M E Sherman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res 14:R64. 2012
  2. pmc Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 105:166-74. 2013
  3. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
  4. ncbi request reprint The Bethesda Interobserver Reproducibility Study (BIRST): a web-based assessment of the Bethesda 2001 System for classifying cervical cytology
    Mark E Sherman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7374, USA
    Cancer 111:15-25. 2007
  5. ncbi request reprint Ovarian volume: determinants and associations with cancer among postmenopausal women
    Mark E Sherman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:1550-4. 2006
  6. ncbi request reprint Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:46-52. 2003
  7. ncbi request reprint Histopathologic extent of cervical intraepithelial neoplasia 3 lesions in the atypical squamous cells of undetermined significance low-grade squamous intraepithelial lesion triage study: implications for subject safety and lead-time bias
    Mark E Sherman
    The National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:372-9. 2003
  8. ncbi request reprint Analysis of racial differences in incidence, survival, and mortality for malignant tumors of the uterine corpus
    Mark E Sherman
    Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer 98:176-86. 2003
  9. pmc Molecular pathology in epidemiologic studies: a primer on key considerations
    Mark E Sherman
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Rockville, MD, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 19:966-72. 2010
  10. ncbi request reprint Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: a population-based analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Int J Cancer 121:1079-85. 2007

Detail Information

Publications106 found, 100 shown here

  1. pmc Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res 14:R64. 2012
    ..Accordingly, we performed a masked microscopic assessment of TDLU involution in benign tissues associated with luminal A and CBP breast cancers diagnosed among women less than age 55 years...
  2. pmc Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 105:166-74. 2013
    ..This report summarizes conclusions of the workshop, proposes avenues for future research on the PLC and its relationship with breast cancer risk, and identifies opportunities to translate this knowledge to improve breast cancer outcomes...
  3. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
    ..It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour...
  4. ncbi request reprint The Bethesda Interobserver Reproducibility Study (BIRST): a web-based assessment of the Bethesda 2001 System for classifying cervical cytology
    Mark E Sherman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7374, USA
    Cancer 111:15-25. 2007
    ..The Bethesda System (TBS) along with its companion atlas was updated in 2001 to improve standardization, clarity, and reproducibility of cervical cytology reporting...
  5. ncbi request reprint Ovarian volume: determinants and associations with cancer among postmenopausal women
    Mark E Sherman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:1550-4. 2006
    ..Confirmation of these findings in future studies, including analyses of serum hormone levels and tissues, may provide insights into hormonal carcinogenesis among older women...
  6. ncbi request reprint Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:46-52. 2003
    ..We evaluated whether simultaneous screening with a Pap test and human papillomavirus (HPV) testing is useful for assessing the risk for cervical intraepithelial neoplasia (CIN) 3 or cervical cancer...
  7. ncbi request reprint Histopathologic extent of cervical intraepithelial neoplasia 3 lesions in the atypical squamous cells of undetermined significance low-grade squamous intraepithelial lesion triage study: implications for subject safety and lead-time bias
    Mark E Sherman
    The National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:372-9. 2003
    ....
  8. ncbi request reprint Analysis of racial differences in incidence, survival, and mortality for malignant tumors of the uterine corpus
    Mark E Sherman
    Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer 98:176-86. 2003
    ..Reasons for the higher level of mortality among blacks have been debated...
  9. pmc Molecular pathology in epidemiologic studies: a primer on key considerations
    Mark E Sherman
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Rockville, MD, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 19:966-72. 2010
    ..Concurrently, methodologic research to extend the range of assays that can be done on fixed tissues is expanding possibilities for molecular pathologic studies in epidemiologic research...
  10. ncbi request reprint Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: a population-based analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Int J Cancer 121:1079-85. 2007
    ..07) for low PR and HER2 expression vs. OR = 1.78 (95% CI = 1.25-2.55) for high expression (p-heterogeneity = 0.001). PR and HER2 levels in breast cancer vary by BMI, suggesting a heterogeneous etiology for tumors related to these markers...
