Min Shen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Hum Genet 119:659-68. 2006
  2. ncbi request reprint Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:299-309. 2005
  3. ncbi request reprint Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:2083-9. 2006
  4. ncbi request reprint Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Int J Cancer 116:768-73. 2005
  5. ncbi request reprint Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7240, USA
    Anticancer Res 25:537-42. 2005
  6. pmc A report of cytokine polymorphisms and COPD risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Int J Hyg Environ Health 211:352-6. 2008
  7. pmc Coal use, stove improvement, and adult pneumonia mortality in Xuanwei, China: a retrospective cohort study
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 117:261-6. 2009
  8. ncbi request reprint A pooled analysis of second primary pancreatic cancer
    Min Shen
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 163:502-11. 2006
  9. pmc Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 50:285-90. 2009
  10. doi request reprint Dietary factors, food contamination and lung cancer risk in Xuanwei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD, United States
    Lung Cancer 61:275-82. 2008

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Hum Genet 119:659-68. 2006
    ..Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies...
  2. ncbi request reprint Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:299-309. 2005
    ..002 and P=0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China...
  3. ncbi request reprint Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:2083-9. 2006
    ..The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity...
  4. ncbi request reprint Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Int J Cancer 116:768-73. 2005
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs...
  5. ncbi request reprint Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7240, USA
    Anticancer Res 25:537-42. 2005
    ..34; 95% CI: 1.16-9.67). We found genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China...
  6. pmc A report of cytokine polymorphisms and COPD risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Int J Hyg Environ Health 211:352-6. 2008
    ..However, in view of our relatively small sample size, this study should be replicated in other populations with substantial exposure to indoor air pollutants such as polycyclic aromatic hydrocarbons (PAH) and particulate matter...
  7. pmc Coal use, stove improvement, and adult pneumonia mortality in Xuanwei, China: a retrospective cohort study
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 117:261-6. 2009
    ..However, the impact of coal burning and stove improvement on risk of pneumonia is not clear...
  8. ncbi request reprint A pooled analysis of second primary pancreatic cancer
    Min Shen
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 163:502-11. 2006
    ..The elevated pancreatic cancer risk in young patients observed among several types of cancer implies a role of genetic factors. Radiotherapy is also suggested as a risk factor...
  9. pmc Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 50:285-90. 2009
    ..Integrin/receptor and complement pathways as well as IgE regulation are particularly noteworthy...
  10. doi request reprint Dietary factors, food contamination and lung cancer risk in Xuanwei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD, United States
    Lung Cancer 61:275-82. 2008
    ..Thus, residents could be exposed to carcinogenic coal emissions not only via inhalation but also via ingestion of these foodstuffs...
  11. pmc Association between mitochondrial DNA copy number, blood cell counts, and occupational benzene exposure
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 49:453-7. 2008
    ..Benzene exposure may induce mtDNA amplification, possibly in response to oxidative stress caused by benzene. The finding needs to be replicated by other studies...
  12. ncbi request reprint Polymorphisms in DNA repair genes and risk of non-Hodgkin's lymphoma in New South Wales, Australia
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7240, USA
    Haematologica 92:1180-5. 2007
    ..We investigated whether putatively functional single-nucleotide polymorphisms (SNP) in DNA repair genes influence susceptibility to NHL in a population-based case-control study conducted in Australia...
  13. ncbi request reprint Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, China
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:317-23. 2005
    ..However, additional studies in other populations with substantial environmental exposures to PAHs are needed to confirm our findings...
  14. ncbi request reprint Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, EPS 8109, Bethesda, MD 20892 7240, USA
    Hum Genet 121:161-8. 2007
    ..013), but was also associated with non-significant increased risks for each of the common B-cell histologies. These results suggest that SNPs in genes related to the oxidative stress pathway may be associated with increased risk of NHL...
  15. ncbi request reprint Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, China
    Kyoung Mu Lee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:1437-41. 2007
    ..11, 95% CI = 0.03-0.44; P(interaction) = 0.03). In conclusion, genetic variation in immunoregulatory genes may play an important role in the development of lung cancer in this population...
  16. ncbi request reprint Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Immunogenetics 59:839-52. 2007
    ..25). These results suggest that there is substantial genetic diversity in immune genes and exploration of SNP associations with immune-related diseases that vary in incidence across these two populations may be warranted...
  17. pmc Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics NCI, NIH, DHHS, Bethesda MD 20892, U S A
    Exp Mol Med 43:374-8. 2011
    ..0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary...
