Gene M Shearer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Alloimmunization for immune-based therapy and vaccine design against HIV/AIDS
    G M Shearer
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Today 20:66-71. 1999
  2. pmc CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA
    Blood 106:3524-31. 2005
  3. pmc Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13974-9. 2005
  4. pmc HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20815, USA
    Blood 109:3351-9. 2007
  5. doi request reprint Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:4313-20. 2009
  6. pmc Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Virol 81:11593-603. 2007
  7. pmc Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    Valentina Cecchinato
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 180:5439-47. 2008
  8. doi request reprint HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques
    Jean Philippe Herbeuval
    Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, Maryland, USA
    AIDS 23:35-40. 2009
  9. ncbi request reprint TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, 9000 Rockville Pike, Bethesda, MD, USA
    Blood 105:2458-64. 2005
  10. pmc PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Clin Immunol 129:132-44. 2008

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Alloimmunization for immune-based therapy and vaccine design against HIV/AIDS
    G M Shearer
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Today 20:66-71. 1999
    ..Here, Gene Shearer, Ligia Pinto and Mario Clerici raise the possibility that alloimmunization against a spectrum of HLA-disparate leukocytes be considered for immune-based therapy and as an AIDS vaccine...
  2. pmc CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA
    Blood 106:3524-31. 2005
    ..We propose a novel model in which a type 1 IFN-regulated TRAIL /DR5 mechanism induces apoptosis of HIV-1-exposed CD4(+) T cells...
  3. pmc Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13974-9. 2005
    ..Our findings suggest a potential unique role of pDCs in the immunopathogenesis of HIV-1 infection by inducing the death molecule TRAIL...
  4. pmc HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20815, USA
    Blood 109:3351-9. 2007
    ..Thus, induction of IDO in pDCs by HIV may contribute to the T-cell functional impairment observed in HIV/AIDS by a non-interferon-dependent mechanism...
  5. doi request reprint Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:4313-20. 2009
    ..Further studies are required to elucidate the immunologic or virologic mechanism by which d-1mT inhibited SIV replication in vivo...
  6. pmc Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Virol 81:11593-603. 2007
    ..Increased T(reg) and IDO in LT of SIV-infected macaques may be the consequence of increased tissue inflammation and/or may favor virus replication during the chronic phase of SIV infection...
  7. pmc Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    Valentina Cecchinato
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 180:5439-47. 2008
    ..These data provide the first direct evidence that immune activation drives viral replication, and suggest caution in the use of therapeutic approaches for HIV infection in vivo that increase CD4(+) T cell proliferation...
  8. doi request reprint HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques
    Jean Philippe Herbeuval
    Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, Maryland, USA
    AIDS 23:35-40. 2009
    ..To determine how antiretroviral therapy (ART) or HAART affects the expression of apoptotic ligands and their death receptors in the blood and lymphoid tissues of HIV-infected patients and simian immunodeficiency virus-infected macaques...
  9. ncbi request reprint TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, 9000 Rockville Pike, Bethesda, MD, USA
    Blood 105:2458-64. 2005
    ..The high production of TRAIL by antigen-presenting cells may contribute to the death of CD4+ T cells during progression to AIDS...
  10. pmc PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Clin Immunol 129:132-44. 2008
    ..Finally, T cell proliferation was improved by PDL-1 blockade in HIV-treated PBMC. In the setting of HIV infection, IFN-alpha may negatively affect T cell responses by inducing PDL-1...
  11. ncbi request reprint Are blockers of gp120/CD4 interaction effective inhibitors of HIV-1 immunopathogenesis?
    Jean Philippe Herbeuval
    Experimental Immunology Branch, Centers for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    AIDS Rev 8:3-8. 2006
    ..We consider here mechanisms that have been suggested, and propose a data-supported model in which CD4+ T-cells undergo apoptosis that is signaled by the binding of viral gp120 to cellular CD4...
  12. ncbi request reprint Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques
    Anna Hryniewicz
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Building 41, Bethesda, MD 20892, USA
    J Immunol 178:3492-504. 2007
    ..These results underscore the importance of testing immunomodulatory approaches in vivo to assess potential risks and benefits for HIV-1-infected individuals...
  13. pmc HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2961. 2008
    ....
  14. pmc Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20092, USA
    Proc Natl Acad Sci U S A 103:7000-5. 2006
    ..TRAIL mRNA levels in LT correlated with plasma viral load. We show that HIV-1 induces IFN-alpha and the TRAIL/DR5 apoptotic pathway in LT, suggesting a role for these cytokines in HIV-1 immunopathogenesis...
  15. pmc Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2',3'-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockade
    Monica Vaccari
    Animal Models and Retroviral Vaccines Section, NCI, NIH, Bethesda, Maryland, USA
    J Virol 86:108-13. 2012
    ..Thus, caution should be used when considering approaches aimed at targeting immune activation during ART...
  16. ncbi request reprint Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:1574-81. 2005
    ....
  17. ncbi request reprint Do regulatory T-cells play a role in AIDS pathogenesis?
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    AIDS Rev 8:141-7. 2006
    ....
  18. pmc HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha
    Andrew W Hardy
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:17453-8. 2007
    ..Finally, IFN-alpha increased the survival of IKpDC. We characterized a subset of pDC with a killer activity that is activated by endosomal-associated viral RNA and not by infection...
  19. pmc CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques
    Anna Hryniewicz
    NCI, Bldg 41 Rm D 804, Bethesda, MD 20892 5065, USA
    Blood 108:3834-42. 2006
    ..Therefore, blunting T(reg) function in macaques infected with SIV did not have detrimental virologic effects and may provide a valuable approach to complement ART and therapeutic vaccination in the treatment of HIV-1 infection...
