Daniel Shriner

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Moving toward System Genetics through Multiple Trait Analysis in Genome-Wide Association Studies
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute Bethesda, MD, USA
    Front Genet 3:1. 2012
  2. pmc Multiple loci associated with renal function in African Americans
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, USA
    PLoS ONE 7:e45112. 2012
  3. pmc Joint ancestry and association testing in admixed individuals
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    PLoS Comput Biol 7:e1002325. 2011
  4. pmc Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate
    Georgina A Ankra-Badu
    Department of Poultry Science Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 11:107. 2010
  5. doi request reprint Approximate and exact tests of Hardy-Weinberg equilibrium using uncertain genotypes
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland 20892 5635, USA
    Genet Epidemiol 35:632-7. 2011
  6. pmc Mapping of disease-associated variants in admixed populations
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA
    Genome Biol 12:223. 2011
  7. pmc Investigating population stratification and admixture using eigenanalysis of dense genotypes
    D Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892 5635, USA
    Heredity (Edinb) 107:413-20. 2011
  8. pmc Mapping multiple quantitative trait loci under Bayes error control
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Institutes of Health, Bethesda, MD 20892, USA
    Genet Res (Camb) 91:147-59. 2009
  9. pmc A unified framework for multi-locus association analysis of both common and rare variants
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
    BMC Genomics 12:89. 2011
  10. pmc Transferability and fine-mapping of genome-wide associated loci for adult height across human populations
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e8398. 2009