  11. pmc Ovarian volumes among women with endometrial carcinoma: associations with risk factors and serum hormones
    Mark E Sherman
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Gynecol Oncol 107:431-5. 2007
    ..Accordingly, we assessed ovarian volumes in relation to serum sex hormone levels among post-menopausal women with endometrial carcinoma who participated in a multi-center case-control study...
  12. ncbi request reprint Survival among women with borderline ovarian tumors and ovarian carcinoma: a population-based analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Cancer 100:1045-52. 2004
    ..Comparison of the survival for women with LMP tumors staged as distant with women who have carcinoma may have important implications for diagnostic terminology and clinical management...
  13. ncbi request reprint Impact of hysterectomy on endometrial carcinoma rates in the United States
    Mark E Sherman
    Hormonal and Reproductive Epidemiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Natl Cancer Inst 97:1700-2. 2005
    ..The high prevalence of hysterectomy among blacks with strong endometrial cancer risk factors may partly account for lower cancer rates in this group...
  14. pmc Performance of cytology and human papillomavirus testing in relation to the menstrual cycle
    M E Sherman
    Division of Cancer Epidemiology and Genetics, The National Cancer Institute, Hormonal and Reproductive Epidemiology Branch, Rockville, MD, USA
    Br J Cancer 94:1690-6. 2006
    ..Standardizing collection times would slightly improve interpretation of trends in HPV load. Finally, these data are consistent with the view that the biological properties of the HPV-infected cervix vary with the date of the LMP...
  15. ncbi request reprint Mortality trends for cervical squamous and adenocarcinoma in the United States. Relation to incidence and survival
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892 7374, USA
    Cancer 103:1258-64. 2005
    ..To make inferences about the effectiveness of screening, the authors assessed mortality trends for squamous and adenocarcinoma in relation to incidence of these tumors, incidence of their precursors and survival...
  16. ncbi request reprint Cervical cytology of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): characteristics and histologic outcomes
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Cancer 108:298-305. 2006
    ....
  17. ncbi request reprint "Sip volume" as a quality indicator in liquid-based cervical cytology
    Mark E Sherman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7374, USA
    Cancer 108:462-7. 2006
    ..It was hypothesized that the volumes required to prepare ThinPreps ("sip volumes") represent indicators of specimen quality...
  18. ncbi request reprint Effects of age and human papilloma viral load on colposcopy triage: data from the randomized Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS)
    Mark E Sherman
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7374, USA
    J Natl Cancer Inst 94:102-7. 2002
    ..Considering age or viral load could improve colposcopy triage...
  19. doi request reprint Reproducibility of biopsy diagnoses of endometrial hyperplasia: evidence supporting a simplified classification
    Mark E Sherman
    Cancer Epidemiology and Genetics, The National Cancer Institute, 6120 Executive Blvd, Room 5028, Rockville, MD 20892 7374, USA
    Int J Gynecol Pathol 27:318-25. 2008
    ..Identifying which categories in the World Health Organization classification of endometrial hyperplasia contribute to suboptimal reproducibility is clinically important...
  20. pmc HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa Rica
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Br J Cancer 84:1219-26. 2001
    ..Among HPV-positive women, multiparity and smoking are risk factors for HSIL/CA. Oral contraceptive use may be associated with HSIL/CA in subgroups of women...
  21. ncbi request reprint An association of cervical inflammation with high-grade cervical neoplasia in women infected with oncogenic human papillomavirus (HPV)
    P E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 10:1021-7. 2001
    ..90-4.1). The results of this study suggest that cervical inflammation may be associated with high-grade lesions and may be a cofactor for high-grade cervical lesions in women infected with oncogenic HPV...
  22. ncbi request reprint HPV DNA testing in cervical cancer screening: results from women in a high-risk province of Costa Rica
    M Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    JAMA 283:87-93. 2000
    ..Human papillomaviruses (HPVs) are known to cause most cervical cancer worldwide, but the utility of HPV DNA testing in cervical cancer prevention has not been determined...
