T S Shippenberg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Dynorphin and the pathophysiology of drug addiction
    T S Shippenberg
    Integrative Neuroscience Section, NIH NIDA Intramural Research Program, 333 Cassell Drive, Baltimore, MD 21224, USA
    Pharmacol Ther 116:306-21. 2007
  2. ncbi request reprint Region-specific enhancement of basal extracellular and cocaine-evoked dopamine levels following constitutive deletion of the Serotonin(1B) receptor
    T S Shippenberg
    Integrative Neuroscience Unit, Behavioral Neuroscience Laboratory, NIH NIDA Intramural Research Program, Baltimore, Maryland, USA
    J Neurochem 75:258-65. 2000
  3. pmc Overview of microdialysis
    T S Shippenberg
    NIH/NIDA Intramural Research Program, Baltimore, Maryland, USA
    Curr Protoc Neurosci . 2001
  4. ncbi request reprint Microdialysis in rodents
    A C Thompson
    NIH/NIDA Intramural Research Program, Baltimore, Maryland, USA
    Curr Protoc Neurosci . 2001
  5. ncbi request reprint Modulation of the behavioral and neurochemical effects of psychostimulants by kappa-opioid receptor systems
    T S Shippenberg
    Integrative Neuroscience Unit, NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ann N Y Acad Sci 937:50-73. 2001
  6. pmc Targeting endogenous mu- and delta-opioid receptor systems for the treatment of drug addiction
    T S Shippenberg
    Integrative Neuroscience Section, NIH NIDA Intramural Research Program, 333 Cassell Drive, Baltimore, MD 21224, USA
    CNS Neurol Disord Drug Targets 7:442-53. 2008
  7. pmc Delta-opioid receptor antagonists prevent sensitization to the conditioned rewarding effects of morphine
    Toni S Shippenberg
    Integrative Neuroscience Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health US DHHS, 333 Cassell Dr, Baltimore, MD 21224, USA
    Biol Psychiatry 65:169-74. 2009
  8. ncbi request reprint Modulation of behavioral sensitization to cocaine by NAALADase inhibition
    T S Shippenberg
    Integrative Neuroscience Unit, Behavioral Neuroscience Laboratory, NIH NIDA Intramural Research Program, Baltimore, Maryland 21224, USA
    Synapse 38:161-6. 2000
  9. ncbi request reprint Dynorphin A (2-17) attenuates the unconditioned but not the conditioned effects of opiate withdrawal in the rat
    T S Shippenberg
    Integrative Neuroscience Unit, Behavioral Pharmacology Branch, National Institute of Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 151:351-8. 2000
  10. ncbi request reprint Kappa-opioid receptor activation prevents alterations in mesocortical dopamine neurotransmission that occur during abstinence from cocaine
    V I Chefer
    Behavioral Neuroscience Laboratory, NIH NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 101:619-27. 2000

Detail Information

Publications25

  1. pmc Dynorphin and the pathophysiology of drug addiction
    T S Shippenberg
    Integrative Neuroscience Section, NIH NIDA Intramural Research Program, 333 Cassell Drive, Baltimore, MD 21224, USA
    Pharmacol Ther 116:306-21. 2007
    ..We will provide evidence that the repeated administration of cocaine and alcohol up-regulates the dynorphin/KOPr system and that pharmacological treatments that target this system may prove effective in the treatment of drug addiction...
  2. ncbi request reprint Region-specific enhancement of basal extracellular and cocaine-evoked dopamine levels following constitutive deletion of the Serotonin(1B) receptor
    T S Shippenberg
    Integrative Neuroscience Unit, Behavioral Neuroscience Laboratory, NIH NIDA Intramural Research Program, Baltimore, Maryland, USA
    J Neurochem 75:258-65. 2000
    ....
  3. pmc Overview of microdialysis
    T S Shippenberg
    NIH/NIDA Intramural Research Program, Baltimore, Maryland, USA
    Curr Protoc Neurosci . 2001
    ..Although the methods described are those used for monitoring CNS function, they can be easily applied with minor modification to other organ systems...
  4. ncbi request reprint Microdialysis in rodents
    A C Thompson
    NIH/NIDA Intramural Research Program, Baltimore, Maryland, USA
    Curr Protoc Neurosci . 2001
    ..Finally, procedures are provided for carrying out quantitative microdialysis techniques...