Collaborators

Detail Information

Publications27

  1. pmc Moving toward System Genetics through Multiple Trait Analysis in Genome-Wide Association Studies
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute Bethesda, MD, USA
    Front Genet 3:1. 2012
    ..The application of network theory to genetics is termed systems genetics and has the potential to address long-standing questions in genetics about complex processes such as coordinate regulation, homeostasis, and pleiotropy...
  2. pmc Multiple loci associated with renal function in African Americans
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, USA
    PLoS ONE 7:e45112. 2012
    ..4% explained by the 24 loci in individuals of European ancestry. Our findings provide insight into the genetic basis of variation in renal function among admixed African Americans...
  3. pmc Joint ancestry and association testing in admixed individuals
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    PLoS Comput Biol 7:e1002325. 2011
    ..The fact that both loci showed ancestry effects may provide novel insight into the genetic architecture of fasting plasma glucose in individuals of African ancestry...
  4. pmc Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate
    Georgina A Ankra-Badu
    Department of Poultry Science Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 11:107. 2010
    ..We used Bayesian model selection to comprehensively map main, epistatic and sex-specific QTL in an F2 reciprocal intercross between two chicken lines divergently selected for high or low growth rate...
  5. doi request reprint Approximate and exact tests of Hardy-Weinberg equilibrium using uncertain genotypes
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland 20892 5635, USA
    Genet Epidemiol 35:632-7. 2011
    ..The tests are compatible with chip-based genotypes for single-nucleotide polymorphisms and copy number polymorphisms, imputed genotypes, and probabilistic assignments of genotype from variable-coverage sequence data...
  6. pmc Mapping of disease-associated variants in admixed populations
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA
    Genome Biol 12:223. 2011
    ..A more refined estimation of ancestry would benefit admixture mapping and association mapping, making disease loci identification in admixed populations more powerful...
  7. pmc Investigating population stratification and admixture using eigenanalysis of dense genotypes
    D Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892 5635, USA
    Heredity (Edinb) 107:413-20. 2011
    ..Velicer's minimum average partial test is implemented in R code and is suitable for genome-wide genotype data with or without population labels...
  8. pmc Mapping multiple quantitative trait loci under Bayes error control
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Institutes of Health, Bethesda, MD 20892, USA
    Genet Res (Camb) 91:147-59. 2009
    ..In the context of mapping QTLs for experimental crosses, the procedure is applicable to mapping main effects, gene-gene interactions and gene-environment interactions...
  9. pmc A unified framework for multi-locus association analysis of both common and rare variants
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
    BMC Genomics 12:89. 2011
    ..The union-intersection test is a composite test of association of genotype frequencies and differential correlation among markers...
  10. pmc Transferability and fine-mapping of genome-wide associated loci for adult height across human populations
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e8398. 2009
    ....
  11. pmc Practical considerations for imputation of untyped markers in admixed populations
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 5635, USA
    Genet Epidemiol 34:258-65. 2010
    ..For our admixed study sample, the optimal strategy involved imputing twice with the HapMap CEU and YRI reference panels separately and then merging the data sets...
  12. pmc A genome-wide association study of serum uric acid in African Americans
    Bashira A Charles
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
    BMC Med Genomics 4:17. 2011
    ....
  13. pmc Transferability and fine mapping of genome-wide associated loci for lipids in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    BMC Med Genet 13:88. 2012
    ....
  14. pmc C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans
    Ayo P Doumatey
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 21:3063-72. 2012
    ....
  15. pmc Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans
    Guanjie Chen
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 8004, USA
    Hum Mol Genet 21:4530-6. 2012
    ..TCERG1L is associated with plasma adiponectin, a key modulator of obesity, inflammation, IR and diabetes...
  16. pmc Development of admixture mapping panels for African Americans from commercial high-density SNP arrays
    Guanjie Chen
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    BMC Genomics 11:417. 2010
    ..The increased availability of dense marker data on commercial chips has made it feasible to develop panels wherein the markers need not be predetermined...
  17. pmc UGT1A1 is a major locus influencing bilirubin levels in African Americans
    Guanjie Chen
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Hum Genet 20:463-8. 2012
    ..In summary, UGT1A1 is a major locus influencing bilirubin levels and the results of this study promise to contribute to understanding of the etiology and treatment of hyperbilirubinaemia in African-ancestry populations...
  18. pmc The roles of IL-6, IL-10, and IL-1RA in obesity and insulin resistance in African-Americans
    Bashira A Charles
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 5635, USA
    J Clin Endocrinol Metab 96:E2018-22. 2011
    ..The aim of the study was to investigate the associations between IL-1 receptor antagonist (IL-1RA), IL-6, IL-10, measures of obesity, and insulin resistance in African-Americans...
  19. pmc Circulating adiponectin is associated with obesity and serum lipids in West Africans
    Katherine G Meilleur
    The Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 95:3517-21. 2010
    ..Although multiple studies have described the relationship between adiponectin and obesity in several human populations, no large studies have evaluated this relationship in Africans...
  20. pmc FTO genetic variation and association with obesity in West Africans and African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 59:1549-54. 2010
    ..However, data from populations of African ancestry are limited. We evaluated genetic variation in the FTO gene and investigated associations with obesity in West Africans and African Americans...
  21. ncbi request reprint Accounting for linkage disequilibrium in association analysis of diverse populations
    Bashira A Charles
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    Genet Epidemiol 38:265-73. 2014
    ..We review application of these methods to a variety of traits and diseases. ..
  22. pmc Overview of admixture mapping
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, USA
    Curr Protoc Hum Genet . 2013
    ..Finally, the author compares and contrasts linkage analysis, association analysis, and admixture mapping, with an emphasis on integrating admixture mapping and association testing...
  23. pmc Gene-based sequencing identifies lipid-influencing variants with ethnicity-specific effects in African Americans
    Amy R Bentley
    Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 10:e1004190. 2014
    ....
  24. pmc Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association
    Amy Rebecca Bentley
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 5635, USA
    Int J Nephrol 2012:748984. 2012
    ..Given the APOL1 × HDLc interaction among AA, genetic factors may contribute to this paradoxical association. Notably, these findings suggest that the unexplained mechanism by which APOL1 affects kidney-disease risk may involve HDLc...
  25. pmc Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans
    Fasil Tekola Ayele
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Immunogenetics 64:351-9. 2012
    ..63 × 10(-9)). To our knowledge, this is the first GWAS on IL-10, IL-1Ra, and IL-6 levels. Follow-up of these findings may provide valuable insight into the pathobiology of IL actions and dysregulations in inflammation and human diseases...
  26. pmc Improved eigenanalysis of discrete subpopulations and admixture using the minimum average partial test
    Daniel Shriner
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892 5635, USA shrinerda mail nih gov
    Hum Hered 73:73-83. 2012
    ..Application of the minimum average partial test to the 11 HapMap Phase III samples, comprising 8 unadmixed samples and 3 admixed samples, revealed 13 significant principal components...
  27. pmc Simultaneous Analysis of Common and Rare Variants in Complex Traits: Application to SNPs (SCARVAsnp)
    Guanjie Chen
    Center for Research on Genomics and Global Health, NHGRI, NIH, Bethesda, Maryland, USA
    Bioinform Biol Insights 6:177-85. 2012
    ..Also, SCARVAsnp takes into consideration the direction of association by effectively modelling positively and negatively associated variants...