  18. pmc Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Blood 107:4101-8. 2006
    ..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL...
  19. pmc Variation in lung cancer risk by smoky coal subtype in Xuanwei, China
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Int J Cancer 123:2164-9. 2008
    ..2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source...
  20. ncbi request reprint Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 25:2177-81. 2004
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and other populations with substantial exposure to PAHs...
  21. ncbi request reprint Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancer
    Matthew R Bonner
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8121, MSC 7240, Bethesda, MD 20892 7240, USA
    Mutat Res 582:53-60. 2005
    ..The chemopreventive effects of green tea in this population may be restricted to individuals who are particularly susceptible to oxidative stress and oxidative DNA damage...
  22. pmc A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, United States
    Lung Cancer 73:133-7. 2011
    ..Telomere length plays an important role in chromosomal stability and tumorigenesis, and its measurement in peripheral white blood cell DNA may be a predictor of the development of lung cancer...
  23. pmc Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Br J Haematol 151:239-44. 2010
    ..These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL...
  24. pmc Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8118, MCS 7240, Bethesda, MD 20892 7240, USA
    Carcinogenesis 31:847-9. 2010
    ....
  25. ncbi request reprint Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, DHHS, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:823-7. 2007
    ..The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL...
  26. ncbi request reprint Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Cancer Res 65:9574-81. 2005
    ..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...
  27. pmc Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)
    Andrew S Rosenthal
    NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892 3370, USA
    Bioorg Med Chem Lett 21:3152-8. 2011
    ..Several of the most potent inhibitors were validated as being highly selective within a comprehensive kinome scan...
  28. pmc Occupational exposure to formaldehyde and alterations in lymphocyte subsets
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Am J Ind Med 56:252-7. 2013
    ..Formaldehyde is used in many occupational settings, most notably in manufacturing, health care, and embalming. Formaldehyde has been classified as a human carcinogen, but its mechanism of action remains uncertain...
  29. pmc Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase
    Jian Kang Jiang
    NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA
    Bioorg Med Chem Lett 20:3387-93. 2010
    ..These agents represent the second reported chemotype for activation of PKM2...
  30. pmc Hematotoxicity in workers exposed to low levels of benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Science 306:1774-6. 2004
    ..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations...
  31. pmc Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Eur J Haematol 85:492-5. 2010
    ..5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese...
  32. ncbi request reprint Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Chem Biol Interact 153:111-5. 2005
    ..Although our study does not rule out counterbalancing alterations of TREC levels in specific T cell subsets, benzene's lymphotoxicity does not appear to be mediated through diminished thymus function...
  33. ncbi request reprint Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
    J Environ Monit 8:1143-8. 2006
    ..The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory...
  34. pmc Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway
    H Dean Hosgood
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 29:1938-43. 2008
    ..These results should be viewed as exploratory until they are replicated in a larger study...
  35. ncbi request reprint Polymorphisms of the DNA repair genes XRCC1, XRCC3, XPD, interaction with environmental exposures, and bladder cancer risk in a case-control study in northern Italy
    Min Shen
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 12:1234-40. 2003
    ..Similarly, the XRCC1 codon 399 polymorphism also had a protective effect on bladder cancer among heavy smokers. The XPD polymorphism was not, however, associated with bladder cancer risk...
  36. pmc Polymorphisms in integrin genes and lymphoma risk
    Min Shen
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7240, USA
    Leuk Res 35:968-70. 2011
    ..01 level. While our results suggest that genetic polymorphisms in integrin genes may play a role in the genesis of lymphoma in women, they should be viewed as exploratory until they are replicated in additional populations...
  37. doi request reprint Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha
    Bryan A Bassig
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Environ Mol Mutagen 54:450-4. 2013
    ..Given that IL-10 plays an important role in immunologic processes, including mediating the Th1/Th2 balance, our findings provide additional evidence that TCE is immunotoxic in humans...
  38. pmc Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 30:50-8. 2009
    ..Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity...
  39. pmc A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety
    Matthew B Boxer
    National Institutes of Health, National Human Genome Research Institute, NIH Chemical Genomics Center, Rockville, Maryland 20850, USA
    ChemMedChem 5:730-8. 2010
    ..Assessment of hydrolytic stability and selected ADME properties highlighted these agents as potentially useful tools for studying caspase 1 down-regulation in various settings, including in vivo analyses...