  23. ncbi request reprint "ASCUS, rule out HSIL": cytologic features, histologic correlates, and human papillomavirus detection
    M E Sherman
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Mod Pathol 12:335-42. 1999
    ..Consequently, women with ASCUS, rule out HSIL should be referred for colposcopic examination...
  24. pmc Determinants of human papillomavirus 16 serological conversion and persistence in a population-based cohort of 10 000 women in Costa Rica
    S S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    Br J Cancer 91:1269-74. 2004
    ..Higher HPV-16 viral load at enrollment was associated with seroconversion, and higher antibody titres at enrollment were associated with seropersistence...
  25. ncbi request reprint Human leukocyte antigen class I/II alleles and development of human papillomavirus-related cervical neoplasia: results from a case-control study conducted in the United States
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7374, USA
    Cancer Epidemiol Biomarkers Prev 7:1035-41. 1998
    ....
  26. ncbi request reprint A comparison between real-time polymerase chain reaction and hybrid capture 2 for human papillomavirus DNA quantitation
    Patti E Gravitt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:477-84. 2003
    ..The nonrandom distribution of multiple infections by case-control status and the apparent differential effect of viral load by genotype warrant caution when using HC 2 measurements to infer viral load associations with SIL and cancer...
  27. pmc High load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only HPV16 load predicts the development of incident disease
    Patti E Gravitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 121:2787-93. 2007
    ..The extent to which these observations can be translated into clinical practice must be rigorously examined in the context of the method of viral load measurement and the type-specific differences observed for incident >/=CIN2...
  28. ncbi request reprint Immune activation in cervical neoplasia: cross-sectional association between plasma soluble interleukin 2 receptor levels and disease
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 6:807-13. 1997
    ..Also, future efforts should be aimed at determining whether the associations observed are causally related to disease progression or an effect of the disease...
  29. pmc A case-control study of endogenous hormones and cervical cancer
    T S Shields
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, MSC 7234, Rockville, MD 20852, USA
    Br J Cancer 90:146-52. 2004
    ..Nonetheless, our results do not support the hypothesis that plasma levels of sex hormones have an important bearing on the risk of cervical neoplasia in HPV-infected women...
  30. ncbi request reprint Human leukocyte antigen class I and II haplotypes and risk of cervical cancer
    J D Carreon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Tissue Antigens 66:321-4. 2005
    ..No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes...
  31. pmc Reproductive risk factors for endometrial cancer among Polish women
    L A Brinton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Suite 550, Rockville, MD 20852 7234, USA
    Br J Cancer 96:1450-6. 2007
    ..Alternative explanations for reproductive effects should be sought, including alterations in endogenous hormones...
  32. pmc Seroprevalence of human papillomavirus-16, -18, -31, and -45 in a population-based cohort of 10000 women in Costa Rica
    S S Wang
    National Cancer Institute, Bethesda, MD 20892 7234, USA
    Br J Cancer 89:1248-54. 2003
    ..DNA- and sero-positive women showed the highest risk for concurrent CIN3/cancer, followed by DNA-positive, sero-negative women...
  33. ncbi request reprint Seroreactivity to human papillomavirus types 16, 18, 31, and 45 virus-like particles in a case-control study of cervical squamous intraepithelial lesions
    L Wideroff
    NCI ARB, EPN 313 MSC 7344, Bethesda, MD 20892 7344, USA
    J Infect Dis 180:1424-8. 1999
    ..These data suggest that seroreactivity to a given type reflects mainly type-specific HPV infection as measured by DNA detection and may also signal past exposure to other types that are now only serologically detected...
  34. ncbi request reprint Determinants of human papillomavirus load among women with histological cervical intraepithelial neoplasia 3: dominant impact of surrounding low-grade lesions
    Mark E Sherman
    Department of Health and Human Services, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland 20892 7374, USA
    Cancer Epidemiol Biomarkers Prev 12:1038-44. 2003
    ..These factors severely limit the clinical use of load measurements irrespective of HPV testing methodology...
