Huang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    FEBS Lett 580:940-7. 2006
    ....
  22. ncbi RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation
    Yang Tian
    College of Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 282:16776-82. 2007
    ..Taken together, our findings suggest that RBCK1 is involved in negative regulation of inflammatory signaling triggered by TNF and IL-1 through targeting TAB2/3 for degradation...
  23. ncbi Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK
    Rui Peng Wang
    College of Life Sciences, Peking University, Beijing, China
    Mol Immunol 45:1926-34. 2008
    ..These findings suggest that IKK alpha-mediated activation of NF-kappaB and IRF3/7 are differentially regulated by NIK, and NIK plays an important role in TLR7/9-mediated IFN-alpha production...
  24. ncbi Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling
    Fang Chen
    College of Life Sciences, Peking University, Beijing 100871, China
    Cell Signal 20:666-74. 2008
    ..These findings suggest that syntenin is a physiological suppressor of TRAF6 and plays an inhibitory role in IL-1R- and TLR4- mediated NF-kappaB activation pathways...
  25. ncbi The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members
    Jikun Zha
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China
    J Immunol 176:1072-80. 2006
    ..Taken together, our findings suggest that RFP negatively regulates signaling involved in the antiviral response and inflammation by targeting the IKKs...
  26. ncbi TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways
    Lianyun Li
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    J Cell Sci 118:555-63. 2005
    ..These data have established a physical and functional association between TRIP6 and RIP2, and suggest that RIP2's involvement in multiple NF-kappaB and ERK activation pathways is mediated through TRIP6...
  27. ncbi A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter
    Yan Yi Wang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    FEBS Lett 576:86-90. 2004
    ..These data suggest that A20 targets TRIF to inhibit TLR3-mediated induction of IFN-beta transcription and functions as a feedback negative regulator for TLR3 signaling and cellular anti-viral response...
  28. ncbi NIK is a component of the EGF/heregulin receptor signaling complexes
    Danying Chen
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    Oncogene 22:4348-55. 2003
    ..Our findings suggest that NIK is a component of the EGF/heregulin receptor signaling complexes and involved in NF-kappaB activation triggered by these receptors...
  29. ncbi A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation
    Danying Chen
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 277:15985-91. 2002
    ..Moreover, immunofluorescent staining indicates that ZIN is a cytoplasmic protein and that it colocalizes with RIP. Our findings suggest that ZIN is an inhibitor of TNF- and IL1-induced NF-kappa B activation pathways...
  30. ncbi Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription
    Jun Huang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    Biochem Biophys Res Commun 309:774-8. 2003
    ..Our findings suggest that SHIK is a negative regulator of NF-kappaB- and p53-mediated gene transcription...
  31. ncbi AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis
    Min Wu
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 277:25617-23. 2002
    ..Furthermore, AMID-induced apoptosis was independent of caspase activation and p53 and was not inhibited by Bcl-2. These findings suggest that AMID induces a novel caspase-independent apoptotic pathway...
  32. ncbi Identification of a nuclear protein that promotes NF-kappaB activation
    Danying Chen
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China
    Biochem Biophys Res Commun 310:720-4. 2003
    ..Immunofluorescent staining indicated that NKAP was localized in the nucleus. Our findings suggest that NKAP is a novel nuclear regulator of TNF- and IL-1-induced NF-kappaB activation...
  33. ncbi ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation
    Jun Huang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 279:16847-53. 2004
    ..Our findings suggest that ZNF216 and A20 have redundant and distinct roles in regulating NFkappaB activation and apoptosis...
  34. ncbi Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
    Robin Lesley
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143 USA
    Immunity 20:441-53. 2004
    ..These findings indicate that under conditions where BAFF levels are elevated, autoantigen-engaged cells will be rescued from rapid competitive elimination, predisposing to the development of autoimmune disease...
  35. ncbi RIP5 is a RIP-homologous inducer of cell death
    Jikun Zha
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    Biochem Biophys Res Commun 319:298-303. 2004
    ..However, RIP5-induced apoptotic morphology is not blocked by crmA. These findings suggest that RIP5 may induce both caspase-dependent apoptosis and caspase-independent cell death...
  36. ncbi SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription
    Min Wu
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 278:27072-9. 2003
    ..Taken together, these data suggest that SINK is critically involved in a novel negative feedback control pathway of NF-kappaB-induced gene expression...
  37. ncbi Regulation of tubulin synthesis and cell cycle progression in mammalian cells by gamma-tubulin-mediated microtubule nucleation
    Jun Zhou
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Department of Cell Biology, Emory University School of Medicine, 1648 Pierce Dtive, Atlanta, GA 30322, USA
    J Cell Biochem 84:472-83. 2002
    ..These results thus suggest that the number of microtubule nucleation sites, or even gamma-tubulin itself, might play an important role in the regulation of tubulin synthesis as well as cell cycle progression...
  38. ncbi Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling
    Lianyun Li
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1783:1140-9. 2008
    ..Interestingly, A20 mutants defective in membrane association also contain reduced NFkappaB inhibitory activity. These findings suggest the involvement of a lysosome-associated mechanism in A20-dependent termination of NFkappaB signaling...
  39. ncbi Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase
    Feici Diao
    College of Life Sciences, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 104:11706-11. 2007
    ..These findings suggest that DAK is a physiological suppressor of MDA5 and specifically inhibits MDA5- but not RIG-I-mediated innate antiviral signaling...
  40. ncbi Casper/c-FLIP is physically and functionally associated with NF-kappaB1 p105
    Zhiqin Li
    Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 10005, China
    Biochem Biophys Res Commun 309:980-5. 2003
    ..Furthermore, Casper and its C-terminal caspase-like domain inhibited p105 processing into p50. Our findings suggest that p105 is involved in Casper-mediated regulation of apoptosis and NF-kappaB activation...
  41. ncbi AMID is a p53-inducible gene downregulated in tumors
    Min Wu
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, PR China
    Oncogene 23:6815-9. 2004
    ..Furthermore, expression array analysis indicated that human AMID mRNA expression was downregulated in a majority of human tumors. Our findings point to the possibility that AMID is a p53-downstream gene involved in tumorigenesis...
  42. ncbi The short splice form of Casper/c-FLIP is a major cellular inhibitor of TRAIL-induced apoptosis
    Lianghua Bin
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson Street, K516c, Denver, CO 80206 USA
    FEBS Lett 510:37-40. 2002
    ..Retroviral-mediated transduction of Casper-S/c-FLIPs into Casper(-/-) EFs restored resistance to TRAIL. These data suggest that Casper-S/c-FLIPs is a major cellular inhibitor of TRAIL-induced apoptosis...

Research Grants8

  1. AMID in Apoptosis and p53-Mediated Downstream Effects
    Hong Bing Shu; Fiscal Year: 2004
    ..Successful completion of the proposed studies will help to understand the molecular mechanisms of caspase-independent apoptosis and roles of AMID in p53-mediated biological effects and tumorigenesis. ..
  2. Intracellular Signaling Triggered by Tall-1/BCMA
    Hong Bing Shu; Fiscal Year: 2005
    ..The genes and their protein products identified in this study may be used as molecular targets for drug development against certain immune-deficient and autoimmune diseases. ..
  3. NKIP signaling and functions
    Hong Bing Shu; Fiscal Year: 2006
    ..Successful completion of these studies will provide important basis for understanding the biochemical and molecular mechanisms of NKIP action in inflammation and innate immunity against viral infection. ..