  40. pmc Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)
    Bryan T Mott
    NIH Chemical Genomics Center, National Human Genome Research Institute, Bethesda, MD 20892 3370, USA
    Bioorg Med Chem Lett 19:6700-5. 2009
    ..Molecular docking provides further evidence that inhibition is the result of binding at the kinase hinge region. Selected compounds represent novel tools capable of potent and selective inhibition of Clk1, Clk4, and Dyrk1A...
  41. pmc A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma
    Qing Lan
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Clin Cancer Res 15:7429-33. 2009
    ..We hypothesized that telomere length in peripheral WBC DNA obtained from healthy individuals would be a predictor of future risk of developing non-Hodgkin lymphoma...
  42. ncbi request reprint Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:772-81. 2006
    ..027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures...
  43. pmc Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors
    Damien Y Duveau
    National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA
    Bioorg Med Chem Lett 23:682-6. 2013
    ..Docking of nilotinib and of analogues 2a-c to the binding pocket of Abl and of Kit showed that the lack of shape complementarity in Kit is compensated by the stabilizing effect from its juxtamembrane region...
  44. pmc Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter
    Natasha Thorne
    National Center for Advancing Translational Sciences, Bethesda, MD 20892 3370, USA
    Chem Biol 19:1060-72. 2012
    ..As in some cell-based FLuc reporter assays, compounds acting as FLuc inhibitors yield paradoxical luminescence increases, thus data on compounds acquired from FLuc-dependent assays require careful analysis as described here...
  45. pmc Decreased Numbers of CD4(+) Naive and Effector Memory T Cells, and CD8(+) Naïve T Cells, are Associated with Trichloroethylene Exposure
    H Dean Hosgood
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, MD, USA
    Front Oncol 1:53. 2011
    ..001). The selective targeting of TCE on CD8(+) naive and possibly CD4(+) naive T cells, and CD4(+) effector memory T cells, provide further insights into the immunosuppression-related response of human immune cells upon TCE exposure...
  46. pmc Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis
    Ganesha Rai
    NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Drive, MSC 3370, Bethesda, Maryland 20892 3370, USA
    J Med Chem 52:6474-83. 2009
    ..The results of these studies verify the utility of oxadiazole-2-oxides as novel inhibitors of TGR and as efficacious antischistosomal agents...
  47. pmc 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
    Martin J Walsh
    NIH Chemical Genomics Center, NIH Center for Translational Therapeutics, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA
    Bioorg Med Chem Lett 21:6322-7. 2011
    ..The synthesis, structure activity relationships, selectivity and notable physiochemical properties are described...
  48. pmc Smoky coal, tobacco smoking, and lung cancer risk in Xuanwei, China
    Christopher Kim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, United States School of Public Health, Yale University, New Haven, CT 06520, United States Electronic address
    Lung Cancer 84:31-5. 2014
    ..Here, we explored the differential association of tobacco use and lung cancer risk by the intensity, duration, and type of coal used...
  49. pmc Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs
    Min Shen
    National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 8:e75252. 2013
    ..The results presented here offer possibilities for the development of novel drug candidates for therapeutic uses to treat CLL and other diseases. ..
  50. pmc Tuberculosis and subsequent risk of lung cancer in Xuanwei, China
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Int J Cancer 124:1183-7. 2009
    ..The increased lung cancer risk, persisting years after a tuberculosis diagnosis, could reflect the effects of chronic pulmonary inflammation and scarring arising from tuberculosis...
  51. doi request reprint TOP2A is overexpressed and is a therapeutic target for adrenocortical carcinoma
    Meenu Jain
    Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Relat Cancer 20:361-70. 2013
    ..Of the TOP2A inhibitors screened, aclarubicin is a good candidate agent to test in future clinical trials for patients with locally advanced and metastatic ACC...
  52. pmc Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Carcinogenesis 31:1592-6. 2010
    ..Given that altered immunity is an established risk factor for NHL, these results add to the biologic plausibility that TCE is a possible lymphomagen...
  53. ncbi request reprint Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia
    Warren Fiskus
    Authors Affiliations Houston Methodist Research Institute The University of Texas M D Anderson Cancer Center, Houston, Texas Hematology Branch, National Heart Lung and Blood Institute NHLBI National Center for Advancing Translational Sciences, NIH, Bethesda, Maryland The University of Kansas Medical Center Institute for Advancing Medical Innovation, Kansas University, Kansas City, Kansas Division of Hematology, Department of Internal Medicine, The Comprehensive Cancer Center at The Ohio State University, Columbus, Ohio and Weill Cornell Medical College, New York, New York
    Cancer Res 74:2520-32. 2014
    ..Our results provide a rationale to reposition the approved drug auranofin for clinical evaluation in the therapy of CLL...