  35. ncbi request reprint Cervicography screening for cervical cancer among 8460 women in a high-risk population
    D L Schneider
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Am J Obstet Gynecol 180:290-8. 1999
    ..Cervicography was evaluated as a primary screening method for cervical cancer...
  36. pmc Human epidermal growth factor receptor-2 and estrogen receptor expression, a demonstration project using the residual tissue repository of the Surveillance, Epidemiology, and End Results (SEER) program
    W F Anderson
    NIH NCI DCEG, EPS Room 8036, 6120 Executive Blvd, Bethesda, MD 20852, USA
    Breast Cancer Res Treat 113:189-96. 2009
    ..To validate the utility of the RTR for supplementing SEER's central database, we assessed human epidermal growth factor receptor-2 (HER2) and estrogen receptor expression (ER) in a demonstration project...
  37. pmc Prolactin serum levels and breast cancer: relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case-control study from Poland
    J M Faupel-Badger
    Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, 6120 Executive Blvd EPS, Suite 150E, MSC 7105, Bethesda, MD 20892, USA
    Br J Cancer 103:1097-102. 2010
    ....
  38. ncbi request reprint Human papillomavirus, anal squamous intraepithelial lesions, and human immunodeficiency virus in a cohort of gay men
    H B Friedman
    Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    J Infect Dis 178:45-52. 1998
    ..Men with a high HC RLU ratio were nearly 3 times more likely to have SIL than were those both PCR- and HC-negative. These data support that HIV augments HPV-associated anal disease in this population...
  39. ncbi request reprint Qualification of ASCUS. A comparison of equivocal LSIL and equivocal HSIL cervical cytology in the ASCUS LSIL Triage Study
    M E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 7080, Rockville, MD 20852-7374, USA
    Am J Clin Pathol 116:386-94. 2001
    ..ASCUS-H is an uncommon interpretation that derives clinical usefulness from its high positive predictive value for lesions CIN 2 or worse...
  40. ncbi request reprint CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samples
    Joseph D Carreon
    Division of Cancer Epidemiology and Genetics, The National Cancer Institute, National Institutes of Health, Department of Health and Human Services Rockville, Maryland 20852, USA
    Int J Gynecol Pathol 26:441-6. 2007
    ..The CIN3 is a substantially more reproducible diagnosis that can be validated more frequently with HPV tests and cytological interpretations than CIN2...
  41. pmc Established breast cancer risk factors by clinically important tumour characteristics
    M Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, MD 20852 7234, USA
    Br J Cancer 95:123-9. 2006
    ..In conclusion, these data support distinctive risk factor relationships by tumour characteristics of prognostic relevance. These findings might be useful in developing targeted prevention efforts...
  42. ncbi request reprint Loss of antigenicity in stored sections of breast cancer tissue microarrays
    Jennifer H Fergenbaum
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Executive Plaza South, Room 7080, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:667-72. 2004
    ..Improved methods for sectioning TMAs and storing tissue sections aimed at reducing loss of immunoreactivity are critical for the use of TMAs in epidemiological studies...
  43. ncbi request reprint Incidence patterns of invasive and borderline ovarian tumors among white women and black women in the United States. Results from the SEER Program, 1978-1998
    Pamela J Mink
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Cancer 95:2380-9. 2002
    ..Population-based incidence data for these neoplasms by histopathologic type and race are limited. Variation in rates may provide clues for future etiologic studies...
  44. pmc Ovarian cancer and menopausal hormone therapy in the NIH-AARP diet and health study
    B Trabert
    Department of Health and Human Services, Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
    Br J Cancer 107:1181-7. 2012
    ..Women using unopposed estrogens during menopause are at increased risk of ovarian cancer. It is uncertain whether oestrogen plus progestin therapy exerts similar effects...
  45. pmc Endometrial carcinoma risk among women diagnosed with endometrial hyperplasia: the 34-year experience in a large health plan
    J V Lacey
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Br J Cancer 98:45-53. 2008
    ..9) were substantially lower and only slightly higher than the progression risk for DPEM. The higher progression risks for AH could foster management guidelines based on markedly different progression risks for atypical vs non-atypical EH...
