Research Topics
Genomes and Genes | Gene M ShearerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Alloimmunization for immune-based therapy and vaccine design against HIV/AIDSG M Shearer
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunol Today 20:66-71. 1999..Here, Gene Shearer, Ligia Pinto and Mario Clerici raise the possibility that alloimmunization against a spectrum of HLA-disparate leukocytes be considered for immune-based therapy and as an AIDS vaccine...
CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosisJean Philippe Herbeuval
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA
Blood 106:3524-31. 2005..We propose a novel model in which a type 1 IFN-regulated TRAIL /DR5 mechanism induces apoptosis of HIV-1-exposed CD4(+) T cells...- Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cellsJean Philippe Herbeuval
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:13974-9. 2005..Our findings suggest a potential unique role of pDCs in the immunopathogenesis of HIV-1 infection by inducing the death molecule TRAIL... - HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cellsAdriano Boasso
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20815, USA
Blood 109:3351-9. 2007..Thus, induction of IDO in pDCs by HIV may contribute to the T-cell functional impairment observed in HIV/AIDS by a non-interferon-dependent mechanism... 
Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaquesAdriano Boasso
Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 182:4313-20. 2009..Further studies are required to elucidate the immunologic or virologic mechanism by which d-1mT inhibited SIV replication in vivo...- Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infectionAdriano Boasso
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
J Virol 81:11593-603. 2007..Increased T(reg) and IDO in LT of SIV-infected macaques may be the consequence of increased tissue inflammation and/or may favor virus replication during the chronic phase of SIV infection... - HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaquesJean Philippe Herbeuval
Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, Maryland, USA
AIDS 23:35-40. 2009..To determine how antiretroviral therapy (ART) or HAART affects the expression of apoptotic ligands and their death receptors in the blood and lymphoid tissues of HIV-infected patients and simian immunodeficiency virus-infected macaques... - TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cellsJean-Philippe Herbeuval
Experimental Immunology Branch, National Cancer Institute (NCI, National Institutes of Health (NIH, 9000 Rockville Pike, Bethesda, MD, USA
Blood 105:2458-64. 2005..The high production of TRAIL by antigen-presenting cells may contribute to the death of CD4+ T cells during progression to AIDS... - PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytesAdriano Boasso
Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
Clin Immunol 129:132-44. 2008..Finally, T cell proliferation was improved by PDL-1 blockade in HIV-treated PBMC. In the setting of HIV infection, IFN-alpha may negatively affect T cell responses by inducing PDL-1... - Are blockers of gp120/CD4 interaction effective inhibitors of HIV-1 immunopathogenesis?Jean Philippe Herbeuval
Experimental Immunology Branch, Centers for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
AIDS Rev 8:3-8. 2006..We consider here mechanisms that have been suggested, and propose a data-supported model in which CD4+ T-cells undergo apoptosis that is signaled by the binding of viral gp120 to cellular CD4... - Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaquesAnna Hryniewicz
Animal Models and Retroviral Vaccines Section, National Cancer Institute, Building 41, Bethesda, MD 20892, USA
J Immunol 178:3492-504. 2007..These results underscore the importance of testing immunomodulatory approaches in vivo to assess potential risks and benefits for HIV-1-infected individuals... - Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infectionValentina Cecchinato
Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
J Immunol 180:5439-47. 2008..These data provide the first direct evidence that immune activation drives viral replication, and suggest caution in the use of therapeutic approaches for HIV infection in vivo that increase CD4(+) T cell proliferation... - HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activationAdriano Boasso
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 3:e2961. 2008.... - Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patientsJean Philippe Herbeuval
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20092, USA
Proc Natl Acad Sci U S A 103:7000-5. 2006..TRAIL mRNA levels in LT correlated with plasma viral load. We show that HIV-1 induces IFN-alpha and the TRAIL/DR5 apoptotic pathway in LT, suggesting a role for these cytokines in HIV-1 immunopathogenesis... - Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2',3'-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockadeMonica Vaccari
Animal Models and Retroviral Vaccines Section, NCI, NIH, Bethesda, Maryland, USA
J Virol 86:108-13. 2012..Thus, caution should be used when considering approaches aimed at targeting immune activation during ART... - Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cellsAdriano Boasso
Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 105:1574-81. 2005.... - HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alphaAndrew W Hardy
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:17453-8. 2007..Finally, IFN-alpha increased the survival of IKpDC. We characterized a subset of pDC with a killer activity that is activated by endosomal-associated viral RNA and not by infection... - Do regulatory T-cells play a role in AIDS pathogenesis?Adriano Boasso
Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
AIDS Rev 8:141-7. 2006.... - CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaquesAnna Hryniewicz
