Erik M Shapiro

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc 23Na MRI accurately measures fixed charge density in articular cartilage
    Erik M Shapiro
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Magn Reson Med 47:284-91. 2002
  2. ncbi request reprint In vivo detection of single cells by MRI
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 55:242-9. 2006
  3. ncbi request reprint Sizing it up: cellular MRI using micron-sized iron oxide particles
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Magn Reson Med 53:329-38. 2005
  4. pmc MRI detection of single particles for cellular imaging
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:10901-6. 2004
  5. pmc Fast MRI of RF heating via phase difference mapping
    Erik M Shapiro
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Magn Reson Med 47:492-8. 2002
  6. ncbi request reprint Proteoglycan loss in human knee cartilage: quantitation with sodium MR imaging--feasibility study
    Andrew J Wheaton
    Department of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104 6100, USA
    Radiology 231:900-5. 2004
  7. ncbi request reprint Cartilage volume quantification via Live Wire segmentation
    Alexander J Gougoutas
    Metabolic Magnetic Resonance Research and Computing Center, Department of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 2045, USA
    Acad Radiol 11:1389-95. 2004
  8. ncbi request reprint Three-dimensional T1rho-weighted MRI at 1.5 Tesla
    Arijitt Borthakur
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6100, USA
    J Magn Reson Imaging 17:730-6. 2003
  9. pmc In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxide: quantification of labeled cell phenotype
    James P Sumner
    Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD 20892, USA
    Neuroimage 44:671-8. 2009
  10. ncbi request reprint Quantifying sodium in the human wrist in vivo by using MR imaging
    Arijitt Borthakur
    Department of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    Radiology 224:598-602. 2002