  46. ncbi request reprint Differences in risk factors for breast cancer molecular subtypes in a population-based study
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7014, 6120 Executive Boulevard, Bethesda, MD 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 16:439-43. 2007
    ..Results from this study have shown that breast cancer risk factors may vary by molecular subtypes identified in expression studies, suggesting etiologic, in addition to clinical, heterogeneity of breast cancer...
  47. pmc Relationships of uterine and ovarian tumors to pre-existing chronic conditions
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Gynecol Oncol 107:487-94. 2007
    ..Several chronic diseases have been hypothesized to affect the risk of subsequent gynecologic malignancies, possibly through shared hormonal mechanisms...
  48. pmc Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes
    Hannah P Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 31:827-33. 2010
    ..Associations with variants in other genes have been suggested, but findings have been inconsistent...
  49. ncbi request reprint The natural history of human papillomavirus infection and cervical intraepithelial neoplasia among young women in the Guanacaste cohort shortly after initiation of sexual life
    Ana Cecilia Rodriguez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, Maryland 20859, USA
    Sex Transm Dis 34:494-502. 2007
    ..We wanted to explore early HPV natural history and CIN 3 prospectively...
  50. ncbi request reprint Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Cancer Res 67:10608-17. 2007
    ....
  51. doi request reprint Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Cancer Res 68:2489-97. 2008
    ..Inclusion of NOL4 and LHFPL4 in evaluating methylation panels for early detection, risk prediction, and etiologic research on cervical cancer is warranted...
  52. pmc Epidemiological study of anti-HPV16/18 seropositivity and subsequent risk of HPV16 and -18 infections
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Ste 550, Rockville, MD 20852, USA
    J Natl Cancer Inst 102:1653-62. 2010
    ..Infection with human papillomavirus (HPV) 16 or HPV18 elicits an antibody response, but whether the elicited antibodies protect women against subsequent infection by a homologous HPV type compared with seronegative women is unknown...
  53. pmc Alcohol and endometrial cancer risk in the NIH-AARP diet and health study
    Hannah P Yang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Int J Cancer 128:2953-61. 2011
    ..Our results do not support that alcohol is a strong contributor to endometrial cancer risk, but slight risk increases may prevail among some users or for selected tumor characteristics...
  54. pmc Determinants of seropositivity among HPV-16/18 DNA positive young women
    Carolina Porras
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    BMC Infect Dis 10:238. 2010
    ..We evaluated determinants of seropositivity among 646 women infected with HPV-16 and/or HPV-18...
  55. pmc A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia
    Mark Schiffman
    Divisions of Cancer Epidemiology and Genetics and Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA
    Cancer Res 70:3159-69. 2010
    ..Larger viral genomic studies are warranted, especially to identify the genetic basis for HPV16's unique carcinogenicity...
  56. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010
    ..Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown...
  57. pmc Active and passive cigarette smoking and the risk of endometrial cancer in Poland
    Hannah P Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, Suite 520, Rockville, MD 20852, USA
    Eur J Cancer 46:690-6. 2010
    ..However, dose-response relationships with quantitative measures of active smoking or passive smoking remain less clear...
  58. pmc Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 121:727-35. 2010
    ..These results warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment...
  59. pmc Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    BMJ 339:b2569. 2009
    ....
  60. pmc Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5012, Rockville, MD 20854 7234, USA
    Gynecol Oncol 112:293-9. 2009
    ..We wanted to identify the most promising methylation marker candidates for cervical cancer early detection...
  61. pmc Recent trends in breast cancer among younger women in the United States
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, MD 20852 7234, USA
    J Natl Cancer Inst 100:1643-8. 2008
    ..Continued surveillance of trends is needed, particularly for molecular subtypes that preferentially occur among young women...
  62. pmc Measurement of sex steroid hormones in breast adipocytes: methods and implications
    Roni T Falk
    Division of Cancer Epidemiology and Genetics, Epidemiology and Biostatistics Program, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard S, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:1891-5. 2008
    ....