  5. ncbi request reprint Modulation of the behavioral and neurochemical effects of psychostimulants by kappa-opioid receptor systems
    T S Shippenberg
    Integrative Neuroscience Unit, NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ann N Y Acad Sci 937:50-73. 2001
    ..The role of this opioid system in mediating alterations in mood and affect that occur during abstinence from repeated psychostimulant use are also discussed...
  6. pmc Targeting endogenous mu- and delta-opioid receptor systems for the treatment of drug addiction
    T S Shippenberg
    Integrative Neuroscience Section, NIH NIDA Intramural Research Program, 333 Cassell Drive, Baltimore, MD 21224, USA
    CNS Neurol Disord Drug Targets 7:442-53. 2008
    ....
  7. pmc Delta-opioid receptor antagonists prevent sensitization to the conditioned rewarding effects of morphine
    Toni S Shippenberg
    Integrative Neuroscience Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health US DHHS, 333 Cassell Dr, Baltimore, MD 21224, USA
    Biol Psychiatry 65:169-74. 2009
    ..This issue was addressed with the conditioned place preference procedure (CPP)...
  8. ncbi request reprint Modulation of behavioral sensitization to cocaine by NAALADase inhibition
    T S Shippenberg
    Integrative Neuroscience Unit, Behavioral Neuroscience Laboratory, NIH NIDA Intramural Research Program, Baltimore, Maryland 21224, USA
    Synapse 38:161-6. 2000
    ..These data demonstrate that NAALADase inhibition attenuates the development of sensitization to the locomotor-activating effects of cocaine. Furthermore, this action cannot be attributed to an antagonism of the acute effects of cocaine...
  9. ncbi request reprint Dynorphin A (2-17) attenuates the unconditioned but not the conditioned effects of opiate withdrawal in the rat
    T S Shippenberg
    Integrative Neuroscience Unit, Behavioral Pharmacology Branch, National Institute of Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 151:351-8. 2000
    ..An unbiased place preference conditioning procedure was used to examine the influence of the non-opioid peptide, dynorphin A 2-17 (DYN 2-17), upon the conditioned and unconditioned effects of opiate withdrawal in the rat...
  10. ncbi request reprint Kappa-opioid receptor activation prevents alterations in mesocortical dopamine neurotransmission that occur during abstinence from cocaine
    V I Chefer
    Behavioral Neuroscience Laboratory, NIH NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 101:619-27. 2000
    ..Furthermore, they raise the possibility that mesocortical dopamine neurons may be an important neural substrate upon which kappa-opioid agonists act to prevent the development of cocaine-induced behavioral sensitization...
  11. ncbi request reprint Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine
    A C Thompson
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 20:9333-40. 2000
    ..kappa-agonist treatment also alters DAT function. The action of kappa-agonists on DA uptake or DAT binding, or both, may be the mechanism(s) mediating the previously reported "cocaine-antagonist" effect of kappa-opioid receptor agonists...
  12. ncbi request reprint Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens
    V I Chefer
    Integrative Neuroscience Section, Behavioral Neuroscience Branch, DHHS NIH NIDA IRP BNRB INS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 23:229-38. 2006
    ..These findings suggest that the phenotype of DYN KO mice is not solely due to loss of endogenous opioid peptide but also reflects developmental compensations that occur at the level of the opioid receptor...
  13. ncbi request reprint Sensitization to the conditioned rewarding effects of morphine and cocaine: differential effects of the kappa-opioid receptor agonist U69593
    T S Shippenberg
    Integrative Neuroscience Unit, Behavioral Neuroscience Branch, NIDA Division of Intramural Research, Baltimore, MD 21224, USA
    Eur J Pharmacol 345:27-34. 1998
    ..U69593 prevents sensitization and cross-sensitization induced by cocaine, but does not modify morphine-induced sensitization or the cross-sensitization which develops to cocaine after morphine administration...
  14. ncbi request reprint Contrasting effects of mu opioid receptor and delta opioid receptor deletion upon the behavioral and neurochemical effects of cocaine
    V I Chefer
    Integrative Neuroscience Section, Behavioral Neuroscience Branch, DHHS NIH National Institute on Drug Abuse IRP BNRB INS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 127:497-503. 2004
    ..These data indicate that constitutive deletion of either MOR or DOR results in contrasting effects upon responsiveness to cocaine, which is consistent with the distinct phenotypes previously described for these mutants...
