Yukitaka Shizukuda

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt
    Yukitaka Shizukuda
    Program in Cardiovascular Sciences, Section of Cardiology, Department of Medicine, University of Illinois at Chicago, M C 787, 840 S Wood St, Chicago, IL 60612, USA
    Am J Physiol Heart Circ Physiol 282:H320-7. 2002
  2. ncbi request reprint Is functional capacity related to left atrial contractile function in nonobstructive hypertrophic cardiomyopathy?
    Yukitaka Shizukuda
    Cardiovascular Branch, National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Congest Heart Fail 11:234-40. 2005
  3. ncbi request reprint Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice
    Yukitaka Shizukuda
    Cardiovascular Branch, National Heart Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell Biochem 273:25-32. 2005
  4. ncbi request reprint Left ventricular systolic function during stress echocardiography exercise in subjects with asymptomatic hereditary hemochromatosis
    Yukitaka Shizukuda
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 98:694-8. 2006
  5. ncbi request reprint Significance of left atrial contractile function in asymptomatic subjects with hereditary hemochromatosis
    Yukitaka Shizukuda
    Cardiovascular Branch, Bethesda, Maryland, USA
    Am J Cardiol 98:954-9. 2006
  6. ncbi request reprint Exercise capacity of cardiac asymptomatic hereditary hemochromatosis subjects
    Yukitaka Shizukuda
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Med Sci Sports Exerc 39:3-7. 2007
  7. pmc Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease
    Vandana Sachdev
    Cardiovascular Branch, Echocardiography Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1454, USA
    J Am Coll Cardiol 49:472-9. 2007
  8. ncbi request reprint Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy
    Vandana Sachdev
    Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am Heart J 149:730-6. 2005
  9. pmc Changes in exercise capacity in subjects with cardiac asymptomatic hereditary hemochromatosis during a follow-up after 5 yrs
    Yukitaka Shizukuda
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Phys Med Rehabil 91:418-24. 2012
  10. pmc Incidence of cardiac arrhythmias in asymptomatic hereditary hemochromatosis subjects with C282Y homozygosity
    Yukitaka Shizukuda
    Cardiopulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 109:856-60. 2012

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt
    Yukitaka Shizukuda
    Program in Cardiovascular Sciences, Section of Cardiology, Department of Medicine, University of Illinois at Chicago, M C 787, 840 S Wood St, Chicago, IL 60612, USA
    Am J Physiol Heart Circ Physiol 282:H320-7. 2002
    ..Therefore, our results suggest that the activation of PKC-zeta modulates TxA(2) receptor-mediated apoptosis at least, in part, through Akt activity in adult cardiac myocytes...
  2. ncbi request reprint Is functional capacity related to left atrial contractile function in nonobstructive hypertrophic cardiomyopathy?
    Yukitaka Shizukuda
    Cardiovascular Branch, National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Congest Heart Fail 11:234-40. 2005
    ..These data, obtained at rest, fail to suggest that NHCM-related heart failure symptoms are due to an atrial myopathy...
  3. ncbi request reprint Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice
    Yukitaka Shizukuda
    Cardiovascular Branch, National Heart Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell Biochem 273:25-32. 2005
    ..These observations suggest that p53 mediated signals are likely to play a significant role in Dox-induced cardiac toxicity and that they may modulate Dox-induced oxidative stress...
  4. ncbi request reprint Left ventricular systolic function during stress echocardiography exercise in subjects with asymptomatic hereditary hemochromatosis
    Yukitaka Shizukuda
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 98:694-8. 2006
    ..In conclusion, LV systolic function during exercise in asymptomatic subjects with HH is preserved, and 6-month induction phlebotomy does not affect stress echocardiographic performance...
  5. ncbi request reprint Significance of left atrial contractile function in asymptomatic subjects with hereditary hemochromatosis
    Yukitaka Shizukuda
    Cardiovascular Branch, Bethesda, Maryland, USA
    Am J Cardiol 98:954-9. 2006
    ....
  6. ncbi request reprint Exercise capacity of cardiac asymptomatic hereditary hemochromatosis subjects
    Yukitaka Shizukuda
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Med Sci Sports Exerc 39:3-7. 2007
    ..In this study, we tested whether the iron overload associated with HH affected exercise capacity with a case control study design...
  7. pmc Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease
    Vandana Sachdev
    Cardiovascular Branch, Echocardiography Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1454, USA
    J Am Coll Cardiol 49:472-9. 2007
    ..The goal of this study was to characterize left ventricular diastolic function in the sickle cell disease (SCD) population and to relate echocardiographic measures of dysfunction with pulmonary hypertension and mortality...
  8. ncbi request reprint Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy
    Vandana Sachdev
    Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am Heart J 149:730-6. 2005
    ..We examined the relationship between left atrial volumetric remodeling and objective measures of exercise capacity in patients with nonobstructive hypertrophic cardiomyopathy (HCM)...
  9. pmc Changes in exercise capacity in subjects with cardiac asymptomatic hereditary hemochromatosis during a follow-up after 5 yrs
    Yukitaka Shizukuda
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Phys Med Rehabil 91:418-24. 2012
    ..A long-term effect of hereditary hemochromatosis (HH) on aerobic exercise capacity (AEC) has not been well described...