  63. pmc PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma
    James V Lacey
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Cancer Res 68:6014-20. 2008
    ..Loss of PTEN expression in endometrial biopsies was neither associated with nor a sensitive and specific marker of subsequent progression to endometrial carcinoma...
  64. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...
  65. pmc Human papillomavirus infection with multiple types: pattern of coinfection and risk of cervical disease
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072 Rockville, MD 20852, USA
    J Infect Dis 203:910-20. 2011
    ..We investigated coinfection patterns for 25 human papillomavirus (HPV) types and assessed the risk conferred by multiple HPV types toward cervical disease...
  66. ncbi request reprint Estimating age-specific breast cancer risks: a descriptive tool to identify age interactions
    William F Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Executive Plaza South 8070, 6120 Executive Plaza Blvd, Rockville, MD 20892 7242, USA
    Cancer Causes Control 18:439-47. 2007
    ..Clarifying age-specific female breast cancer risks and interactions may provide important etiologic clues...
  67. ncbi request reprint Relationships of human papillomavirus type, qualitative viral load, and age with cytologic abnormality
    Melinda Butsch Kovacic
    Division of Cancer Epidemiology and Genetics and Cancer Prevention Fellowship Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:10112-9. 2006
    ..The lack of evident severe abnormalities associated with HPV18 and related HPV types might have implications for screening for poorly detected glandular and alpha7-related lesions...
  68. ncbi request reprint A prospective study of age trends in cervical human papillomavirus acquisition and persistence in Guanacaste, Costa Rica
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
    J Infect Dis 191:1808-16. 2005
    ..In some populations, HPV prevalence demonstrates a second peak in older women. Longitudinal data may help to explain this second peak...
  69. ncbi request reprint Etiology of hormone receptor-defined breast cancer: a systematic review of the literature
    Michelle D Althuis
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7084, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:1558-68. 2004
    ..Large population-based studies of determinants of hormone receptor-defined breast cancers defined using state-of-the-art quantitative immunostaining methods are needed to clarify the role of ER/PR expression in breast cancer etiology...
  70. ncbi request reprint Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 13:1355-60. 2004
    ..Whereas our data support the diagnostic potential for p16INK4a, further prospective studies with detailed follow-up determining the prognostic capacity of this marker are needed...
  71. ncbi request reprint Comparison of age-specific incidence rate patterns for different histopathologic types of breast carcinoma
    William F Anderson
    Division of Cancer Prevention, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 13:1128-35. 2004
    ..In this analysis, our objective was to compare age-specific incidence rate patterns for different morphologic types of breast carcinoma...
  72. ncbi request reprint Risk of malignant mixed mullerian tumors after tamoxifen therapy for breast cancer
    Rochelle E Curtis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7362, USA
    J Natl Cancer Inst 96:70-4. 2004
    ..These findings indicate that tamoxifen may have delayed effects, such as the increased risk of MMMTs, rare but aggressive tumors of unclear pathogenesis...
  73. ncbi request reprint Serum concentrations of IGF-I, IGFBP-3 and c-peptide and risk of hyperplasia and cancer of the breast in postmenopausal women
    Catherine Schairer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Int J Cancer 108:773-9. 2004
    ..5 (95% CI 0.7-3.0) and 1.6 (95% CI 0.8-3.2), respectively (p trend = 0.35 and 0.25, respectively). Our results suggest that insulin and insulin resistance may play a role in breast pathology in postmenopausal women...
  74. ncbi request reprint Medication use and risk of ovarian carcinoma: a prospective study
    James V Lacey
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852 7234, USA
    Int J Cancer 108:281-6. 2004
    ..5) appeared to increase risk. In our study, neither anti-inflammatory medications nor anti-psychotic medications were associated with ovarian cancer. Potential associations with histamine-receptor antagonists may warrant further study...