  54. pmc Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB
    Bryan T Mott
    NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, MSC 3370 Bethesda, Maryland 20892 3370, USA
    J Med Chem 53:52-60. 2010
    ..brucei parasites. Selected compounds were screened against a panel of human cysteine and serine proteases to determine selectivity, and a cocrystal was obtained of our most potent analogue bound to cruzain...
  55. pmc Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries
    Henrike Veith
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland, USA
    Nat Biotechnol 27:1050-5. 2009
    ..We also identified chemical substructures that differentiated between the five isozymes. The pharmacological compendium described here should further the understanding of CYP isozymes...
  56. pmc Application of a homogenous membrane potential assay to assess mitochondrial function
    Srilatha Sakamuru
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892 3370, USA
    Physiol Genomics 44:495-503. 2012
    ..Our results demonstrate that this homogenous cell-based Mito-MPS assay can be used to evaluate the ability of large numbers of chemicals to decrease mitochondrial function...
  57. pmc Chiral kinase inhibitors
    Jian Kang Jiang
    NIH Chemical Genomics Center, NHGRI, National Institutes of Health, Bethesda, MD 20892 3370, USA
    Curr Top Med Chem 11:800-9. 2011
    ..Here we discuss several advanced chiral small molecule kinase inhibitors where stereochemistry plays an important role in terms of potency and selectivity...
  58. ncbi request reprint Census and geographic differences between respondents and nonrespondents in a case-control study of non-Hodgkin lymphoma
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Epidemiol 167:350-61. 2008
    ..The bias was 8%, indicating that the socioeconomic and demographic differences between respondents and nonrespondents did not result in a large bias in the risk estimate for education...
  59. pmc Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay
    John A Blackford
    Steroid Hormones Section J A B, E J D, M P, S S S, Laboratory of Endocrinology and Receptor Biology, and Laboratory of Biological Modeling C C C, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 and National Center for Advancing Translational Sciences K R B, M S, Z L, D S A, C P A, National Institutes of Health, Rockville, Maryland 20892
    Mol Endocrinol 28:1194-206. 2014
    ..These combined assays offer a straightforward method of identifying numerous new pharmaceuticals that can alter GR transactivation in ways that could be clinically useful. ..
  60. pmc A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation
    Mindy I Davis
    National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 8:e54127. 2013
    ..This homogeneous assay may apply to other lipid kinases and should help in the identification of leads for this class of enzymes by enabling high-throughput screening efforts...
  61. pmc Comparison of bioluminescent kinase assays using substrate depletion and product formation
    Cordelle Tanega
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland, USA
    Assay Drug Dev Technol 7:606-14. 2009
    ..We conclude that the bioluminescence ADP detection assay system is a viable generic alternative to the widely used ATP-depletion assay for ATPases and discuss the advantages and disadvantages of both approaches...
  62. pmc A panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human disease
    Matthew G Rees
    National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, United Kingdom
    PLoS ONE 9:e89335. 2014
    ..The assay panel developed here should help direct future investigation of the GCK-GKRP interaction in these or other physiologically relevant human systems. ..
  63. pmc Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
    Matthew B Boxer
    NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, MSC 3370 Bethesda, Maryland 20850, USA
    J Med Chem 53:1048-55. 2010
    ..7 microg/mL), and 58 (AC(50) = 38 nM, maximum response = 82%; solubility = 51.2 microg/mL). The small molecules described here represent first-in-class activators of PKM2...
  64. pmc Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1
    Anton Simeonov
    NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS ONE 4:e5740. 2009
    ..The studies herein report on the identification of novel, small molecule APE1-targeted bioactive inhibitor probes, which represent initial chemotypes towards the development of potential pharmaceuticals...
  65. pmc A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor
    Jian Kang Jiang
    NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, United States
    Bioorg Med Chem Lett 24:1148-53. 2014
    ....
  66. pmc Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening
    Naris Nilubol
    Endocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 10 Center Drive, MSC 1201, Bethesda, MD 20892, USA
    J Transl Med 10:198. 2012
    ..The objective of this study was to identify and validate drugs with antineoplastic effect in ACC cells using a novel quantitative high-throughput drug screening (qHTS) technique...
