Wei Shao

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy
    Wei Shao
    Advanced Biomedical Computing Center, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD, USA
    Retrovirology 6:101. 2009
  2. ncbi request reprint PAPNC, a novel method to calculate nucleotide diversity from large scale next generation sequencing data
    Wei Shao
    Advanced Biomedical Computing Center, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, United States Electronic address
    J Virol Methods 203:73-80. 2014
  3. pmc Analysis of 454 sequencing error rate, error sources, and artifact recombination for detection of Low-frequency drug resistance mutations in HIV-1 DNA
    Wei Shao
    Advanced Biomedical Computing Center, SAIC Frederick, Frederick National Laboratory for Cancer Research, PO Box B, Frederick, MD, USA
    Retrovirology 10:18. 2013
  4. pmc Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy
    Mary Kearney
    HIV Drug Resistance Program, National Cancer Institute at Frederick, 1050 Boyles Street, Building 535, Room 109, Frederick, MD 21702 1201, USA
    J Virol 85:1067-76. 2011
  5. pmc Ultrasensitive allele-specific PCR reveals rare preexisting drug-resistant variants and a large replicating virus population in macaques infected with a simian immunodeficiency virus containing human immunodeficiency virus reverse transcriptase
    Valerie F Boltz
    HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA
    J Virol 86:12525-30. 2012
  6. pmc HIV populations are large and accumulate high genetic diversity in a nonlinear fashion
    Frank Maldarelli
    HIV Drug Resistance Program, NCI Frederick, NIH, Frederick, Maryland, USA
    J Virol 87:10313-23. 2013
  7. pmc Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy
    Zandrea Ambrose
    HIV Drug Resistance Program, National Cancer Institute, Building 535, Room 123, Frederick, MD 21702, USA
    J Virol 81:12145-55. 2007
  8. pmc Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase
    Mary Kearney
    HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    AIDS 22:497-501. 2008
  9. ncbi request reprint Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication
    Michael E Abram
    HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA
    J Virol 88:7589-601. 2014
  10. pmc Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication
    Michael E Abram
    HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    J Virol 84:9864-78. 2010

Detail Information

Publications10

  1. pmc RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy
    Wei Shao
    Advanced Biomedical Computing Center, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD, USA
    Retrovirology 6:101. 2009
    ..Bioinformatics tools were constructed to trace individual genomes from the beginning of infection to the end of the treatment...
  2. ncbi request reprint PAPNC, a novel method to calculate nucleotide diversity from large scale next generation sequencing data
    Wei Shao
    Advanced Biomedical Computing Center, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, United States Electronic address
    J Virol Methods 203:73-80. 2014
    ..A Perl script implementing this method is available upon request. ..
  3. pmc Analysis of 454 sequencing error rate, error sources, and artifact recombination for detection of Low-frequency drug resistance mutations in HIV-1 DNA
    Wei Shao
    Advanced Biomedical Computing Center, SAIC Frederick, Frederick National Laboratory for Cancer Research, PO Box B, Frederick, MD, USA
    Retrovirology 10:18. 2013
    ..We evaluated the performance of 454 sequencing for characterizing HIV populations with defined allele frequencies...
  4. pmc Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy
    Mary Kearney
    HIV Drug Resistance Program, National Cancer Institute at Frederick, 1050 Boyles Street, Building 535, Room 109, Frederick, MD 21702 1201, USA
    J Virol 85:1067-76. 2011
    ....
  5. pmc Ultrasensitive allele-specific PCR reveals rare preexisting drug-resistant variants and a large replicating virus population in macaques infected with a simian immunodeficiency virus containing human immunodeficiency virus reverse transcriptase
    Valerie F Boltz
    HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA
    J Virol 86:12525-30. 2012
    ..The rapid increase of 103N mutations from <0.001% to 20% of the viral population indicates that the replicating virus population size in RT-SHIV-infected macaques must be 10(6) or more infected cells per replication cycle...
  6. pmc HIV populations are large and accumulate high genetic diversity in a nonlinear fashion
    Frank Maldarelli
    HIV Drug Resistance Program, NCI Frederick, NIH, Frederick, Maryland, USA
    J Virol 87:10313-23. 2013
    ....
  7. pmc Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy
    Zandrea Ambrose
    HIV Drug Resistance Program, National Cancer Institute, Building 535, Room 123, Frederick, MD 21702, USA
    J Virol 81:12145-55. 2007
    ..By contrast, ART effectively suppressed RT-SHIV in 5/6 animals. These data indicate that suboptimal therapy facilitates HIV-1 drug resistance and suggest that this model can be used to investigate persisting viral reservoirs...
  8. pmc Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase
    Mary Kearney
    HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    AIDS 22:497-501. 2008
    ..Failure of antiretroviral therapy may result from the selection of pre-existing, drug-resistant HIV-1 variants, but the frequency and type of such variants have not been defined...
  9. ncbi request reprint Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication
    Michael E Abram
    HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA
    J Virol 88:7589-601. 2014
    ..This could, by implication, affect the generation of drug-resistant mutants and immunological-escape mutants in patients...
  10. pmc Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication
    Michael E Abram
    HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    J Virol 84:9864-78. 2010
    ..The pattern of hot spots seen in lacZalpha in vivo did not match any of the published data obtained when purified RT was used to copy lacZalpha in vitro...