  75. ncbi request reprint A prospective study of high-grade cervical neoplasia risk among human papillomavirus-infected women
    Philip E Castle
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD 20892, USA
    J Natl Cancer Inst 94:1406-14. 2002
    ..However, these potential risk factors have not been adequately studied in prospective studies...
  76. ncbi request reprint Menopausal hormone replacement therapy and risk of ovarian cancer
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, MSC 7234, Rockville, MD 20852, USA
    JAMA 288:334-41. 2002
    ..The association between menopausal hormone replacement therapy and ovarian cancer is unclear...
  77. ncbi request reprint Human leukocyte antigen class I alleles and cervical neoplasia: no heterozygote advantage
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:419-20. 2002
  78. pmc Results of human papillomavirus DNA testing with the hybrid capture 2 assay are reproducible
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
    J Clin Microbiol 40:1088-90. 2002
    ..68 and the linear-weighted kappa was 0.76. The results of this study indicate that HC 2 testing is reproducible even among cytologically normal women with low test values...
  79. ncbi request reprint Sexual behavior, human papillomavirus type 16 (HPV 16) infection, and HPV 16 seropositivity
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Sex Transm Dis 29:182-7. 2002
    ..Sexual behaviors have been linked to seropositivity for human papillomavirus (HPV) but not with the magnitude of the seroreactivity...
  80. ncbi request reprint The carcinogenicity of human papillomavirus types reflects viral evolution
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MA, USA
    Virology 337:76-84. 2005
    ..These results present several clear clues and research directions in our ongoing efforts to understand HPV carcinogenesis...
  81. ncbi request reprint Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Pharmacogenet Genomics 16:547-53. 2006
    ..The present study provides strong evidence against the existence of a substantial overall association between common genetic variation in CYP1B1 and breast cancer risk...
  82. ncbi request reprint Pathological characteristics of cervical adenocarcinoma in a multi-center US-based study
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Bethesda, MD 20852 7234, USA
    Gynecol Oncol 103:541-6. 2006
    ..We report a detailed pathology review of cervical adenocarcinoma subtypes, comparing growth patterns and appearance of non-neoplastic epithelium to inform possible clues for disease progression and early detection...
  83. ncbi request reprint Weight, height, and body mass index and risk for ovarian cancer in a cohort study
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville 20852 7234, MD
    Ann Epidemiol 16:869-76. 2006
    ..Reported associations between ovarian cancer and body size are inconsistent. We assessed ovarian cancer and anthropometry in the Breast Cancer Detection Demonstration Project Follow-Up Study...
  84. ncbi request reprint Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7068, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:2929-35. 2005
    ..Although endometriosis and uterine leiomyomas are common conditions, the extent to which either is associated with certain types of malignancies remains uncertain...
  85. ncbi request reprint Comparison of age distribution patterns for different histopathologic types of breast carcinoma
    William F Anderson
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS, Room 8036, 6120 Executive Boulevard, Bethesda, MD 20892 7244, USA
    Cancer Epidemiol Biomarkers Prev 15:1899-905. 2006
    ..More recent studies, however, have shown distinct age incidence patterns for female breast cancer when stratified by estrogen receptor (ER) expression and/or histopathologic subtypes, suggesting etiologic heterogeneity...
  86. ncbi request reprint Endometrial carcinoma risks among menopausal estrogen plus progestin and unopposed estrogen users in a cohort of postmenopausal women
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 14:1724-31. 2005
    ..However, endometrial carcinoma risks among estrogen plus progestin users and among former unopposed estrogen users are not firmly established...
  87. pmc Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20952 7234, USA
    BMC Cancer 7:60. 2007
    ..We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of epithelial ovarian cancer...
  88. pmc Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Sciences, Rockville, MD 20852, USA
    J Natl Cancer Inst 103:250-63. 2011
    ..Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors...
  89. ncbi request reprint Cervical tissue collection methods for RNA preservation: comparison of snap-frozen, ethanol-fixed, and RNAlater-fixation
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Diagn Mol Pathol 15:144-8. 2006
    ....