  15. ncbi request reprint Autoradiographic evidence that prolonged withdrawal from intermittent cocaine reduces mu-opioid receptor expression in limbic regions of the rat brain
    L G Sharpe
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
    Synapse 37:292-7. 2000
    ..05). The mu-receptor may manifest, as do other neural markers (e.g., dopamine transporter, dopamine efflux), a biphasic temporal pattern with upregulation during early phases of cocaine withdrawal but a downregulation at later times...
  16. ncbi request reprint Selective D3 receptor agonist effects of (+)-PD 128907 on dialysate dopamine at low doses
    A Zapata
    Integrative Neuroscience Unit, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 41:351-9. 2001
    ..We conclude that the activation of the D3 receptor decreases extracellular dopamine levels and that, at sufficiently low doses, the effects of (+)-PD 128907 on extracellular dopamine are selectively mediated by the D3 receptor...
  17. ncbi request reprint Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions
    V I Chefer
    Integrative Neuroscience Unit, Behavioral Neuroscience Laboratory, NIH NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 112:907-19. 2002
    ....
  18. pmc Augmentation of morphine-induced sensitization but reduction in morphine tolerance and reward in delta-opioid receptor knockout mice
    V I Chefer
    Integrative Neuroscience Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropsychopharmacology 34:887-98. 2009
    ....
  19. ncbi request reprint Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction
    R B Rothman
    Clinical Psychopharmacology Section, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 844:59-74. 1998
    ..The preclinical data obtained with PHEN/FEN in various models of drug provide a strong rationale for pursuing controlled clinical trials in humans with agents that act via a similar mechanism of action...
  20. pmc Mu opioid receptor modulation of somatodendritic dopamine overflow: GABAergic and glutamatergic mechanisms
    V I Chefer
    Integrative Neuroscience Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Eur J Neurosci 30:272-8. 2009
    ..Together, our findings indicate a critical role of VTA MOR in maintaining an intricate balance between excitatory and inhibitory inputs to dopaminergic neurons...
  21. ncbi request reprint Severe brain hypothermia as a factor underlying behavioral immobility during cold-water forced swim
    J F Taltavull
    Integrative Neuroscience Section, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 975:244-7. 2003
    ..These data suggest that immobility, which rapidly develops during forced swim in cold water, may result from dramatic inhibition of neural functions because of severe brain hypothermia...
  22. ncbi request reprint D(3) receptor ligands modulate extracellular dopamine clearance in the nucleus accumbens
    A Zapata
    Integrative Neuroscience Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Neurochem 81:1035-42. 2002
    ..These data indicate that D(3) receptor activation increases dopamine uptake in the nucleus accumbens and suggest that this receptor subtype can regulate extracellular dopamine by modulating the DA transporter activity...
  23. ncbi request reprint Evidence for an involvement of muscarinic cholinergic systems in the induction but not expression of behavioral sensitization to cocaine
    C A Heidbreder
    National Institutes of Health NIH, National Institute on Drug Abuse NIDA, Behavioral Pharmacology and Genetics Section, Baltimore, Maryland 21224, USA
    Synapse 24:182-92. 1996
    ..In contrast, the enhanced stereotypic effects in response to the repeated administration of cocaine seem to be independent of alterations in muscarine cholinergic transmission...
  24. ncbi request reprint Evaluation of rat ultrasonic vocalizations as predictors of the conditioned aversive effects of drugs
    J Burgdorf
    Integrative Neuroscience Unit, Behavioral Neuroscience Laboratory, Intramural Research Program, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 155:35-42. 2001
    ..CONCLUSIONS: In rats, cues associated with drugs with aversive effects increase 20 kHz USVs and decrease 50 kHz USVs, suggesting that USVs may provide a useful model for predicting the conditioned aversive effects of drugs...
  25. doi request reprint The dynorphin/κ-opioid receptor system and its role in psychiatric disorders
    H A Tejeda
    Integrative Neuroscience Section, Integrative Neuroscience Research Branch, NIDA IRP, NIH, Baltimore, MD 21224, USA
    Cell Mol Life Sci 69:857-96. 2012
    ..We also overview the dynorphin/κ-opioid receptor system in the genetics of psychiatric disorders and discuss implications of the reviewed material for therapeutics development...