Chong Shan Shi

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:255-63. 2012
  2. ncbi MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:33175-82. 2008
  3. ncbi TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 3:ra42. 2010
  4. ncbi Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles
    Sang Bae Han
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious, Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 22:343-54. 2005
  5. ncbi Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2)
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:15429-34. 2003
  6. ncbi Regulator of G-protein signaling 3 isoform 1 (PDZ-RGS3) enhances canonical Wnt signaling and promotes epithelial mesenchymal transition
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:33480-7. 2012
  7. ncbi Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3
    John H Kehrl
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Genomics 79:860-8. 2002
  8. ncbi Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
    J Biol Chem 279:17224-31. 2004
  9. ncbi Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Autophagy 6:986-7. 2010
  10. ncbi The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes
    Chong Shan Shi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Room 11B08, 10 Center Dr MSC 1876, Bethesda, MD 20892, USA
    Mol Cell Biol 26:6511-21. 2006

Collaborators

Detail Information

Publications10

  1. ncbi Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:255-63. 2012
    ..Our data indicate that autophagy accompanies inflammasome activation to temper inflammation by eliminating active inflammasomes...
  2. ncbi MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:33175-82. 2008
    ..These findings indicate TLR signaling via its adaptor proteins reduces the binding of Beclin 1 to Bcl-2 by recruiting Beclin 1 into the TLR-signaling complex leading to autophagy...
  3. ncbi TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 3:ra42. 2010
    ..These results indicate that the status of K63-linked ubiquitination of Beclin-1 plays a key role in regulating autophagy during inflammatory responses...
  4. ncbi Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles
    Sang Bae Han
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious, Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 22:343-54. 2005
    ..These results demonstrate opposing roles for Rgs1 and Gnai2 in B cell trafficking into and within lymph nodes...
  5. ncbi Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2)
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:15429-34. 2003
    ..These results indicate that the assembly of a TRAF2 lysine 63-linked polyubiquitin chain by Ubc13/Uev1A is required for TNF-mediated GCKR and SAPK activation, but may not be required for ASK1 activation...
  6. ncbi Regulator of G-protein signaling 3 isoform 1 (PDZ-RGS3) enhances canonical Wnt signaling and promotes epithelial mesenchymal transition
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:33480-7. 2012
    ..These results indicate that PDZ-RGS3 can enhance signals generated by the Wnt canonical pathway and that plays a pivotal role in EMT...
  7. ncbi Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3
    John H Kehrl
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Genomics 79:860-8. 2002
    ..For each RGS3 isoform, RT-PCR detected specific mRNA transcripts and immunoblot analysis identified specific bands for RGS3 and PDZ-RGS3. RGS3 provides an example of the complex origins of the coding regions of mammalian proteins...
  8. ncbi Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
    J Biol Chem 279:17224-31. 2004
    ..These results indicate that Pyk2 facilitates EGFR- and c-Src-mediated Stat3 activation, thereby implicating Pyk2 activation as a potential co-mediator in triggering Stat3-induced oncogenesis...
  9. ncbi Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Autophagy 6:986-7. 2010
    ..These results indicate that the status of K63-linked ubiquitination of Beclin 1 plays a key role in regulating autophagy during inflammatory responses...
  10. ncbi The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes
    Chong Shan Shi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Room 11B08, 10 Center Dr MSC 1876, Bethesda, MD 20892, USA
    Mol Cell Biol 26:6511-21. 2006
    ..Furthermore, Wnt signaling induces an interaction between GCKR and GSK3beta. Our findings demonstrate that GCKR facilitates both canonical and noncanonical Wnt signaling in B lymphocytes...