  90. pmc Skewed X chromosome inactivation and early-onset breast cancer
    J P Struewing
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Med Genet 43:48-53. 2006
    ..We tested this hypothesis in a group of 235 breast cancer patients and 253 controls (mean age 45.8 years) from a larger population based case control study...
  91. ncbi request reprint Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica
    S S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 184:1310-4. 2001
    ..2-23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection...
  92. ncbi request reprint Microsatellite instability is infrequent in medullary breast cancer
    S C Lee
    Department of Oncology, Johns Hopkins University, Baltimore, MD, USA
    Am J Clin Pathol 115:823-7. 2001
    ....
  93. ncbi request reprint Use of human papillomavirus DNA testing to compare equivocal cervical cytologic interpretations in the United States, Scandinavia, and the United Kingdom
    David R Scott
    Kaiser Permanente Department of Pathology, Portland, Oregon, USA
    Cancer 96:14-20. 2002
    ..Because international differences may be particularly marked, international comparisons of emerging data will require clear translations of "equivocal" and similar terms...
  94. doi request reprint Adulthood lifetime physical activity and breast cancer
    Beata Peplonska
    Department of Occupational and Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland
    Epidemiology 19:226-36. 2008
    ..However, the effects of moderate activities, timing of activities, and intervening effects of other risk factors remain less clear...
  95. ncbi request reprint Absolute risk models for subtypes of breast cancer
    Mitchell H Gail
    J Natl Cancer Inst 99:1657-9. 2007
  96. ncbi request reprint Family history as a co-factor for adenocarcinoma and squamous cell carcinoma of the uterine cervix: results from two studies conducted in Costa Rica and the United States
    Alice de M Zelmanowicz
    Programa de Pós Graduação em Epidemiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Int J Cancer 116:599-605. 2005
    ..These results are consistent with a role of host factors in the pathogenesis of squamous cell cervical cancer, although familial aggregation due to shared environmental exposures cannot be ruled out...
  97. pmc Evaluation of candidate methylation markers to detect cervical neoplasia
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75930, USA
    Gynecol Oncol 107:549-53. 2007
    ..We used quantitative PCR assays to evaluate methylation in five candidate genes (TNFRSF10C, DAPK1, SOCS3, HS3ST2 and CDH1) previously demonstrated as methylated in cervical cancer...
  98. ncbi request reprint Description of a seven-year prospective study of human papillomavirus infection and cervical neoplasia among 10000 women in Guanacaste, Costa Rica,
    M Concepcion Bratti
    FUCODOCSA Costa Rican Foundation for Training in Health Sciences, Proyecto Epidemiologico Guanacaste, San Jose, Costa Rica
    Rev Panam Salud Publica 15:75-89. 2004
    ..The purpose of this article is to describe this prospective study in detail and to present the preliminary findings regarding the incidence of cervical neoplasia...
  99. ncbi request reprint Seroreactivity to human papillomavirus (HPV) types 16, 18, or 31 and risk of subsequent HPV infection: results from a population-based study in Costa Rica
    Raphael P Viscidi
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Epidemiol Biomarkers Prev 13:324-7. 2004
    ..3; 95% CI 1.0-1.8). Thus, we did not observe immunity, although a protective effect from natural infection cannot be excluded because of the limits of available assays and study designs...
  100. ncbi request reprint Viral load of human papillomavirus and risk of CIN3 or cervical cancer
    Attila T Lorincz
    Digene Corporation, Gaithersburg, MD 20708, USA
    Lancet 360:228-9. 2002
    ..Results were stratified into four groups (RLU/PC 1 to <10, 10 to <100, 100 to <1000, > or = 1000). Although presence of HPV strongly increased risk of CIN3+, high viral load did not further predict risk of CIN3+...
  101. ncbi request reprint Hormone receptor immunohistochemistry and human papillomavirus in situ hybridization are useful for distinguishing endocervical and endometrial adenocarcinomas
    Annette Staebler
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U S A
    Am J Surg Pathol 26:998-1006. 2002
    ..The clinical utility of these techniques should be evaluated in studies that include curettage and biopsy specimens...