  10. pmc Incidence of cardiac arrhythmias in asymptomatic hereditary hemochromatosis subjects with C282Y homozygosity
    Yukitaka Shizukuda
    Cardiopulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 109:856-60. 2012
    ..In conclusion, our data suggest that the incidence of cardiac arrhythmias is, at most, marginally increased in asymptomatic subjects with HH. A larger clinical study is warranted to further clarify our observation...
  11. doi request reprint Changes in left ventricular diastolic function of asymptomatic hereditary hemochromatosis subjects during five years of follow-up
    Yukitaka Shizukuda
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Am J Cardiol 108:1796-800. 2011
    ..In conclusion, LV diastolic function does not significantly deteriorate statistically during a 5-year period in subjects with cardiac asymptomatic HH after conventional phlebotomy treatment, regardless of their treatment history...
  12. pmc Does oxidative stress modulate left ventricular diastolic function in asymptomatic subjects with hereditary hemochromatosis?
    Yukitaka Shizukuda
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Echocardiography 26:1153-8. 2009
    ..However, the increased oxidative stress related to iron overload may be involved in this process, and strain rate (SR), a sensitive echocardiography-derived measure of diastolic function, may detect such changes...
  13. ncbi request reprint Evaluation of pulsed Doppler tissue velocity imaging for assessing systolic function of murine global heart failure
    Satoaki Matoba
    Cardiovascular Branch, National Heart, Lung, and Blood Institute NIH, Building 10 7B15, 10 Center Drive, MSC 1650, Bethesda, MD 20892, USA
    J Am Soc Echocardiogr 18:148-54. 2005
    ..Our results indicate that these new DTI measurements appear feasible to assess global left ventricular systolic dysfunction in mice...
  14. ncbi request reprint Myocardial strain decreases with increasing transmurality of infarction: a Doppler echocardiographic and magnetic resonance correlation study
    Vandana Sachdev
    Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Soc Echocardiogr 19:34-9. 2006
    ..We studied longitudinal strain measurements in patients with evidence of myocardial infarction by cardiac magnetic resonance imaging to determine whether end-systolic strain could identify the severity of the infarction...
  15. pmc Pulmonary artery pressure in lymphangioleiomyomatosis: an echocardiographic study
    Angelo M Taveira-Dasilva
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 6D05, MSC 1590, Bethesda, MD 20892 1590, USA
    Chest 132:1573-8. 2007
    ..The aims of this study were to determine the prevalence of pulmonary hypertension in patients with LAM, to identify physiologic parameters associated with its occurrence, and to evaluate the effect of oxygen on response to exercise...
  16. ncbi request reprint Pulmonary hypertension as a risk factor for death in patients with sickle cell disease
    Mark T Gladwin
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1662, USA
    N Engl J Med 350:886-95. 2004
    ..The prevalence of pulmonary hypertension in adults with sickle cell disease, the mechanism of its development, and its prospective prognostic significance are unknown...
  17. ncbi request reprint Current and future applications of SAGE to cardiovascular medicine
    Willmar D Patino
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, The National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cardiovasc Med 13:163-8. 2003
    ..This review describes current cardiovascular studies using the SAGE technique and outlines some potential strategies for employing this powerful tool to further our understanding of the cardiovascular system in health and in disease...
  18. ncbi request reprint Effect of a histone deacetylase inhibitor on human cardiac mass
    Yukitaka Shizukuda
    Cardiovasc Drugs Ther 19:89-90. 2005
  19. ncbi request reprint Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes
    Yukitaka Shizukuda
    Section of Cardiology, Department of Medicine, University of Illinois, Chicago 60612, USA
    Am J Physiol Heart Circ Physiol 282:H1625-34. 2002
    ....
  20. ncbi request reprint Heart rate recovery is lower following supine exercise in asymptomatic hereditary hemochromatosis subjects compared with healthy controls
    Ross Arena
    Department of Physical Therapy, Virginia Commonwealth University, VA 23298 0224, USA
    J Cardiopulm Rehabil Prev 27:157-60. 2007
    ..The purpose of the present study is to examine differences in HRR between subjects with HH and healthy controls during treadmill (TM) and supine lower extremity ergometry (SLEE) exercise testing...
  21. ncbi request reprint Oxygen free radicals and heart failure: new insight into an old question
    Yukitaka Shizukuda
    Am J Physiol Lung Cell Mol Physiol 283:L237-8. 2002
  22. ncbi request reprint Can we use heart rate recovery information generated by supine ergometry exercise?
    Yukitaka Shizukuda
    Am J Cardiol 98:1297-8. 2006
  23. ncbi request reprint Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes
    Yukitaka Shizukuda
    Section of Cardiology, Department of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    J Mol Cell Cardiol 34:823-31. 2002
    ..Therefore, our findings suggest a rather complex role for beta-AR subtypes in the regulation of apoptosis in adult ventricular myocytes...
  24. ncbi request reprint Oxidative stress in asymptomatic subjects with hereditary hemochromatosis
    Yukitaka Shizukuda
    Am J Hematol 82:249-50. 2007
  25. ncbi request reprint Isoprotrenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin
    Yukitaka Shizukuda
    Circulation 105:E9. 2002