  20. doi request reprint Differential effect of type I and type II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells
    Oscar D Cano
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Neurosci Lett 438:22-5. 2008
    ..Thus type I and type II IFN stimulate astrocyte-derived cells to produce neopterin and exert differential effects on amino acid metabolism...
  21. pmc Chronic innate immune activation as a cause of HIV-1 immunopathogenesis
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Immunol 126:235-42. 2008
    ..Subsequent production of type I interferon and indoleamine 2,3-dioxygenase may exert suppressive and cytotoxic effects on T cells...
  22. ncbi request reprint HIV inhibitory activity generated by antigen-stimulated cord blood leukocytes
    Ligia A Pinto
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    AIDS 17:1389-92. 2003
  23. ncbi request reprint How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    Curr Drug Metab 8:217-23. 2007
    ..Therapeutic approaches aimed at manipulating this powerful immune suppressive mechanism might be considered in the setting of HIV infection...
  24. pmc Defective in vitro IL-2 production in lupus is an early but secondary event paralleling disease activity: evidence from the murine parent-into-F1 model supports staging of IL-2 defects in human lupus
    Charles S Via
    Department of Pathology, Uniformed Services University of Health Sciences, Bethesda, MD 20841, USA
    Autoimmunity 43:23-31. 2010
    ..Successful adaptation of this approach to the clinical setting could allow not only earlier therapeutic intervention and reduced organ damage but also earlier tapering of pharmacological agents and reduced untoward effects...
  25. ncbi request reprint Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognition
    Maria T Rugeles
    Universidad de Antioquia, Medellin, Colombia, The Experimental Immunology Branch, NCI, NIH, Bethesda, USA
    AIDS 17:481-6. 2003
    ..This study was performed to determine whether ribonucleases (RNases) contribute to the soluble HIV-1 inhibitory activity that results from the recognition of HLA alloantigens...
  26. ncbi request reprint Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis
    Kenichi Sakurai
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4B36, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Neuroimmunol 129:186-96. 2002
    ..These results suggest that IDO may contribute to the regulation of T cell activity associated with the different phases of this animal model of multiple sclerosis (MS)...
  27. ncbi request reprint B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression
    Daria Trabattoni
    Chair of Immunolgy, Dipartimento Scienze Precliniche Laboratorio Integrato Tecnologie Avanzate DISP LITA Vialba, University of Milano, Milano, Italy
    Blood 101:2514-20. 2003
    ..B7-H1 is a surrogate marker potentially involved in AIDS disease progression...
  28. ncbi request reprint Alternative HIV vaccine strategies
    Thomas Lehner
    Science 297:1276-7. 2002
  29. ncbi request reprint The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients
    Jan Andersson
    Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Immunol 174:3143-7. 2005
    ..Our data could provide a new basis for immune-based therapies that counteract in vivo Treg and thereby reinforce appropriate antiviral immunity...
  30. pmc HIV-1 immunopathogenesis: how good interferon turns bad
    Jean Philippe Herbeuval
    UMR CNRS 8147, Hopital Necker, Universite Paris V, Paris, France
    Clin Immunol 123:121-8. 2007
    ..The binding of infectious or noninfectious HIV-1 to CD4 on these T cells results in expression of the TRAIL death receptor 5 (DR5), leading to the selective death of HIV-exposed CD4+ T cells...
  31. pmc HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS
    Jakob Nilsson
    Division of Molecular Immunology ML 7021, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 108:3808-17. 2006
    ..Considered together, our findings imply that therapeutic manipulation of Treg-cell number and/or function could improve immune control of HIV infection...
  32. ncbi request reprint Ribonucleases in HIV type 1 inhibition: effect of recombinant RNases on infection of primary T cells and immune activation-induced RNase gene and protein expression
    Victoria I Bedoya
    Immunovirology Group, Universidad de Antioquia, Medelin, Colombia
    AIDS Res Hum Retroviruses 22:897-907. 2006
    ..These findings raise the possibilities that multiple naturally occurring RNases may contribute to protection against HIV-1 infection and could be considered for utilization in HIV-1 therapy...
  33. ncbi request reprint Regulatory T cells (Treg) and HIV/AIDS: summary of the September 7-8, 2006 workshop
    Claire A Chougnet
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    AIDS Res Hum Retroviruses 23:945-52. 2007
    ....
  34. doi request reprint The hunt for an HIV vaccine: time to rethink recent failures
    Adriano Boasso
    Department of Immunology, Chelsea and Westminster Hospital, Imperial College, London, UK
    Lancet 371:1897-8. 2008
  35. ncbi request reprint Immunologic profile of highly exposed yet HIV type 1-seronegative men
    Otto O Yang
    Department of Medicine, UCLA Medical Center, Los Angeles, California 90095, USA
    AIDS Res Hum Retroviruses 18:1051-65. 2002
    ..General immune parameters reflected by CD8(+) T cell levels and activation, and monocyte concentrations may affect the risk of infection with HIV-1, and/or serve as markers of exposure...
  36. ncbi request reprint Alloantigen recognition in utero: dual advantage for the fetus?
    Maria T Rugeles
    Immunovirology Group, AA 1226 Universidad de Antioquia, Medellin, Colombia
    Trends Immunol 25:348-52. 2004
  37. ncbi request reprint Antigen-presenting cells in HIV pathogenesis and therapy: summary of the October 17-18, 2002, Think Tank meeting
    Alan Landay
    Rush Medical College, Chicago, Illinois, USA
    Clin Immunol 103:243-8. 2002