  67. pmc Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124
    Douglas S Auld
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892 3370, USA
    Proc Natl Acad Sci U S A 107:4878-83. 2010
    ..To our knowledge, this is an unusual example in which the "off-target" effect of a small molecule is mediated by an MAI mechanism...
  68. pmc Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
    ..Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts...
  69. ncbi request reprint Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Pharmacogenet Genomics 17:789-801. 2007
    ....
  70. ncbi request reprint The opposite-direction modulation of CD4+CD25+ Tregs and T helper 1 cells in acute coronary syndromes
    Shu fang HAN
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi an, PR China
    Clin Immunol 124:90-7. 2007
    ..The reversed development between CD4+CD25+ Tregs and Th1 cells might contribute to plaque destabilization...
  71. ncbi request reprint Modeling human metabolism of benzene following occupational and environmental exposures
    Sungkyoon Kim
    School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
    Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006
    ..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers...
  72. pmc Aberrant gene promoter methylation in sputum from individuals exposed to smoky coal emissions
    Yang Liu
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Anticancer Res 28:2061-6. 2008
    ..Here, the promoter methylation of p16, MGMT, RASSF1A and DAPK genes was investigated in sputum of individuals exposed to smoky coal emissions in Xuan Wei, China, where the lung cancer rate more than 6 times the Chinese national average...
  73. ncbi request reprint Use of 'Omic' technologies to study humans exposed to benzene
    Martyn T Smith
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:123-7. 2005
    ..Omic technologies therefore have significant potential in generating novel biomarkers of exposure, susceptibility and response to benzene...
  74. pmc Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workers
    Matthew S Forrest
    School of Public Health, University of California, Berkeley, California 94720 7360, USA
    Environ Health Perspect 113:801-7. 2005
    ..Thus, microarray analysis along with real-time PCR confirmation reveals that altered expressions of CXCL16, ZNF331, JUN, and PF4 are potential biomarkers of benzene exposure...
  75. ncbi request reprint Serum cotinine level as predictor of lung cancer risk
    Paolo Boffetta
    IARC, 150 cours Albert Thomas, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 15:1184-8. 2006
    ..No prospective studies are available on serum cotinine level as a marker of lung cancer risk...
  76. ncbi request reprint [Primary study on establishment of namalwa 12/MTX resistant cell strain and its mechanism]
    Jing Chen
    Shanghai Xinhua Hospital, Shanghai Children s Medical Center, Shanghai Second Medical University, Shanghai 200092, P R China
    Ai Zheng 21:1335-40. 2002
    ..However, there was few report about its drug resistance mechanism in lymphoma. This study was designed to establish Burkitt's lymphoma methotrexate resistant cell strain--Namlwa 12/MTX and study its resistant mechanism...
  77. ncbi request reprint Polychlorinated biphenyls and polybrominated diphenyl ethers in surface sediments from the Yangtze River Delta
    Min Shen
    State Key Laboratory of Pollution Control and Resources, School of the Environment, Nanjing University, Nanjing 210093, China
    Mar Pollut Bull 52:1299-304. 2006
  78. ncbi request reprint [Pleuropulmonary manifestations of systemic lupus erythematosus]
    Min Shen
    Department of Rheumatology and Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 85:3392-5. 2005
    ..To analyze the incidence, clinical features, and prognosis of pleuropulmonary involvement in patients with systemic lupus erythematosus (SLE)...
  79. ncbi request reprint [ABO genotyping by duplex amplification and oligonucleotide arrays assay]
    Li Li
    Institute of Forensic Sciences, Ministry of Justice, PRChina, Shanghai 200063, China
    Fa Yi Xue Za Zhi 20:193-6. 2004
    ..ABO genotyping for forensic identification by oligonucleotide chip...
  80. ncbi request reprint [A case-control study on urinary calculi and dietary factors]
    Min Shen
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Liu Xing Bing Xue Za Zhi 23:134-7. 2002
    ..To study the role of dietary and nutritional factors in the etiology of urolithiasis...
  81. ncbi request reprint Angelica sinensis: a novel adjunct to prevent doxorubicin-induced chronic cardiotoxicity
    Yan Fei Xin
    State Key Laboratory of Safety Evaluation for New Drugs, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China
    Basic Clin Pharmacol Toxicol 101:421-6. 2007
    ..These results suggested that A. sinensis elicited a typical cardioprotective effect on doxorubicin-related oxidative stress, and could be a novel adjunct in the combination with doxorubicin chemotherapy...