Collaborators

Detail Information

Publications20

  1. pmc 23Na MRI accurately measures fixed charge density in articular cartilage
    Erik M Shapiro
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Magn Reson Med 47:284-91. 2002
    ..Both methodologies gave similar results, with the average sodium concentration of normal human patellar cartilage ranging from approximately 240 to 260 mM. This corresponds to FCDs of -158 mM to -182 mM...
  2. ncbi request reprint In vivo detection of single cells by MRI
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 55:242-9. 2006
    ..Detecting single cells in vivo opens the door to a number of experiments, such as monitoring rare cellular events, assessing the kinetics of stem cell homing, and achieving early detection of metastases...
  3. ncbi request reprint Sizing it up: cellular MRI using micron-sized iron oxide particles
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Magn Reson Med 53:329-38. 2005
    ..We demonstrate that these large particles and the cells labeled with them can be detected by spin echo (SE)-based imaging methods. These measurements indicate that MPIOs should be useful for improving cell tracking by MRI...
  4. pmc MRI detection of single particles for cellular imaging
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:10901-6. 2004
    ..These results demonstrate that MRI can detect single particles and indicate that single-particle detection will be useful for cellular imaging...
  5. pmc Fast MRI of RF heating via phase difference mapping
    Erik M Shapiro
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Magn Reson Med 47:492-8. 2002
    ..Applications of this technique in assessing the safety of pulse sequences and MR coils are discussed...
  6. ncbi request reprint Proteoglycan loss in human knee cartilage: quantitation with sodium MR imaging--feasibility study
    Andrew J Wheaton
    Department of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104 6100, USA
    Radiology 231:900-5. 2004
    ..The data suggest that sodium MR imaging has potential for use as a quantitative diagnostic tool to measure changes in proteoglycan content in early-stage osteoarthritis...
  7. ncbi request reprint Cartilage volume quantification via Live Wire segmentation
    Alexander J Gougoutas
    Metabolic Magnetic Resonance Research and Computing Center, Department of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 2045, USA
    Acad Radiol 11:1389-95. 2004
    ..In the present work, the accuracy and reproducibility of the Live Wire method for the quantification of cartilage volume in MR images is evaluated...
  8. ncbi request reprint Three-dimensional T1rho-weighted MRI at 1.5 Tesla
    Arijitt Borthakur
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6100, USA
    J Magn Reson Imaging 17:730-6. 2003
    ....
  9. pmc In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxide: quantification of labeled cell phenotype
    James P Sumner
    Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD 20892, USA
    Neuroimage 44:671-8. 2009
    ..Using MRI to visualize neural progenitor cell behavior in individual animals during plasticity or disease models should be a useful tool, especially in combination with other information that MRI can supply...
  10. ncbi request reprint Quantifying sodium in the human wrist in vivo by using MR imaging
    Arijitt Borthakur
    Department of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    Radiology 224:598-602. 2002
    ..The feasibility of quantifying sodium in vivo was demonstrated. This method has potential applications in monitoring the integrity of cartilaginous tissue in vivo...
  11. pmc Delivery of fluorescent probes using iron oxide particles as carriers enables in-vivo labeling of migrating neural precursors for magnetic resonance imaging and optical imaging
    James P Sumner
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Laboratory of Functional and Molecular Imaging, Bethesda, Maryland 20892, USA
    J Biomed Opt 12:051504. 2007
    ..These data suggest that using MPIOs to deliver fluorescent probes should make it possible to combine MRI and optical imaging for in vivo cell tracking...
  12. pmc Effect of IL-1beta-induced macromolecular depletion on residual quadrupolar interaction in articular cartilage
    Arijitt Borthakur
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6100, USA
    J Magn Reson Imaging 15:315-23. 2002
    ..The purpose of this work was to quantify the effect of interleukin-1 (IL-1beta)-induced macromolecule depletion on the residual quadrupolar interaction (RQI) of sodium in bovine cartilage plugs...
  13. pmc Controlled aggregation of ferritin to modulate MRI relaxivity
    Kevin M Bennett
    Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD 20892 1065, USA
    Biophys J 95:342-51. 2008
    ..The modulation of ferritin aggregation by binding to cytoskeletal elements may be a useful strategy to make a functional reporter gene for magnetic resonance imaging...
  14. ncbi request reprint Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells
    Kathleen A Hinds
    Hematology Branch, Laboratory of Molecular Biology, Laboratory National Heart, Lung, and Blood Institute NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:867-72. 2003
    ..MRI studies could detect labeled CD34+ cells and mesenchymal stem cells (MSCs) at single cell resolution. This appears to be a promising tool for serial noninvasive monitoring of in vivo cell homing and localization using MRI...
  15. ncbi request reprint Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brain
    Erik M Shapiro
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 32:1150-7. 2006
    ..This work demonstrates that in vivo cell labeling of progenitor cells for MRI is possible and enables the serial, non-invasive visualization of endogenous progenitor/precursor cell migration...
  16. pmc Self-assembling DNA quadruplex conjugated to MRI contrast agents
    Jianfeng Cai
    Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, USA
    Bioconjug Chem 20:205-8. 2009
    ..Importantly, the DNA quadruplex scaffold is approximately 2.5 nm(3) in size, potentially enabling this type of contrast agent to be used for targeted delivery in vivo to detect specific cells or tissues, even behind intact blood vessels...
  17. ncbi request reprint Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI
    Erik M Shapiro
    Molecular and Cellular Imaging Laboratory, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Contrast Media Mol Imaging 2:147-53. 2007
    ..Therefore, the use of MPIOs for achieving high iron concentrations for cellular MRI is potentially an effective new modality for non-invasive imaging of lymphocytes...
  18. ncbi request reprint Cellular magnetic resonance imaging: nanometer and micrometer size particles for noninvasive cell localization
    Jonathan R Slotkin
    Department of Neurosurgery, The Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurotherapeutics 4:428-33. 2007
    ..The ability of this technique to allow for the noninvasive detection of in vivo transplants on the single-cell level is highlighted...
  19. pmc Convertible manganese contrast for molecular and cellular MRI
    Erik M Shapiro
    Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510 8043, USA
    Magn Reson Med 60:265-9. 2008
    ..These particles are the potential building blocks for an entire class of new environmentally responsive MRI contrast agents...
  20. ncbi request reprint Detection of the anoxic depolarization of focal ischemia using manganese-enhanced MRI
    Ichio Aoki
    Department of Neurosurgery, Meiji University of Oriental Medicine, Kyoto, Japan
    Magn Reson Med 50:7-12. 2003
    ..0 +/- 17.5% in MCAO group and 108.4 +/- 13.2% in the sham group. In addition, the enhanced region was much smaller than the area which was detected as having a reduced ADC...