NCI, Bldg 41 Rm D 804, Bethesda, MD 20892 5065, USA
Blood 108:3834-42. 2006..Therefore, blunting T(reg) function in macaques infected with SIV did not have detrimental virologic effects and may provide a valuable approach to complement ART and therapeutic vaccination in the treatment of HIV-1 infection... - Differential effect of type I and type II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cellsOscar D Cano
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Neurosci Lett 438:22-5. 2008..Thus type I and type II IFN stimulate astrocyte-derived cells to produce neopterin and exert differential effects on amino acid metabolism... - Chronic innate immune activation as a cause of HIV-1 immunopathogenesisAdriano Boasso
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Clin Immunol 126:235-42. 2008..Subsequent production of type I interferon and indoleamine 2,3-dioxygenase may exert suppressive and cytotoxic effects on T cells... - HIV inhibitory activity generated by antigen-stimulated cord blood leukocytesLigia A Pinto
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
AIDS 17:1389-92. 2003 - How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulationAdriano Boasso
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
Curr Drug Metab 8:217-23. 2007..Therapeutic approaches aimed at manipulating this powerful immune suppressive mechanism might be considered in the setting of HIV infection... - Defective in vitro IL-2 production in lupus is an early but secondary event paralleling disease activity: evidence from the murine parent-into-F1 model supports staging of IL-2 defects in human lupusCharles S Via
Department of Pathology, Uniformed Services University of Health Sciences, Bethesda, MD 20841, USA
Autoimmunity 43:23-31. 2010..Successful adaptation of this approach to the clinical setting could allow not only earlier therapeutic intervention and reduced organ damage but also earlier tapering of pharmacological agents and reduced untoward effects... - Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognitionMaria T Rugeles
Universidad de Antioquia, Medellin, Colombia, The Experimental Immunology Branch, NCI, NIH, Bethesda, USA
AIDS 17:481-6. 2003..CONCLUSION: These findings indicate that the majority of the soluble HIV-1 inhibitory activity contained in the supernatants of mixed lymphocyte reactions is due to EDN or a closely related RNase... - Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitisKenichi Sakurai
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4B36, 9000 Rockville Pike, Bethesda, MD 20892, USA
J Neuroimmunol 129:186-96. 2002..These results suggest that IDO may contribute to the regulation of T cell activity associated with the different phases of this animal model of multiple sclerosis (MS)... - B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progressionDaria Trabattoni
Chair of Immunolgy, Dipartimento Scienze Precliniche Laboratorio Integrato Tecnologie Avanzate DISP LITA Vialba, University of Milano, Milano, Italy
Blood 101:2514-20. 2003..B7-H1 is a surrogate marker potentially involved in AIDS disease progression... - Alternative HIV vaccine strategiesThomas Lehner
Science 297:1276-7. 2002 - The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patientsJan Andersson
Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
J Immunol 174:3143-7. 2005..Our data could provide a new basis for immune-based therapies that counteract in vivo Treg and thereby reinforce appropriate antiviral immunity... - HIV-1 immunopathogenesis: how good interferon turns badJean Philippe Herbeuval
UMR CNRS 8147, Hopital Necker, Universite Paris V, Paris, France
Clin Immunol 123:121-8. 2007..The binding of infectious or noninfectious HIV-1 to CD4 on these T cells results in expression of the TRAIL death receptor 5 (DR5), leading to the selective death of HIV-exposed CD4+ T cells... - HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDSJakob Nilsson
Division of Molecular Immunology (ML#7021, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Blood 108:3808-17. 2006..Considered together, our findings imply that therapeutic manipulation of Treg-cell number and/or function could improve immune control of HIV infection... - Ribonucleases in HIV type 1 inhibition: effect of recombinant RNases on infection of primary T cells and immune activation-induced RNase gene and protein expressionVictoria I Bedoya
Immunovirology Group, Universidad de Antioquia, , Colombia
AIDS Res Hum Retroviruses 22:897-907. 2006..These findings raise the possibilities that multiple naturally occurring RNases may contribute to protection against HIV-1 infection and could be considered for utilization in HIV-1 therapy... - Regulatory T cells (Treg) and HIV/AIDS: summary of the September 7-8, 2006 workshopClaire A Chougnet
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
AIDS Res Hum Retroviruses 23:945-52. 2007.... - The hunt for an HIV vaccine: time to rethink recent failuresAdriano Boasso
Department of Immunology, Chelsea and Westminster Hospital, Imperial College, London, UK
Lancet 371:1897-8. 2008 - Immunologic profile of highly exposed yet HIV type 1-seronegative menOtto O Yang
Department of Medicine, UCLA Medical Center, Los Angeles, California 90095, USA
AIDS Res Hum Retroviruses 18:1051-65. 2002..General immune parameters reflected by CD8(+) T cell levels and activation, and monocyte concentrations may affect the risk of infection with HIV-1, and/or serve as markers of exposure... - Alloantigen recognition in utero: dual advantage for the fetus?Maria T Rugeles
Immunovirology Group, AA 1226 Universidad de Antioquia, Medellin, Colombia
Trends Immunol 25:348-52. 2004 - Antigen-presenting cells in HIV pathogenesis and therapy: summary of the October 17-18, 2002, Think Tank meetingAlan Landay
Rush Medical College, Chicago, Illinois, USA
Clin Immunol 103:243-8. 2002