Jeffrey G Shannon

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Yersinia pestis subverts the dermal neutrophil response in a mouse model of bubonic plague
    Jeffrey G Shannon
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutesof Health, Hamilton, Montana, USA
    MBio 4:e00170-13. 2013
  2. pmc Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independent
    Jeffrey G Shannon
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    BMC Immunol 10:26. 2009
  3. pmc Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages
    Dale Howe
    Coxiella Pathogenesis Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 78:3465-74. 2010
  4. ncbi request reprint Infection of human monocyte-derived macrophages with Coxiella burnetii
    Jeffrey G Shannon
    Coxiella Pathogenesis Section, Laboratory of Interacellular Parasites, Rocky Mountain Laboratoties, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Methods Mol Biol 431:189-200. 2008
  5. ncbi request reprint Lack of dendritic cell maturation following infection by Coxiella burnetii synthesizing different lipopolysaccharide chemotypes
    Jeffrey G Shannon
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Ann N Y Acad Sci 1063:154-60. 2005
  6. pmc Specificity of Legionella pneumophila and Coxiella burnetii vacuoles and versatility of Legionella pneumophila revealed by coinfection
    John Demian Sauer
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 S 4th St, Hamilton, MT 59840, USA
    Infect Immun 73:4494-504. 2005
  7. pmc Adaptive immunity to the obligate intracellular pathogen Coxiella burnetii
    Jeffrey G Shannon
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, USA
    Immunol Res 43:138-48. 2009
  8. pmc Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist
    Sonja M Best
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    J Virol 79:12828-39. 2005
  9. pmc Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexes
    Paul J Brett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    Mol Microbiol 63:379-90. 2007
  10. doi request reprint Yersinia pestis survival and replication within human neutrophil phagosomes and uptake of infected neutrophils by macrophages
    Justin L Spinner
    1 Rocky Mountain Laboratories, NIAID, NIH, 903 South 4th St, Hamilton, MT 59840, USA
    J Leukoc Biol 95:389-98. 2014

Collaborators

Detail Information

Publications11

  1. pmc Yersinia pestis subverts the dermal neutrophil response in a mouse model of bubonic plague
    Jeffrey G Shannon
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutesof Health, Hamilton, Montana, USA
    MBio 4:e00170-13. 2013
    ..Taken together, the results of this study show a very rapid, robust neutrophil response to Y. pestis in the dermis and that the virulence plasmid pCD1 is important for the evasion of this response...
  2. pmc Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independent
    Jeffrey G Shannon
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    BMC Immunol 10:26. 2009
    ..The mechanism of this Ab-mediated protection is unknown. Therefore, we conducted a study to determine whether Fc receptors (FcR) or complement contribute to Ab-mediated immunity (AMI) to C. burnetii...
  3. pmc Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages
    Dale Howe
    Coxiella Pathogenesis Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 78:3465-74. 2010
    ..burnetii does not actively inhibit phagolysosome function as a survival mechanism. Instead, NMI and NMII resist degradation to replicate in indistinguishable digestive PVs that fully mature through the endolysosomal pathway...
  4. ncbi request reprint Infection of human monocyte-derived macrophages with Coxiella burnetii
    Jeffrey G Shannon
    Coxiella Pathogenesis Section, Laboratory of Interacellular Parasites, Rocky Mountain Laboratoties, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Methods Mol Biol 431:189-200. 2008
    ....
  5. ncbi request reprint Lack of dendritic cell maturation following infection by Coxiella burnetii synthesizing different lipopolysaccharide chemotypes
    Jeffrey G Shannon
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Ann N Y Acad Sci 1063:154-60. 2005
    ..Our data indicate that LPS chemotype is not a determinant of DC maturation or cytokine production in response to C. burnetii...
  6. pmc Specificity of Legionella pneumophila and Coxiella burnetii vacuoles and versatility of Legionella pneumophila revealed by coinfection
    John Demian Sauer
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 S 4th St, Hamilton, MT 59840, USA
    Infect Immun 73:4494-504. 2005
    ..pneumophila replication vacuole. Moreover, L. pneumophila can replicate efficiently in either lysosomal vacuoles of A/J mouse cells or in nonlysosomal vacuoles of primate cells...
  7. pmc Adaptive immunity to the obligate intracellular pathogen Coxiella burnetii
    Jeffrey G Shannon
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, USA
    Immunol Res 43:138-48. 2009
    ..burnetii are needed. This review summarizes our current understanding of adaptive immunity to C. burnetii with a focus on recent developments in the field...
  8. pmc Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist
    Sonja M Best
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    J Virol 79:12828-39. 2005
    ..Because NS5 may interfere with both innate and acquired immune responses to virus infection, this protein may have a significant role in viral pathogenesis...
  9. pmc Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexes
    Paul J Brett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    Mol Microbiol 63:379-90. 2007
    ..Based upon these results, it appears that B. mallei LPS is likely to play a significant role in the pathogenesis of human disease...
  10. doi request reprint Yersinia pestis survival and replication within human neutrophil phagosomes and uptake of infected neutrophils by macrophages
    Justin L Spinner
    1 Rocky Mountain Laboratories, NIAID, NIH, 903 South 4th St, Hamilton, MT 59840, USA
    J Leukoc Biol 95:389-98. 2014
    ..pestis) and increased secretion of the anti-inflammatory cytokine IL-1ra. Thus, Y. pestis can survive and replicate within PMNs, and infected PMNs may be a route for noninflammatory infection of macrophages. ..
  11. pmc Virulent Coxiella burnetii does not activate human dendritic cells: role of lipopolysaccharide as a shielding molecule
    Jeffrey G Shannon
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 102:8722-7. 2005
    ..This immune evasion strategy may allow C. burnetii to persist in an immunocompetent host...